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PDBsum entry 1tcf

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protein metals links
Calcium-regulated muscle contraction PDB id
1tcf
Jmol
Contents
Protein chain
156 a.a. *
Metals
_CA ×5
Waters ×197
* Residue conservation analysis
PDB id:
1tcf
Name: Calcium-regulated muscle contraction
Title: Crystal structure of calcium-saturated rabbit skeletal troponin c
Structure: Troponin c. Chain: a. Engineered: yes. Mutation: yes
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.90Å     R-factor:   0.278     R-free:   0.358
Authors: J.Soman,G.N.Phillips Jr.
Key ref:
J.Soman et al. (1999). Conformational variation of calcium-bound troponin C. Proteins, 37, 510-511. PubMed id: 10651267 DOI: 10.1002/(SICI)1097-0134(19991201)37:4<510::AID-PROT2>3.3.CO;2-K
Date:
04-Mar-98     Release date:   27-May-98    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P02586  (TNNC2_RABIT) -  Troponin C, skeletal muscle
Seq:
Struc:
160 a.a.
156 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     troponin T binding     3 terms  

 

 
DOI no: 10.1002/(SICI)1097-0134(19991201)37:4<510::AID-PROT2>3.3.CO;2-K Proteins 37:510-511 (1999)
PubMed id: 10651267  
 
 
Conformational variation of calcium-bound troponin C.
J.Soman, T.Tao, G.N.Phillips.
 
  ABSTRACT  
 
No abstract given.

 
  Selected figure(s)  
 
Figure 1.
Figure 1. Diagram illustrating the flexibility of the linker in the central helix of TnC. When the C-domains of the three 4-Ca^2+crystal structures are superposed, the variation in the N-domains is much larger (a) than the variation in the C-domains when the N-domains are superposed (b). This suggests the presence of a hinge region in the central helix where the D-helix enters the C-domain.
 
  The above figure is reprinted by permission from John Wiley & Sons, Inc.: Proteins (1999, 37, 510-511) copyright 1999.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
16243837 T.T.Brandhorst, G.M.Gauthier, R.A.Stein, and B.S.Klein (2005).
Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis.
  J Biol Chem, 280, 42156-42163.  
11423417 Z.Li, J.Gergely, and T.Tao (2001).
Proximity relationships between residue 117 of rabbit skeletal troponin-I and residues in troponin-C and actin.
  Biophys J, 81, 321-333.  
  10933496 C.S.Tung, M.E.Wall, S.C.Gallagher, and J.Trewhella (2000).
A model of troponin-I in complex with troponin-C using hybrid experimental data: the inhibitory region is a beta-hairpin.
  Protein Sci, 9, 1312-1326.
PDB code: 1ew7
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.