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Complex (small gtpase/nuclear protein) PDB id
1rrp
Jmol
Contents
Protein chains
204 a.a. *
134 a.a. *
180 a.a. *
Ligands
GNP ×2
Metals
_MG ×2
Waters ×36
* Residue conservation analysis
PDB id:
1rrp
Name: Complex (small gtpase/nuclear protein)
Title: Structure of the ran-gppnhp-ranbd1 complex
Structure: Ran. Chain: a, c. Engineered: yes. Nuclear pore complex protein nup358. Chain: b, d. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Biol. unit: Dimer (from PQS)
Resolution:
2.96Å     R-factor:   0.252     R-free:   0.304
Authors: I.R.Vetter,C.Nowak,T.Nishimoto,J.Kuhlmann,A.Wittinghofer
Key ref:
I.R.Vetter et al. (1999). Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. Nature, 398, 39-46. PubMed id: 10078529 DOI: 10.1038/17969
Date:
15-Jan-99     Release date:   18-May-99    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P62826  (RAN_HUMAN) -  GTP-binding nuclear protein Ran
Seq:
Struc: 		216 a.a.
204 a.a.
Protein chains
Pfam   ArchSchema ?
P49792  (RBP2_HUMAN) -  E3 SUMO-protein ligase RanBP2
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		3224 a.a.
134 a.a.
Protein chain
Pfam   ArchSchema ?
P62826  (RAN_HUMAN) -  GTP-binding nuclear protein Ran
Seq:
Struc: 		216 a.a.
180 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains B, D: E.C.5.2.1.8  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
 = peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   7 terms 
  Biological process     viral reproduction   21 terms 
  Biochemical function     nucleotide binding     7 terms  

 

 
    Added reference    
 
 
DOI no: 10.1038/17969 Nature 398:39-46 (1999)
PubMed id: 10078529  
 
 
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.
I.R.Vetter, C.Nowak, T.Nishimoto, J.Kuhlmann, A.Wittinghofer.
 
  ABSTRACT  
 
The protein Ran is a small GTP-binding protein that binds to two types of effector inside the cell: Ran-binding proteins, which have a role in terminating export processes from the nucleus to the cytoplasm, and importin-beta-like molecules that bind cargo proteins during nuclear transport. The Ran-binding domain is a conserved sequence motif found in several proteins that participate in these transport processes. The Ran-binding protein RanBP2 contains four of these domains and constitutes a large part of the cytoplasmic fibrils that extend from the nuclear-pore complex. The structure of Ran bound to a non-hydrolysable GTP analogue (Ran x GppNHp) in complex with the first Ran-binding domain (RanBD1) of human RanBP2 reveals not only that RanBD1 has a pleckstrin-homology domain fold, but also that the switch-I region of Ran x GppNHp resembles the canonical Ras GppNHp structure and that the carboxy terminus of Ran is wrapped around RanBD1, contacting a basic patch on RanBD1 through its acidic end. This molecular 'embrace' enables RanBDs to sequester the Ran carboxy terminus, triggering the dissociation of Ran x GTP from importin-beta-related transport factors and facilitating GTP hydrolysis by the GTPase-activating protein ranGAP. Such a mechanism represents a new type of switch mechanism and regulatory protein-protein interaction for a Ras-related protein.
 
  Selected figure(s)  
 
Figure 1.
Figure 1: Representative electron density around switch I in Ran dot-GppNHp and the conserved WKER motif of RanBD1 (residues 57–60). Residues from RanBD1 are represented by white carbon traces, residues from Ran by yellow carbon traces. The omit map is contoured at 1.1 . The figure was prepared with BOBSCRIPT^46. 		Figure 5.
Figure 5: Molecular embrace and the DEDDDL motif. Surface representation of RanBD1, showing the basic region where the DEDDDL motif of Ran is expected to bind after the C terminus wraps itself around RanBD1. Ran is shown as a backbone (green), and GppNHp and the magnesium ion as ball and stick. The figure was produced using GRASP^50.
 
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (1999, 398, 39-46) copyright 1999.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference Google scholar

  PubMed id Reference
21364925 K.Langer, C.Dian, V.Rybin, C.W.Müller, and C.Petosa (2011).
Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain.
  PLoS One, 6, e17011.
PDB codes: 2y8f 2y8g
21145229 S.J.Lee, C.Jiko, E.Yamashita, and T.Tsukihara (2011).
Selective nuclear export mechanism of small RNAs.
  Curr Opin Struct Biol, 21, 101-108.  
  21113240 M.Mossalam, A.S.Dixon, and C.S.Lim (2010).
Controlling subcellular delivery to optimize therapeutic effect.
  Ther Deliv, 1, 169-193.  
20062059 M.Yamashita, K.Kurokawa, Y.Sato, A.Yamagata, H.Mimura, A.Yoshikawa, K.Sato, A.Nakano, and S.Fukai (2010).
Structural basis for the Rho- and phosphoinositide-dependent localization of the exocyst subunit Sec3.
  Nat Struct Mol Biol, 17, 180-186.
PDB code: 3a58
20739938 R.D.Makde, J.R.England, H.P.Yennawar, and S.Tan (2010).
Structure of RCC1 chromatin factor bound to the nucleosome core particle.
  Nature, 467, 562-566.
PDB code: 3mvd
19893486 S.Terawaki, K.Kitano, T.Mori, Y.Zhai, Y.Higuchi, N.Itoh, T.Watanabe, K.Kaibuchi, and T.Hakoshima (2010).
The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.
  EMBO J, 29, 236-250.
PDB codes: 3a8n 3a8p 3a8q
19505478 J.R.Partridge, and T.U.Schwartz (2009).
Crystallographic and biochemical analysis of the Ran-binding zinc finger domain.
  J Mol Biol, 391, 375-389.
PDB codes: 3gj0 3gj3 3gj4 3gj5 3gj6 3gj7 3gj8
19748337 S.G.Brohawn, J.R.Partridge, J.R.Whittle, and T.U.Schwartz (2009).
The nuclear pore complex has entered the atomic age.
  Structure, 17, 1156-1168.  
19394299 T.D.Bunney, O.Opaleye, S.M.Roe, P.Vatter, R.W.Baxendale, C.Walliser, K.L.Everett, M.B.Josephs, C.Christow, F.Rodrigues-Lima, P.Gierschik, L.H.Pearl, and M.Katan (2009).
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
  Mol Cell, 34, 223-233.
PDB codes: 2w2t 2w2v 2w2w 2w2x
19368893 T.Zhang, S.Li, Y.Zhang, C.Zhong, Z.Lai, and J.Ding (2009).
Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.
  Structure, 17, 602-610.
PDB codes: 3doe 3dof
18801747 J.Sudhamsu, G.I.Lee, D.F.Klessig, and B.R.Crane (2008).
The Structure of YqeH: AN AtNOS1/AtNOA1 ORTHOLOG THAT COUPLES GTP HYDROLYSIS TO MOLECULAR RECOGNITION.
  J Biol Chem, 283, 32968-32976.
PDB code: 3ec1
18611384 N.Schrader, C.Koerner, K.Koessmeier, J.A.Bangert, A.Wittinghofer, R.Stoll, and I.R.Vetter (2008).
The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex.
  Structure, 16, 1116-1125.
PDB codes: 2k0c 3ch5
18206968 N.Schrader, P.Stelter, D.Flemming, R.Kunze, E.Hurt, and I.R.Vetter (2008).
Structural basis of the nic96 subcomplex organization in the nuclear pore channel.
  Mol Cell, 29, 46-55.
PDB code: 2rfo
18478030 P.R.Clarke, and C.Zhang (2008).
Spatial and temporal coordination of mitosis by Ran GTPase.
  Nat Rev Mol Cell Biol, 9, 464-477.  
18727838 R.Mosca, B.Brannetti, and T.R.Schneider (2008).
Alignment of protein structures in the presence of domain motions.
  BMC Bioinformatics, 9, 352.  
17506639 A.Cook, F.Bono, M.Jinek, and E.Conti (2007).
Structural biology of nucleocytoplasmic transport.
  Annu Rev Biochem, 76, 647-671.  
17347647 J.Ménétrey, M.Perderiset, J.Cicolari, T.Dubois, N.Elkhatib, F.El Khadali, M.Franco, P.Chavrier, and A.Houdusse (2007).
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes.
  EMBO J, 26, 1953-1962.
PDB code: 2j59
17426026 M.M.Higa, S.L.Alam, W.I.Sundquist, and K.S.Ullman (2007).
Molecular characterization of the Ran-binding zinc finger domain of Nup153.
  J Biol Chem, 282, 17090-17100.
PDB code: 2gqe
17287812 M.Stewart (2007).
Molecular mechanism of the nuclear protein import cycle.
  Nat Rev Mol Cell Biol, 8, 195-208.  
16421734 A.S.Madrid, and K.Weis (2006).
Nuclear transport is becoming crystal clear.
  Chromosoma, 115, 98.  
16902583 C.Rollenhagen, and N.Panté (2006).
Nuclear import of spliceosomal snRNPs.
  Can J Physiol Pharmacol, 84, 367-376.  
16565070 K.L.Damm, and H.A.Carlson (2006).
Gaussian-weighted RMSD superposition of proteins: a structural comparison for flexible proteins and predicted protein structures.
  Biophys J, 90, 4558-4573.  
17031879 L.Brunsveld, J.Kuhlmann, K.Alexandrov, A.Wittinghofer, R.S.Goody, and H.Waldmann (2006).
Lipidated ras and rab peptides and proteins--synthesis, structure, and function.
  Angew Chem Int Ed Engl, 45, 6622-6646.  
15744307 D.B.van Rossum, R.L.Patterson, S.Sharma, R.K.Barrow, M.Kornberg, D.L.Gill, and S.H.Snyder (2005).
Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain.
  Nature, 434, 99.  
15710750 F.D.Ciccarelli, C.von Mering, M.Suyama, E.D.Harrington, E.Izaurralde, and P.Bork (2005).
Complex genomic rearrangements lead to novel primate gene function.
  Genome Res, 15, 343-351.  
16167204 K.M.Wagstaff, M.M.Dias, G.Alvisi, and D.A.Jans (2005).
Quantitative analysis of protein-protein interactions by native page/fluorimaging.
  J Fluoresc, 15, 469-473.  
16292343 M.Lammers, R.Rose, A.Scrima, and A.Wittinghofer (2005).
The regulation of mDia1 by autoinhibition and its release by Rho*GTP.
  EMBO J, 24, 4176-4187.
PDB code: 2bap
16207360 R.Riley, C.Lee, C.Sabatti, and D.Eisenberg (2005).
Inferring protein domain interactions from databases of interacting proteins.
  Genome Biol, 6, R89.  
16040597 S.Balaji, M.M.Babu, L.M.Iyer, and L.Aravind (2005).
Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains.
  Nucleic Acids Res, 33, 3994-4006.  
15864302 S.J.Lee, Y.Matsuura, S.M.Liu, and M.Stewart (2005).
Structural basis for nuclear import complex dissociation by RanGTP.
  Nature, 435, 693-696.
PDB code: 2bku
15869386 W.Cho, and R.V.Stahelin (2005).
Membrane-protein interactions in cell signaling and membrane trafficking.
  Annu Rev Biophys Biomol Struct, 34, 119-151.  
14749388 A.B.Jaffe, P.Aspenström, and A.Hall (2004).
Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways.
  Mol Cell Biol, 24, 1736-1746.  
14978301 C.Blouin, D.Butt, and A.J.Roger (2004).
Rapid evolution in conformational space: a study of loop regions in a ubiquitous GTP binding domain.
  Protein Sci, 13, 608-616.  
15574330 C.S.Weirich, J.P.Erzberger, J.M.Berger, and K.Weis (2004).
The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore.
  Mol Cell, 16, 749-760.
PDB code: 1xip
15329671 D.Engelsma, R.Bernad, J.Calafat, and M.Fornerod (2004).
Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358.
  EMBO J, 23, 3643-3652.  
15653425 E.J.Helmreich (2004).
Structural flexibility of small GTPases. Can it explain their functional versatility?
  Biol Chem, 385, 1121-1136.  
14758354 M.She, C.J.Decker, K.Sundramurthy, Y.Liu, N.Chen, R.Parker, and H.Song (2004).
Crystal structure of Dcp1p and its functional implications in mRNA decapping.
  Nat Struct Mol Biol, 11, 249-256.
PDB code: 1q67
15454457 R.Nevo, V.Brumfeld, M.Elbaum, P.Hinterdorfer, and Z.Reich (2004).
Direct discrimination between models of protein activation by single-molecule force measurements.
  Biophys J, 87, 2630-2634.  
15602554 Y.Matsuura, and M.Stewart (2004).
Structural basis for the assembly of a nuclear export complex.
  Nature, 432, 872-877.
PDB code: 1wa5
12671004 A.F.Neuwald, N.Kannan, A.Poleksic, N.Hata, and J.S.Liu (2003).
Ran's C-terminal, basic patch, and nucleotide exchange mechanisms in light of a canonical structure for Rab, Rho, Ras, and Ran GTPases.
  Genome Res, 13, 673-692.  
12581669 C.Herrmann (2003).
Ras-effector interactions: after one decade.
  Curr Opin Struct Biol, 13, 122-129.  
12657629 J.T.Snyder, A.U.Singer, M.R.Wing, T.K.Harden, and J.Sondek (2003).
The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.
  J Biol Chem, 278, 21099-21104.  
  12547434 J.W.Yu, and M.A.Lemmon (2003).
Genome-wide analysis of signaling domain function.
  Curr Opin Chem Biol, 7, 103-109.  
14585972 M.J.Seewald, A.Kraemer, M.Farkasovsky, C.Körner, A.Wittinghofer, and I.R.Vetter (2003).
Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?
  Mol Cell Biol, 23, 8124-8136.  
12808444 R.Nevo, C.Stroh, F.Kienberger, D.Kaftan, V.Brumfeld, M.Elbaum, Z.Reich, and P.Hinterdorfer (2003).
A molecular switch between alternative conformational states in the complex of Ran and importin beta1.
  Nat Struct Biol, 10, 553-557.  
12839989 S.Fukai, H.T.Matern, J.R.Jagath, R.H.Scheller, and A.T.Brunger (2003).
Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex.
  EMBO J, 22, 3267-3278.
PDB code: 1uad
12661011 Z.Ma, D.A.Hill, M.H.Collins, S.W.Morris, J.Sumegi, M.Zhou, C.Zuppan, and J.A.Bridge (2003).
Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor.
  Genes Chromosomes Cancer, 37, 98.  
12437929 B.F.Volkman, K.E.Prehoda, J.A.Scott, F.C.Peterson, and W.A.Lim (2002).
Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome.
  Cell, 111, 565-576.
PDB code: 1mke
11940112 C.K.Chan, and D.A.Jans (2002).
Using nuclear targeting signals to enhance non-viral gene transfer.
  Immunol Cell Biol, 80, 119-130.  
12034733 K.Plafker, and I.G.Macara (2002).
Fluorescence resonance energy transfer biosensors that detect Ran conformational changes and a Ran x GDP-importin-beta -RanBP1 complex in vitro and in intact cells.
  J Biol Chem, 277, 30121-30127.  
11923538 P.Kalab, K.Weis, and R.Heald (2002).
Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts.
  Science, 295, 2452-2456.  
12466527 R.Pandey, A.Müller, C.A.Napoli, D.A.Selinger, C.S.Pikaard, E.J.Richards, J.Bender, D.W.Mount, and R.A.Jorgensen (2002).
Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes.
  Nucleic Acids Res, 30, 5036-5055.  
11729264 I.G.Macara (2001).
Transport into and out of the nucleus.
  Microbiol Mol Biol Rev, 65, 570.  
11701921 I.R.Vetter, and A.Wittinghofer (2001).
The guanine nucleotide-binding switch in three dimensions.
  Science, 294, 1299-1304.  
11738594 K.D.Corbett, and T.Alber (2001).
The many faces of Ras: recognition of small GTP-binding proteins.
  Trends Biochem Sci, 26, 710-716.  
11328871 L.Queimado, M.Rao, R.A.Schultz, E.V.Koonin, L.Aravind, T.Nardo, M.Stefanini, and E.C.Friedberg (2001).
Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant.
  Nucleic Acids Res, 29, 1884-1891.  
11336674 L.Renault, J.Kuhlmann, A.Henkel, and A.Wittinghofer (2001).
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).
  Cell, 105, 245-255.
PDB code: 1i2m
11447597 M.Clément, H.Fournier, I.I.Ouspenski, L.de Repentigny, and P.Belhumeur (2001).
Molecular cloning of CaYRB1, the Candida albicans RanBP1/YRB1 homologue.
  Yeast, 18, 915-922.  
  11238397 M.Künzler, J.Trueheart, C.Sette, E.Hurt, and J.Thorner (2001).
Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects.
  Genetics, 157, 1089-1105.  
11163242 O.J.Gruss, R.E.Carazo-Salas, C.A.Schatz, G.Guarguaglini, J.Kast, M.Wilm, N.Le Bot, I.Vernos, E.Karsenti, and I.W.Mattaj (2001).
Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.
  Cell, 104, 83-93.  
  11251069 P.Maurer, M.Redd, J.Solsbacher, F.R.Bischoff, M.Greiner, A.V.Podtelejnikov, M.Mann, K.Stade, K.Weis, and G.Schlenstedt (2001).
The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p).
  Mol Biol Cell, 12, 539-549.  
11209047 T.Harmer, M.Wu, and R.Schleif (2001).
The role of rigidity in DNA looping-unlooping by AraC.
  Proc Natl Acad Sci U S A, 98, 427-431.  
10995230 C.I.Villa Braslavsky, C.Nowak, D.Görlich, A.Wittinghofer, and J.Kuhlmann (2000).
Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta.
  Biochemistry, 39, 11629-11639.  
10660567 C.Petersen, N.Orem, J.Trueheart, J.W.Thorner, and I.G.Macara (2000).
Random mutagenesis and functional analysis of the Ran-binding protein, RanBP1.
  J Biol Chem, 275, 4081-4091.  
10684602 D.Owen, H.R.Mott, E.D.Laue, and P.N.Lowe (2000).
Residues in Cdc42 that specify binding to individual CRIB effector proteins.
  Biochemistry, 39, 1243-1250.  
11208133 J.A.Ybe, D.E.Wakeham, F.M.Brodsky, and P.K.Hwang (2000).
Molecular structures of proteins involved in vesicle fusion.
  Traffic, 1, 474-479.  
10940243 J.H.Hurley, and S.Misra (2000).
Signaling and subcellular targeting by membrane-binding domains.
  Annu Rev Biophys Biomol Struct, 29, 49-79.  
10779340 K.Plafker, and I.G.Macara (2000).
Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.
  Mol Cell Biol, 20, 3510-3521.  
10825193 M.Künzler, T.Gerstberger, F.Stutz, F.R.Bischoff, and E.Hurt (2000).
Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway.
  Mol Cell Biol, 20, 4295-4308.  
  11080629 N.Blomberg, E.Baraldi, M.Sattler, M.Saraste, and M.Nilges (2000).
Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.
  Structure, 8, 1079-1087.
PDB code: 1fho
  10679025 S.M.Steggerda, B.E.Black, and B.M.Paschal (2000).
Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran.
  Mol Biol Cell, 11, 703-719.  
10937870 T.Nishimoto (2000).
Upstream and downstream of ran GTPase.
  Biol Chem, 381, 397-405.  
10801459 Y.Azuma, and M.Dasso (2000).
The role of Ran in nuclear function.
  Curr Opin Cell Biol, 12, 302-307.  
  10567585 B.E.Black, L.Lévesque, J.M.Holaska, T.C.Wood, and B.M.Paschal (1999).
Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.
  Mol Cell Biol, 19, 8616-8624.  
10611974 D.Görlich, and U.Kutay (1999).
Transport between the cell nucleus and the cytoplasm.
  Annu Rev Cell Dev Biol, 15, 607-660.  
10375521 I.G.Macara (1999).
Nuclear transport: randy couples.
  Curr Biol, 9, R436-R439.  
  10397757 I.Novoa, M.G.Rush, and P.D'Eustachio (1999).
Isolated mammalian and Schizosaccharomyces pombe ran-binding domains rescue S. pombe sbp1 (RanBP1) genomic mutants.
  Mol Biol Cell, 10, 2175-2190.  
10367892 I.R.Vetter, A.Arndt, U.Kutay, D.Görlich, and A.Wittinghofer (1999).
Structural view of the Ran-Importin beta interaction at 2.3 A resolution.
  Cell, 97, 635-646.
PDB code: 1ibr
10607674 J.D.Forman-Kay, and T.Pawson (1999).
Diversity in protein recognition by PTB domains.
  Curr Opin Struct Biol, 9, 690-695.  
10591105 J.Ménétrey, and J.Cherfils (1999).
Structure of the small G protein Rap2 in a non-catalytic complex with GTP.
  Proteins, 37, 465-473.
PDB code: 3rap
  10567565 K.Welch, J.Franke, M.Köhler, and I.G.Macara (1999).
RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3.
  Mol Cell Biol, 19, 8400-8411.  
10542412 N.Blomberg, E.Baraldi, M.Nilges, and M.Saraste (1999).
The PH superfold: a structural scaffold for multiple functions.
  Trends Biochem Sci, 24, 441-445.  
10394366 R.C.Hillig, L.Renault, I.R.Vetter, T.Drell, A.Wittinghofer, and J.Becker (1999).
The crystal structure of rna1p: a new fold for a GTPase-activating protein.
  Mol Cell, 3, 781-791.
PDB code: 1yrg
  10508790 S.J.Gamblin, and S.J.Smerdon (1999).
Nuclear transport: what a kary-on!
  Structure, 7, R199-R204.  
10490335 Y.M.Chook, G.Cingolani, E.Conti, M.Stewart, I.Vetter, and A.Wittinghofer (1999).
Pictures in cell biology. Structures of nuclear-transport components.
  Trends Cell Biol, 9, 310-311.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.