PDBsum entry: 1x48

RNA binding protein

PDB id: 1x48

Contents

Protein chain

88 a.a. *

* Residue conservation analysis

PDB id:

1x48

Name:

RNA binding protein

Title:

Solution structure of the second dsrm domain in interferon- induced, double-stranded RNA-activated protein kinase

Structure:

Interferon-induced, double-stranded RNA- activated protein kinase. Chain: a. Fragment: dsrm domain. Synonym: interferon-inducible RNA-dependent protein kinase, p68 kinase, p1/eif-2a protein kinase, serine/threonine- protein kinase tik. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: prkr, eif2ak2, pkr, tik. Other_details: cell free protein synthesis

NMR struc:

20 models

Authors:

F.He,Y.Muto,M.Inoue,T.Tarada,M.Shirouzu,T.Kigawa,S.Yokoyama, Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

F.He et al. Solution structure of the second dsrm domain in interferon-Induced, Double-Stranded RNA-Activated protein kinase. To be published,

Date:

14-May-05 Release date: 14-Nov-05

Protein chain

Q03963  (E2AK2_MOUSE) -  Interferon-induced, double-stranded RNA-activated protein kinase

Seq: 515 a.a.

Struc: 88 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class 1: E.C.2.7.10.2 - Non-specific protein-tyrosine kinase.
• Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
• Enzyme class 2: E.C.2.7.11.1 - Non-specific serine/threonine protein kinase.
• Reaction: ATP + a protein = ADP + a phosphoprotein

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: intracellular (1 term)
• Biochemical function: RNA binding (2 terms)