 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Kinase inhibitor/peptide
|
PDB id
|
|
|
|
1qjb
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Kinase inhibitor/peptide
|
|
|
Title:
|
|
14-3-3 zeta/phosphopeptide complex (mode 1)
|
|
Structure:
|
|
14-3-3 protein zeta/delta. Chain: a, b. Engineered: yes. Biological_unit: dimer. Phosphopeptide. Chain: s, q
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
Biol. unit:
|
|
Dimer (from PDB file)
|
|
Resolution:
|
|
|
2.0Å
|
R-factor:
|
0.210
|
R-free:
|
0.288
|
|
|
Authors:
|
|
K.Rittinger,J.Budman,J.Xu,S.Volinia,L.C.Cantley,S.J.Smerdon, S.J.Gamblin,M.B.Yaffe
|
Key ref:
|
|
K.Rittinger
et al.
(1999).
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
Mol Cell,
4,
153-166.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
23-Jun-99
|
Release date:
|
15-Sep-99
|
|
|
Supersedes:
|
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
|
|
|
|
P63104
(1433Z_HUMAN) -
14-3-3 protein zeta/delta
|
|
|
|
Seq:
Struc:
|
|
|
|
245 a.a.
228 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gene Ontology (GO) functional annotation
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cellular component
|
protein complex
|
11 terms
|
|
|
Biological process
|
response to drug
|
10 terms
|
|
|
Biochemical function
|
protein binding
|
3 terms
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
DOI no:
|
Mol Cell
4:153-166
(1999)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
|
|
K.Rittinger,
J.Budman,
J.Xu,
S.Volinia,
L.C.Cantley,
S.J.Smerdon,
S.J.Gamblin,
M.B.Yaffe.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
We have solved the high-resolution X-ray structure of 14-3-3 bound to two
different phosphoserine peptides, representing alternative substrate-binding
motifs. These structures reveal an evolutionarily conserved network of
peptide-protein interactions within all 14-3-3 isotypes, explain both binding
motifs, and identify a novel intrachain phosphorylation-mediated loop structure
in one of the peptides. A 14-3-3 mutation disrupting Raf signaling alters the
ligand-binding cleft, selecting a different phosphopeptide-binding motif and
different substrates than the wild-type protein. Many 14-3-3: peptide contacts
involve a C-terminal amphipathic alpha helix containing a putative nuclear
export signal, implicating this segment in both ligand and Crm1 binding.
Structural homology between the 14-3-3 NES structure and those within I kappa B
alpha and p53 reveals a conserved topology recognized by the Crm1 nuclear export
machinery.
|
|
|
|
|
|
| |
Selected figure(s)
|
|
|
|
| |
|
|
|
|
|
|
Figure 1.
Figure 1. Structure of a 14-3-3:Mode-2 Peptide Complex(A)
An end-on view of 14-3-3 bound to the phosphoserine peptide
RLYHpSLP (stick representation shown with carbons colored
yellow, nitrogens blue, oxygens red, and phosphate green).
Residues whose side chains form the phosphoserine-binding pocket
lie within helices αC and αE (white) whereas 14-3-3 side
chains that interact with the remainder of the peptide arise
from helices αG (magenta) and αI (blue).(B) A stereo view of
the peptide-binding pocket. The view is within the center of the
14-3-3 dimer, rotated 90° to the view in (A), and with the
same color scheme. 14-3-3 side chains contributing to peptide
binding are shown. Note in particular the large contribution of
residues from helix αI extending into the peptide-binding
groove.(C) Full atom representation of the m1 and m2
phosphopeptides with (F[o] − F[c]) omit electron density maps,
contoured at 2σ superimposed. The back bonding between the
guanidino group of the pSer −4 Arg residue and the Ser
phosphate in the m2 structure is evident, along with the
trans-conformation of the Pro residue in the pSer +2
position.(D) An extensive interface between 14-3-3 and bound
phosphopeptide. The view is in the same orientation as in (B)
with the mode 2 peptide rotated out of the binding cleft.
Regions on the peptide and 14-3-3 molecular surfaces lying <3
Å apart are shaded red. The interface between 14-3-3 and
the mode 1 phosphopeptide (not shown) is nearly identical.
|
|
Figure 3.
Figure 3. Details of the 14-3-3 Protein:Phosphoserine
Peptide Interactions Illustrating Specific Interresidue
ContactsColor coding is as described in Figure 1.
|
|
|
|
|
|
| |
The above figures are
reprinted
by permission from Cell Press:
Mol Cell
(1999,
4,
153-166)
copyright 1999.
|
|
| |
Figures were
selected
by an automated process.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
A.H.Benkovics,
T.Nyikó,
Z.Mérai,
D.Silhavy,
and
G.D.Bisztray
(2011).
Functional analysis of the grapevine paralogs of the SMG7 NMD factor using a heterolog VIGS-based gene depletion-complementation system.
|
| |
Plant Mol Biol, 75,
277-290.
|
|
|
|
|
|
|
G.Messaritou,
S.Grammenoudi,
and
E.M.Skoulakis
(2010).
Dimerization is essential for 14-3-3zeta stability and function in vivo.
|
| |
J Biol Chem, 285,
1692-1700.
|
|
|
|
|
|
|
K.Weigand,
A.Knaust,
and
H.Schaller
(2010).
Assembly and export determine the intracellular distribution of hepatitis B virus core protein subunits.
|
| |
J Gen Virol, 91,
59-67.
|
|
|
|
|
|
|
L.Yasmin,
J.L.Veesenmeyer,
M.H.Diaz,
M.S.Francis,
C.Ottmann,
R.H.Palmer,
A.R.Hauser,
and
B.Hallberg
(2010).
Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins.
|
| |
Biochem J, 427,
217-224.
|
|
|
|
|
|
|
M.E.Douglas,
T.Davies,
N.Joseph,
and
M.Mishima
(2010).
Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis.
|
| |
Curr Biol, 20,
927-933.
|
|
|
|
|
|
|
R.S.Agnes,
F.Jernigan,
J.R.Shell,
V.Sharma,
and
D.S.Lawrence
(2010).
Suborganelle sensing of mitochondrial cAMP-dependent protein kinase activity.
|
| |
J Am Chem Soc, 132,
6075-6080.
|
|
|
|
|
|
|
S.Rajagopalan,
R.S.Sade,
F.M.Townsley,
and
A.R.Fersht
(2010).
Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms.
|
| |
Nucleic Acids Res, 38,
893-906.
|
|
|
|
|
|
|
B.Kostelecky,
A.T.Saurin,
A.Purkiss,
P.J.Parker,
and
N.Q.McDonald
(2009).
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.
|
| |
EMBO Rep, 10,
983-989.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.Choudhary,
C.Kumar,
F.Gnad,
M.L.Nielsen,
M.Rehman,
T.C.Walther,
J.V.Olsen,
and
M.Mann
(2009).
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
|
| |
Science, 325,
834-840.
|
|
|
|
|
|
|
D.Chevalier,
E.R.Morris,
and
J.C.Walker
(2009).
14-3-3 and FHA domains mediate phosphoprotein interactions.
|
| |
Annu Rev Plant Biol, 60,
67-91.
|
|
|
|
|
|
|
E.F.Barry,
F.A.Felquer,
J.A.Powell,
L.Biggs,
F.C.Stomski,
A.Urbani,
H.Ramshaw,
P.Hoffmann,
M.C.Wilce,
M.A.Grimbaldeston,
A.F.Lopez,
and
M.A.Guthridge
(2009).
14-3-3:shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival.
|
| |
J Biol Chem, 284,
12080-12090.
|
|
|
|
|
|
|
G.M.Bokoch,
B.Diebold,
J.S.Kim,
and
D.Gianni
(2009).
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases.
|
| |
Antioxid Redox Signal, 11,
2429-2441.
|
|
|
|
|
|
|
J.Silhan,
P.Vacha,
P.Strnadova,
J.Vecer,
P.Herman,
M.Sulc,
J.Teisinger,
V.Obsilova,
and
T.Obsil
(2009).
14-3-3 Protein Masks the DNA Binding Interface of Forkhead Transcription Factor FOXO4.
|
| |
J Biol Chem, 284,
19349-19360.
|
|
|
|
|
|
|
L.K.Nutt,
M.R.Buchakjian,
E.Gan,
R.Darbandi,
S.Y.Yoon,
J.Q.Wu,
Y.J.Miyamoto,
J.A.Gibbons,
J.A.Gibbon,
J.L.Andersen,
C.D.Freel,
W.Tang,
C.He,
M.Kurokawa,
Y.Wang,
S.S.Margolis,
R.A.Fissore,
and
S.Kornbluth
(2009).
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.
|
| |
Dev Cell, 16,
856-866.
|
|
|
|
|
|
|
M.Lin,
C.D.Morrison,
S.Jones,
N.Mohamed,
J.Bacher,
and
C.Plass
(2009).
Copy number gain and oncogenic activity of YWHAZ/14-3-3zeta in head and neck squamous cell carcinoma.
|
| |
Int J Cancer, 125,
603-611.
|
|
|
|
|
|
|
N.Flamand,
M.Luo,
M.Peters-Golden,
and
T.G.Brock
(2009).
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.
|
| |
J Biol Chem, 284,
306-313.
|
|
|
|
|
|
|
S.Sun,
E.W.Wong,
M.W.Li,
W.M.Lee,
and
C.Y.Cheng
(2009).
14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis.
|
| |
J Endocrinol, 202,
327-336.
|
|
|
|
|
|
|
U.H.Saxena,
C.M.Powell,
J.K.Fecko,
R.Cacioppo,
H.S.Chou,
G.M.Cooper,
and
U.Hansen
(2009).
Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.
|
| |
Mol Cell Biol, 29,
2335-2345.
|
|
|
|
|
|
|
Z.Li,
J.Y.Liu,
and
J.T.Zhang
(2009).
14-3-3sigma, the double-edged sword of human cancers.
|
| |
Am J Transl Res, 1,
326-340.
|
|
|
|
|
|
|
A.J.VanMeter,
A.S.Rodriguez,
E.D.Bowman,
J.Jen,
C.C.Harris,
J.Deng,
V.S.Calvert,
A.Silvestri,
C.Fredolini,
V.Chandhoke,
E.F.Petricoin,
L.A.Liotta,
and
V.Espina
(2008).
Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type.
|
| |
Mol Cell Proteomics, 7,
1902-1924.
|
|
|
|
|
|
|
C.J.Oldfield,
J.Meng,
J.Y.Yang,
M.Q.Yang,
V.N.Uversky,
and
A.K.Dunker
(2008).
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners.
|
| |
BMC Genomics, 9,
S1.
|
|
|
|
|
|
|
D.M.Gwinn,
D.B.Shackelford,
D.F.Egan,
M.M.Mihaylova,
A.Mery,
D.S.Vasquez,
B.E.Turk,
and
R.J.Shaw
(2008).
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
|
| |
Mol Cell, 30,
214-226.
|
|
|
|
|
|
|
I.E.Sánchez,
P.Beltrao,
F.Stricher,
J.Schymkowitz,
J.Ferkinghoff-Borg,
F.Rousseau,
and
L.Serrano
(2008).
Genome-wide prediction of SH2 domain targets using structural information and the FoldX algorithm.
|
| |
PLoS Comput Biol, 4,
e1000052.
|
|
|
|
|
|
|
L.Demmel,
M.Beck,
C.Klose,
A.L.Schlaitz,
Y.Gloor,
P.P.Hsu,
J.Havlis,
A.Shevchenko,
E.Krause,
Y.Kalaidzidis,
and
C.Walch-Solimena
(2008).
Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth.
|
| |
Mol Biol Cell, 19,
1046-1061.
|
|
|
|
|
|
|
M.E.Grespin,
G.M.Bonamy,
V.R.Roggero,
N.G.Cameron,
L.E.Adam,
A.P.Atchison,
V.M.Fratto,
and
L.A.Allison
(2008).
Thyroid hormone receptor alpha1 follows a cooperative CRM1/calreticulin-mediated nuclear export pathway.
|
| |
J Biol Chem, 283,
25576-25588.
|
|
|
|
|
|
|
M.Jinek,
A.Eulalio,
A.Lingel,
S.Helms,
E.Conti,
and
E.Izaurralde
(2008).
The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.
|
| |
RNA, 14,
1991-1998.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
P.Puri,
K.Myers,
D.Kline,
and
S.Vijayaraghavan
(2008).
Proteomic analysis of bovine sperm YWHA binding partners identify proteins involved in signaling and metabolism.
|
| |
Biol Reprod, 79,
1183-1191.
|
|
|
|
|
|
|
S.Rajagopalan,
A.M.Jaulent,
M.Wells,
D.B.Veprintsev,
and
A.R.Fersht
(2008).
14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers.
|
| |
Nucleic Acids Res, 36,
5983-5991.
|
|
|
|
|
|
|
T.Obsil,
and
V.Obsilova
(2008).
Structure/function relationships underlying regulation of FOXO transcription factors.
|
| |
Oncogene, 27,
2263-2275.
|
|
|
|
|
|
|
B.Luke,
C.M.Azzalin,
N.Hug,
A.Deplazes,
M.Peter,
and
J.Lingner
(2007).
Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.
|
| |
Nucleic Acids Res, 35,
7688-7697.
|
|
|
|
|
|
|
B.Pauly,
M.Lasi,
C.MacKintosh,
N.Morrice,
A.Imhof,
J.Regula,
S.Rudd,
C.N.David,
and
A.Böttger
(2007).
Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling.
|
| |
BMC Cell Biol, 8,
31.
|
|
|
|
|
|
|
C.Ottmann,
L.Yasmin,
M.Weyand,
J.L.Veesenmeyer,
M.H.Diaz,
R.H.Palmer,
M.S.Francis,
A.R.Hauser,
A.Wittinghofer,
and
B.Hallberg
(2007).
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis.
|
| |
EMBO J, 26,
902-913.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
F.L.Aachmann,
D.E.Fomenko,
A.Soragni,
V.N.Gladyshev,
and
A.Dikiy
(2007).
Solution structure of selenoprotein w and NMR analysis of its interaction with 14-3-3 proteins.
|
| |
J Biol Chem, 282,
37036-37044.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Rong,
S.Li,
G.Sheng,
M.Wu,
B.Coblitz,
M.Li,
H.Fu,
and
X.J.Li
(2007).
14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
|
| |
J Biol Chem, 282,
4748-4756.
|
|
|
|
|
|
|
J.S.Kim,
B.A.Diebold,
B.M.Babior,
U.G.Knaus,
and
G.M.Bokoch
(2007).
Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.
|
| |
J Biol Chem, 282,
34787-34800.
|
|
|
|
|
|
|
J.von Blume,
U.Knippschild,
F.Dequiedt,
G.Giamas,
A.Beck,
A.Auer,
J.Van Lint,
G.Adler,
and
T.Seufferlein
(2007).
Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.
|
| |
EMBO J, 26,
4619-4633.
|
|
|
|
|
|
|
M.Lee,
and
H.S.Yoo
(2007).
Human Raf-1 proteins associate with Rad24 and Cdc25 in cell-cycle checkpoint pathway of fission yeast, Schizosaccharomyces pombe.
|
| |
J Cell Biochem, 101,
488-497.
|
|
|
|
|
|
|
O.Golubnitschaja
(2007).
Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases.
|
| |
Amino Acids, 32,
359-371.
|
|
|
|
|
|
|
P.Radivojac,
L.M.Iakoucheva,
C.J.Oldfield,
Z.Obradovic,
V.N.Uversky,
and
A.K.Dunker
(2007).
Intrinsic disorder and functional proteomics.
|
| |
Biophys J, 92,
1439-1456.
|
|
|
|
|
|
|
S.S.Gouraud,
S.T.Yao,
K.J.Heesom,
J.F.Paton,
and
D.Murphy
(2007).
14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies.
|
| |
J Neuroendocrinol, 19,
913-922.
|
|
|
|
|
|
|
T.Nilsen,
K.R.Rosendal,
V.Sørensen,
J.Wesche,
S.Olsnes,
and
A.Wiedłocha
(2007).
A nuclear export sequence located on a beta-strand in fibroblast growth factor-1.
|
| |
J Biol Chem, 282,
26245-26256.
|
|
|
|
|
|
|
T.Usui,
and
J.H.Petrini
(2007).
The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.
|
| |
Proc Natl Acad Sci U S A, 104,
2797-2802.
|
|
|
|
|
|
|
Y.Honma,
and
M.Akimoto
(2007).
Therapeutic strategy using phenotypic modulation of cancer cells by differentiation-inducing agents.
|
| |
Cancer Sci, 98,
1643-1651.
|
|
|
|
|
|
|
A.Aitken
(2006).
14-3-3 proteins: a historic overview.
|
| |
Semin Cancer Biol, 16,
162-172.
|
|
|
|
|
|
|
A.H.Milton,
N.Khaire,
L.Ingram,
A.J.O'Donnell,
and
N.B.La Thangue
(2006).
14-3-3 proteins integrate E2F activity with the DNA damage response.
|
| |
EMBO J, 25,
1046-1057.
|
|
|
|
|
|
|
A.K.Gardino,
S.J.Smerdon,
and
M.B.Yaffe
(2006).
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms.
|
| |
Semin Cancer Biol, 16,
173-182.
|
|
|
|
|
|
|
A.K.Rishi,
L.Zhang,
Y.Yu,
Y.Jiang,
J.Nautiyal,
A.Wali,
J.A.Fontana,
E.Levi,
and
A.P.Majumdar
(2006).
Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor.
|
| |
J Biol Chem, 281,
13188-13198.
|
|
|
|
|
|
|
D.J.Park,
T.A.Freitas,
C.J.Wallick,
C.V.Guyette,
and
B.J.Warn-Cramer
(2006).
Molecular dynamics and in vitro analysis of Connexin43: A new 14-3-3 mode-1 interacting protein.
|
| |
Protein Sci, 15,
2344-2355.
|
|
|
|
|
|
|
D.M.Bustos,
and
A.A.Iglesias
(2006).
Intrinsic disorder is a key characteristic in partners that bind 14-3-3 proteins.
|
| |
Proteins, 63,
35-42.
|
|
|
|
|
|
|
H.Hermeking,
and
A.Benzinger
(2006).
14-3-3 proteins in cell cycle regulation.
|
| |
Semin Cancer Biol, 16,
183-192.
|
|
|
|
|
|
|
H.Y.Meng,
K.M.Thomas,
A.E.Lee,
and
N.J.Zondlo
(2006).
Effects of i and i+3 residue identity on cis-trans isomerism of the aromatic(i+1)-prolyl(i+2) amide bond: implications for type VI beta-turn formation.
|
| |
Biopolymers, 84,
192-204.
|
|
|
|
|
|
|
L.Yasmin,
A.L.Jansson,
T.Panahandeh,
R.H.Palmer,
M.S.Francis,
and
B.Hallberg
(2006).
Delineation of exoenzyme S residues that mediate the interaction with 14-3-3 and its biological activity.
|
| |
FEBS J, 273,
638-646.
|
|
|
|
|
|
|
R.M.Seiser,
A.E.Sundberg,
B.J.Wollam,
P.Zobel-Thropp,
K.Baldwin,
M.D.Spector,
and
D.E.Lycan
(2006).
Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae.
|
| |
Genetics, 174,
679-691.
|
|
|
|
|
|
|
S.Shikano,
B.Coblitz,
M.Wu,
and
M.Li
(2006).
14-3-3 proteins: regulation of endoplasmic reticulum localization and surface expression of membrane proteins.
|
| |
Trends Cell Biol, 16,
370-375.
|
|
|
|
|
|
|
V.Neduva,
and
R.B.Russell
(2006).
Peptides mediating interaction networks: new leads at last.
|
| |
Curr Opin Biotechnol, 17,
465-471.
|
|
|
|
|
|
|
X.Yang,
W.H.Lee,
F.Sobott,
E.Papagrigoriou,
C.V.Robinson,
J.G.Grossmann,
M.Sundström,
D.A.Doyle,
and
J.M.Elkins
(2006).
Structural basis for protein-protein interactions in the 14-3-3 protein family.
|
| |
Proc Natl Acad Sci U S A, 103,
17237-17242.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.K.Dunker,
M.S.Cortese,
P.Romero,
L.M.Iakoucheva,
and
V.N.Uversky
(2005).
Flexible nets. The roles of intrinsic disorder in protein interaction networks.
|
| |
FEBS J, 272,
5129-5148.
|
|
|
|
|
|
|
B.A.Joughin,
B.Tidor,
and
M.B.Yaffe
(2005).
A computational method for the analysis and prediction of protein:phosphopeptide-binding sites.
|
| |
Protein Sci, 14,
131-139.
|
|
|
|
|
|
|
B.Coblitz,
S.Shikano,
M.Wu,
S.B.Gabelli,
L.M.Cockrell,
M.Spieker,
Y.Hanyu,
H.Fu,
L.M.Amzel,
and
M.Li
(2005).
C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors.
|
| |
J Biol Chem, 280,
36263-36272.
|
|
|
|
|
|
|
B.J.Herron,
R.A.Liddell,
A.Parker,
S.Grant,
J.Kinne,
J.K.Fisher,
and
L.D.Siracusa
(2005).
A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice.
|
| |
Nat Genet, 37,
1210-1212.
|
|
|
|
|
|
|
E.W.Wilker,
R.A.Grant,
S.C.Artim,
and
M.B.Yaffe
(2005).
A structural basis for 14-3-3sigma functional specificity.
|
| |
J Biol Chem, 280,
18891-18898.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
F.Pan,
A.R.Means,
and
J.O.Liu
(2005).
Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
|
| |
EMBO J, 24,
2104-2113.
|
|
|
|
|
|
|
I.Jéru,
S.Papin,
S.L'hoste,
P.Duquesnoy,
C.Cazeneuve,
J.Camonis,
and
S.Amselem
(2005).
Interaction of pyrin with 14.3.3 in an isoform-specific and phosphorylation-dependent manner regulates its translocation to the nucleus.
|
| |
Arthritis Rheum, 52,
1848-1857.
|
|
|
|
|
|
|
K.Briknarová,
F.Nasertorabi,
M.L.Havert,
E.Eggleston,
D.W.Hoyt,
C.Li,
A.J.Olson,
K.Vuori,
and
K.R.Ely
(2005).
The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle.
|
| |
J Biol Chem, 280,
21908-21914.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Inoue,
Y.Nakamura,
K.Yasuda,
N.Yasaka,
T.Hara,
A.Schnaufer,
K.Stuart,
and
T.Fukuma
(2005).
The 14-3-3 proteins of Trypanosoma brucei function in motility, cytokinesis, and cell cycle.
|
| |
J Biol Chem, 280,
14085-14096.
|
|
|
|
|
|
|
M.Wanzel,
D.Kleine-Kohlbrecher,
S.Herold,
A.Hock,
K.Berns,
J.Park,
B.Hemmings,
and
M.Eilers
(2005).
Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage.
|
| |
Nat Cell Biol, 7,
30-41.
|
|
|
|
|
|
|
N.Macdonald,
J.P.Welburn,
M.E.Noble,
A.Nguyen,
M.B.Yaffe,
D.Clynes,
J.G.Moggs,
G.Orphanides,
S.Thomson,
J.W.Edmunds,
A.L.Clayton,
J.A.Endicott,
and
L.C.Mahadevan
(2005).
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
|
| |
Mol Cell, 20,
199-211.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
R.A.Cartlidge,
A.Knebel,
M.Peggie,
A.Alexandrov,
E.M.Phizicky,
and
P.Cohen
(2005).
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.
|
| |
EMBO J, 24,
1696-1705.
|
|
|
|
|
|
|
S.I.Gringhuis,
J.J.García-Vallejo,
B.van Het Hof,
and
W.van Dijk
(2005).
Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin.
|
| |
Mol Cell Biol, 25,
6454-6463.
|
|
|
|
|
|
|
T.Kino,
A.Gragerov,
A.Valentin,
M.Tsopanomihalou,
G.Ilyina-Gragerova,
R.Erwin-Cohen,
G.P.Chrousos,
and
G.N.Pavlakis
(2005).
Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest.
|
| |
J Virol, 79,
2780-2787.
|
|
|
|
|
|
|
A.Kulma,
D.Villadsen,
D.G.Campbell,
S.E.Meek,
J.E.Harthill,
T.H.Nielsen,
and
C.MacKintosh
(2004).
Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
|
| |
Plant J, 37,
654-667.
|
|
|
|
|
|
|
A.Nguyen,
D.M.Rothman,
J.Stehn,
B.Imperiali,
and
M.B.Yaffe
(2004).
Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function.
|
| |
Nat Biotechnol, 22,
993.
|
|
|
|
|
|
|
J.Gu,
X.Xia,
P.Yan,
H.Liu,
V.N.Podust,
A.B.Reynolds,
and
E.Fanning
(2004).
Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci.
|
| |
Mol Biol Cell, 15,
3320-3332.
|
|
|
|
|
|
|
J.Silhan,
V.Obsilova,
J.Vecer,
P.Herman,
M.Sulc,
J.Teisinger,
and
T.Obsil
(2004).
14-3-3 protein C-terminal stretch occupies ligand binding groove and is displaced by phosphopeptide binding.
|
| |
J Biol Chem, 279,
49113-49119.
|
|
|
|
|
|
|
L.Le Gallic,
L.Virgilio,
P.Cohen,
B.Biteau,
and
G.Mavrothalassitis
(2004).
ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression.
|
| |
Mol Cell Biol, 24,
1206-1218.
|
|
|
|
|
|
|
M.A.Davare,
T.Saneyoshi,
E.S.Guire,
S.C.Nygaard,
and
T.R.Soderling
(2004).
Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3.
|
| |
J Biol Chem, 279,
52191-52199.
|
|
|
|
|
|
|
M.B.Yaffe,
and
S.J.Smerdon
(2004).
The use of in vitro peptide-library screens in the analysis of phosphoserine/threonine-binding domain structure and function.
|
| |
Annu Rev Biophys Biomol Struct, 33,
225-244.
|
|
|
|
|
|
|
M.Soler-Lopez,
C.Petosa,
M.Fukuzawa,
R.Ravelli,
J.G.Williams,
and
C.W.Müller
(2004).
Structure of an activated Dictyostelium STAT in its DNA-unbound form.
|
| |
Mol Cell, 13,
791-804.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.Walter,
C.Chaban,
K.Schütze,
O.Batistic,
K.Weckermann,
C.Näke,
D.Blazevic,
C.Grefen,
K.Schumacher,
C.Oecking,
K.Harter,
and
J.Kudla
(2004).
Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation.
|
| |
Plant J, 40,
428-438.
|
|
|
|
|
|
|
R.J.Ferl
(2004).
14-3-3 proteins: regulation of signal-induced events.
|
| |
Physiol Plant, 120,
173-178.
|
|
|
|
|
|
|
T.Kino,
and
G.N.Pavlakis
(2004).
Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.
|
| |
DNA Cell Biol, 23,
193-205.
|
|
|
|
|
|
|
T.Kino,
and
G.P.Chrousos
(2004).
Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?
|
| |
Ann N Y Acad Sci, 1024,
153-167.
|
|
|
|
|
|
|
T.Sekimoto,
M.Fukumoto,
and
Y.Yoneda
(2004).
14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).
|
| |
EMBO J, 23,
1934-1942.
|
|
|
|
|
|
|
V.Obsilova,
P.Herman,
J.Vecer,
M.Sulc,
J.Teisinger,
and
T.Obsil
(2004).
14-3-3zeta C-terminal stretch changes its conformation upon ligand binding and phosphorylation at Thr232.
|
| |
J Biol Chem, 279,
4531-4540.
|
|
|
|
|
|
|
D.C.Klein,
S.Ganguly,
S.L.Coon,
Q.Shi,
P.Gaildrat,
F.Morin,
J.L.Weller,
T.Obsil,
A.Hickman,
and
F.Dyda
(2003).
14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?
|
| |
J Neuroendocrinol, 15,
370-377.
|
|
|
|
|
|
|
H.Hermeking
(2003).
The 14-3-3 cancer connection.
|
| |
Nat Rev Cancer, 3,
931-943.
|
|
|
|
|
|
|
H.Kim,
J.H.Lee,
and
Y.Lee
(2003).
Regulation of poly(A) polymerase by 14-3-3epsilon.
|
| |
EMBO J, 22,
5208-5219.
|
|
|
|
|
|
|
J.Won,
D.Y.Kim,
M.La,
D.Kim,
G.G.Meadows,
and
C.O.Joe
(2003).
Cleavage of 14-3-3 protein by caspase-3 facilitates bad interaction with Bcl-x(L) during apoptosis.
|
| |
J Biol Chem, 278,
19347-19351.
|
|
|
|
|
|
|
K.Jiang,
E.Pereira,
M.Maxfield,
B.Russell,
D.M.Goudelock,
and
Y.Sanchez
(2003).
Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.
|
| |
J Biol Chem, 278,
25207-25217.
|
|
|
|
|
|
|
M.F.Henry,
D.Mandel,
V.Routson,
and
P.A.Henry
(2003).
The yeast hnRNP-like protein Hrp1/Nab4 sccumulates in the cytoplasm after hyperosmotic stress: a novel Fps1-dependent response.
|
| |
Mol Biol Cell, 14,
3929-3941.
|
|
|
|
|
|
|
M.Pozuelo Rubio,
M.Peggie,
B.H.Wong,
N.Morrice,
and
C.MacKintosh
(2003).
14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase.
|
| |
EMBO J, 22,
3514-3523.
|
|
|
|
|
|
|
M.Rodriguez,
X.Yu,
J.Chen,
and
Z.Songyang
(2003).
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.
|
| |
J Biol Chem, 278,
52914-52918.
|
|
|
|
|
|
|
M.Würtele,
C.Jelich-Ottmann,
A.Wittinghofer,
and
C.Oecking
(2003).
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex.
|
| |
EMBO J, 22,
987-994.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
N.Dumaz,
and
R.Marais
(2003).
Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.
|
| |
J Biol Chem, 278,
29819-29823.
|
|
|
|
|
|
|
S.Visconti,
L.Camoni,
M.R.Fullone,
M.Lalle,
M.Marra,
and
P.Aducci
(2003).
Mutational analysis of the interaction between 14-3-3 proteins and plant plasma membrane H+-ATPase.
|
| |
J Biol Chem, 278,
8172-8178.
|
|
|
|
|
|
|
T.B.Huber,
B.Hartleben,
J.Kim,
M.Schmidts,
B.Schermer,
A.Keil,
L.Egger,
R.L.Lecha,
C.Borner,
H.Pavenstädt,
A.S.Shaw,
G.Walz,
and
T.Benzing
(2003).
Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.
|
| |
Mol Cell Biol, 23,
4917-4928.
|
|
|
|
|
|
|
T.Kino,
E.Souvatzoglou,
M.U.De Martino,
M.Tsopanomihalu,
Y.Wan,
and
G.P.Chrousos
(2003).
Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway.
|
| |
J Biol Chem, 278,
25651-25656.
|
|
|
|
|
|
|
T.Obsil,
R.Ghirlando,
D.E.Anderson,
A.B.Hickman,
and
F.Dyda
(2003).
Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.
|
| |
Biochemistry, 42,
15264-15272.
|
|
|
|
|
|
|
X.Wang,
N.Grammatikakis,
A.Siganou,
and
S.K.Calderwood
(2003).
Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.
|
| |
Mol Cell Biol, 23,
6013-6026.
|
|
|
|
|
|
|
Y.H.Shen,
J.Godlewski,
A.Bronisz,
J.Zhu,
M.J.Comb,
J.Avruch,
and
G.Tzivion
(2003).
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding.
|
| |
Mol Biol Cell, 14,
4721-4733.
|
|
|
|
|
|
|
Y.Zhou,
S.Reddy,
H.Murrey,
H.Fei,
and
I.B.Levitan
(2003).
Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calcium-dependent potassium channel.
|
| |
J Biol Chem, 278,
10073-10080.
|
|
|
|
|
|
|
Z.Liu,
T.Sekito,
M.Spírek,
J.Thornton,
and
R.A.Butow
(2003).
Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p.
|
| |
Mol Cell, 12,
401-411.
|
|
|
|
|
|
|
A.Brunet,
F.Kanai,
J.Stehn,
J.Xu,
D.Sarbassova,
J.V.Frangioni,
S.N.Dalal,
J.A.DeCaprio,
M.E.Greenberg,
and
M.B.Yaffe
(2002).
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.
|
| |
J Cell Biol, 156,
817-828.
|
|
|
|
|
|
|
A.Kagan,
Y.F.Melman,
A.Krumerman,
and
T.V.McDonald
(2002).
14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity.
|
| |
EMBO J, 21,
1889-1898.
|
|
|
|
|
|
|
B.A.Johnson,
J.R.Stehn,
M.B.Yaffe,
and
T.K.Blackwell
(2002).
Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.
|
| |
J Biol Chem, 277,
18029-18036.
|
|
|
|
|
|
|
B.S.Lommer,
and
M.Luo
(2002).
Structural plasticity in influenza virus protein NS2 (NEP).
|
| |
J Biol Chem, 277,
7108-7117.
|
|
|
|
|
|
|
G.Tzivion,
and
J.Avruch
(2002).
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.
|
| |
J Biol Chem, 277,
3061-3064.
|
|
|
|
|
|
|
I.O'Kelly,
M.H.Butler,
N.Zilberberg,
and
S.A.Goldstein
(2002).
Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.
|
| |
Cell, 111,
577-588.
|
|
|
|
|
|
|
J.J.Tong,
J.Liu,
N.R.Bertos,
and
X.J.Yang
(2002).
Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain.
|
| |
Nucleic Acids Res, 30,
1114-1123.
|
|
|
|
|
|
|
L.Tickenbrock,
J.Cramer,
I.R.Vetter,
and
O.Muller
(2002).
The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1).
|
| |
J Biol Chem, 277,
32332-32338.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Callejo,
D.Alvarez,
G.B.Price,
and
M.Zannis-Hadjopoulos
(2002).
The 14-3-3 protein homologues from Saccharomyces cerevisiae, Bmh1p and Bmh2p, have cruciform DNA-binding activity and associate in vivo with ARS307.
|
| |
J Biol Chem, 277,
38416-38423.
|
|
|
|
|
|
|
M.L.Henriksson,
M.S.Francis,
A.Peden,
M.Aili,
K.Stefansson,
R.Palmer,
A.Aitken,
and
B.Hallberg
(2002).
A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo.
|
| |
Eur J Biochem, 269,
4921-4929.
|
|
|
|
|
|
|
O.C.Leeksma,
T.A.Van Achterberg,
Y.Tsumura,
J.Toshima,
E.Eldering,
W.G.Kroes,
C.Mellink,
M.Spaargaren,
K.Mizuno,
H.Pannekoek,
and
C.J.de Vries
(2002).
Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.
|
| |
Eur J Biochem, 269,
2546-2556.
|
|
|
|
|
|
|
O.Novac,
D.Alvarez,
C.E.Pearson,
G.B.Price,
and
M.Zannis-Hadjopoulos
(2002).
The human cruciform-binding protein, CBP, is involved in DNA replication and associates in vivo with mammalian replication origins.
|
| |
J Biol Chem, 277,
11174-11183.
|
|
|
|
|
|
|
R.J.Ferl,
M.S.Manak,
and
M.F.Reyes
(2002).
The 14-3-3s.
|
| |
Genome Biol, 3,
REVIEWS3010.
|
|
|
|
|
|
|
S.Rajan,
R.Preisig-Müller,
E.Wischmeyer,
R.Nehring,
P.J.Hanley,
V.Renigunta,
B.Musset,
G.Schlichthörl,
C.Derst,
A.Karschin,
and
J.Daut
(2002).
Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3.
|
| |
J Physiol, 545,
13-26.
|
|
|
|
|
|
|
S.Sato,
N.Fujita,
and
T.Tsuruo
(2002).
Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.
|
| |
J Biol Chem, 277,
39360-39367.
|
|
|
|
|
|
|
T.Benzing,
M.Köttgen,
M.Johnson,
B.Schermer,
H.Zentgraf,
G.Walz,
and
E.Kim
(2002).
Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha.
|
| |
J Biol Chem, 277,
32954-32962.
|
|
|
|
|
|
|
W.Meng,
L.L.Swenson,
M.J.Fitzgibbon,
K.Hayakawa,
E.Ter Haar,
A.E.Behrens,
J.R.Fulghum,
and
J.A.Lippke
(2002).
Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.
|
| |
J Biol Chem, 277,
37401-37405.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Y.Light,
H.Paterson,
and
R.Marais
(2002).
14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity.
|
| |
Mol Cell Biol, 22,
4984-4996.
|
|
|
|
|
|
|
A.H.Wang,
and
X.J.Yang
(2001).
Histone deacetylase 4 possesses intrinsic nuclear import and export signals.
|
| |
Mol Cell Biol, 21,
5992-6005.
|
|
|
|
|
|
|
A.M.Brownawell,
G.J.Kops,
I.G.Macara,
and
B.M.Burgering
(2001).
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.
|
| |
Mol Cell Biol, 21,
3534-3546.
|
|
|
|
|
|
|
D.Heerklotz,
P.Döring,
F.Bonzelius,
S.Winkelhaus,
and
L.Nover
(2001).
The balance of nuclear import and export determines the intracellular distribution and function of tomato heat stress transcription factor HsfA2.
|
| |
Mol Cell Biol, 21,
1759-1768.
|
|
|
|
|
|
|
E.A.Miska,
E.Langley,
D.Wolf,
C.Karlsson,
J.Pines,
and
T.Kouzarides
(2001).
Differential localization of HDAC4 orchestrates muscle differentiation.
|
| |
Nucleic Acids Res, 29,
3439-3447.
|
|
|
|
|
|
|
F.Michel,
M.Soler-Lopez,
C.Petosa,
P.Cramer,
U.Siebenlist,
and
C.W.Müller
(2001).
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.
|
| |
EMBO J, 20,
6180-6190.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
H.Poulsen,
J.Nilsson,
C.K.Damgaard,
J.Egebjerg,
and
J.Kjems
(2001).
CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain.
|
| |
Mol Cell Biol, 21,
7862-7871.
|
|
|
|
|
|
|
H.Y.Kao,
A.Verdel,
C.C.Tsai,
C.Simon,
H.Juguilon,
and
S.Khochbin
(2001).
Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7.
|
| |
J Biol Chem, 276,
47496-47507.
|
|
|
|
|
|
|
M.A.Scidmore,
and
T.Hackstadt
(2001).
Mammalian 14-3-3beta associates with the Chlamydia trachomatis inclusion membrane via its interaction with IncG.
|
| |
Mol Microbiol, 39,
1638-1650.
|
|
|
|
|
|
|
N.R.Bertos,
A.H.Wang,
and
X.J.Yang
(2001).
Class II histone deacetylases: structure, function, and regulation.
|
| |
Biochem Cell Biol, 79,
243-252.
|
|
|
|
|
|
|
S.Ganguly,
J.A.Gastel,
J.L.Weller,
C.Schwartz,
H.Jaffe,
M.A.Namboodiri,
S.L.Coon,
A.B.Hickman,
M.Rollag,
T.Obsil,
P.Beauverger,
G.Ferry,
J.A.Boutin,
and
D.C.Klein
(2001).
Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.
|
| |
Proc Natl Acad Sci U S A, 98,
8083-8088.
|
|
|
|
|
|
|
T.D.Bunney,
H.S.van Walraven,
and
A.H.de Boer
(2001).
14-3-3 protein is a regulator of the mitochondrial and chloroplast ATP synthase.
|
| |
Proc Natl Acad Sci U S A, 98,
4249-4254.
|
|
|
|
|
|
|
T.Obsil,
R.Ghirlando,
D.C.Klein,
S.Ganguly,
and
F.Dyda
(2001).
Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
|
| |
Cell, 105,
257-267.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.H.Wang,
M.J.Kruhlak,
J.Wu,
N.R.Bertos,
M.Vezmar,
B.I.Posner,
D.P.Bazett-Jones,
and
X.J.Yang
(2000).
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins.
|
| |
Mol Cell Biol, 20,
6904-6912.
|
|
|
|
|
|
|
A.L.Jones,
B.B.Quimby,
J.K.Hood,
P.Ferrigno,
P.H.Keshava,
P.A.Silver,
and
A.H.Corbett
(2000).
SAC3 may link nuclear protein export to cell cycle progression.
|
| |
Proc Natl Acad Sci U S A, 97,
3224-3229.
|
|
|
|
|
|
|
C.M.Grozinger,
and
S.L.Schreiber
(2000).
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.
|
| |
Proc Natl Acad Sci U S A, 97,
7835-7840.
|
|
|
|
|
|
|
C.W.Chow,
and
R.J.Davis
(2000).
Integration of calcium and cyclic AMP signaling pathways by 14-3-3.
|
| |
Mol Cell Biol, 20,
702-712.
|
|
|
|
|
|
|
D.Durocher,
I.A.Taylor,
D.Sarbassova,
L.F.Haire,
S.L.Westcott,
S.P.Jackson,
S.J.Smerdon,
and
M.B.Yaffe
(2000).
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
|
| |
Mol Cell, 6,
1169-1182.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.Durocher,
S.J.Smerdon,
M.B.Yaffe,
and
S.P.Jackson
(2000).
The FHA domain in DNA repair and checkpoint signaling.
|
| |
Cold Spring Harb Symp Quant Biol, 65,
423-431.
|
|
|
|
|
|
|
F.Kanai,
P.A.Marignani,
D.Sarbassova,
R.Yagi,
R.A.Hall,
M.Donowitz,
A.Hisaminato,
T.Fujiwara,
Y.Ito,
L.C.Cantley,
and
M.B.Yaffe
(2000).
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
|
| |
EMBO J, 19,
6778-6791.
|
|
|
|
|
|
|
H.Fu,
R.R.Subramanian,
and
S.C.Masters
(2000).
14-3-3 proteins: structure, function, and regulation.
|
| |
Annu Rev Pharmacol Toxicol, 40,
617-647.
|
|
|
|
|
|
|
H.Seimiya,
H.Sawada,
Y.Muramatsu,
M.Shimizu,
K.Ohko,
K.Yamane,
and
T.Tsuruo
(2000).
Involvement of 14-3-3 proteins in nuclear localization of telomerase.
|
| |
EMBO J, 19,
2652-2661.
|
|
|
|
|
|
|
H.Xing,
S.Zhang,
C.Weinheimer,
A.Kovacs,
and
A.J.Muslin
(2000).
14-3-3 proteins block apoptosis and differentially regulate MAPK cascades.
|
| |
EMBO J, 19,
349-358.
|
|
|
|
|
|
|
J.H.Ho,
G.Kallstrom,
and
A.W.Johnson
(2000).
Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit.
|
| |
J Cell Biol, 151,
1057-1066.
|
|
|
|
|
|
|
K.M.McBride,
C.McDonald,
and
N.C.Reich
(2000).
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor.
|
| |
EMBO J, 19,
6196-6206.
|
|
|
|
|
|
|
M.R.Roberts
(2000).
Regulatory 14-3-3 protein-protein interactions in plant cells.
|
| |
Curr Opin Plant Biol, 3,
400-405.
|
|
|
|
|
|
|
R.L.Rich,
and
D.G.Myszka
(2000).
Skerra A, 2000. Engineered scaffolds for molecular recognition. Journal of Molecular Recognition13:167-187.
|
| |
J Mol Recognit, 13,
409-410.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
|
Links
