PDBsum entry 1y0h

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Structural genomics, unknown function PDB id
Protein chains
101 a.a. *
ACT ×3
Waters ×208
* Residue conservation analysis
PDB id:
Name: Structural genomics, unknown function
Title: Structure of rv0793 from mycobacterium tuberculosis
Structure: Hypothetical protein rv0793. Chain: a, b. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: rv0793. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PQS)
1.60Å     R-factor:   0.202     R-free:   0.219
Authors: M.J.Lemieux,C.Ference,M.M.Cherney,M.Wang,C.Garen,M.N.James,T Structural Genomics Consortium (Tbsgc)
Key ref: M.J.Lemieux et al. (2005). The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis. J Struct Funct Genomics, 6, 245-257. PubMed id: 16496224
15-Nov-04     Release date:   28-Dec-04    
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Protein chains
Pfam   ArchSchema ?
O86332  (O86332_MYCTU) -  Putative monooxygenase Rv0793
101 a.a.
101 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   1 term 
  Biochemical function     oxidoreductase activity     2 terms  


J Struct Funct Genomics 6:245-257 (2005)
PubMed id: 16496224  
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis.
M.J.Lemieux, C.Ference, M.M.Cherney, M.Wang, C.Garen, M.N.James.
Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6 A resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.