PDBsum entry: 1wep

DNA binding protein

PDB id

1wep

Contents

			Protein chain

					79 a.a. *

			Metals

					_ZN ×2

* Residue conservation analysis

PDB id:

1wep

Links
- PDBe
- RCSB
- SRS
- MMDB
- JenaLib
- OCA
- PDBWiki
- Proteopedia
- CATH
- SCOP
- FSSP
- HSSP
- PDBSWS
- BMRB
- ProSAT
- Whatcheck

Name:

DNA binding protein

Title:

Solution structure of phd domain in phf8

Structure:

Phf8. Chain: a. Fragment: phd domain. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 4921501e09. Other_details: cell free protein synthesis

NMR struc:

20 models

Authors:

F.He,M.Inoue,T.Kigawa,M.Shirouzu,T.Terada,Y.Muto,S.Yokoyama, Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

F.He et al. Solution structure of phd domain in protein aa017385. To be published,

Date:

25-May-04

Release date:

25-Nov-04

PROCHECK

	Headers

	References

Protein chain

Q80TJ7 (PHF8_MOUSE) - Histone lysine demethylase PHF8

Seq: Struc:

Seq: Struc:

Seq: Struc:					1023 a.a. 79 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 21 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.1.14.11.27 - [Histone H3]-lysine-36 demethylase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

1.	Protein N₆,N₆-dimethyl-L-lysine + 2-oxoglutarate + O₂ = protein N₆-methyl-L-lysine + succinate + formaldehyde + CO₂
2.	Protein N₆-methyl-L-lysine + 2-oxoglutarate + O₂ = protein L-lysine + succinate + formaldehyde + CO₂

Protein N(6),N(6)-dimethyl-L-lysine	+	2-oxoglutarate	+	O(2)	=	protein N(6)-methyl-L-lysine	+	succinate	+	formaldehyde	+	CO(2)

Protein N(6)-methyl-L-lysine	+	2-oxoglutarate	+	O(2)	=	protein L-lysine	+	succinate	+	formaldehyde	+	CO(2)

Cofactor:

Fe(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site



		Gene Ontology (GO) functional annotation

Biochemical function

protein binding

2 terms