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PDBsum entry 1w20

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protein ligands metals Protein-protein interface(s) links
Hydrolase PDB id
1w20
Jmol
Contents
Protein chains
389 a.a. *
Ligands
SIA ×8
GOL ×4
NAG ×6
NAG-NAG ×3
BMA ×4
MAN ×11
Metals
_CA ×4
Waters ×1727
* Residue conservation analysis
PDB id:
1w20
Name: Hydrolase
Title: Structure of neuraminidase from english duck subtype n6 complexed with 30 mm sialic acid (nana, neu5ac), crystal soaked for 3 hours at 291 k
Structure: Neuraminidase subtype n6. Chain: a, b, c, d. Engineered: yes
Source: Influenza virus type a. Organism_taxid: 11320. Expressed in: gallus gallus. Expression_system_taxid: 9031. Other_details: influenza virus grown in embrionated chicken egg
Biol. unit: Tetramer (from PDB file)
Resolution:
2.08Å     R-factor:   0.153     R-free:   0.195
Authors: E.Rudino-Pinera,P.Tunnah,S.J.Crennell,R.G.Webster,W.G.Laver, E.F.Garman
Key ref: E.Rudino-Pinera et al. The crystal structure of type a influenza virus neuraminidase of the n6 subtype reveals the existence of two separate neu5ac binding sites. To be published, .
Date:
24-Jun-04     Release date:   25-Jan-06    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q6XV27  (NRAM_I56A2) -  Neuraminidase
Seq:
Struc:
470 a.a.
389 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.2.1.18  - Exo-alpha-sialidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   3 terms 
  Biological process     carbohydrate metabolic process   1 term 
  Biochemical function     exo-alpha-sialidase activity     1 term