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PDBsum entry 1y0m

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protein links
Hydrolase PDB id
1y0m
Jmol
Contents
Protein chain
61 a.a. *
Waters ×122
* Residue conservation analysis
PDB id:
1y0m
Name: Hydrolase
Title: Crystal structure of of the sh3 domain of phospholipasE C gamma-1
Structure: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1. Chain: a. Fragment: sh3 domain: sequence database residues 791-851. Synonym: phosphoinositide phospholipasE C, plc-gamma-1, phospholipasE C-gamma-1, plc-ii, plc-148. Engineered: yes. Mutation: yes
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: plcg1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.20Å     R-factor:   0.151     R-free:   0.177
Authors: R.Mariuzza,C.Sangwoo
Key ref: R.Mariuzza and c.sangwoo Crystal structure of of the sh3 domain of phospholipase c gamma-1. To be published, .
Date:
15-Nov-04     Release date:   21-Feb-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P10686  (PLCG1_RAT) -  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1290 a.a.
61 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.1.4.11  - Phosphoinositide phospholipase C.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
myo-Inositol Phosphate Metabolism
      Reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
+ H(2)O
= 1D-myo-inositol 1,4,5-trisphosphate
+ diacylglycerol
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     intracellular signal transduction   1 term