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PDBsum entry 1th3

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
1th3
Jmol
Contents
Protein chains
499 a.a. *
Ligands
CYN-HEM ×2
HEM ×2
Waters ×688
* Residue conservation analysis
PDB id:
1th3
Name: Oxidoreductase
Title: Crystal structure of NADPH depleted bovine live catalase complexed with cyanide
Structure: Catalase. Chain: a, b, c, d. Ec: 1.11.1.6
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: liver
Biol. unit: Tetramer (from PQS)
Resolution:
2.80Å     R-factor:   0.198     R-free:   0.261
Authors: R.Sugadev,D.Balasundaresan,M.N.Ponnuswamy,D.Kumaran, S.Swaminathan,K.Sekar
Key ref: R.Sugadev et al. The crystal structure of bovine liver catalase. To be published, .
Date:
01-Jun-04     Release date:   05-Jul-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P00432  (CATA_BOVIN) -  Catalase
Seq:
Struc:
 
Seq:
Struc:
527 a.a.
499 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.11.1.6  - Catalase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 2 H2O2 = O2 + 2 H2O
2 × H(2)O(2)
= O(2)
+ 2 × H(2)O
      Cofactor: Heme; Mn(2+)
Heme
Bound ligand (Het Group name = HEM) matches with 95.00% similarity
Mn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   6 terms 
  Biological process     oxidation-reduction process   17 terms 
  Biochemical function     antioxidant activity     12 terms