PDBsum entry: 1s38

Transferase

PDB id: 1s38

Contents

Protein chain

364 a.a. *

Ligands

MAQ

Metals

_ZN

Waters ×344

* Residue conservation analysis

PDB id:

1s38

Name:

Transferase

Title:

Crystal structure of tgt in complex with 2-amino-8-methylqui 4(3h)-one

Structure:

tRNA guanine transglycosylase. Chain: a. Synonym: tgt. Engineered: yes

Source:

Zymomonas mobilis. Organism_taxid: 542. Gene: tgt. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Dimer (from PQS)

Resolution:

1.81Å R-factor: 0.197 R-free: 0.222

Authors:

E.A.Meyer,M.Furler,F.Diederich,R.Brenk,G.Klebe

Key ref:

E.A.Meyer et al. (2004). Synthesis and in vitro evaluation of 2-Aminoquinazolin-4(3h)-One-Based inhibitors for tRNA-Guanine transglycosylase (tgt). Helv.Chim.Acta, 87, 1333-1356.