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Cell adhesion
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PDB id
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1xm9
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Contents |
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* Residue conservation analysis
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Gene Ontology (GO) functional annotation
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Biochemical function
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binding
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1 term
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DOI no:
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J Mol Biol
346:367-376
(2005)
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PubMed id:
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Structure of the armadillo repeat domain of plakophilin 1.
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H.J.Choi,
W.I.Weis.
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ABSTRACT
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The p120ctn subfamily of armadillo domain proteins has roles in modulating
intercellular adhesion by cadherin-containing junctions. We have determined the
crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member
of the p120ctn subfamily that is found in desmosomes. The structure reveals that
the domain has nine instead of the expected ten arm repeats. A sequence
predicted to be an arm repeat is instead a large insert which serves as a wedge
that produces a significant bend in the overall domain structure.
Structure-based sequence alignments indicate that the nine repeats and large
insert are common to this subfamily of armadillo proteins. A prominent basic
patch on the surface of the protein may serve as a binding site for partners of
these proteins.
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Selected figure(s)
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Figure 5.
Figure 5. Comparison of repeat motif structures. (a) A
comparison of PKP1 R3 with b-catenin R3. The backbones are
overlaid on the left. The individual repeats are shown on the
right, with the side-chains of the conserved consensus residues
shown in ball-and-stick representation. (b) A comparison of PKP1
arm repeat 3 with importin-b HEAT repeat 3.
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Figure 6.
Figure 6. The effect of the H1-H2 turn on arm repeat
structure. Comparison of PKP1 repeat 4, which does not contain
the glycine residue found frequently in the H1-H2 turn, with
b-catenin repeat 3, which has this glycine residue.
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The above figures are
reprinted
by permission from Elsevier:
J Mol Biol
(2005,
346,
367-376)
copyright 2005.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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A.Al-Amoudi,
D.Castaño-Diez,
D.P.Devos,
R.B.Russell,
G.T.Johnson,
and
A.S.Frangakis
(2011).
The three-dimensional molecular structure of the desmosomal plaque.
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Proc Natl Acad Sci U S A, 108,
6480-6485.
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H.A.Thomason,
A.Scothern,
S.McHarg,
and
D.R.Garrod
(2010).
Desmosomes: adhesive strength and signalling in health and disease.
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Biochem J, 429,
419-433.
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N.Ishiyama,
S.H.Lee,
S.Liu,
G.Y.Li,
M.J.Smith,
L.F.Reichardt,
and
M.Ikura
(2010).
Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.
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Cell, 141,
117-128.
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PDB codes:
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P.D.McCrea,
and
D.Gu
(2010).
The catenin family at a glance.
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J Cell Sci, 123,
637-642.
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S.Neuber,
M.Mühmer,
D.Wratten,
P.J.Koch,
R.Moll,
and
A.Schmidt
(2010).
The desmosomal plaque proteins of the plakophilin family.
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Dermatol Res Pract, 2010,
101452.
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A.E.Bass-Zubek,
L.M.Godsel,
M.Delmar,
and
K.J.Green
(2009).
Plakophilins: multifunctional scaffolds for adhesion and signaling.
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Curr Opin Cell Biol, 21,
708-716.
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D.Gu,
A.K.Sater,
H.Ji,
K.Cho,
M.Clark,
S.A.Stratton,
M.C.Barton,
Q.Lu,
and
P.D.McCrea
(2009).
Xenopus delta-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases.
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J Cell Sci, 122,
4049-4061.
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E.Delva,
D.K.Tucker,
and
A.P.Kowalczyk
(2009).
The desmosome.
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Cold Spring Harbor Perspect Biol, 1,
a002543.
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L.Shapiro,
and
W.I.Weis
(2009).
Structure and biochemistry of cadherins and catenins.
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Cold Spring Harbor Perspect Biol, 1,
a003053.
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D.Acehan,
C.Petzold,
I.Gumper,
D.D.Sabatini,
E.J.Müller,
P.Cowin,
and
D.L.Stokes
(2008).
Plakoglobin is required for effective intermediate filament anchorage to desmosomes.
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J Invest Dermatol, 128,
2665-2675.
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S.E.Grosskurth,
D.Bhattacharya,
Q.Wang,
and
J.J.Lin
(2008).
Emergence of Xin demarcates a key innovation in heart evolution.
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PLoS ONE, 3,
e2857.
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D.L.Stokes
(2007).
Desmosomes from a structural perspective.
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Curr Opin Cell Biol, 19,
565-571.
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J.E.Lai-Cheong,
K.Arita,
and
J.A.McGrath
(2007).
Genetic diseases of junctions.
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J Invest Dermatol, 127,
2713-2725.
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J.Uitto,
G.Richard,
and
J.A.McGrath
(2007).
Diseases of epidermal keratins and their linker proteins.
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Exp Cell Res, 313,
1995-2009.
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K.J.Green,
and
C.L.Simpson
(2007).
Desmosomes: new perspectives on a classic.
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J Invest Dermatol, 127,
2499-2515.
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S.Pokutta,
and
W.I.Weis
(2007).
Structure and mechanism of cadherins and catenins in cell-cell contacts.
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Annu Rev Cell Dev Biol, 23,
237-261.
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J.A.McGrath
(2005).
Inherited disorders of desmosomes.
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Australas J Dermatol, 46,
221-229.
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J.K.Wahl
(2005).
A role for plakophilin-1 in the initiation of desmosome assembly.
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J Cell Biochem, 96,
390-403.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
