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PDBsum entry 1v93

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protein ligands links
Oxidoreductase PDB id
1v93
Jmol
Contents
Protein chain
292 a.a. *
Ligands
FAD
DIO ×6
Waters ×230
* Residue conservation analysis
PDB id:
1v93
Name: Oxidoreductase
Title: 5,10-methylenetetrahydrofolate reductase from thermus thermo
Structure: 5,10-methylenetetrahydrofolate reductase. Chain: a. Engineered: yes
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PQS)
Resolution:
1.90Å     R-factor:   0.199     R-free:   0.236
Authors: Y.Nakajima,I.Miyahara,K.Hirotsu,Riken Structural Genomics/pr Initiative (Rsgi)
Key ref: Y.Nakajima et al. Crystal structure of 5,10-Methylenetetrahydrofolate reductase from thermus thermophilus hb8. To be published, .
Date:
20-Jan-04     Release date:   03-Feb-04    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9RA47  (Q9RA47_THETH) -  Methylenetetrahydrofolate reductase (Fragment)
Seq:
Struc:
229 a.a.
292 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 11 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.5.1.20  - Methylenetetrahydrofolate reductase (NAD(P)H).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Folate Coenzymes
      Reaction: 5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H
5-methyltetrahydrofolate
+ NAD(P)(+)
= 5,10-methylenetetrahydrofolate
+ NAD(P)H
      Cofactor: FAD
FAD
Bound ligand (Het Group name = FAD) corresponds exactly
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytosol   1 term 
  Biological process     oxidation-reduction process   3 terms 
  Biochemical function     nucleotide binding     3 terms