PDBsum entry: 1s9k

Transcription/DNA

PDB id: 1s9k

Contents

Protein chains

280 a.a. *

53 a.a. *

52 a.a. *

DNA/RNA

* Residue conservation analysis

PDB id:

1s9k

Name:

Transcription/DNA

Title:

Crystal structure of human nfat1 and fos-jun on the il-2 arre1 site

Structure:

Human il-2 arre1 promoter element, plus strand. Chain: a. Engineered: yes. Human il-2 arre1 promoter element, minus strand. Chain: b. Engineered: yes. Nuclear factor of activated t-cells, cytoplasmic 2. Chain: c.

Source:

Synthetic: yes. Other_details: solid phase synthesis. Homo sapiens. Human. Organism_taxid: 9606. Gene: nfatc2, nfat1, nfatp. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fos, g0s7.

Biol. unit:

Pentamer (from PQS)

Resolution:

3.10Å R-factor: 0.242 R-free: 0.275

Authors:

D.Wang,J.C.Stroud,L.Chen

Key ref:

D.Wang et al. Crystal structure of human nfat1 and fos-Jun on the il-2 arre1 site. To be published,

Date:

04-Feb-04 Release date: 14-Jun-05

Protein chain

Q13469  (NFAC2_HUMAN) -  Nuclear factor of activated T-cells, cytoplasmic 2

Seq: 925 a.a.

Struc: 280 a.a.

Protein chain

P01100  (FOS_HUMAN) -  Proto-oncogene c-Fos

Seq: 380 a.a.

Struc: 53 a.a.

Protein chain

P05412  (JUN_HUMAN) -  Transcription factor AP-1

Seq: 331 a.a.

Struc: 52 a.a.

 Gene Ontology (GO) functional annotation 

• Cellular component: nucleus (1 term)
• Biological process: regulation of transcription (2 terms)
• Biochemical function: transcription factor activity (4 terms)