PDBsum entry: 1z8f

Transferase

PDB id: 1z8f

Contents

Protein chain

184 a.a. *

Ligands

FMT ×2

Waters ×22

* Residue conservation analysis

PDB id:

1z8f

Name:

Transferase

Title:

Guanylate kinase double mutant a58c, t157c from mycobacteriu tuberculosis (rv1389)

Structure:

Guanylate kinase. Chain: a. Synonym: gmp kinase. Engineered: yes. Mutation: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: gmk. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.50Å R-factor: 0.183 R-free: 0.236

Authors:

S.Chan,M.R.Sawaya,B.Choi,G.Zocchi,L.J.Perry,Mycobacterium Tuberculosis Structural Proteomics Project (Xmtb)

Key ref:

S.Chan et al. Crystal structure of guanylate kinase from mycobacterium tuberculosis (rv1389). To be published,

Date:

30-Mar-05 Release date: 12-Apr-05

Protein chain

P0A5I4  (KGUA_MYCTU) -  Guanylate kinase

Seq: 208 a.a.

Struc: 184 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.4.8 - Guanylate kinase.
• Reaction: ATP + GMP = ADP + GDP

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (1 term)
• Biological process: growth (3 terms)
• Biochemical function: nucleotide binding (10 terms)