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PDBsum entry 1sem

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protein ligands Protein-protein interface(s) links
Signal transduction protein PDB id
1sem
Jmol
Contents
Protein chains
58 a.a. *
Ligands
ACE-PRO-PRO-PRO-
VAL-PRO-PRO-ARG
×2
Waters ×67
* Residue conservation analysis
PDB id:
1sem
Name: Signal transduction protein
Title: Structural determinants of peptide-binding orientation and of sequence specificity in sh3 domains
Structure: Sem-5. Chain: a, b. Engineered: yes. 10-residue proline-rich peptide from msos (ace- pro-pro-pro-val-pro-pro-arg-arg-arg). Chain: c, d
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: grb2. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090
Biol. unit: Dimer (from PQS)
Resolution:
2.00Å     R-factor:   0.189    
Authors: W.A.Lim,F.M.Richards,R.O.Fox
Key ref: W.A.Lim et al. (1994). Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature, 372, 375-379. PubMed id: 7802869
Date:
28-Mar-95     Release date:   10-Jul-95    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P29355  (SEM5_CAEEL) -  Sex muscle abnormal protein 5
Seq:
Struc:
228 a.a.
58 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
Nature 372:375-379 (1994)
PubMed id: 7802869  
 
 
Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains.
W.A.Lim, F.M.Richards, R.O.Fox.
 
  ABSTRACT  
 
The Src-homology-3 (SH3) domains of the Caenorhabditis elegans protein SEM-5 and its human and Drosophila homologues, Grb2 and Drk (refs 1-4), bind proline-rich sequences found in the nucleotide-exchange factor Sos as part of their proposed function linking receptor tyrosine kinase activation to Ras activation. Here we report the crystal structure at 2.0 A resolution of the carboxy-terminal SH3 domain from SEM-5 complexed to the mSos-derived amino-acid sequence PPPVPPRRR. The peptide is found to bind in an orientation ('minus') that is precisely opposite to that observed previously ('plus' orientation) in other SH3-peptide complexes. This novel ability of peptide-recognition proteins to recognize peptides in two distinct modes may play an important role in the signalling specificity of pathways involving SH3 domains. Comparison of this structure with other SH3 complexes reveals how a conserved binding face can be used to recognize peptides in different orientations, and why the Sos peptide binds in this particular orientation.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21472810 C.B.McDonald, K.L.Seldeen, B.J.Deegan, V.Bhat, and A.Farooq (2011).
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  Proc Natl Acad Sci U S A, 98, 5515-5520.
PDB code: 1i1j
11316885 K.V.Kishan, M.E.Newcomer, T.H.Rhodes, and S.D.Guilliot (2001).
Effect of pH and salt bridges on structural assembly: molecular structures of the monomer and intertwined dimer of the Eps8 SH3 domain.
  Protein Sci, 10, 1046-1055.
PDB codes: 1i07 1i0c
  11463741 M.Geyer, O.T.Fackler, and B.M.Peterlin (2001).
Structure--function relationships in HIV-1 Nef.
  EMBO Rep, 2, 580-585.  
11406576 M.Nishida, K.Nagata, Y.Hachimori, M.Horiuchi, K.Ogura, V.Mandiyan, J.Schlessinger, and F.Inagaki (2001).
Novel recognition mode between Vav and Grb2 SH3 domains.
  EMBO J, 20, 2995-3007.
PDB codes: 1gcp 1gcq
11682324 M.Vidal, V.Gigoux, and C.Garbay (2001).
SH2 and SH3 domains as targets for anti-proliferative agents.
  Crit Rev Oncol Hematol, 40, 175-186.  
11685249 R.Ghose, A.Shekhtman, M.J.Goger, H.Ji, and D.Cowburn (2001).
A novel, specific interaction involving the Csk SH3 domain and its natural ligand.
  Nat Struct Biol, 8, 998.
PDB code: 1jeg
11782293 V.Agrawal, and R.K.Kishan (2001).
Functional evolution of two subtly different (similar) folds.
  BMC Struct Biol, 1, 5.  
  11206067 A.Rath, and A.R.Davidson (2000).
The design of a hyperstable mutant of the Abp1p SH3 domain by sequence alignment analysis.
  Protein Sci, 9, 2457-2469.  
10873829 D.J.Owen, and J.P.Luzio (2000).
Structural insights into clathrin-mediated endocytosis.
  Curr Opin Cell Biol, 12, 467-474.  
  11071920 G.Bottger, P.Barnett, A.T.Klein, A.Kragt, H.F.Tabak, and B.Distel (2000).
Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner.
  Mol Biol Cell, 11, 3963-3976.  
10856234 H.Kang, C.Freund, J.S.Duke-Cohan, A.Musacchio, G.Wagner, and C.E.Rudd (2000).
SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.
  EMBO J, 19, 2889-2899.  
10662684 J.E.Ladbury, and S.Arold (2000).
Searching for specificity in SH domains.
  Chem Biol, 7, R3-R8.  
10931866 K.Oegema, M.S.Savoian, T.J.Mitchison, and C.M.Field (2000).
Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis.
  J Cell Biol, 150, 539-552.  
10723797 L.A.Norian, and G.A.Koretzky (2000).
Intracellular adapter molecules.
  Semin Immunol, 12, 43-54.  
10930849 M.Barzik, W.D.Schubert, U.Carl, J.Wehland, and D.W.Heinz (2000).
Crystallization and preliminary X-ray analysis of the EVH1 domain of Vesl-2b.
  Acta Crystallogr D Biol Crystallogr, 56, 930-932.  
10744724 M.T.Bedford, D.Sarbassova, J.Xu, P.Leder, and M.B.Yaffe (2000).
A novel pro-Arg motif recognized by WW domains.
  J Biol Chem, 275, 10359-10369.  
10861385 N.Okishio, M.Nagai, R.Fukuda, S.Nagatomo, and T.Kitagawa (2000).
Interactions of phosphatidylinositol 3-kinase Src homology 3 domain with its ligand peptide studied by absorption, circular dichroism, and UV resonance raman spectroscopies.
  Biopolymers, 57, 208-217.  
11063574 N.Schiering, E.Casale, P.Caccia, P.Giordano, and C.Battistini (2000).
Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.
  Biochemistry, 39, 13376-13382.
PDB code: 1fyr
11206058 P.A.Dalby, R.H.Hoess, and W.F.DeGrado (2000).
Evolution of binding affinity in a WW domain probed by phage display.
  Protein Sci, 9, 2366-2376.  
11101511 P.Barnett, G.Bottger, A.T.Klein, H.F.Tabak, and B.Distel (2000).
The peroxisomal membrane protein Pex13p shows a novel mode of SH3 interaction.
  EMBO J, 19, 6382-6391.  
10933808 R.Kleene, B.Classen, J.Zdzieblo, and M.Schrader (2000).
SH3 binding sites of ZG29p mediate an interaction with amylase and are involved in condensation-sorting in the exocrine rat pancreas.
  Biochemistry, 39, 9893-9900.  
  11152127 S.M.Larson, and A.R.Davidson (2000).
The identification of conserved interactions within the SH3 domain by alignment of sequences and structures.
  Protein Sci, 9, 2170-2180.  
10716926 X.K.Tong, N.K.Hussain, E.de Heuvel, A.Kurakin, E.Abi-Jaoude, C.C.Quinn, M.F.Olson, R.Marais, D.Baranes, B.K.Kay, and P.S.McPherson (2000).
The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.
  EMBO J, 19, 1263-1271.  
10611245 Y.T.Yan, S.M.Stein, J.Ding, M.M.Shen, and C.Abate-Shen (2000).
A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein.
  Mol Cell Biol, 20, 661-671.  
10805734 Z.S.Zhao, E.Manser, and L.Lim (2000).
Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation.
  Mol Cell Biol, 20, 3906-3917.  
10508163 A.M.Mongioví, P.R.Romano, S.Panni, M.Mendoza, W.T.Wong, A.Musacchio, G.Cesareni, and P.P.Di Fiore (1999).
A novel peptide-SH3 interaction.
  EMBO J, 18, 5300-5309.  
10467125 B.Aghazadeh, and M.K.Rosen (1999).
Ligand recognition by SH3 and WW domains: the role of N-alkylation in PPII helices.
  Chem Biol, 6, R241-R246.  
  10022919 F.J.King, E.Hu, D.F.Harris, P.Sarraf, B.M.Spiegelman, and T.M.Roberts (1999).
DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines.
  Mol Cell Biol, 19, 2330-2337.  
10542231 G.Cestra, L.Castagnoli, L.Dente, O.Minenkova, A.Petrelli, N.Migone, U.Hoffmüller, J.Schneider-Mergener, and G.Cesareni (1999).
The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.
  J Biol Chem, 274, 32001-32007.  
10339551 G.Wang, G.P.Wylie, P.D.Twigg, D.L.Caspar, J.R.Murphy, and T.M.Logan (1999).
Solution structure and peptide binding studies of the C-terminal src homology 3-like domain of the diphtheria toxin repressor protein.
  Proc Natl Acad Sci U S A, 96, 6119-6124.
PDB code: 1bym
10518213 H.Ye, Y.C.Park, M.Kreishman, E.Kieff, and H.Wu (1999).
The structural basis for the recognition of diverse receptor sequences by TRAF2.
  Mol Cell, 4, 321-330.
PDB codes: 1czy 1czz 1d00 1d01 1d0a 1d0j
10338211 K.E.Prehoda, D.J.Lee, and W.A.Lim (1999).
Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly.
  Cell, 97, 471-480.
PDB code: 1evh
10393272 L.Buday (1999).
Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins.
  Biochim Biophys Acta, 1422, 187-204.  
10491105 R.P.Menon, and R.C.Hughes (1999).
Determinants in the N-terminal domains of galectin-3 for secretion by a novel pathway circumventing the endoplasmic reticulum-Golgi complex.
  Eur J Biochem, 264, 569-576.  
10535922 S.Hirotsu, Y.Abe, K.Okada, N.Nagahara, H.Hori, T.Nishino, and T.Hakoshima (1999).
Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.
  Proc Natl Acad Sci U S A, 96, 12333-12338.
PDB code: 1qq2
10492401 Shivakrupa, R.Singh, and G.Swarup (1999).
Identification of a novel splice variant of C3G which shows tissue-specific expression.
  DNA Cell Biol, 18, 701-708.  
10559253 T.Ago, H.Nunoi, T.Ito, and H.Sumimoto (1999).
Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase.
  J Biol Chem, 274, 33644-33653.  
10595512 W.Ruan, P.Pang, and Y.Rao (1999).
The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility.
  Neuron, 24, 595-605.  
10593988 Y.Mochizuki, and T.Takenawa (1999).
Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles.
  J Biol Chem, 274, 36790-36795.  
9582365 A.Gregorieff, J.F.Cloutier, and A.Veillette (1998).
Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk).
  J Biol Chem, 273, 13217-13222.  
  9418863 A.R.Comer, S.M.Ahern-Djamali, J.L.Juang, P.D.Jackson, and F.M.Hoffmann (1998).
Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled.
  Mol Cell Biol, 18, 152-160.  
9500553 D.Barilá, and G.Superti-Furga (1998).
An intramolecular SH3-domain interaction regulates c-Abl activity.
  Nat Genet, 18, 280-282.  
9736607 D.J.Owen, P.Wigge, Y.Vallis, J.D.Moore, P.R.Evans, and H.T.McMahon (1998).
Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation.
  EMBO J, 17, 5273-5285.
PDB code: 1bb9
9485443 H.Hansson, P.T.Mattsson, P.Allard, P.Haapaniemi, M.Vihinen, C.I.Smith, and T.Hard (1998).
Solution structure of the SH3 domain from Bruton's tyrosine kinase.
  Biochemistry, 37, 2912-2924.
PDB codes: 1aww 1awx
  9621042 I.H.Khan, E.T.Sawai, E.Antonio, C.J.Weber, C.P.Mandell, P.Montbriand, and P.A.Luciw (1998).
Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques.
  J Virol, 72, 5820-5830.  
9612082 J.C.Williams, R.K.Wierenga, and M.Saraste (1998).
Insights into Src kinase functions: structural comparisons.
  Trends Biochem Sci, 23, 179-184.  
  9475731 J.Collet, C.A.Spike, E.A.Lundquist, J.E.Shaw, and R.K.Herman (1998).
Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans.
  Genetics, 148, 187-200.  
10417854 J.Dorrestijn, F.J.van Bussel, J.A.Maassen, and D.S.Gomes de Mesquita (1998).
Early steps in insulin action.
  Arch Physiol Biochem, 106, 269-289.  
9851931 J.T.Nguyen, C.W.Turck, F.E.Cohen, R.N.Zuckermann, and W.A.Lim (1998).
Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
  Science, 282, 2088-2092.
PDB codes: 1b07 2sem 3sem
9748234 K.H.Kirsch, M.M.Georgescu, and H.Hanafusa (1998).
Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G.
  J Biol Chem, 273, 25673-25679.  
9529254 R.Steven, T.J.Kubiseski, H.Zheng, S.Kulkarni, J.Mancillas, A.Ruiz Morales, C.W.Hogue, T.Pawson, and J.Culotti (1998).
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.
  Cell, 92, 785-795.  
9778343 S.Arold, R.O'Brien, P.Franken, M.P.Strub, F.Hoh, C.Dumas, and J.E.Ladbury (1998).
RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.
  Biochemistry, 37, 14683-14691.
PDB code: 1bu1
9593201 S.Knapp, P.T.Mattson, P.Christova, K.D.Berndt, A.Karshikoff, M.Vihinen, C.I.Smith, and R.Ladenstein (1998).
Thermal unfolding of small proteins with SH3 domain folding pattern.
  Proteins, 31, 309-319.  
9799227 S.Simon, E.Krejci, and J.Massoulié (1998).
A four-to-one association between peptide motifs: four C-terminal domains from cholinesterase assemble with one proline-rich attachment domain (PRAD) in the secretory pathway.
  EMBO J, 17, 6178-6187.  
9209158 A.Borroto, M.A.Jiménez, B.Alarcón, and M.Rico (1997).
1H-NMR analysis of CD3-epsilon reveals the presence of turn-helix structures around the ITAM motif in an otherwise random coil cytoplasmic tail.
  Biopolymers, 42, 75-88.  
9182529 C.Leprince, F.Romero, D.Cussac, B.Vayssiere, R.Berger, A.Tavitian, and J.H.Camonis (1997).
A new member of the amphiphysin family connecting endocytosis and signal transduction pathways.
  J Biol Chem, 272, 15101-15105.  
9122235 C.W.So, C.Caldas, M.M.Liu, S.J.Chen, Q.H.Huang, L.J.Gu, M.H.Sham, L.M.Wiedemann, and L.C.Chan (1997).
EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.
  Proc Natl Acad Sci U S A, 94, 2563-2568.  
9566119 D.C.Dalgarno, M.C.Botfield, and R.J.Rickles (1997).
SH3 domains and drug design: ligands, structure, and biological function.
  Biopolymers, 43, 383-400.  
9434895 F.Sicheri, and J.Kuriyan (1997).
Structures of Src-family tyrosine kinases.
  Curr Opin Struct Biol, 7, 777-785.  
9261721 G.E.Morley, J.F.Ek-Vitorín, S.M.Taffet, and M.Delmar (1997).
Structure of connexin43 and its regulation by pHi.
  J Cardiovasc Electrophysiol, 8, 939-951.  
9408950 H.V.Patel, S.R.Tzeng, C.Y.Liao, S.H.Chen, and J.W.Cheng (1997).
SH3 domain of Bruton's tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cbl.
  Proteins, 29, 545-552.  
9210364 J.A.Frazier, and C.M.Field (1997).
Actin cytoskeleton: are FH proteins local organizers?
  Curr Biol, 7, R414-R417.  
9241420 J.Kuriyan, and D.Cowburn (1997).
Modular peptide recognition domains in eukaryotic signaling.
  Annu Rev Biophys Biomol Struct, 26, 259-288.  
9095189 J.T.Nguyen, and W.A.Lim (1997).
How Src exercises self-restraint.
  Nat Struct Biol, 4, 256-260.  
9016723 K.S.Thorn, H.E.Christensen, R.Shigeta, D.Huddler, L.Shalaby, U.Lindberg, N.H.Chua, and C.E.Schutt (1997).
The crystal structure of a major allergen from plants.
  Structure, 5, 19-32.
PDB codes: 1a0k 1plm 3nul
9303002 K.V.Kishan, G.Scita, W.T.Wong, P.P.Di Fiore, and M.E.Newcomer (1997).
The SH3 domain of Eps8 exists as a novel intertwined dimer.
  Nat Struct Biol, 4, 739-743.
PDB code: 1aoj
9346925 M.Anafi, F.Kiefer, G.D.Gish, G.Mbamalu, N.N.Iscove, and T.Pawson (1997).
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.
  J Biol Chem, 272, 27804-27811.  
9428519 M.B.Yaffe, K.Rittinger, S.Volinia, P.R.Caron, A.Aitken, H.Leffers, S.J.Gamblin, S.J.Smerdon, and L.C.Cantley (1997).
The structural basis for 14-3-3:phosphopeptide binding specificity.
  Cell, 91, 961-971.
PDB code: 14ps
9326643 M.I.Wahl, A.C.Fluckiger, R.M.Kato, H.Park, O.N.Witte, and D.J.Rawlings (1997).
Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.
  Proc Natl Acad Sci U S A, 94, 11526-11533.  
9360613 N.M.Mahoney, P.A.Janmey, and S.C.Almo (1997).
Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation.
  Nat Struct Biol, 4, 953-960.
PDB code: 1awi
9111080 P.M.Okamoto, J.S.Herskovits, and R.B.Vallee (1997).
Role of the basic, proline-rich region of dynamin in Src homology 3 domain binding and endocytosis.
  J Biol Chem, 272, 11629-11635.  
9108038 P.Xu, K.I.Mitchelhill, B.Kobe, B.E.Kemp, and H.G.Zot (1997).
The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins.
  Proc Natl Acad Sci U S A, 94, 3685-3690.  
9006950 S.Bon, F.Coussen, and J.Massoulié (1997).
Quaternary associations of acetylcholinesterase. II. The polyproline attachment domain of the collagen tail.
  J Biol Chem, 272, 3016-3021.  
  9045850 S.Negrete-Urtasun, S.H.Denison, and H.N.Arst (1997).
Characterization of the pH signal transduction pathway gene palA of Aspergillus nidulans and identification of possible homologs.
  J Bacteriol, 179, 1832-1835.  
9630982 A.B.Sparks, N.G.Hoffman, S.J.McConnell, D.M.Fowlkes, and B.K.Kay (1996).
Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.
  Nat Biotechnol, 14, 741-744.  
8807882 A.J.Wilkinson (1996).
Accommodating structurally diverse peptides in proteins.
  Chem Biol, 3, 519-524.  
8805554 C.J.Morton, D.J.Pugh, E.L.Brown, J.D.Kahmann, D.A.Renzoni, and I.D.Campbell (1996).
Solution structure and peptide binding of the SH3 domain from human Fyn.
  Structure, 4, 705-714.
PDB codes: 1nyf 1nyg
8570618 C.Tribioli, S.Droetto, S.Bione, G.Cesareni, M.R.Torrisi, L.V.Lotti, L.Lanfrancone, D.Toniolo, and P.Pelicci (1996).
An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.
  Proc Natl Acad Sci U S A, 93, 695-699.  
8961927 D.A.Renzoni, D.J.Pugh, G.Siligardi, P.Das, C.J.Morton, C.Rossi, M.D.Waterfield, I.D.Campbell, and J.E.Ladbury (1996).
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
  Biochemistry, 35, 15646-15653.
PDB codes: 1a0n 1azg
8987987 E.C.Petrella, L.M.Machesky, D.A.Kaiser, and T.D.Pollard (1996).
Structural requirements and thermodynamics of the interaction of proline peptides with profilin.
  Biochemistry, 35, 16535-16543.  
  8649363 F.Parker, F.Maurier, I.Delumeau, M.Duchesne, D.Faucher, L.Debussche, A.Dugue, F.Schweighoffer, and B.Tocque (1996).
A Ras-GTPase-activating protein SH3-domain-binding protein.
  Mol Cell Biol, 16, 2561-2569.  
8647900 G.Weskamp, J.Krätzschmar, M.S.Reid, and C.P.Blobel (1996).
MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.
  J Cell Biol, 132, 717-726.  
8630736 H.Park, M.I.Wahl, D.E.Afar, C.W.Turck, D.J.Rawlings, C.Tam, A.M.Scharenberg, J.P.Kinet, and O.N.Witte (1996).
Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
  Immunity, 4, 515-525.  
  8635453 I.de Mendez, A.G.Adams, R.A.Sokolic, H.L.Malech, and T.L.Leto (1996).
Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells.
  EMBO J, 15, 1211-1220.  
8824292 J.A.Donovan, Y.Ota, W.Y.Langdon, and L.E.Samelson (1996).
Regulation of the association of p120cbl with Grb2 in Jurkat T cells.
  J Biol Chem, 271, 26369-26374.  
8874002 J.F.Ek-Vitorín, G.Calero, G.E.Morley, W.Coombs, S.M.Taffet, and M.Delmar (1996).
PH regulation of connexin43: molecular analysis of the gating particle.
  Biophys J, 71, 1273-1284.  
8617717 J.Krätzschmar, L.Lum, and C.P.Blobel (1996).
Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.
  J Biol Chem, 271, 4593-4596.  
8736558 J.Qin, G.M.Clore, W.P.Kennedy, J.Kuszewski, and A.M.Gronenborn (1996).
The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal.
  Structure, 4, 613-620.
PDB codes: 1cqg 1cqh
8650211 J.Shi, C.R.Ross, T.L.Leto, and F.Blecha (1996).
PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox.
  Proc Natl Acad Sci U S A, 93, 6014-6018.  
8663276 J.W.Nelson, J.Zhu, C.C.Smith, M.Kulka, and L.Aurelian (1996).
ATP and SH3 binding sites in the protein kinase of the large subunit of herpes simplex virus type 2 of ribonucleotide reductase (ICP10).
  J Biol Chem, 271, 17021-17027.  
  8670803 J.den Hertog, and T.Hunter (1996).
Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.
  EMBO J, 15, 3016-3027.  
8702917 M.Anafi, M.K.Rosen, G.D.Gish, L.E.Kay, and T.Pawson (1996).
A potential SH3 domain-binding site in the Crk SH2 domain.
  J Biol Chem, 271, 21365-21374.  
8906616 M.C.Weiler, J.L.Smith, and J.N.Masters (1996).
CR16, a novel proline-rich protein expressed in rat brain neurons, binds to SH3 domains and is a MAP kinase substrate.
  J Mol Neurosci, 7, 203-215.  
  8649366 M.E.Nickas, and M.P.Yaffe (1996).
BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae.
  Mol Cell Biol, 16, 2585-2593.  
8662907 M.Matsuda, S.Ota, R.Tanimura, H.Nakamura, K.Matuoka, T.Takenawa, K.Nagashima, and T.Kurata (1996).
Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.
  J Biol Chem, 271, 14468-14472.  
8718852 M.T.Pisabarro, and L.Serrano (1996).
Rational design of specific high-affinity peptide ligands for the Abl-SH3 domain.
  Biochemistry, 35, 10634-10640.  
9238627 N.G.Hoffman, A.B.Sparks, J.M.Carter, and B.K.Kay (1996).
Binding properties of SH3 peptide ligands identified from phage-displayed random peptide libraries.
  Mol Divers, 2, 5.  
8799133 P.A.Rejto, and G.M.Verkhivker (1996).
Unraveling principles of lead discovery: from unfrustrated energy landscapes to novel molecular anchors.
  Proc Natl Acad Sci U S A, 93, 8945-8950.  
8807900 S.Feng, T.M.Kapoor, F.Shirai, A.P.Combs, and S.L.Schreiber (1996).
Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis.
  Chem Biol, 3, 661-670.
PDB codes: 1nlo 1nlp
8599760 S.Grzesiek, A.Bax, G.M.Clore, A.M.Gronenborn, J.S.Hu, J.Kaufman, I.Palmer, S.J.Stahl, and P.T.Wingfield (1996).
The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase.
  Nat Struct Biol, 3, 340-345.
PDB code: 1nef
8805558 W.A.Lim (1996).
Reading between the lines: SH3 recognition of an intact protein.
  Structure, 4, 657-659.  
7890694 A.Fuchs, M.C.Dagher, and P.V.Vignais (1995).
Mapping the domains of interaction of p40phox with both p47phox and p67phox of the neutrophil oxidase complex using the two-hybrid system.
  J Biol Chem, 270, 5695-5697.  
7542990 B.J.Mayer, and M.J.Eck (1995).
SH3 domains. Minding your p's and q's.
  Curr Biol, 5, 364-367.  
  7774577 B.S.Knudsen, J.Zheng, S.M.Feller, J.P.Mayer, S.K.Burrell, D.Cowburn, and H.Hanafusa (1995).
Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins.
  EMBO J, 14, 2191-2198.  
  7588629 C.H.Lee, B.Leung, M.A.Lemmon, J.Zheng, D.Cowburn, J.Kuriyan, and K.Saksela (1995).
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.
  EMBO J, 14, 5006-5015.  
7559773 C.M.Field, and B.M.Alberts (1995).
Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex.
  J Cell Biol, 131, 165-178.  
7797522 C.Schumacher, B.S.Knudsen, T.Ohuchi, P.P.Di Fiore, R.H.Glassman, and H.Hanafusa (1995).
The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R.
  J Biol Chem, 270, 15341-15347.  
  7588608 D.N.Sgouras, M.A.Athanasiou, G.J.Beal, R.J.Fisher, D.G.Blair, and G.J.Mavrothalassitis (1995).
ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.
  EMBO J, 14, 4781-4793.  
7834743 G.B.Cohen, R.Ren, and D.Baltimore (1995).
Modular binding domains in signal transduction proteins.
  Cell, 80, 237-248.  
7629518 G.O.Cory, R.C.Lovering, S.Hinshelwood, L.MacCarthy-Morrogh, R.J.Levinsky, and C.Kinnon (1995).
The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.
  J Exp Med, 182, 611-615.  
7540055 G.Siligardi, and A.F.Drake (1995).
The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides.
  Biopolymers, 37, 281-292.  
7592945 I.Van Seuningen, J.Ostrowski, X.R.Bustelo, P.R.Sleath, and K.Bomsztyk (1995).
The K protein domain that recruits the interleukin 1-responsive K protein kinase lies adjacent to a cluster of c-Src and Vav SH3-binding sites. Implications that K protein acts as a docking platform.
  J Biol Chem, 270, 26976-26985.  
9383403 J.A.Simon, and S.L.Schreiber (1995).
Grb2 SH3 binding to peptides from Sos: evaluation of a general model for SH3-ligand interactions.
  Chem Biol, 2, 53-60.  
7553130 J.M.Robinson, and J.A.Badwey (1995).
The NADPH oxidase complex of phagocytic leukocytes: a biochemical and cytochemical view.
  Histochem Cell Biol, 103, 163-180.  
  8535233 J.W.Becker, A.I.Marcy, L.L.Rokosz, M.G.Axel, J.J.Burbaum, P.M.Fitzgerald, P.M.Cameron, C.K.Esser, W.K.Hagmann, and J.D.Hermes (1995).
Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme.
  Protein Sci, 4, 1966-1976.
PDB codes: 1slm 1sln
7536925 K.Alexandropoulos, G.Cheng, and D.Baltimore (1995).
Proline-rich sequences that bind to Src homology 3 domains with individual specificities.
  Proc Natl Acad Sci U S A, 92, 3110-3114.  
9383454 K.M.Shokat (1995).
Tyrosine kinases: modular signaling enzymes with tunable specificities.
  Chem Biol, 2, 509-514.  
7592689 P.Xu, A.S.Zot, and H.G.Zot (1995).
Identification of Acan125 as a myosin-I-binding protein present with myosin-I on cellular organelles of Acanthamoeba.
  J Biol Chem, 270, 25316-25319.  
7479908 R.J.Rickles, M.C.Botfield, X.M.Zhou, P.A.Henry, J.S.Brugge, and M.J.Zoller (1995).
Phage display selection of ligand residues important for Src homology 3 domain binding specificity.
  Proc Natl Acad Sci U S A, 92, 10909-10913.  
8618911 S.Feng, C.Kasahara, R.J.Rickles, and S.L.Schreiber (1995).
Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands.
  Proc Natl Acad Sci U S A, 92, 12408-12415.
PDB codes: 1qwe 1qwf
7629138 S.S.Yang, L.Van Aelst, and D.Bar-Sagi (1995).
Differential interactions of human Sos1 and Sos2 with Grb2.
  J Biol Chem, 270, 18212-18215.  
7642581 T.Fukazawa, K.A.Reedquist, T.Trub, S.Soltoff, G.Panchamoorthy, B.Druker, L.Cantley, S.E.Shoelson, and H.Band (1995).
The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase.
  J Biol Chem, 270, 19141-19150.  
  7781603 T.Raabe, J.P.Olivier, B.Dickson, X.Liu, G.D.Gish, T.Pawson, and E.Hafen (1995).
Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.
  EMBO J, 14, 2509-2518.  
7657668 W.Yang, S.N.Malek, and S.Desiderio (1995).
An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo.
  J Biol Chem, 270, 20832-20840.  
7735837 X.Wu, B.Knudsen, S.M.Feller, J.Zheng, A.Sali, D.Cowburn, H.Hanafusa, and J.Kuriyan (1995).
Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk.
  Structure, 3, 215-226.
PDB codes: 1cka 1ckb
7775479 X.X.Xu, W.Yang, S.Jackowski, and C.O.Rock (1995).
Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product.
  J Biol Chem, 270, 14184-14191.  
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