PDBsum entry 1spr

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Transferase(phosphotransferase) PDB id
Protein chains
103 a.a. *
Waters ×399
* Residue conservation analysis
PDB id:
Name: Transferase(phosphotransferase)
Title: Binding of a high affinity phosphotyrosyl peptide to the src sh2 domain: crystal structures of the complexed and peptide-free forms
Structure: Src tyrosine kinase sh2 domain. Chain: a, b, c, d. Engineered: yes
Source: Rous sarcoma virus. Organism_taxid: 11886
2.50Å     R-factor:   0.185    
Authors: G.Waksman,J.Kuriyan
Key ref: G.Waksman et al. (1993). Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell, 72, 779-790. PubMed id: 7680960 DOI: 10.1016/0092-8674(93)90405-F
05-Mar-93     Release date:   31-May-94    
Go to PROCHECK summary

Protein chains
Pfam   ArchSchema ?
P00524  (SRC_RSVSA) -  Tyrosine-protein kinase transforming protein Src
526 a.a.
103 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.  - Non-specific protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
+ [protein]-L-tyrosine
+ [protein]-L-tyrosine phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site


DOI no: 10.1016/0092-8674(93)90405-F Cell 72:779-790 (1993)
PubMed id: 7680960  
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.
G.Waksman, S.E.Shoelson, N.Pant, D.Cowburn, J.Kuriyan.
The crystal structure of the Src SH2 domain complexed with a high affinity 11-residue phosphopeptide has been determined at 2.7 A resolution by X-ray diffraction. The peptide binds in an extended conformation and makes primary interactions with the SH2 domain at six central residues: PQ(pY)EEI. The phosphotyrosine and the isoleucine are tightly bound by two well-defined pockets on the protein surface, resulting in a complex that resembles a two-pronged plug engaging a two-holed socket. The glutamate residues are in solvent-exposed environments in the vicinity of basic side chains of the SH2 domain, and the two N-terminal residues cap the phosphotyrosine-binding site. The crystal structure of Src SH2 in the absence of peptide has been determined at 2.5 A resolution, and comparison with the structure of the high affinity complex reveals only localized and relatively small changes.

Literature references that cite this PDB file's key reference

  PubMed id Reference
21419780 D.Close, S.J.Johnson, M.A.Sdano, S.M.McDonald, H.Robinson, T.Formosa, and C.P.Hill (2011).
Crystal Structures of the S. cerevisiae Spt6 Core and C-Terminal Tandem SH2 Domain.
  J Mol Biol, 408, 697-713.
PDB codes: 3psf 3psi 3psj 3psk
21227701 T.Kaneko, S.S.Sidhu, and S.S.Li (2011).
Evolving specificity from variability for protein interaction domains.
  Trends Biochem Sci, 36, 183-190.  
20574521 J.Nachman, G.Gish, C.Virag, T.Pawson, R.Pomès, and E.Pai (2010).
Conformational determinants of phosphotyrosine peptides complexed with the Src SH2 domain.
  PLoS One, 5, e11215.  
20357770 J.Wojcik, O.Hantschel, F.Grebien, I.Kaupe, K.L.Bennett, J.Barkinge, R.B.Jones, A.Koide, G.Superti-Furga, and S.Koide (2010).
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.
  Nat Struct Mol Biol, 17, 519-527.
PDB code: 3k2m
20533885 S.B.Padrick, and M.K.Rosen (2010).
Physical mechanisms of signal integration by WASP family proteins.
  Annu Rev Biochem, 79, 707-735.  
20205869 S.Pati, G.U.Gurudutta, O.P.Kalra, and A.Mukhopadhyay (2010).
The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): An in silico analysis.
  BMC Res Notes, 3, 14.  
20338519 S.Virdee, D.Macmillan, and G.Waksman (2010).
Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives.
  Chem Biol, 17, 274-284.  
19665973 J.H.Bae, E.D.Lew, S.Yuzawa, F.Tomé, I.Lax, and J.Schlessinger (2009).
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
  Cell, 138, 514-524.
PDB codes: 3gqi 3gql
19269286 L.D.Covassin, A.F.Siekmann, M.C.Kacergis, E.Laver, J.C.Moore, J.A.Villefranc, B.M.Weinstein, and N.D.Lawson (2009).
A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development.
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19241406 L.Röglin, F.Altenbrunn, and O.Seitz (2009).
DNA and RNA-controlled switching of protein kinase activity.
  Chembiochem, 10, 758-765.  
19408297 Busch, D.Mignon, and T.Simonson (2009).
Computational protein design as a tool for fold recognition.
  Proteins, 77, 139-158.  
19334714 P.K.Mandal, D.Limbrick, D.R.Coleman, G.A.Dyer, Z.Ren, J.S.Birtwistle, C.Xiong, X.Chen, J.M.Briggs, and J.S.McMurray (2009).
Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.
  J Med Chem, 52, 2429-2442.  
19427382 S.Hammond, A.Wagenknecht-Wiesner, S.L.Veatch, D.Holowka, and B.Baird (2009).
Roles for SH2 and SH3 domains in Lyn kinase association with activated FcepsilonRI in RBL mast cells revealed by patterned surface analysis.
  J Struct Biol, 168, 161-167.  
18767163 W.Gan, and B.Roux (2009).
Binding specificity of SH2 domains: insight from free energy simulations.
  Proteins, 74, 996.  
19502496 Z.Wunderlich, and L.A.Mirny (2009).
Using genome-wide measurements for computational prediction of SH2-peptide interactions.
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18536014 J.D.Taylor, A.Ababou, R.R.Fawaz, C.J.Hobbs, M.A.Williams, and J.E.Ladbury (2008).
Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design.
  Proteins, 73, 929-940.
PDB code: 2jyq
18056706 S.A.Solheim, K.M.Torgersen, K.Taskén, and T.Berge (2008).
Regulation of FynT Function by Dual Domain Docking on PAG/Cbp.
  J Biol Chem, 283, 2773-2783.  
18484636 T.Ozawa, and K.Okazaki (2008).
CH/pi hydrogen bonds determine the selectivity of the Src homology 2 domain to tyrosine phosphotyrosyl peptides: an ab initio fragment molecular orbital study.
  J Comput Chem, 29, 2656-2666.  
17705331 A.M.Spuches, H.J.Argiros, K.H.Lee, L.L.Haas, S.C.Pero, D.N.Krag, P.P.Roller, D.E.Wilcox, and B.A.Lyons (2007).
Calorimetric investigation of phosphorylated and non-phosphorylated peptide ligand binding to the human Grb7-SH2 domain.
  J Mol Recognit, 20, 245-252.  
17894853 C.J.Porter, J.M.Matthews, J.P.Mackay, S.E.Pursglove, J.W.Schmidberger, P.J.Leedman, S.C.Pero, D.N.Krag, M.C.Wilce, and J.A.Wilce (2007).
Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
  BMC Struct Biol, 7, 58.
PDB code: 2qms
17698610 D.E.Shvartsman, J.C.Donaldson, B.Diaz, O.Gutman, G.S.Martin, and Y.I.Henis (2007).
Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets.
  J Cell Biol, 178, 675-686.  
17393456 J.D.Taylor, P.J.Gilbert, M.A.Williams, W.R.Pitt, and J.E.Ladbury (2007).
Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation.
  Proteins, 67, 981-990.  
17164523 J.E.Ladbury (2007).
Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction.
  Acta Crystallogr D Biol Crystallogr, 63, 26-31.  
17380483 N.K.Banavali, and B.Roux (2007).
Anatomy of a structural pathway for activation of the catalytic domain of Src kinase Hck.
  Proteins, 67, 1096-1112.  
17683370 S.Geroult, M.Hooda, S.Virdee, and G.Waksman (2007).
Prediction of solvation sites at the interface of Src SH2 domain complexes using molecular dynamics simulations.
  Chem Biol Drug Des, 70, 87-99.  
17084981 S.Hehlgans, M.Haase, and N.Cordes (2007).
Signalling via integrins: implications for cell survival and anticancer strategies.
  Biochim Biophys Acta, 1775, 163-180.  
17624955 S.M.Grande, G.Bannish, E.M.Fuentes-Panana, E.Katz, and J.G.Monroe (2007).
Tonic B-cell and viral ITAM signaling: context is everything.
  Immunol Rev, 218, 214-234.  
16793553 B.A.Liu, K.Jablonowski, M.Raina, M.Arcé, T.Pawson, and P.D.Nash (2006).
The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling.
  Mol Cell, 22, 851-868.  
16829979 B.T.Seet, I.Dikic, M.M.Zhou, and T.Pawson (2006).
Reading protein modifications with interaction domains.
  Nat Rev Mol Cell Biol, 7, 473-483.  
16751610 D.Wildes, L.M.Anderson, A.Sabogal, and S.Marqusee (2006).
Native state energetics of the Src SH2 domain: evidence for a partially structured state in the denatured ensemble.
  Protein Sci, 15, 1769-1779.  
16905102 E.Bergamin, J.Wu, and S.R.Hubbard (2006).
Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.
  Structure, 14, 1285-1292.
PDB code: 2hmh
16943434 F.Abtahian, N.Bezman, R.Clemens, E.Sebzda, L.Cheng, S.J.Shattil, M.L.Kahn, and G.A.Koretzky (2006).
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.
  Mol Cell Biol, 26, 6936-6949.  
16245368 F.Nasertorabi, K.Tars, K.Becherer, R.Kodandapani, L.Liljas, K.Vuori, and K.R.Ely (2006).
Molecular basis for regulation of Src by the docking protein p130Cas.
  J Mol Recognit, 19, 30-38.
PDB code: 1x27
16990796 L.V.Kalia, G.M.Pitcher, K.A.Pelkey, and M.W.Salter (2006).
PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex.
  EMBO J, 25, 4971-4982.  
16492147 S.Geroult, S.Virdee, and G.Waksman (2006).
The role of water in computational and experimental derivation of binding thermodynamics in SH2 domains.
  Chem Biol Drug Des, 67, 38-45.  
19444322 T.R.Burke (2006).
Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents.
  Int J Pept Res Ther, 12, 33-48.  
17081313 V.Ahola, T.Aittokallio, M.Vihinen, and E.Uusipaikka (2006).
A statistical score for assessing the quality of multiple sequence alignments.
  BMC Bioinformatics, 7, 484.  
15959902 A.C.Roque, and C.R.Lowe (2005).
Lessons from nature: On the molecular recognition elements of the phosphoprotein binding-domains.
  Biotechnol Bioeng, 91, 546-555.  
15929003 A.Scott, D.Pantoja-Uceda, S.Koshiba, M.Inoue, T.Kigawa, T.Terada, M.Shirouzu, A.Tanaka, S.Sugano, S.Yokoyama, and P.Güntert (2005).
Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes.
  J Biomol NMR, 31, 357-361.
PDB code: 1wqu
15576564 B.A.Joughin, B.Tidor, and M.B.Yaffe (2005).
A computational method for the analysis and prediction of protein:phosphopeptide-binding sites.
  Protein Sci, 14, 131-139.  
15851033 C.H.Benes, N.Wu, A.E.Elia, T.Dharia, L.C.Cantley, and S.P.Soltoff (2005).
The C2 domain of PKCdelta is a phosphotyrosine binding domain.
  Cell, 121, 271-280.  
15841400 C.J.Porter, M.C.Wilce, J.P.Mackay, P.Leedman, and J.A.Wilce (2005).
Grb7-SH2 domain dimerisation is affected by a single point mutation.
  Eur Biophys J, 34, 454-460.  
15817454 D.Humphrey, Z.Rajfur, M.E.Vazquez, D.Scheswohl, M.D.Schaller, K.Jacobson, and B.Imperiali (2005).
In situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells.
  J Biol Chem, 280, 22091-22101.  
15867154 H.J.Woo, and B.Roux (2005).
Calculation of absolute protein-ligand binding free energy from computer simulations.
  Proc Natl Acad Sci U S A, 102, 6825-6830.  
15737992 J.Hu, and S.R.Hubbard (2005).
Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.
  J Biol Chem, 280, 18943-18949.
PDB code: 1yvh
16302975 J.J.Babon, S.Yao, D.P.DeSouza, C.F.Harrison, L.J.Fabri, E.Liepinsh, S.D.Scrofani, M.Baca, and R.S.Norton (2005).
Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain.
  FEBS J, 272, 6120-6130.  
15914019 M.I.Catalina, M.J.Fischer, F.J.Dekker, R.M.Liskamp, and A.J.Heck (2005).
Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.
  J Am Soc Mass Spectrom, 16, 1039-1051.  
15930003 M.Ivancic, A.M.Spuches, E.C.Guth, M.A.Daugherty, D.E.Wilcox, and B.A.Lyons (2005).
Backbone nuclear relaxation characteristics and calorimetric investigation of the human Grb7-SH2/erbB2 peptide complex.
  Protein Sci, 14, 1556-1569.  
15890649 M.K.Ayrapetov, N.H.Nam, G.Ye, A.Kumar, K.Parang, and G.Sun (2005).
Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation.
  J Biol Chem, 280, 25780-25787.  
15767667 M.Nishi, E.D.Werner, B.C.Oh, J.D.Frantz, S.Dhe-Paganon, L.Hansen, J.Lee, and S.E.Shoelson (2005).
Kinase activation through dimerization by human SH2-B.
  Mol Cell Biol, 25, 2607-2621.  
16160160 M.S.Rajala, R.V.Rajala, R.A.Astley, A.L.Butt, and J.Chodosh (2005).
Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation.
  J Virol, 79, 12332-12341.  
  16511241 N.Umadevi, S.Kumar, and N.Narayana (2005).
Crystallization and preliminary X-ray diffraction studies of the WW4 domain of the Nedd4-2 ubiquitin-protein ligase.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 61, 1084-1086.  
15634336 P.Hekerman, J.Zeidler, S.Bamberg-Lemper, H.Knobelspies, D.Lavens, J.Tavernier, H.G.Joost, and W.Becker (2005).
Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines.
  FEBS J, 272, 109-119.  
16135792 S.Y.Ren, E.Bolton, M.G.Mohi, A.Morrione, B.G.Neel, and T.Skorski (2005).
Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.
  Mol Cell Biol, 25, 8001-8008.  
15764601 X.Ran, and J.Song (2005).
Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain.
  J Biol Chem, 280, 19205-19212.
PDB code: 1z3k
15194700 A.Dreuw, S.Radtke, S.Pflanz, B.E.Lippok, P.C.Heinrich, and H.M.Hermanns (2004).
Characterization of the signaling capacities of the novel gp130-like cytokine receptor.
  J Biol Chem, 279, 36112-36120.  
15297464 C.M.Rohde, J.Schrum, and A.W.Lee (2004).
A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation.
  J Biol Chem, 279, 43448-43461.  
14966128 H.Shao, X.Xu, M.A.Mastrangelo, N.Jing, R.G.Cook, G.B.Legge, and D.J.Tweardy (2004).
Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif.
  J Biol Chem, 279, 18967-18973.  
14766744 M.Encinas, R.J.Crowder, J.Milbrandt, and E.M.Johnson (2004).
Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival.
  J Biol Chem, 279, 18262-18269.  
15339926 M.On, J.M.Billingsley, M.H.Jouvin, and J.P.Kinet (2004).
Molecular dissection of the FcRbeta signaling amplifier.
  J Biol Chem, 279, 45782-45790.  
15322292 P.J.Scharf, J.Witney, R.Daly, and B.A.Lyons (2004).
Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain.
  Protein Sci, 13, 2541-2546.  
14696074 S.Donnini, and A.H.Juffer (2004).
Calculation of affinities of peptides for proteins.
  J Comput Chem, 25, 393-411.  
15096211 Z.Su, P.Xu, and F.Ni (2004).
Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein.
  Eur J Biochem, 271, 1725-1736.  
12493827 D.D.Ojennus, S.E.Lehto, and D.S.Wuttke (2003).
Electrostatic interactions in the reconstitution of an SH2 domain from constituent peptide fragments.
  Protein Sci, 12, 44-55.  
12551896 E.G.Stein, R.Ghirlando, and S.R.Hubbard (2003).
Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
  J Biol Chem, 278, 13257-13264.
PDB code: 1nrv
14690593 J.Hu, J.Liu, R.Ghirlando, A.R.Saltiel, and S.R.Hubbard (2003).
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
  Mol Cell, 12, 1379-1389.
PDB codes: 1rpy 1rqq
12766170 L.S.Lock, M.M.Frigault, C.Saucier, and M.Park (2003).
Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain.
  J Biol Chem, 278, 30083-30090.  
12591923 M.Wiederkehr-Adam, P.Ernst, K.Müller, E.Bieck, F.O.Gombert, J.Ottl, P.Graff, F.Grossmüller, and M.H.Heim (2003).
Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3.
  J Biol Chem, 278, 16117-16128.  
14991680 R.Sundaramoorthi, N.Kawahata, M.G.Yang, W.C.Shakespeare, C.A.Metcalf, Y.Wang, T.Merry, C.J.Eyermann, R.S.Bohacek, S.Narula, D.C.Dalgarno, and T.K.Sawyer (2003).
Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain:phosphotyrosine mimetics exploiting multifunctional group replacement chemistry.
  Biopolymers, 71, 717-729.  
12411494 A.Klejman, S.J.Schreiner, M.Nieborowska-Skorska, A.Slupianek, M.Wilson, T.E.Smithgall, and T.Skorski (2002).
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.
  EMBO J, 21, 5766-5774.  
12119038 D.De Souza, L.J.Fabri, A.Nash, D.J.Hilton, N.A.Nicola, and M.Baca (2002).
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.
  Biochemistry, 41, 9229-9236.  
11909938 L.A.Cary, R.A.Klinghoffer, C.Sachsenmaier, and J.A.Cooper (2002).
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
  Mol Cell Biol, 22, 2427-2440.  
12058075 L.S.Lock, C.R.Maroun, M.A.Naujokas, and M.Park (2002).
Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.
  Mol Biol Cell, 13, 2132-2146.  
11994738 M.B.Yaffe (2002).
Phosphotyrosine-binding domains in signal transduction.
  Nat Rev Mol Cell Biol, 3, 177-186.  
12122014 S.Kim, R.Zagozdzon, A.Meisler, J.D.Baleja, Y.Fu, S.Avraham, and H.Avraham (2002).
Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.
  J Biol Chem, 277, 36465-36470.  
12121645 T.S.Ulmer, J.M.Werner, and I.D.Campbell (2002).
SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn.
  Structure, 10, 901-911.  
11160680 C.A.Mainville, K.Parmar, I.Unnikrishnan, L.Gong, G.D.Raffel, and N.Rosenberg (2001).
Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain.
  J Virol, 75, 1816-1823.  
11604523 D.D.Ojennus, M.R.Fleissner, and D.S.Wuttke (2001).
Reconstitution of a native-like SH2 domain from disordered peptide fragments examined by multidimensional heteronuclear NMR.
  Protein Sci, 10, 2162-2175.  
11746693 G.M.Verkhivker, D.Bouzida, D.K.Gehlhaar, P.A.Rejto, L.Schaffer, S.Arthurs, A.B.Colson, S.T.Freer, V.Larson, B.A.Luty, T.Marrone, and P.W.Rose (2001).
Hierarchy of simulation models in predicting molecular recognition mechanisms from the binding energy landscapes: structural analysis of the peptide complexes with SH2 domains.
  Proteins, 45, 456-470.  
11689425 M.Morra, J.Lu, F.Poy, M.Martin, J.Sayos, S.Calpe, C.Gullo, D.Howie, S.Rietdijk, A.Thompson, A.J.Coyle, C.Denny, M.B.Yaffe, P.Engel, M.J.Eck, and C.Terhorst (2001).
Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
  EMBO J, 20, 5840-5852.
PDB code: 1i3z
11828442 R.Ruijtenbeek, J.A.Kruijtzer, W.van de Wiel, M.J.Fischer, M.Flück, F.A.Redegeld, R.M.Liskamp, and F.P.Nijkamp (2001).
Peptoid - peptide hybrids that bind Syk SH2 domains involved in signal transduction.
  Chembiochem, 2, 171-179.  
11044086 C.C.Smith, J.Nelson, L.Aurelian, M.Gober, and B.B.Goswami (2000).
Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth.
  J Virol, 74, 10417-10429.  
  11106171 D.A.Henriques, J.E.Ladbury, and R.M.Jackson (2000).
Comparison of binding energies of SrcSH2-phosphotyrosyl peptides with structure-based prediction using surface area based empirical parameterization.
  Protein Sci, 9, 1975-1985.  
12760058 D.Durocher, S.J.Smerdon, M.B.Yaffe, and S.P.Jackson (2000).
The FHA domain in DNA repair and checkpoint signaling.
  Cold Spring Harb Symp Quant Biol, 65, 423-431.  
10842311 D.E.Richards, J.Peng, and N.P.Harberd (2000).
Plant GRAS and metazoan STATs: one family?
  Bioessays, 22, 573-577.  
11080160 D.J.Owen, P.Ornaghi, J.C.Yang, N.Lowe, P.R.Evans, P.Ballario, D.Neuhaus, P.Filetici, and A.A.Travers (2000).
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p.
  EMBO J, 19, 6141-6149.
PDB code: 1e6i
10652315 G.E.Begg, S.L.Harper, M.B.Morris, and D.W.Speicher (2000).
Initiation of spectrin dimerization involves complementary electrostatic interactions between paired triple-helical bundles.
  J Biol Chem, 275, 3279-3287.  
10911998 M.S.Kimber, J.Nachman, A.M.Cunningham, G.D.Gish, T.Pawson, and E.F.Pai (2000).
Structural basis for specificity switching of the Src SH2 domain.
  Mol Cell, 5, 1043-1049.
PDB codes: 1f1w 1f2f
  10752619 R.O'Brien, P.Rugman, D.Renzoni, M.Layton, R.Handa, K.Hilyard, M.D.Waterfield, P.C.Driscoll, and J.E.Ladbury (2000).
Alternative modes of binding of proteins with tandem SH2 domains.
  Protein Sci, 9, 570-579.  
10827454 S.C.Robertson, J.A.Tynan, and D.J.Donoghue (2000).
RTK mutations and human syndromeswhen good receptors turn bad.
  Trends Genet, 16, 265-271.  
10938113 S.L.Moores, L.M.Selfors, J.Fredericks, T.Breit, K.Fujikawa, F.W.Alt, J.S.Brugge, and W.Swat (2000).
Vav family proteins couple to diverse cell surface receptors.
  Mol Cell Biol, 20, 6364-6373.  
  10850802 S.P.Edgcomb, B.M.Baker, and K.P.Murphy (2000).
The energetics of phosphate binding to a protein complex.
  Protein Sci, 9, 927-933.  
  11206059 S.R.Tzeng, M.T.Pai, F.D.Lung, C.W.Wu, P.P.Roller, B.Lei, C.J.Wei, S.C.Tu, S.H.Chen, W.J.Soong, and J.W.Cheng (2000).
Stability and peptide binding specificity of Btk SH2 domain: molecular basis for X-linked agammaglobulinemia.
  Protein Sci, 9, 2377-2385.  
10944210 W.Shakespeare, M.Yang, R.Bohacek, F.Cerasoli, K.Stebbins, R.Sundaramoorthi, M.Azimioara, C.Vu, S.Pradeepan, C.Metcalf, C.Haraldson, T.Merry, D.Dalgarno, S.Narula, M.Hatada, X.Lu, M.R.van Schravendijk, S.Adams, S.Violette, J.Smith, W.Guan, C.Bartlett, J.Herson, J.Iuliucci, M.Weigele, and T.Sawyer (2000).
Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.
  Proc Natl Acad Sci U S A, 97, 9373-9378.
PDB code: 1fbz
10467125 B.Aghazadeh, and M.K.Rosen (1999).
Ligand recognition by SH3 and WW domains: the role of N-alkylation in PPII helices.
  Chem Biol, 6, R241-R246.  
  10548041 E.W.Chung, D.A.Henriques, D.Renzoni, C.J.Morton, T.D.Mulhern, M.C.Pitkeathly, J.E.Ladbury, and C.V.Robinson (1999).
Probing the nature of interactions in SH2 binding interfaces--evidence from electrospray ionization mass spectrometry.
  Protein Sci, 8, 1962-1970.  
10549287 F.Poy, M.B.Yaffe, J.Sayos, K.Saxena, M.Morra, J.Sumegi, L.C.Cantley, C.Terhorst, and M.J.Eck (1999).
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
  Mol Cell, 4, 555-561.
PDB codes: 1d1z 1d4t 1d4w
10476869 J.L.Buchanan, C.B.Vu, T.J.Merry, E.G.Corpuz, S.G.Pradeepan, U.N.Mani, M.Yang, H.R.Plake, V.M.Varkhedkar, B.A.Lynch, I.A.MacNeil, K.A.Loiacono, C.L.Tiong, and D.A.Holt (1999).
Structure-activity relationships of a novel class of Src SH2 inhibitors.
  Bioorg Med Chem Lett, 9, 2359-2364.  
10476868 J.L.Buchanan, R.S.Bohacek, G.P.Luke, M.Hatada, X.Lu, D.C.Dalgarno, S.S.Narula, R.Yuan, and D.A.Holt (1999).
Structure-based design and synthesis of a novel class of Src SH2 inhibitors.
  Bioorg Med Chem Lett, 9, 2353-2358.  
10213620 J.M.Bradshaw, and G.Waksman (1999).
Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: dissection of the phosphopeptide sequence specificity and coupling energetics.
  Biochemistry, 38, 5147-5154.  
10413466 J.R.Engen, W.H.Gmeiner, T.E.Smithgall, and D.L.Smith (1999).
Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2.
  Biochemistry, 38, 8926-8935.  
10352010 J.S.Bonifacino, and E.C.Dell'Angelica (1999).
Molecular bases for the recognition of tyrosine-based sorting signals.
  J Cell Biol, 145, 923-926.  
10518561 K.Ohya, S.Kajigaya, A.Kitanaka, K.Yoshida, A.Miyazato, Y.Yamashita, T.Yamanaka, U.Ikeda, K.Shimada, K.Ozawa, and H.Mano (1999).
Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.
  Proc Natl Acad Sci U S A, 96, 11976-11981.  
10393272 L.Buday (1999).
Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins.
  Biochim Biophys Acta, 1422, 187-204.  
10195453 L.F.Bonewald, L.Bibbs, S.A.Kates, A.Khatri, J.S.McMurray, K.F.Medzihradszky, and S.T.Weintraub (1999).
Study on the synthesis and characterization of peptides containing phosphorylated tyrosine.
  J Pept Res, 53, 161-169.  
10213634 N.R.Glover, and A.S.Tracey (1999).
Nuclear magnetic resonance and restrained molecular dynamics studies of the interaction of an epidermal growth factor-derived peptide with protein tyrosine phosphatase 1B.
  Biochemistry, 38, 5256-5271.  
10593610 N.R.Glover, and A.S.Tracey (1999).
Structure, modelling, and molecular dynamics studies of the inhibition of protein tyrosine phosphatase 1B by sulfotyrosine peptides.
  Biochem Cell Biol, 77, 469-486.  
10398925 R.A.Grucza, J.M.Bradshaw, K.Fütterer, and G.Waksman (1999).
SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships.
  Med Res Rev, 19, 273-293.  
10213605 R.A.Grucza, K.Fütterer, A.C.Chan, and G.Waksman (1999).
Thermodynamic study of the binding of the tandem-SH2 domain of the Syk kinase to a dually phosphorylated ITAM peptide: evidence for two conformers.
  Biochemistry, 38, 5024-5033.  
10607564 S.C.Li, G.Gish, D.Yang, A.J.Coffey, J.D.Forman-Kay, I.Ernberg, L.E.Kay, and T.Pawson (1999).
Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.
  Curr Biol, 9, 1355-1362.  
10091682 T.R.Burke, J.Luo, Z.J.Yao, Y.Gao, H.Zhao, G.W.Milne, R.Guo, J.H.Voigt, C.R.King, and D.Yang (1999).
Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors.
  Bioorg Med Chem Lett, 9, 347-352.  
10430888 X.Zhang, A.Chattopadhyay, Q.S.Ji, J.D.Owen, P.J.Ruest, G.Carpenter, and S.K.Hanks (1999).
Focal adhesion kinase promotes phospholipase C-gamma1 activity.
  Proc Natl Acad Sci U S A, 96, 9021-9026.  
9553107 A.Nantel, K.Mohammad-Ali, J.Sherk, B.I.Posner, and D.Y.Thomas (1998).
Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases.
  J Biol Chem, 273, 10475-10484.  
9419348 B.K.Patel, J.H.Pierce, and W.J.LaRochelle (1998).
Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.
  Proc Natl Acad Sci U S A, 95, 172-177.  
9422724 E.A.Ottinger, M.C.Botfield, and S.E.Shoelson (1998).
Tandem SH2 domains confer high specificity in tyrosine kinase signaling.
  J Biol Chem, 273, 729-735.  
9753693 E.Chung, D.Henriques, D.Renzoni, M.Zvelebil, J.M.Bradshaw, G.Waksman, C.V.Robinson, and J.E.Ladbury (1998).
Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides.
  Structure, 6, 1141-1151.  
9485424 G.Huyer, and C.Ramachandran (1998).
The specificity of the N-terminal SH2 domain of SHP-2 is modified by a single point mutation.
  Biochemistry, 37, 2741-2747.  
9799501 J.M.Bradshaw, and G.Waksman (1998).
Calorimetric investigation of proton linkage by monitoring both the enthalpy and association constant of binding: application to the interaction of the Src SH2 domain with a high-affinity tyrosyl phosphopeptide.
  Biochemistry, 37, 15400-15407.  
9636054 J.M.Bradshaw, R.A.Grucza, J.E.Ladbury, and G.Waksman (1998).
Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study.
  Biochemistry, 37, 9083-9090.  
9873628 J.M.Fu, and A.L.Castelhano (1998).
Design and synthesis of a pyridone-based phosphotyrosine mimetic.
  Bioorg Med Chem Lett, 8, 2813-2816.  
9871733 K.J.Alligood, P.S.Charifson, R.Crosby, T.G.Consler, P.L.Feldman, R.T.Gampe, T.M.Gilmer, S.R.Jordan, M.W.Milstead, C.Mohr, M.R.Peel, W.Rocque, M.Rodriguez, D.W.Rusnak, L.M.Shewchuk, and D.D.Sternbach (1998).
The formation of a covalent complex between a dipeptide ligand and the src SH2 domain.
  Bioorg Med Chem Lett, 8, 1189-1194.  
9677371 K.Krishnan, B.Singh, and J.J.Krolewski (1998).
Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor.
  J Biol Chem, 273, 19495-19501.  
9461082 L.E.Kay, D.R.Muhandiram, G.Wolf, S.E.Shoelson, and J.D.Forman-Kay (1998).
Correlation between binding and dynamics at SH2 domain interfaces.
  Nat Struct Biol, 5, 156-163.  
9694882 L.Rui, and C.Carter-Su (1998).
Platelet-derived growth factor (PDGF) stimulates the association of SH2-Bbeta with PDGF receptor and phosphorylation of SH2-Bbeta.
  J Biol Chem, 273, 21239-21245.  
9685372 L.Tong, T.C.Warren, S.Lukas, J.Schembri-King, R.Betageri, J.R.Proudfoot, and S.Jakes (1998).
Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
  J Biol Chem, 273, 20238-20242.
PDB codes: 1bhf 1bhh
9737977 M.Chen, H.She, E.M.Davis, C.M.Spicer, L.Kim, R.Ren, M.M.Le Beau, and W.Li (1998).
Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.
  J Biol Chem, 273, 25171-25178.  
9838094 M.J.Bottomley, K.Salim, and G.Panayotou (1998).
Phospholipid-binding protein domains.
  Biochim Biophys Acta, 1436, 165-183.  
  9528781 M.Kozlowski, L.Larose, F.Lee, D.M.Le, R.Rottapel, and K.A.Siminovitch (1998).
SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.
  Mol Cell Biol, 18, 2089-2099.  
9789053 M.Narazaki, M.Fujimoto, T.Matsumoto, Y.Morita, H.Saito, T.Kajita, K.Yoshizaki, T.Naka, and T.Kishimoto (1998).
Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.
  Proc Natl Acad Sci U S A, 95, 13130-13134.  
9660863 R.G.Kibbey, J.Rizo, L.M.Gierasch, and R.G.Anderson (1998).
The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation.
  J Cell Biol, 142, 59-67.  
9602534 T.Hunter (1998).
The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease.
  Philos Trans R Soc Lond B Biol Sci, 353, 583-605.  
9817027 T.K.Sawyer (1998).
Src homology-2 domains: structure, mechanisms, and drug discovery.
  Biopolymers, 47, 243-261.  
9651359 T.Mikita, C.Daniel, P.Wu, and U.Schindler (1998).
Mutational analysis of the STAT6 SH2 domain.
  J Biol Chem, 273, 17634-17642.  
9585523 W.Zhang, T.E.Smithgall, and W.H.Gmeiner (1998).
Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms.
  Biochemistry, 37, 7119-7126.  
9364610 A.F.Rocha (1997).
The brain as a symbol-processing machine.
  Prog Neurobiol, 53, 121-198.  
  9300491 A.U.Singer, and J.D.Forman-Kay (1997).
pH titration studies of an SH2 domain-phosphopeptide complex: unusual histidine and phosphate pKa values.
  Protein Sci, 6, 1910-1919.  
9153411 B.Gay, P.Furet, C.García-Echeverría, J.Rahuel, P.Chène, H.Fretz, J.Schoepfer, and G.Caravatti (1997).
Dual specificity of Src homology 2 domains for phosphotyrosine peptide ligands.
  Biochemistry, 36, 5712-5718.  
9325331 C.Tiruppathi, W.Song, M.Bergenfeldt, P.Sass, and A.B.Malik (1997).
Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway.
  J Biol Chem, 272, 25968-25975.  
9241420 J.Kuriyan, and D.Cowburn (1997).
Modular peptide recognition domains in eukaryotic signaling.
  Annu Rev Biophys Biomol Struct, 26, 259-288.  
9095189 J.T.Nguyen, and W.A.Lim (1997).
How Src exercises self-restraint.
  Nat Struct Biol, 4, 256-260.  
9108016 K.Shah, Y.Liu, C.Deirmengian, and K.M.Shokat (1997).
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates.
  Proc Natl Acad Sci U S A, 94, 3565-3570.  
  9168470 M.F.Verderame (1997).
pp60v-src transformation of rat cells but not chicken cells strongly correlates with low-affinity phosphopeptide binding by the SH2 domain.
  Mol Biol Cell, 8, 843-854.  
9238025 M.Perego (1997).
A peptide export-import control circuit modulating bacterial development regulates protein phosphatases of the phosphorelay.
  Proc Natl Acad Sci U S A, 94, 8612-8617.  
9043656 M.S.Plummer, E.A.Lunney, K.S.Para, A.Shahripour, C.J.Stankovic, C.Humblet, J.H.Fergus, J.S.Marks, R.Herrera, S.Hubbell, A.Saltiel, and T.K.Sawyer (1997).
Design of peptidomimetic ligands for the pp60src SH2 domain.
  Bioorg Med Chem, 5, 41-47.  
9278444 M.Y.Kanemitsu, L.W.Loo, S.Simon, A.F.Lau, and W.Eckhart (1997).
Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions.
  J Biol Chem, 272, 22824-22831.  
9174343 P.S.Charifson, L.M.Shewchuk, W.Rocque, C.W.Hummel, S.R.Jordan, C.Mohr, G.J.Pacofsky, M.R.Peel, M.Rodriguez, D.D.Sternbach, and T.G.Consler (1997).
Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
  Biochemistry, 36, 6283-6293.
PDB codes: 1a07 1a08 1a09 1a1a 1a1b 1a1c 1a1e
  9192269 R.A.Brooimans, A.J.van den Berg, G.T.Rijkers, L.A.Sanders, J.K.van Amstel, M.G.Tilanus, M.J.Grubben, and B.J.Zegers (1997).
Identification of novel Bruton's tyrosine kinase mutations in 10 unrelated subjects with X linked agammaglobulinaemia.
  J Med Genet, 34, 484-488.  
9250364 R.L.Brockbank, and H.J.Vogel (1997).
NMR studies of the RRsrc peptide, a tyrosine kinase substrate.
  Biochem Cell Biol, 75, 163-169.  
9667855 S.E.Shoelson (1997).
SH2 and PTB domain interactions in tyrosine kinase signal transduction.
  Curr Opin Chem Biol, 1, 227-234.  
9442882 S.M.Thomas, and J.S.Brugge (1997).
Cellular functions regulated by Src family kinases.
  Annu Rev Cell Dev Biol, 13, 513-609.  
9351806 T.D.Mulhern, G.L.Shaw, C.J.Morton, A.J.Day, and I.D.Campbell (1997).
The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
  Structure, 5, 1313-1323.
PDB codes: 1aot 1aou
9321393 Z.Zhang, C.H.Lee, V.Mandiyan, J.P.Borg, B.Margolis, J.Schlessinger, and J.Kuriyan (1997).
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
  EMBO J, 16, 6141-6150.
PDB codes: 1aqc 1x11
  8670861 A.L.Breeze, B.V.Kara, D.G.Barratt, M.Anderson, J.C.Smith, R.W.Luke, J.R.Best, and S.A.Cartlidge (1996).
Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.
  EMBO J, 15, 3579-3589.
PDB code: 1pic
8919876 A.L.Hughes (1996).
Evolution of the src-related protein tyrosine kinases.
  J Mol Evol, 42, 247-256.  
8639559 D.Liu, R.Prasad, S.H.Wilson, E.F.DeRose, and G.P.Mullen (1996).
Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface.
  Biochemistry, 35, 6188-6200.
PDB codes: 1bno 1bnp
8577729 D.Pei, J.Wang, and C.T.Walsh (1996).
Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.
  Proc Natl Acad Sci U S A, 93, 1141-1145.  
8647855 D.R.Stover, P.Furet, and N.B.Lydon (1996).
Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain.
  J Biol Chem, 271, 12481-12487.  
9115846 F.Romero, and S.Fischer (1996).
Structure and function of vav.
  Cell Signal, 8, 545-553.  
8805596 H.J.Nam, W.G.Haser, T.M.Roberts, and C.A.Frederick (1996).
Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism.
  Structure, 4, 1105-1114.
PDB code: 2abl
  8605876 H.Yan, K.Krishnan, A.C.Greenlund, S.Gupta, J.T.Lim, R.D.Schreiber, C.W.Schindler, and J.J.Krolewski (1996).
Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.
  EMBO J, 15, 1064-1074.  
8780508 J.E.Ladbury, M.Hensmann, G.Panayotou, and I.D.Campbell (1996).
Alternative modes of tyrosyl phosphopeptide binding to a Src family SH2 domain: implications for regulation of tyrosine kinase activity.
  Biochemistry, 35, 11062-11069.  
8633037 J.Fujimoto, M.Shiota, T.Iwahara, N.Seki, H.Satoh, S.Mori, and T.Yamamoto (1996).
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).
  Proc Natl Acad Sci U S A, 93, 4181-4186.  
8589253 J.J.Barchi, M.Nomizu, A.Otaka, P.P.Roller, and T.R.Burke (1996).
Conformational analysis of cyclic hexapeptides designed as constrained ligands for the SH2 domain of the p85 subunit of phosphatidylinositol-3-OH kinase.
  Biopolymers, 38, 191-208.  
8662772 J.P.O'Bryan, C.B.Martin, Z.Songyang, L.C.Cantley, and C.J.Der (1996).
Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.
  J Biol Chem, 271, 11787-11791.  
8610109 J.P.O'Bryan, Z.Songyang, L.Cantley, C.J.Der, and T.Pawson (1996).
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.
  Proc Natl Acad Sci U S A, 93, 2729-2734.  
8673601 J.Rahuel, B.Gay, D.Erdmann, A.Strauss, C.Garcia-Echeverría, P.Furet, G.Caravatti, H.Fretz, J.Schoepfer, and M.G.Grütter (1996).
Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode.
  Nat Struct Biol, 3, 586-589.
PDB code: 1tze
8794768 K.H.Thornton, W.T.Mueller, P.McConnell, G.Zhu, A.R.Saltiel, and V.Thanabal (1996).
Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain.
  Biochemistry, 35, 11852-11864.
PDB code: 1ghu
8555205 L.E.Kay, D.R.Muhandiram, N.A.Farrow, Y.Aubin, and J.D.Forman-Kay (1996).
Correlation between dynamics and high affinity binding in an SH2 domain interaction.
  Biochemistry, 35, 361-368.  
8672527 M.T.Brown, and J.A.Cooper (1996).
Regulation, substrates and functions of src.
  Biochim Biophys Acta, 1287, 121-149.  
8646773 P.A.Garrity, Y.Rao, I.Salecker, J.McGlade, T.Pawson, and S.L.Zipursky (1996).
Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.
  Cell, 85, 639-650.  
8824280 P.M.Finan, C.J.Soames, L.Wilson, D.L.Nelson, D.M.Stewart, O.Truong, J.J.Hsuan, and S.Kellie (1996).
Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains.
  J Biol Chem, 271, 26291-26295.  
8577769 P.van der Geer, S.Wiley, G.D.Gish, V.K.Lai, R.Stephens, M.F.White, D.Kaplan, and T.Pawson (1996).
Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.
  Proc Natl Acad Sci U S A, 93, 963-968.  
8988011 R.C.Cousins-Wasti, R.H.Ingraham, M.M.Morelock, and C.A.Grygon (1996).
Determination of affinities for lck SH2 binding peptides using a sensitive fluorescence assay: comparison between the pYEEIP and pYQPQP consensus sequences reveals context-dependent binding specificity.
  Biochemistry, 35, 16746-16752.  
8599763 R.T.Nolte, M.J.Eck, J.Schlessinger, S.E.Shoelson, and S.C.Harrison (1996).
Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes.
  Nat Struct Biol, 3, 364-374.
PDB codes: 2iug 2iuh 2iui
  8868476 S.Réty, K.Fütterer, R.A.Grucza, C.M.Munoz, W.A.Frazier, and G.Waksman (1996).
pH-Dependent self-association of the Src homology 2 (SH2) domain of the Src homologous and collagen-like (SHC) protein.
  Protein Sci, 5, 405-413.  
8810294 T.Chen, B.Repetto, R.Chizzonite, C.Pullar, C.Burghardt, E.Dharm, Z.Zhao, R.Carroll, P.Nunes, M.Basu, W.Danho, M.Visnick, J.Kochan, D.Waugh, and A.M.Gilfillan (1996).
Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kinetics.
  J Biol Chem, 271, 25308-25315.  
8910394 T.Itoh, K.Miura, H.Miki, and T.Takenawa (1996).
Beta-tubulin binds Src homology 2 domains through a region different from the tyrosine-phosphorylated protein-recognizing site.
  J Biol Chem, 271, 27931-27935.  
  8816495 T.Mikita, D.Campbell, P.Wu, K.Williamson, and U.Schindler (1996).
Requirements for interleukin-4-induced gene expression and functional characterization of Stat6.
  Mol Cell Biol, 16, 5811-5820.  
8621540 T.Nakamoto, R.Sakai, K.Ozawa, Y.Yazaki, and H.Hirai (1996).
Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase.
  J Biol Chem, 271, 8959-8965.  
8662795 U.Hemmann, C.Gerhartz, B.Heesel, J.Sasse, G.Kurapkat, J.Grötzinger, A.Wollmer, Z.Zhong, J.E.Darnell, L.Graeve, P.C.Heinrich, and F.Horn (1996).
Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation.
  J Biol Chem, 271, 12999-13007.  
8952511 U.L.Günther, Y.Liu, D.Sanford, W.W.Bachovchin, and B.Schaffhausen (1996).
NMR analysis of interactions of a phosphatidylinositol 3'-kinase SH2 domain with phosphotyrosine peptides reveals interdependence of major binding sites.
  Biochemistry, 35, 15570-15581.  
8632995 W.G.Kerr, M.Heller, and L.A.Herzenberg (1996).
Analysis of lipopolysaccharide-response genes in B-lineage cells demonstrates that they can have differentiation stage-restricted expression and contain SH2 domains.
  Proc Natl Acad Sci U S A, 93, 3947-3952.  
8639560 W.J.Metzler, B.Leiting, K.Pryor, L.Mueller, and B.T.Farmer (1996).
The three-dimensional solution structure of the SH2 domain from p55blk kinase.
  Biochemistry, 35, 6201-6211.
PDB codes: 1blj 1blk
8681956 W.Weissenhorn, M.J.Eck, S.C.Harrison, and D.C.Wiley (1996).
Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro.
  Eur J Biochem, 238, 440-445.  
8663052 Y.P.Pang, B.Cusack, K.Groshan, and E.Richelson (1996).
Proposed ligand binding site of the transmembrane receptor for neurotensin(8-13).
  J Biol Chem, 271, 15060-15068.  
7844150 A.H.Ahn, and L.M.Kunkel (1995).
Syntrophin binds to an alternatively spliced exon of dystrophin.
  J Cell Biol, 128, 363-371.  
  7774584 A.Mallabiabarrena, M.A.Jiménez, M.Rico, and B.Alarcón (1995).
A tyrosine-containing motif mediates ER retention of CD3-epsilon and adopts a helix-turn structure.
  EMBO J, 14, 2257-2268.  
  7796808 A.Yoshimura, T.Ohkubo, T.Kiguchi, N.A.Jenkins, D.J.Gilbert, N.G.Copeland, T.Hara, and A.Miyajima (1995).
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
  EMBO J, 14, 2816-2826.  
8590006 B.J.Mayer (1995).
Why two heads are better.
  Structure, 3, 977-980.  
7542925 B.Schaffhausen (1995).
SH2 domain structure and function.
  Biochim Biophys Acta, 1242, 61-75.  
7834741 C.H.Heldin (1995).
Dimerization of cell surface receptors in signal transduction.
  Cell, 80, 213-223.  
8846213 D.Barford, Z.Jia, and N.K.Tonks (1995).
Protein tyrosine phosphatases take off.
  Nat Struct Biol, 2, 1043-1053.  
7592905 D.Cowburn, J.Zheng, Q.Xu, and G.Barany (1995).
Enhanced affinities and specificities of consolidated ligands for the Src homology (SH) 3 and SH2 domains of Abelson protein-tyrosine kinase.
  J Biol Chem, 270, 26738-26741.  
  7773170 D.MacLean, A.M.Sefler, G.Zhu, S.J.Decker, A.R.Saltiel, J.Singh, D.McNamara, E.M.Dobrusin, and T.K.Sawyer (1995).
Differentiation of peptide molecular recognition by phospholipase C gamma-1 Src homology-2 domain and a mutant Tyr phosphatase PTP1bC215S.
  Protein Sci, 4, 13-20.  
  7708014 E.M.Phizicky, and S.Fields (1995).
Protein-protein interactions: methods for detection and analysis.
  Microbiol Rev, 59, 94.  
7730365 G.Alonso, M.Koegl, N.Mazurenko, and S.A.Courtneidge (1995).
Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors.
  J Biol Chem, 270, 9840-9848.  
7834743 G.B.Cohen, R.Ren, and D.Baltimore (1995).
Modular binding domains in signal transduction proteins.
  Cell, 80, 237-248.  
7540055 G.Siligardi, and A.F.Drake (1995).
The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides.
  Biopolymers, 37, 281-292.  
7537961 G.Superti-Furga, and S.A.Courtneidge (1995).
Structure-function relationships in Src family and related protein tyrosine kinases.
  Bioessays, 17, 321-330.  
7536927 J.E.Ladbury, M.A.Lemmon, M.Zhou, J.Green, M.C.Botfield, and J.Schlessinger (1995).
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
  Proc Natl Acad Sci U S A, 92, 3199-3203.  
7657647 K.K.Teng, H.Lander, J.E.Fajardo, H.Hanafusa, B.L.Hempstead, and R.B.Birge (1995).
v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway.
  J Biol Chem, 270, 20677-20685.  
9383454 K.M.Shokat (1995).
Tyrosine kinases: modular signaling enzymes with tunable specificities.
  Chem Biol, 2, 509-514.  
  7528327 L.Shiue, J.Green, O.M.Green, J.L.Karas, J.P.Morgenstern, M.K.Ram, M.K.Taylor, M.J.Zoller, L.D.Zydowsky, and J.B.Bolen (1995).
Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI.
  Mol Cell Biol, 15, 272-281.  
7486683 M.G.Myers, B.Cheatham, T.L.Fisher, B.R.Jachna, C.R.Kahn, J.M.Backer, and M.F.White (1995).
Common and distinct elements in insulin and PDGF signaling.
  Ann N Y Acad Sci, 766, 369-387.  
7612892 M.H.Jouvin, R.P.Numerof, and J.P.Kinet (1995).
Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI.
  Semin Immunol, 7, 29-35.  
7544002 M.M.Zhou, R.P.Meadows, T.M.Logan, H.S.Yoon, W.S.Wade, K.S.Ravichandran, S.J.Burakoff, and S.W.Fesik (1995).
Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
  Proc Natl Acad Sci U S A, 92, 7784-7788.
PDB code: 1tce
  8722577 M.Stefanescu, A.Onu, C.Matache, F.Ramos-Morales, S.Fischer, and G.Szegli (1995).
Naturally occurring anti-idiotypic antibodies to anti-phosphotyrosine in systemic lupus erythematosus interact with SRC-homology 2 domains.
  Autoimmunity, 22, 81-86.  
7773739 R.L.Stanfield, and I.A.Wilson (1995).
Protein-peptide interactions.
  Curr Opin Struct Biol, 5, 103-113.  
8590001 S.S.Narula, R.W.Yuan, S.E.Adams, O.M.Green, J.Green, T.B.Philips, L.D.Zydowsky, M.C.Botfield, M.Hatada, and E.R.Laird (1995).
Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.
  Structure, 3, 1061-1073.
PDB codes: 1csy 1csz
7627183 T.L.Hagemann, F.S.Rosen, and S.P.Kwan (1995).
Characterization of germline mutations of the gene encoding Bruton's tyrosine kinase in families with X-linked agammaglobulinemia.
  Hum Mutat, 5, 296-302.  
7543098 T.Trüb, W.E.Choi, G.Wolf, E.Ottinger, Y.Chen, M.Weiss, and S.E.Shoelson (1995).
Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine.
  J Biol Chem, 270, 18205-18208.  
8590002 Y.Q.Gosser, J.Zheng, M.Overduin, B.J.Mayer, and D.Cowburn (1995).
The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.
  Structure, 3, 1075-1086.
PDB code: 1awo
7541030 Z.Songyang, B.Margolis, M.Chaudhuri, S.E.Shoelson, and L.C.Cantley (1995).
The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif.
  J Biol Chem, 270, 14863-14866.  
7592796 Z.Songyang, G.Gish, G.Mbamalu, T.Pawson, and L.C.Cantley (1995).
A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.
  J Biol Chem, 270, 26029-26032.  
8578591 Z.Songyang, and L.C.Cantley (1995).
Recognition and specificity in protein tyrosine kinase-mediated signalling.
  Trends Biochem Sci, 20, 470-475.  
  7518560 A.G.Batzer, D.Rotin, J.M.Ureña, E.Y.Skolnik, and J.Schlessinger (1994).
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
  Mol Cell Biol, 14, 5192-5201.  
7521735 C.H.Lee, D.Kominos, S.Jacques, B.Margolis, J.Schlessinger, S.E.Shoelson, and J.Kuriyan (1994).
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
  Structure, 2, 423-438.
PDB codes: 1aya 1ayb 1ayc 1ayd
8183901 C.M.Pleiman, C.Abrams, L.T.Gauen, W.Bedzyk, J.Jongstra, A.S.Shaw, and J.C.Cambier (1994).
Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha.
  Proc Natl Acad Sci U S A, 91, 4268-4272.  
7513258 C.Ponzetto, A.Bardelli, Z.Zhen, F.Maina, P.dalla Zonca, S.Giordano, A.Graziani, G.Panayotou, and P.M.Comoglio (1994).
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family.
  Cell, 77, 261-271.  
  7521298 D.Cussac, M.Frech, and P.Chardin (1994).
Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.
  EMBO J, 13, 4011-4021.  
9383382 D.J.Austin, G.R.Crabtree, and S.L.Schreiber (1994).
Proximity versus allostery: the role of regulated protein dimerization in biology.
  Chem Biol, 1, 131-136.  
8070812 D.J.Rawlings, and O.N.Witte (1994).
Bruton's tyrosine kinase is a key regulator in B-cell development.
  Immunol Rev, 138, 105-119.  
8193535 G.A.Rodrigues, and M.Park (1994).
Oncogenic activation of tyrosine kinases.
  Curr Opin Genet Dev, 4, 15-24.  
7519995 G.Baumann, D.Maier, F.Freuler, C.Tschopp, K.Baudisch, and J.Wienands (1994).
In vitro characterization of major ligands for Src homology 2 domains derived from protein tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells.
  Eur J Immunol, 24, 1799-1807.  
  8114695 G.J.Pronk, Vries-Smits, L.Buday, J.Downward, J.A.Maassen, R.H.Medema, and J.L.Bos (1994).
Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras.
  Mol Cell Biol, 14, 1575-1581.  
  7520528 G.Panchamoorthy, T.Fukazawa, L.Stolz, G.Payne, K.Reedquist, S.Shoelson, Z.Songyang, L.Cantley, C.Walsh, and H.Band (1994).
Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn.
  Mol Cell Biol, 14, 6372-6385.  
9383377 G.Payne, L.A.Stolz, D.Pei, H.Band, S.E.Shoelson, and C.T.Walsh (1994).
The phosphopeptide-binding specificity of Src family SH2 domains.
  Chem Biol, 1, 99.  
  7514531 H.Wakao, F.Gouilleux, and B.Groner (1994).
Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.
  EMBO J, 13, 2182-2191.  
7545075 H.Yu, and S.L.Schreiber (1994).
Signalling an interest.
  Nat Struct Biol, 1, 417-420.  
8193536 J.Schlessinger (1994).
SH2/SH3 signaling proteins.
  Curr Opin Genet Dev, 4, 25-30.  
  7933110 K.M.Woods, and M.F.Verderame (1994).
Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.
  J Virol, 68, 7267-7274.  
  8007943 K.Yamamoto, F.W.Quelle, W.E.Thierfelder, B.L.Kreider, D.J.Gilbert, N.A.Jenkins, N.G.Copeland, O.Silvennoinen, and J.N.Ihle (1994).
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
  Mol Cell Biol, 14, 4342-4349.  
  8112292 L.Puil, J.Liu, G.Gish, G.Mbamalu, D.Bowtell, P.G.Pelicci, R.Arlinghaus, and T.Pawson (1994).
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
  EMBO J, 13, 764-773.  
  7509446 M.D.Schaller, J.D.Hildebrand, J.D.Shannon, J.W.Fox, R.R.Vines, and J.T.Parsons (1994).
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.
  Mol Cell Biol, 14, 1680-1688.  
  8196603 M.G.Myers, L.M.Wang, X.J.Sun, Y.Zhang, L.Yenush, J.Schlessinger, J.H.Pierce, and M.F.White (1994).
Role of IRS-1-GRB-2 complexes in insulin signaling.
  Mol Cell Biol, 14, 3577-3587.  
  7522724 M.Hensmann, G.W.Booker, G.Panayotou, J.Boyd, J.Linacre, M.Waterfield, and I.D.Campbell (1994).
Phosphopeptide binding to the N-terminal SH2 domain of the p85 alpha subunit of PI 3'-kinase: a heteronuclear NMR study.
  Protein Sci, 3, 1020-1030.  
  7513045 M.Raab, M.Yamamoto, and C.E.Rudd (1994).
The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck.
  Mol Cell Biol, 14, 2862-2870.  
  8065326 M.Yoakim, W.Hou, Z.Songyang, Y.Liu, L.Cantley, and B.Schaffhausen (1994).
Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.
  Mol Cell Biol, 14, 5929-5938.  
7840771 R.A.Saavedra (1994).
The roles of autophosphorylation and phosphorylation in the life of osteopontin.
  Bioessays, 16, 913-918.  
7517560 S.Koyasu, A.G.Tse, P.Moingeon, R.E.Hussey, A.Mildonian, J.Hannisian, L.K.Clayton, and E.L.Reinherz (1994).
Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains.
  Proc Natl Acad Sci U S A, 91, 6693-6697.  
8197134 T.Improta, C.Schindler, C.M.Horvath, I.M.Kerr, G.R.Stark, and J.E.Darnell (1994).
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.
  Proc Natl Acad Sci U S A, 91, 4776-4780.  
7738603 Y.P.Pang, and A.P.Kozikowski (1994).
Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies.
  J Comput Aided Mol Des, 8, 669-681.  
  8139002 Y.Zhao, C.Thomas, C.Bremer, and P.Roy (1994).
Deletion and mutational analyses of bluetongue virus NS2 protein indicate that the amino but not the carboxy terminus of the protein is critical for RNA-protein interactions.
  J Virol, 68, 2179-2185.  
  7511210 Z.Songyang, S.E.Shoelson, J.McGlade, P.Olivier, T.Pawson, X.R.Bustelo, M.Barbacid, H.Sabe, H.Hanafusa, and T.Yi (1994).
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
  Mol Cell Biol, 14, 2777-2785.  
7545930 Z.Zhong, Z.Wen, and J.E.Darnell (1994).
Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
  Proc Natl Acad Sci U S A, 91, 4806-4810.  
  7694720 A.Tsygankov, and J.Bolen (1993).
The Src family of tyrosine protein kinases in hemopoietic signal transduction.
  Stem Cells, 11, 371-380.  
8357828 C.E.Rudd, O.Janssen, K.V.Prasad, M.Raab, A.da Silva, J.C.Telfer, and M.Yamamoto (1993).
src-related protein tyrosine kinases and their surface receptors.
  Biochim Biophys Acta, 1155, 239-266.  
8265614 C.H.Lee, W.Li, R.Nishimura, M.Zhou, A.G.Batzer, M.G.Myers, M.F.White, J.Schlessinger, and E.Y.Skolnik (1993).
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.
  Proc Natl Acad Sci U S A, 90, 11713-11717.  
  8395016 C.M.Pleiman, M.R.Clark, L.K.Gauen, S.Winitz, K.M.Coggeshall, G.L.Johnson, A.S.Shaw, and J.C.Cambier (1993).
Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.
  Mol Cell Biol, 13, 5877-5887.  
8275088 E.Friedman, P.V.Gejman, G.A.Martin, and F.McCormick (1993).
Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.
  Nat Genet, 5, 242-247.  
7685110 G.Payne, S.E.Shoelson, G.D.Gish, T.Pawson, and C.T.Walsh (1993).
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.
  Proc Natl Acad Sci U S A, 90, 4902-4906.  
  7504171 K.B.Bibbins, H.Boeuf, and H.E.Varmus (1993).
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.
  Mol Cell Biol, 13, 7278-7287.  
  7687536 M.E.Noble, A.Musacchio, M.Saraste, S.A.Courtneidge, and R.K.Wierenga (1993).
Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.
  EMBO J, 12, 2617-2624.
PDB code: 1shf
  8268793 M.J.Fry, G.Panayotou, G.W.Booker, and M.D.Waterfield (1993).
New insights into protein-tyrosine kinase receptor signaling complexes.
  Protein Sci, 2, 1785-1797.  
  8305738 M.J.Stern, L.E.Marengere, R.J.Daly, E.J.Lowenstein, M.Kokel, A.Batzer, P.Olivier, T.Pawson, and J.Schlessinger (1993).
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
  Mol Biol Cell, 4, 1175-1188.  
8022970 M.J.Zvelebil, and J.M.Thornton (1993).
Peptide-protein interactions: an overview.
  Q Rev Biophys, 26, 333-363.  
7688784 M.Sanchez, Z.Misulovin, A.L.Burkhardt, S.Mahajan, T.Costa, R.Franke, J.B.Bolen, and M.Nussenzweig (1993).
Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.
  J Exp Med, 178, 1049-1055.  
8298582 R.K.Sweeb, and J.H.Beijnen (1993).
Signal transduction pathways: new targets in oncology.
  Pharm World Sci, 15, 233-242.  
  7692233 R.Nishimura, W.Li, A.Kashishian, A.Mondino, M.Zhou, J.Cooper, and J.Schlessinger (1993).
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
  Mol Cell Biol, 13, 6889-6896.  
15335710 T.Pawson, and J.Schlessingert (1993).
SH2 and SH3 domains.
  Curr Biol, 3, 434-442.  
  8246974 T.Yi, A.L.Mui, G.Krystal, and J.N.Ihle (1993).
Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.
  Mol Cell Biol, 13, 7577-7586.  
  7504175 X.J.Sun, D.L.Crimmins, M.G.Myers, M.Miralpeix, and M.F.White (1993).
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.
  Mol Cell Biol, 13, 7418-7428.  
8402883 X.Y.Fu, and J.J.Zhang (1993).
Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter.
  Cell, 74, 1135-1145.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.