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Contents |
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* Residue conservation analysis
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PDB id:
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Ligase
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Title:
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Novel ubiquitin-conjugating enzyme
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Structure:
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Ubiquitin-conjugating ligase mgc351130. Chain: a. Fragment: residues 1-150. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: mgc35130. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: the n-terminal cloning tag mgsshhhhhhssglvprgs has not been removed from the protein
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Biol. unit:
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Tetramer (from
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Resolution:
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2.18Å
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R-factor:
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0.244
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R-free:
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0.294
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Authors:
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J.R.Walker,J.Choe,G.V.Avvakumov,E.M.Newman,F.Mackenzie, M.Sundstrom,C.Arrowsmith,A.Edwards,A.Bochkarev,S.Dhe- Paganon,Structural Genomics Consortium (Sgc)
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Key ref:
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J.R.Walker
et al.
Novel ubiquitin-Conjugating enzyme.
To be published,
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Date:
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04-Feb-05
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Release date:
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22-Mar-05
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PROCHECK
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Headers
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References
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Q5VVX9
(UBE2U_HUMAN) -
Ubiquitin-conjugating enzyme E2 U
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Seq:
Struc:
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321 a.a.
153 a.a.
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Key: |
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PfamA domain |
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PfamB domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.6.3.2.19
- Ubiquitin--protein ligase.
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Reaction:
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ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
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ATP
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+
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ubiquitin
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+
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protein lysine
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=
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AMP
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+
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diphosphate
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+
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protein N-ubiquityllysine
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Gene Ontology (GO) functional annotation
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Biological process
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regulation of protein metabolic process
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2 terms
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Biochemical function
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small conjugating protein ligase activity
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1 term
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Links
