spacer
spacer

PDBsum entry 1wxj

Go to PDB code: 
protein ligands links
Lyase PDB id
1wxj
Jmol
Contents
Protein chain
239 a.a. *
Ligands
SO4 ×4
IPL
Waters ×278
* Residue conservation analysis
PDB id:
1wxj
Name: Lyase
Title: Crystal structure of tryptophan synthase a-subunit with indo propanol phosphate from thermus thermophilus hb8
Structure: Tryptophan synthase alpha chain. Chain: a. Synonym: tryptophan synthase a-subunit. Engineered: yes
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Resolution:
1.70Å     R-factor:   0.189     R-free:   0.210
Authors: Y.Asada,N.Kunishima,Riken Structural Genomics/proteomics Ini (Rsgi)
Key ref: Y.Asada and n.kunishima Crystal structure of tryptophan synthase a-Subunit with indole-3-Propanol phosphate from thermus thermophilus hb8. To be published, .
Date:
24-Jan-05     Release date:   01-Feb-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P16608  (TRPA_THET2) -  Tryptophan synthase alpha chain
Seq:
Struc:
271 a.a.
239 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.20  - Tryptophan synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Tryptophan Biosynthesis
      Reaction: L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
L-serine
+
1-C-(indol-3-yl)glycerol 3-phosphate
Bound ligand (Het Group name = IPL)
matches with 89.47% similarity
= L-tryptophan
+ D-glyceraldehyde 3-phosphate
+ H(2)O
      Cofactor: Pyridoxal 5'-phosphate
Pyridoxal 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     metabolic process   5 terms 
  Biochemical function     catalytic activity     3 terms