PDBsum entry: 1obg

Ligase

PDB id: 1obg

Contents

Protein chain

305 a.a. *

Ligands

AMP ×2

SO4 ×2

Metals

_MG

Waters ×273

* Residue conservation analysis

PDB id:

1obg

Name:

Ligase

Title:

Saicar-synthase complexed with atp

Structure:

Phosphoribosylamidoimidazole- succinocarboxamide synthase. Chain: a. Synonym: saicar synthetase. Ec: 6.3.2.6

Source:

Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932

Resolution:

2.05Å R-factor: 0.168 R-free: 0.206

Authors:

S.V.Antonyuk,A.I.Grebenko,V.M.Levdikov,D.V.Urusova, W.R.Melik-Adamyan,V.S.Lamzin,K.Wilson

Key ref:

S.V.Antonyuk et al. (2001). X-Ray structure of saicar-Synthase complexed with atp. Kristallografiya, 46, PubMed id: -1

Date:

30-Jan-03 Release date: 06-Mar-03

Protein chain

P27616  (PUR7_YEAST) -  Phosphoribosylaminoimidazole-succinocarboxamide synthase

Seq: 306 a.a.

Struc: 305 a.a.

Enzyme reactions

• Enzyme class: E.C.6.3.2.6 - Phosphoribosylaminoimidazolesuccinocarboxamide synthase.
• Pathway: Purine Biosynthesis (late stages)
• Reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP (Bound ligand (Het Group name = AMP) matches with 85.00% similarity) + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 Gene Ontology (GO) functional annotation 

• Cellular component: cytoplasm (2 terms)
• Biological process: purine nucleotide biosynthetic process (2 terms)
• Biochemical function: catalytic activity (6 terms)