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PDBsum entry 1okn

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protein ligands metals links
Lyase PDB id
1okn
Jmol
Contents
Protein chain
256 a.a. *
Ligands
STB
Metals
_HG
_ZN
Waters ×145
* Residue conservation analysis
PDB id:
1okn
Name: Lyase
Title: Carbonic anhydrase ii complex with the 1okn inhibitor 4- sulfonamide-[1-(4-n-(5-fluorescein thiourea)butane)]
Structure: Carbonic anhydrase ii. Chain: a. Ec: 4.2.1.1
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
2.40Å     R-factor:   0.153     R-free:   0.268
Authors: D.Elbaum,S.K.Nair,M.W.Patchan,R.B.Thompson,D.W.Christianson
Key ref: D.Elbaum et al. (1996). Structure-Based design of a sulfonamide probe for fluorescence anisotropy detection of zinc with a carbonic anhydrase-Based biosensor.. J.Am.Chem.Soc., 118, 8381-8387.
Date:
25-Jun-96     Release date:   11-Jan-97    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
256 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   22 terms 
  Biochemical function     protein binding     5 terms