PDBsum entry: 1of6

Lyase

PDB id: 1of6

Contents

Protein chains

(+ 2 more) 350 a.a. *

Ligands

DTY ×8

Metals

_MN ×8

Waters ×667

* Residue conservation analysis

PDB id:

1of6

Name:

Lyase

Title:

Crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with tyrosine and manganese

Structure:

Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited. Chain: a, b, c, d, e, f, g, h. Synonym: phospho-2-keto-3-deoxyheptonate aldolase dahp synthetase, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase, phospho-2-dehydro- 3-deoxyheptonate aldolase. Engineered: yes

Source:

Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: rh1326. Other_details: saccharomyces cerevisiae

Biol. unit:

Dimer (from PDB file)

Resolution:

2.1Å R-factor: 0.195 R-free: 0.237

Authors:

V.Koenig,A.Pfeil,G.Heinrich,G.Braus,T.R.Schneider

Key ref:

V.Koenig et al. Crystal structure of the double complex of the tyrosine sensitive dahp synthase from yeast. To be published,

Date:

08-Apr-03 Release date: 06-May-04

Protein chains

P32449  (AROG_YEAST) -  Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited

Seq: 370 a.a.

Struc: 350 a.a.

Enzyme reactions

• Enzyme class: E.C.2.5.1.54 - 3-deoxy-7-phosphoheptulonate synthase.
• Pathway: Shikimate and Chorismate Biosynthesis
• Reaction: Phosphoenolpyruvate + D-erythrose 4-phosphate + H₂O = 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate + phosphate

Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate (Bound ligand (Het Group name = DTY) matches with 47.00% similarity) + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (2 terms)
• Biological process: metabolic process (5 terms)
• Biochemical function: catalytic activity (5 terms)