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PDBsum entry 1vr8

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Signaling protein PDB id
1vr8
Jmol
Contents
Protein chain
135 a.a.
Ligands
AZI ×2
GOL ×3
Waters ×172
PDB id:
1vr8
Name: Signaling protein
Title: Crystal structure of gtp binding regulator (tm1622) from the maritima at 1.75 a resolution
Structure: Gtp binding regulator. Chain: a. Fragment: residues 25-154. Engineered: yes
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm1622. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.75Å     R-factor:   0.150     R-free:   0.182
Authors: Joint Center For Structural Genomics (Jcsg)
Key ref:
Q.Xu et al. (2006). Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins, 65, 777-782. PubMed id: 16948158 DOI: 10.1002/prot.21015
Date:
16-Feb-05     Release date:   15-Mar-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9X1V7  (Q9X1V7_THEMA) -  Uncharacterized protein
Seq:
Struc:
154 a.a.
135 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 8 residue positions (black crosses)

 

 
DOI no: 10.1002/prot.21015 Proteins 65:777-782 (2006)
PubMed id: 16948158  
 
 
Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p.
Q.Xu, S.S.Krishna, D.McMullan, R.Schwarzenbacher, M.D.Miller, P.Abdubek, S.Agarwalla, E.Ambing, T.Astakhova, H.L.Axelrod, J.M.Canaves, D.Carlton, H.J.Chiu, T.Clayton, M.DiDonato, L.Duan, M.A.Elsliger, J.Feuerhelm, S.K.Grzechnik, J.Hale, E.Hampton, G.W.Han, J.Haugen, L.Jaroszewski, K.K.Jin, H.E.Klock, M.W.Knuth, E.Koesema, A.Kreusch, P.Kuhn, A.T.Morse, E.Nigoghossian, L.Okach, S.Oommachen, J.Paulsen, K.Quijano, R.Reyes, C.L.Rife, G.Spraggon, R.C.Stevens, H.van den Bedem, A.White, G.Wolf, K.O.Hodgson, J.Wooley, A.M.Deacon, A.Godzik, S.A.Lesley, I.A.Wilson.
 
  ABSTRACT  
 
No abstract given.

 
  Selected figure(s)  
 
Figure 1.
Figure 1. A: Crystal structure of TM1622. Stereo ribbon diagram of TM1622 monomer color-coded from N-terminus (blue) to C-terminus (red). Helices (H1-H3) and -strands ( 1- 7) are labeled. The structure includes eight residues from the expression and purification tag at the N-terminus. The cloned protein lacks residues 1-24 of the TM1622 gene product. Residue P25, which corresponds to the first TM1622 residue, is indicated. B: Diagram showing the secondary structural elements in TM1622 superimposed on its primary sequence. The -helices, -strands (indicated by red A for -Sheet A), and -bulges are indicated. The -hairpins are depicted as red loops. A dashed line indicates that no electron density was observed for these residues.
Figure 2.
Figure 2. A: Structural superposition of the Ran-binding protein Mogp1 from S. cerevisiae (blue; PDB: 1jhs) and TM1622 (gray; PDB: 1vr8). Regions of Mogp1 proposed to be involved in Ran binding are colored red, and the N-terminal -hairpin is indicated with an arrow. B: Structural superposition of the Ran-binding protein Mogp1 from S. cerevisiae (blue; PDB: 1jhs) and the hypothetical protein Pa94 from P. aeruginosa [chain A (red), chain B (green); PDB: 1tu1]. Pa94 forms a segment-swapped dimer. C: Structural superposition of the PsbP protein (green; PDB: 1v2b) and the hypothetical protein Pa94 from P. aeruginosa (red; PDB: 1tu1).
 
  The above figures are reprinted by permission from John Wiley & Sons, Inc.: Proteins (2006, 65, 777-782) copyright 2006.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
18369189 C.J.McCleverty, L.Columbus, A.Kreusch, and S.A.Lesley (2008).
Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634.
  Protein Sci, 17, 869-877.
PDB codes: 2vkj 2vko
18924109 H.P.Narra, M.H.Cordes, and H.Ochman (2008).
Structural features and the persistence of acquired proteins.
  Proteomics, 8, 4772-4781.  
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