PDBsum entry: 1onk

Hydrolase/sugar binding protein

PDB id: 1onk

Contents

Protein chains

249 a.a. *

263 a.a. *

Ligands

PO4

AZI ×9

GOL ×8

NAG ×2

Waters ×341

* Residue conservation analysis

PDB id:

1onk

Name:

Hydrolase/sugar binding protein

Title:

Mistletoe lectin i from viscum album

Structure:

Beta-galactoside specific lectin i a chain. Chain: a. Synonym: ribosome-inactivating protein type ii, mla. Galactose specific lectin i b chain. Chain: b. Synonym: ribosome-inactivating protein type ii, mlb

Source:

Viscum album. European mistletoe. Organism_taxid: 3972. Organism_taxid: 3972

Biol. unit:

Dimer (from PDB file)

Resolution:

2.10Å R-factor: 0.172 R-free: 0.223

Authors:

A.G.Gabdoulkhakov,Y.Savoshkina,R.Krauspenhaar,S.Stoeva,N.Kon V.Kornilov,A.N.Kornev,W.Voelter,S.V.Nikonov,C.Betzel,A.M.Mi

Key ref:

A.G.Gabdoulkhakov et al. Mistletoe lectin i from viscum album. To be published,

Date:

28-Feb-03 Release date: 28-Feb-04

Protein chain

P81446  (ML1_VISAL) -  Beta-galactoside-specific lectin 1

Seq: 564 a.a.

Struc: 249 a.a.*

Protein chain

P81446  (ML1_VISAL) -  Beta-galactoside-specific lectin 1

Seq: 564 a.a.

Struc: 263 a.a.*

* PDB and UniProt seqs differ at 20 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.2.2.22 - rRNA N-glycosylase.
• Reaction: Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

 Gene Ontology (GO) functional annotation 

• Biological process: negative regulation of translation (1 term)
• Biochemical function: rRNA N-glycosylase activity (1 term)