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Isomerase PDB id
1x94
Jmol
Contents
Protein chains
176 a.a. *
Waters ×68
* Residue conservation analysis
PDB id:
1x94
Name: Isomerase
Title: Crystal structure of a hypothetical protein
Structure: Putative phosphoheptose isomerase. Chain: a, b. Engineered: yes
Source: Vibrio cholerae. Organism_taxid: 666. Gene: lpca, gmha. Expressed in: escherichia coli. Expression_system_taxid: 562
Biol. unit: Tetramer (from PQS)
Resolution:
2.50Å     R-factor:   0.229     R-free:   0.285
Authors: J.Seetharaman,S.Swaminathan,S.K.Burley,New York Sgx Research For Structural Genomics (Nysgxrc)
Key ref:
J.Seetharaman et al. (2006). Crystal structures of two putative phosphoheptose isomerases. Proteins, 63, 1092-1096. PubMed id: 16477602 DOI: 10.1002/prot.20908
Date:
19-Aug-04     Release date:   14-Sep-04    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9KPY2  (GMHA_VIBCH) -  Phosphoheptose isomerase
Seq:
Struc: 		191 a.a.
176 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.5.3.1.28  - D-sedoheptulose 7-phosphate isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate
D-sedoheptulose 7-phosphate
 = D-glycero-D-manno-heptose 7-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     carbohydrate metabolic process   3 terms 
  Biochemical function     isomerase activity     4 terms  

 

 
    Added reference    
 
 
DOI no: 10.1002/prot.20908 Proteins 63:1092-1096 (2006)
PubMed id: 16477602  
 
 
Crystal structures of two putative phosphoheptose isomerases.
J.Seetharaman, K.R.Rajashankar, V.Solorzano, R.Kniewel, C.D.Lima, J.B.Bonanno, S.K.Burley, S.Swaminathan.
 
  ABSTRACT  
 
No abstract given.

 
  Selected figure(s)  
 
Figure 1.
Figure 1. Secondary structural elements of T1485 and T1512. Helix H3 shown in gray is absent in T1485. 		Figure 3.
Figure 3. Sequence comparison of T1485 (1X94) and T1512 (1TK9) with Phosphoheptose Isomerase (1TK9), Phosphoglucose/Phosphomannose Isomerase (1TZC), and Isomerase Domain of Glucosamine 6-Phosphate Synthase (1MOQ). PO4 binding site residues are highlighted in black with white lettering. Conserved residues in T1485 and T1512 are denoted in gray.
 
  The above figures are reprinted from an Open Access publication published by John Wiley & Sons, Inc.: Proteins (2006, 63, 1092-1096) copyright 2006.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
19234762 Y.Kim, P.Quartey, R.Ng, T.I.Zarembinski, and A.Joachimiak (2009).
Crystal structure of YfeU protein from Haemophilus influenzae: a predicted etherase involved in peptidoglycan recycling.
  J Struct Funct Genomics, 10, 151-156.  
18056714 P.L.Taylor, K.M.Blakely, G.P.de Leon, J.R.Walker, F.McArthur, E.Evdokimova, K.Zhang, M.A.Valvano, G.D.Wright, and M.S.Junop (2008).
Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants.
  J Biol Chem, 283, 2835-2845.
PDB codes: 1x92 2i22 2i2w 3bjz
17683397 G.Natrajan, D.R.Hall, A.C.Thompson, I.Gutsche, and L.Terradot (2007).
Structural similarity between the DnaA-binding proteins HobA (HP1230) from Helicobacter pylori and DiaA from Escherichia coli.
  Mol Microbiol, 65, 995.
PDB code: 2uvp
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.