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protein ligands metals links
Ligase PDB id
1wl8
Jmol
Contents
Protein chain
188 a.a. *
Ligands
ACY
Metals
_CL
Waters ×211
* Residue conservation analysis
PDB id:
1wl8
Name: Ligase
Title: Crystal structure of ph1346 protein from pyrococcus horikoshii
Structure: Gmp synthase [glutamine-hydrolyzing] subunit a. Chain: a. Synonym: glutamine amido transferase. Engineered: yes
Source: Pyrococcus horikoshii. Organism_taxid: 53953. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Resolution:
1.45Å     R-factor:   0.156     R-free:   0.174
Authors: N.K.Lokanath,N.Kunishima,Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: N.K.Lokanath and n.kunishima Crystal structure of glutamide amido transferase from pyrococcus horikoshii ot3. To be published,
Date:
21-Jun-04     Release date:   16-Aug-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
O59071  (GUAAA_PYRHO) -  GMP synthase [glutamine-hydrolyzing] subunit A
Seq:
Struc: 		189 a.a.
188 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.6.3.5.2  - Gmp synthase (glutamine-hydrolyzing).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway: 		AMP and GMP Biosynthesis
      Reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate
ATP
 + xanthosine 5'-phosphate
 +
L-glutamine
Bound ligand (Het Group name = ACY)
matches with 40.00% similarity 		+ H(2)O
 = AMP
 + diphosphate
 + GMP
 + L-glutamate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     biosynthetic process   4 terms 
  Biochemical function     catalytic activity     5 terms