PDBsum entry 1xp9

Go to PDB code: 
protein ligands links
Hormone/growth factor receptor PDB id
Protein chain
245 a.a. *
Waters ×159
* Residue conservation analysis
PDB id:
Name: Hormone/growth factor receptor
Title: Human estrogen receptor alpha ligand-binding domain in compl compound 18
Structure: Estrogen receptor. Chain: a. Fragment: ligand binding domain. Synonym: er, estradiol receptor, er-alpha. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: esr1, nr3a1, esr. Expressed in: escherichia coli. Expression_system_taxid: 562
Biol. unit: Dimer (from PDB file)
1.80Å     R-factor:   0.187     R-free:   0.299
Authors: P.M.D.Fitzgerald,N.Sharma
Key ref: T.A.Blizzard et al. (2005). Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers. Bioorg Med Chem Lett, 15, 107-113. PubMed id: 15582421 DOI: 10.1016/j.bmcl.2004.10.036
08-Oct-04     Release date:   07-Dec-04    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
P03372  (ESR1_HUMAN) -  Estrogen receptor
595 a.a.
245 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     3 terms  


DOI no: 10.1016/j.bmcl.2004.10.036 Bioorg Med Chem Lett 15:107-113 (2005)
PubMed id: 15582421  
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
T.A.Blizzard, F.Dininno, J.D.Morgan, H.Y.Chen, J.Y.Wu, S.Kim, W.Chan, E.T.Birzin, Y.T.Yang, L.Y.Pai, P.M.Fitzgerald, N.Sharma, Y.Li, Z.Zhang, E.C.Hayes, C.A.Dasilva, W.Tang, S.P.Rohrer, J.M.Schaeffer, M.L.Hammond.
A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.

Literature references that cite this PDB file's key reference

  PubMed id Reference
19063592 A.Amadasi, A.Mozzarelli, C.Meda, A.Maggi, and P.Cozzini (2009).
Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach.
  Chem Res Toxicol, 22, 52-63.  
17456742 F.F.Vajdos, L.R.Hoth, K.F.Geoghegan, S.P.Simons, P.K.LeMotte, D.E.Danley, M.J.Ammirati, and J.Pandit (2007).
The 2.0 A crystal structure of the ERalpha ligand-binding domain complexed with lasofoxifene.
  Protein Sci, 16, 897-905.
PDB code: 2ouz
16914190 P.Ascenzi, A.Bocedi, and M.Marino (2006).
Structure-function relationship of estrogen receptor alpha and beta: impact on human health.
  Mol Aspects Med, 27, 299-402.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.