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PDBsum entry 1vzq
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Hydrolase/hydrolase inhibitor
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PDB id
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1vzq
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Complex of thrombin with designed inhibitor 7165
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Structure:
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Thrombin heavy. Chain: h. Fragment: serine protease domain, residues 364-620. Synonym: coagulation factor ii. Engineered: yes. Hirudin variant-2. Chain: i. Fragment: c-terminal peptide, residues 62-72. Synonym: hirudin iib.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421.
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Biol. unit:
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Trimer (from PDB file)
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Resolution:
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1.54Å
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R-factor:
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0.181
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R-free:
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0.209
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Authors:
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K.Shaerer,M.Morgenthaler,P.Seiler,F.Diederich,D.W.Banner,T.Tschopp, U.Obst-Sander
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Key ref:
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K.Schaerer
et al.
(2004).
Enantiomerically pure thrombin inhibitors for exploring the molecular-Recognition features of the oxyanion hole.
Helv chim acta,
87,
2517.
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Date:
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24-May-04
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Release date:
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20-Jun-05
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PROCHECK
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Headers
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References
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Enzyme class:
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Chains H, L:
E.C.3.4.21.5
- thrombin.
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Reaction:
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Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
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Links
