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PDBsum entry 1of7

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Oxidoreductase PDB id
1of7
Jmol
Contents
Protein chains
(+ 2 more) 494 a.a. *
Ligands
DZN ×8
Waters ×1323
* Residue conservation analysis
Superseded by: 2vle
PDB id:
1of7
Name: Oxidoreductase
Title: The structure of human mitochondrial aldehyde dehydrogenase in complex with the antidipsotropic inhibitor daidzin
Structure: Aldehyde dehydrogenase, mitochondrial. Chain: a, b, c, d, e, f, g, h. Synonym: aldh class 2, aldhi, aldh-e2. Engineered: yes
Source: Homo sapiens. Human. Organ: liver. Expressed in: escherichia coli.
Biol. unit: Tetramer (from PDB file)
Resolution:
2.40Å     R-factor:   0.192     R-free:   0.275
Authors: E.D.Lowe,G.-Y.Gao,W.M.Keung
Key ref: E.D.Lowe et al. Crystal structure of human mitochondrial aldehyde dehydroganse in complex with the antidipsotropic inhibitor daidzin. To be published, .
Date:
08-Apr-03     Release date:   21-May-04    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P05091  (ALDH2_HUMAN) -  Aldehyde dehydrogenase, mitochondrial
Seq:
Struc:
517 a.a.
494 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.2.1.3  - Aldehyde dehydrogenase (NAD(+)).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: An aldehyde + NAD+ + H2O = a carboxylate + NADH
aldehyde
+ NAD(+)
+ H(2)O
= carboxylate
+ NADH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site