 |
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Ligase
|
|
|
Title:
|
|
Crystal structure of ubch8
|
|
Structure:
|
|
Ubiquitin-conjugating enzyme e2 l6. Chain: a, b. Synonym: ubiquitin-conjugating enzyme ubch8, ubiquitin- protein ligase l6, ubiquitin carrier protein l6, ubch8, retinoic acid induced gene b protein, rig-b. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
Resolution:
|
|
|
2.10Å
|
R-factor:
|
0.210
|
R-free:
|
0.267
|
|
|
Authors:
|
|
T.Mizushima,M.Suzuki,N.Teshima,T.Yamane,S.Murata,K.Tanaka
|
|
Key ref:
|
|
T.Mizushima
et al.
Crystal structure of ubch8.
To be published,
|
|
|
Date:
|
|
|
10-Mar-05
|
Release date:
|
22-Mar-05
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
|
|
|
|
O14933
(UB2L6_HUMAN) -
Ubiquitin/ISG15-conjugating enzyme E2 L6
|
|
|
|
Seq:
Struc:
|
|
|
|
153 a.a.
150 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.6.3.2.19
- Ubiquitin--protein ligase.
|
|
|
|
|
|
|
Reaction:
|
|
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
|
|
|
|
|
|
ATP
|
+
|
ubiquitin
|
+
|
protein lysine
|
=
|
AMP
|
+
|
diphosphate
|
+
|
protein N-ubiquityllysine
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
Gene Ontology (GO) functional annotation
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Biological process
|
regulation of protein metabolic process
|
5 terms
|
|
|
Biochemical function
|
protein binding
|
5 terms
|
|
|
|
|
|
|
|
|
|
|
Links
