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Hydrolase PDB-id
1whb
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Protein chain
157 a.a. *

* Residue conservation analysis
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PDB id: 1whb
Name: Hydrolase
Title: Solution structure of the rhodanese-like domain in human ubiquitin specific protease 8 (ubp8)

Structure:
Kiaa0055. Chain: a. Fragment: rhodanese-like domain. Synonym: ubiquitin specific protease 8, ubp8. Engineered: yes

Source:
Homo sapiens. Human. Organism_taxid: 9606. Gene: kazusa cdna ha01049. Other_details: cell-free protein synthesis

UniProt:
P40818 (UBP8_HUMAN) Pfam   ArchSchema ?
Seq:
Struc:
Seq:
Struc:
Seq:
Struc:
Seq:
Struc:
Seq: 1118 a.a.
Struc: 157 a.a.*
Key:    PfamA domain
 Secondary structure  CATH domain
* PDB and UniProt seqs differ at 10 residue positions (black crosses)

Enzyme class:
E.C.3.1.2.15   [IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

Reaction:
Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol (see diagram below)

Resolution:
not givenÅ

NMR structure:
20 models

Authors:
K.Saito,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:
k.saito et al. solution structure of the rhodanese-like domain in human ubiquitin specific protease 8 (ubp8). TO BE PUBLISHED, .

Date:
28-May-04

Release date:
28-Nov-04

Related entries:
Hsk002000052.1 related db: targetdb
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Enzyme reaction for E.C.3.1.2.15

Ubiquitin C-terminal thiolester
+ H(2)O
= ubiquitin
+
a thiol
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.