PDBsum entry: 1u4g

Hydrolase

PDB id: 1u4g

Contents

Protein chain

298 a.a. *

Ligands

SO4

HPI

Metals

_ZN

_CA

Waters ×227

* Residue conservation analysis

PDB id:

1u4g

Name:

Hydrolase

Title:

Elastase of pseudomonas aeruginosa with an inhibitor

Structure:

Elastase. Chain: a. Synonym: pseudolysin. Neutral metalloproteinase. Other_details: inhibited by hpi

Source:

Pseudomonas aeruginosa. Organism_taxid: 287. Secretion: extracellular. Other_details: protein from nagase, japan. Isolated as extracellular protease from cultures of pseudomonas aeruginosa

Resolution:

1.40Å R-factor: 0.180 R-free: 0.197

Authors:

E.Bitto,D.B.Mckay

Key ref:

E.Bitto and d.b.mckay (2004). Elastase of pseudomonas aeruginosa with an inhibitor. To be published,

Date:

25-Jul-04 Release date: 24-Aug-04

Protein chain

P14756  (ELAS_PSEAE) -  Pseudolysin

Seq: 498 a.a.

Struc: 298 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.24.26 - Pseudolysin.
• Reaction: Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic groups at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects.
• Cofactor: Calcium; Zinc

 Gene Ontology (GO) functional annotation 

• Cellular component: extracellular region (1 term)
• Biological process: proteolysis (1 term)
• Biochemical function: metalloendopeptidase activity (1 term)