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PDBsum entry 1qh9

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protein ligands links
Hydrolase PDB id
1qh9
Jmol
Contents
Protein chain
221 a.a. *
Ligands
LAC
Waters ×16
* Residue conservation analysis
PDB id:
1qh9
Name: Hydrolase
Title: Enzyme-product complex of l-2-haloacid dehalogenase
Structure: 2-haloacid dehalogenase. Chain: a. Engineered: yes. Other_details: complexed with d-lactate
Source: Pseudomonas sp.. Organism_taxid: 66693. Strain: yl. Gene: dex yl. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PDB file)
Resolution:
2.50Å     R-factor:   0.194     R-free:   0.287
Authors: Y.-F.Li,Y.Hata,T.Fujii,T.Kurihara,N.Esaki
Key ref: Y.-F.Li et al. The structure of l-2-Haloacid dehalogenase complexed with a reaction product reveals the mechanism of intermediate hydrolysis in dehalogenase. To be published, .
Date:
12-May-99     Release date:   24-May-00    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q53464  (HAD_PSEUY) -  (S)-2-haloacid dehalogenase
Seq:
Struc:
232 a.a.
221 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.8.1.2  - (S)-2-haloacid dehalogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
2-Haloacid Dehalogenase (configuration-inverting)
      Reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide
(S)-2-haloacid
+ H(2)O
=
(R)-2-hydroxyacid
Bound ligand (Het Group name = LAC)
matches with 71.43% similarity
+ halide
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     metabolic process   1 term 
  Biochemical function     hydrolase activity     3 terms