PDBsum entry 1qym

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protein links
Oncoprotein PDB id
Protein chain
223 a.a. *
Waters ×53
* Residue conservation analysis
PDB id:
Name: Oncoprotein
Title: X-ray structure of human gankyrin
Structure: 26s proteasome non-atpase regulatory subunit 10. Chain: a. Synonym: 26s proteasome regulatory subunit p28, gankyrin. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: psmd10. Expressed in: escherichia coli. Expression_system_taxid: 562.
2.80Å     R-factor:   0.187     R-free:   0.233
Authors: B.A.Manjasetty,C.Quedenau,V.Sievert,K.Buessow,F.Niesen,H.Del U.Heinemann
Key ref:
B.A.Manjasetty et al. (2004). X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. Proteins, 55, 214-217. PubMed id: 14997555 DOI: 10.1002/prot.20028
11-Sep-03     Release date:   18-Nov-03    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
O75832  (PSD10_HUMAN) -  26S proteasome non-ATPase regulatory subunit 10
226 a.a.
223 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     proteasome complex   8 terms 
  Biological process     viral reproduction   32 terms 
  Biochemical function     protein binding     2 terms  


DOI no: 10.1002/prot.20028 Proteins 55:214-217 (2004)
PubMed id: 14997555  
X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma.
B.A.Manjasetty, C.Quedenau, V.Sievert, K.Büssow, F.Niesen, H.Delbrück, U.Heinemann.

  Selected figure(s)  
Figure 1.
Figure 1. (a) Sequence of human gankyrin. The six ankyrin repeats are aligned with the ankyrin consensus sequence.[30] In the fifth ankyrin repeat, the potentially Rb-interacting LXCXE sequence motif is highlighted. Below the sequence, the position of the -helices are indicated. (b) Ribbon diagram of human gankyrin. The N-terminal domain is colored red, and the six ankyrin repeats are colored individually. (c) Structure of the fifth ankyrin repeat. Side chains of the Rb-binding motif are shown explicitly. The residues corresponding to the Rb-binding motif (LXCXE) are indicated within the brackets. (d) Superposition of the structures of gankyrin and p16^INK4A (bound to CDK6, PDB entry 1BI7). The ankyrin repeats are numbered.
  The above figure is reprinted by permission from John Wiley & Sons, Inc.: Proteins (2004, 55, 214-217) copyright 2004.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
17935131 C.M.Ortiz, T.Ito, E.Tanaka, S.Tsunoda, S.Nagayama, Y.Sakai, H.Higashitsuji, J.Fujita, and Y.Shimada (2008).
Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance.
  Int J Cancer, 122, 325-332.  
17881001 A.Mahajan, Y.Guo, C.Yuan, C.M.Weghorst, M.D.Tsai, and J.Li (2007).
Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.
  J Mol Biol, 373, 990.  
17292836 Y.Nakamura, K.Nakano, T.Umehara, M.Kimura, Y.Hayashizaki, A.Tanaka, M.Horikoshi, B.Padmanabhan, and S.Yokoyama (2007).
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
  Structure, 15, 179-189.
PDB codes: 2dvw 2dwz
  17329811 Y.Nakamura, T.Umehara, A.Tanaka, M.Horikoshi, B.Padmanabhan, and S.Yokoyama (2007).
Purification, crystallization and preliminary X-ray diffraction analysis of the non-ATPase subunit Nas6 in complex with the ATPase subunit Rpt3 of the 26S proteasome from Saccharomyces cerevisiae.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 63, 190-192.  
15998469 K.Büssow, C.Scheich, V.Sievert, U.Harttig, J.Schultz, B.Simon, P.Bork, H.Lehrach, and U.Heinemann (2005).
Structural genomics of human proteins--target selection and generation of a public catalogue of expression clones.
  Microb Cell Fact, 4, 21.  
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