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Cell adhesion protein PDB-id
1nch
Biological unit* = asymmetric unit,
as shown
(*as deduced by PQS)
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Contents
Description
Header details
Header records
References
PROCHECK
Protein chains
98 a.a. *
100 a.a. *
Metal ions
_YB ×2
Waters ×231

* Residue conservation analysis
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PDB id: 1nch
Name: Cell adhesion protein
Title: Structural basis of cell-cell adhesion by cadherins

Structure:
N-cadherin. Chain: a, b. Engineered: yes

Source:
Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biological unit:
Dimer (from PQS)

UniProt:
Chain A: P15116 (CADH2_MOUSE)
Pfam   ArchSchema ?
Seq:
Struc:
Seq:
Struc:
Seq:
Struc:
Seq: 906 a.a.
Struc: 98 a.a.*

Chain B: P15116 (CADH2_MOUSE)
Pfam   ArchSchema ?
Seq:
Struc:
Seq:
Struc:
Seq:
Struc:
Seq: 906 a.a.
Struc: 100 a.a.*
Key:    PfamA domain
 Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Resolution:
2.10Å

R-factor:
0.224

R-free:
0.309

Authors:
L.Shapiro,A.M.Fannon,P.D.Kwong,A.Thompson,M.S.Lehmann, G.Grubel,J.-F.Legrand,J.Als-Nielsen,D.R.Colman, W.A.Hendrickson

Key ref:
L.Shapiro et al. (1995). Structural basis of cell-cell adhesion by cadherins.. Nature, 374, 327-337. [PubMed id: 7885471] [DOI: 10.1038/374327a0]

Date:
23-Mar-95

Release date:
10-Jul-95
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    Key reference    
 
 
DOI no: 10.1038/374327a0 Nature 374:327-337 (1995)
PubMed id: 7885471  
 
 
Structural basis of cell-cell adhesion by cadherins.
L.Shapiro, A.M.Fannon, P.D.Kwong, A.Thompson, M.S.Lehmann, G.Grübel, J.F.Legrand, J.Als-Nielsen, D.R.Colman, W.A.Hendrickson.
 
  ABSTRACT  
 
Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
19919954 C.Ozaki, S.Obata, H.Yamanaka, S.Tominaga, and S.T.Suzuki (2010).
The extracellular domains of E- and N-cadherin determine the scattered punctate localization in epithelial cells and the cytoplasmic domains modulate the localization.
  J Biochem, 147, 415-425.  
20010843 Q.Zhou, M.Kapoor, M.Guo, R.Belani, X.Xu, W.B.Kiosses, M.Hanan, C.Park, E.Armour, M.H.Do, L.A.Nangle, P.Schimmel, and X.L.Yang (2010).
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality.
  Nat Struct Mol Biol, 17, 57-61.  
20056855 S.R.Grossman, I.Shylakhter, E.K.Karlsson, E.H.Byrne, S.Morales, G.Frieden, E.Hostetter, E.Angelino, M.Garber, O.Zuk, E.S.Lander, S.F.Schaffner, and P.C.Sabeti (2010).
A composite of multiple signals distinguishes causal variants in regions of positive selection.
  Science, 327, 883-886.  
19855082 C.Banh, C.Fugère, and L.Brossay (2009).
Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling.
  Blood, 114, 5299-5306.  
19048595 C.Qi, Y.T.Zhu, L.Hu, and Y.J.Zhu (2009).
Identification of Fat4 as a candidate tumor suppressor gene in breast cancers.
  Int J Cancer, 124, 793-798.  
19302578 C.Rollenhagen, T.Wöllert, G.M.Langford, and P.Sundstrom (2009).
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  Cell Microbiol, 11, 946-966.  
19302290 D.Osumi, M.Takahashi, E.Miyoshi, S.Yokoe, S.H.Lee, K.Noda, S.Nakamori, J.Gu, Y.Ikeda, Y.Kuroki, K.Sengoku, M.Ishikawa, and N.Taniguchi (2009).
Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells.
  Cancer Sci, 100, 888-895.  
19718715 D.Yeh, C.Chen, M.Z.Sun, S.Shao, L.Hao, Y.Song, L.Gong, J.Hu, and Q.Wang (2009).
Caveolin-1 is an important factor for the metastasis and proliferation of human small cell lung cancer NCI-H446 cell.
  Anat Rec (Hoboken), 292, 1584-1592.  
  20066110 L.Shapiro, and W.I.Weis (2009).
Structure and biochemistry of cadherins and catenins.
  Cold Spring Harbor Perspect Biol, 1, a003053.  
19199298 M.Trivedi, R.A.Davis, Y.Shabaik, A.Roy, G.Verkhivker, J.S.Laurence, C.R.Middaugh, and T.J.Siahaan (2009).
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  J Pharm Sci, 98, 3562-3574.  
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Linking molecular affinity and cellular specificity in cadherin-mediated adhesion.
  Proc Natl Acad Sci U S A, 106, 11594-11599.  
19164289 W.M.Heupel, T.Müller, A.Efthymiadis, E.Schmidt, D.Drenckhahn, and J.Waschke (2009).
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  J Biol Chem, 284, 8589-8595.  
19114658 Y.Zhang, S.Sivasankar, W.J.Nelson, and S.Chu (2009).
Resolving cadherin interactions and binding cooperativity at the single-molecule level.
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18795316 D.Studer, B.M.Humbel, and M.Chiquet (2008).
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18064706 I.H.Bekirov, V.Nagy, A.Svoronos, G.W.Huntley, and D.L.Benson (2008).
Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway.
  Hippocampus, 18, 349-363.  
18408767 J.S.Yu, S.Koujak, S.Nagase, C.M.Li, T.Su, X.Wang, M.Keniry, L.Memeo, A.Rojtman, M.Mansukhani, H.Hibshoosh, B.Tycko, and R.Parsons (2008).
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  19262148 L.A.Taneyhill (2008).
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18379416 L.Da Silva, S.Parry, L.Reid, P.Keith, N.Waddell, M.Kossai, C.Clarke, S.R.Lakhani, and P.T.Simpson (2008).
Aberrant expression of E-cadherin in lobular carcinomas of the breast.
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18421501 M.Auer, A.J.Koster, U.Ziese, C.Bajaj, N.Volkmann, d.a. .N.Wang, and A.J.Hudspeth (2008).
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18633485 M.P.Stemmler (2008).
Cadherins in development and cancer.
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18326636 M.Sotomayor, and K.Schulten (2008).
The allosteric role of the Ca2+ switch in adhesion and elasticity of C-cadherin.
  Biophys J, 94, 4621-4633.  
18707582 N.A.Gloushankova (2008).
Changes in regulation of cell-cell adhesion during tumor transformation.
  Biochemistry (Mosc), 73, 742-750.  
18521104 P.Xia, S.Wang, Z.Guo, and X.Yao (2008).
Emperipolesis, entosis and beyond: dance with fate.
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18552401 Q.Shi, Y.H.Chien, and D.Leckband (2008).
Biophysical properties of cadherin bonds do not predict cell sorting.
  J Biol Chem, 283, 28454-28463.  
18550521 S.A.Dames, E.Bang, D.Haüssinger, T.Ahrens, J.Engel, and S.Grzesiek (2008).
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PDB code: 2v37
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Establishment of cell-cell junctions depends on the oligomeric states of VE-cadherin.
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Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region.
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Cell adhesion proteins and alpha-fetoprotein. Similar structural motifs as prerequisites for common functions.
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N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation.
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19305742 D.Kiryushko, E.Bock, and V.Berezin (2007).
Pharmacology of cell adhesion molecules of the nervous system.
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17564818 G.Agiostratidou, J.Hulit, G.R.Phillips, and R.B.Hazan (2007).
Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progression.
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17414625 H.Li, D.K.Price, and W.D.Figg (2007).
ADH1, an N-cadherin inhibitor, evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer.
  Anticancer Drugs, 18, 563-568.  
17347145 H.Tsuiji, L.Xu, K.Schwartz, and B.M.Gumbiner (2007).
Cadherin conformations associated with dimerization and adhesion.
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18001487 J.Paredes, A.L.Correia, A.S.Ribeiro, A.Albergaria, F.Milanezi, and F.C.Schmitt (2007).
P-cadherin expression in breast cancer: a review.
  Breast Cancer Res, 9, 214.  
17600523 L.Shapiro, J.Love, and D.R.Colman (2007).
Adhesion molecules in the nervous system: structural insights into function and diversity.
  Annu Rev Neurosci, 30, 451-474.  
  17877791 M.Emily, and O.Francois (2007).
A statistical approach to estimating the strength of cell-cell interactions under the differential adhesion hypothesis.
  Theor Biol Med Model, 4, 37.  
17766378 M.Mörtl, P.Sonderegger, K.Diederichs, and W.Welte (2007).
The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.
  Protein Sci, 16, 2174-2183.
PDB code: 2om5
17133224 M.Takeichi (2007).
The cadherin superfamily in neuronal connections and interactions.
  Nat Rev Neurosci, 8, 11-20.  
17761538 R.B.Troyanovsky, O.Laur, and S.M.Troyanovsky (2007).
Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion.
  Mol Biol Cell, 18, 4343-4352.  
17060446 R.Siu, C.Fladd, and D.Rotin (2007).
N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth.
  Mol Cell Biol, 27, 208-219.  
17539752 S.Pokutta, and W.I.Weis (2007).
Structure and mechanism of cadherins and catenins in cell-cell contacts.
  Annu Rev Cell Dev Biol, 23, 237-261.  
17023539 A.K.Prakasam, V.Maruthamuthu, and D.E.Leckband (2006).
Similarities between heterophilic and homophilic cadherin adhesion.
  Proc Natl Acad Sci U S A, 103, 15434-15439.  
16440298 A.M.Elste, and D.L.Benson (2006).
Structural basis for developmentally regulated changes in cadherin function at synapses.
  J Comp Neurol, 495, 324-335.  
16287100 A.Prasad, H.Zhao, J.M.Rutherford, N.Housley, C.Nichols, and S.Pedigo (2006).
Effect of linker segments on the stability of epithelial cadherin Domain 2.
  Proteins, 62, 111-121.  
16834557 D.Leckband, and A.Prakasam (2006).
Mechanism and dynamics of cadherin adhesion.
  Annu Rev Biomed Eng, 8, 259-287.  
16980367 F.Cailliez, and R.Lavery (2006).
Dynamics and stability of E-cadherin dimers.
  Biophys J, 91, 3964-3971.  
16916795 H.Morishita, M.Umitsu, Y.Murata, N.Shibata, K.Udaka, Y.Higuchi, H.Akutsu, T.Yamaguchi, T.Yagi, and T.Ikegami (2006).
Structure of the cadherin-related neuronal receptor/protocadherin-alpha first extracellular cadherin domain reveals diversity across cadherin families.
  J Biol Chem, 281, 33650-33663.  
16247458 J.Ying, H.Li, T.J.Seng, C.Langford, G.Srivastava, S.W.Tsao, T.Putti, P.Murray, A.T.Chan, and Q.Tao (2006).
Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation.
  Oncogene, 25, 1070-1080.  
16326909 M.V.Bayas, A.Leung, E.Evans, and D.Leckband (2006).
Lifetime measurements reveal kinetic differences between homophilic cadherin bonds.
  Biophys J, 90, 1385-1395.  
16760429 R.B.Troyanovsky, E.P.Sokolov, and S.M.Troyanovsky (2006).
Endocytosis of cadherin from intracellular junctions is the driving force for cadherin adhesive dimer disassembly.
  Mol Biol Cell, 17, 3484-3493.  
16439973 Y.Shimomura, F.Sakamoto, N.Kariya, K.Matsunaga, and M.Ito (2006).
Mutations in the desmoglein 4 gene are associated with monilethrix-like congenital hypotrichosis.
  J Invest Dermatol, 126, 1281-1285.  
16030252 A.M.Shewan, M.Maddugoda, A.Kraemer, S.J.Stehbens, S.Verma, E.M.Kovacs, and A.S.Yap (2005).
Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts.
  Mol Biol Cell, 16, 4531-4542.  
15854040 A.Shimizu, A.Ishiko, T.Ota, H.Saito, H.Oka, K.Tsunoda, M.Amagai, and T.Nishikawa (2005).
In vivo ultrastructural localization of the desmoglein 3 adhesive interface to the desmosome mid-line.
  J Invest Dermatol, 124, 984-989.  
16224208 A.Triana, C.Sen, D.Wolfe, and R.Hazan (2005).
Cadherins and catenins in clival chordomas: correlation of expression with tumor aggressiveness.
  Am J Surg Pathol, 29, 1422-1434.  
16025097 B.M.Gumbiner (2005).
Regulation of cadherin-mediated adhesion in morphogenesis.
  Nat Rev Mol Cell Biol, 6, 622-634.  
16354833 B.Zuber, I.Nikonenko, P.Klauser, D.Muller, and J.Dubochet (2005).
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes.
  Proc Natl Acad Sci U S A, 102, 19192-19197.  
15937105 C.P.Chen, S.Posy, A.Ben-Shaul, L.Shapiro, and B.H.Honig (2005).
Specificity of cell-cell adhesion by classical cadherins: Critical role for low-affinity dimerization through beta-strand swapping.
  Proc Natl Acad Sci U S A, 102, 8531-8536.  
16556042 C.Salon, S.Lantuejoul, B.Eymin, S.Gazzeri, C.Brambilla, and E.Brambilla (2005).
The E-cadherin-beta-catenin complex and its implication in lung cancer progression and prognosis.
  Future Oncol, 1, 649-660.  
15715668 G.Williams, B.J.Eickholt, P.Maison, R.Prinjha, F.S.Walsh, and P.Doherty (2005).
A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonists.
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16199889 H.Andersen, J.Mejlvang, S.Mahmood, I.Gromova, P.Gromov, E.Lukanidin, M.Kriajevska, J.K.Mellon, and E.Tulchinsky (2005).
Immediate and delayed effects of E-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells.
  Mol Cell Biol, 25, 9138-9150.  
15743489 H.P.Kiener, and M.B.Brenner (2005).
Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion.
  Arthritis Res Ther, 7, 49-54.  
15790695 K.S.Nair, R.Naidoo, and R.Chetty (2005).
Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value.
  J Clin Pathol, 58, 343-351.  
15817439 K.Summers, and B.Crespi (2005).
Cadherins in maternal-foetal interactions: red queen with a green beard?
  Proc Biol Sci, 272, 643-649.  
16143457 L.Cao, X.Yan, C.W.Borysenko, H.C.Blair, C.Wu, and L.Yu (2005).
CHDL: a cadherin-like domain in Proteobacteria and Cyanobacteria.
  FEMS Microbiol Lett, 251, 203-209.  
15917256 M.C.Moh, C.Zhang, C.Luo, L.H.Lee, and S.Shen (2005).
Structural and functional analyses of a novel ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells.
  J Biol Chem, 280, 27366-27374.  
15705066 R.T.Bryan, S.A.Hussain, N.D.James, J.A.Jankowski, and D.M.Wallace (2005).
Molecular pathways in bladder cancer: part 2.
  BJU Int, 95, 491-496.  
16045455 V.V.Kiselyov, V.Soroka, V.Berezin, and E.Bock (2005).
Structural biology of NCAM homophilic binding and activation of FGFR.
  J Neurochem, 94, 1169-1179.  
15047711 C.Castillejo-López, W.M.Arias, and S.Baumgartner (2004).
The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs.
  J Biol Chem, 279, 24034-24043.  
15071499 D.Häussinger, T.Ahrens, T.Aberle, J.Engel, J.Stetefeld, and S.Grzesiek (2004).
Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography.
  EMBO J, 23, 1699-1708.
PDB code: 1q1p
15153429 D.Kiryushko, V.Berezin, and E.Bock (2004).
Regulators of neurite outgrowth: role of cell adhesion molecules.
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15057938 D.Rasskin-Gutman, and J.C.Izpisúa-Belmonte (2004).
Theoretical morphology of developmental asymmetries.
  Bioessays, 26, 405-412.  
15546992 E.Perret, A.Leung, H.Feracci, and E.Evans (2004).
Trans-bonded pairs of E-cadherin exhibit a remarkable hierarchy of mechanical strengths.
  Proc Natl Acad Sci U S A, 101, 16472-16477.  
15702378 F.Lacaz-Vieira, and M.M.Marques (2004).
Lanthanum effect on the dynamics of tight junction opening and closing.
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15309553 G.Tanriover, U.A.Kayisli, R.Demir, E.Pestereli, S.Karaveli, and N.Demir (2004).
Distribution of N-cadherin in human cerebral cortex during prenatal development.
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Dual roles of E-cadherin in prostate cancer invasion.
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Beta-1 integrin-mediated adhesion may be initiated by multiple incomplete bonds, thus accounting for the functional importance of receptor clustering.
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15166221 L.S.Price, A.Hajdo-Milasinovic, J.Zhao, F.J.Zwartkruis, J.G.Collard, and J.L.Bos (2004).
Rap1 regulates E-cadherin-mediated cell-cell adhesion.
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15259055 M.Fuchs, P.Hutzler, G.Handschuh, C.Hermannstädter, I.Brunner, H.Höfler, and B.Luber (2004).
Dynamics of cell adhesion and motility in living cells is altered by a single amino acid change in E-cadherin fused to enhanced green fluorescent protein.
  Cell Motil Cytoskeleton, 59, 50-61.  
15516560 M.J.Arrizubieta, A.Toledo-Arana, B.Amorena, J.R.Penadés, and I.Lasa (2004).
Calcium inhibits bap-dependent multicellular behavior in Staphylococcus aureus.
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15247242 M.W.Chan, T.Y.El Sayegh, P.D.Arora, C.A.Laschinger, C.M.Overall, C.Morrison, and C.A.McCulloch (2004).
Regulation of intercellular adhesion strength in fibroblasts.
  J Biol Chem, 279, 41047-41057.  
15153430 R.B.Hazan, R.Qiao, R.Keren, I.Badano, and K.Suyama (2004).
Cadherin switch in tumor progression.
  Ann N Y Acad Sci, 1014, 155-163.  
14718570 R.Islam, L.V.Kristiansen, S.Romani, L.Garcia-Alonso, and M.Hortsch (2004).
Activation of EGF receptor kinase by L1-mediated homophilic cell interactions.
  Mol Biol Cell, 15, 2003-2012.  
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Darwin's abominable mystery: Insights from a supertree of the angiosperms.
  Proc Natl Acad Sci U S A, 101, 1904-1909.  
15366765 V.M.Bowers-Morrow, S.O.Ali, and K.L.Williams (2004).
Comparison of molecular mechanisms mediating cell contact phenomena in model developmental systems: an exploration of universality.
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15485826 W.Shan, Y.Yagita, Z.Wang, A.Koch, A.F.Svenningsen, E.Gruzglin, L.Pedraza, and D.R.Colman (2004).
The minimal essential unit for cadherin-mediated intercellular adhesion comprises extracellular domains 1 and 2.
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14523994 A.A.Capehart, and C.B.Kern (2003).
Identification of gammaA-like protocadherin expressed during chick development.
  J Cell Biochem, 90, 608-618.  
14573948 A.González (2003).
Optimizing data collection for structure determination.
  Acta Crystallogr D Biol Crystallogr, 59, 1935-1942.  
12712492 A.Gupta, C.G.Deshpande, and S.Badve (2003).
Role of E-cadherins in development of lymphatic tumor emboli.
  Cancer, 97, 2341-2347.  
12444085 A.Yokota, K.Tsumoto, M.Shiroishi, H.Kondo, and I.Kumagai (2003).
The role of hydrogen bonding via interfacial water molecules in antigen-antibody complexation. The HyHEL-10-HEL interaction.
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PDB codes: 1j1o 1j1p 1j1x
12770907 B.Zhu, S.Chappuis-Flament, E.Wong, I.E.Jensen, B.M.Gumbiner, and D.Leckband (2003).
Functional analysis of the structural basis of homophilic cadherin adhesion.
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12647996 C.Oliveira, R.Seruca, and C.Caldas (2003).
Genetic screening for hereditary diffuse gastric cancer.
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12855811 J.J.Dumas, R.Kumar, J.Seehra, W.S.Somers, and L.Mosyak (2003).
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation.
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PDB code: 1p8v
  14511406 J.Nightingale, K.S.Chaudhary, P.D.Abel, A.P.Stubbs, H.M.Romanska, S.E.Mitchell, G.W.Stamp, and e.l.-.N.Lalani (2003).
Ligand activation of the androgen receptor downregulates E-cadherin-mediated cell adhesion and promotes apoptosis of prostatic cancer cells.
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12724416 L.Ciani, A.Patel, N.D.Allen, and C.ffrench-Constant (2003).
Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.
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14570569 M.J.Wheelock, and K.R.Johnson (2003).
Cadherins as modulators of cellular phenotype.
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12672106 M.Nitz, K.J.Franz, R.L.Maglathlin, and B.Imperiali (2003).
A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides.
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12533412 N.P.Lee, D.Mruk, W.M.Lee, and C.Y.Cheng (2003).
Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?
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12845611 O.De Wever, and M.Mareel (2003).
Role of tissue stroma in cancer cell invasion.
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12626697 P.Scheiffele (2003).
Cell-cell signaling during synapse formation in the CNS.
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14585958 R.B.Troyanovsky, E.Sokolov, and S.M.Troyanovsky (2003).
Adhesive and lateral E-cadherin dimers are mediated by the same interface.
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14532801 R.T.Bryan, J.H.Nicholls, R.F.Harrison, J.A.Jankowski, and D.M.Wallace (2003).
The role of beta-catenin signaling in the malignant potential of cystitis glandularis.
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14526082 W.He, P.Cowin, and D.L.Stokes (2003).
Untangling desmosomal knots with electron tomography.
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PDB codes: 1q55 1q5a 1q5b 1q5c
12880431 Y.Hanakawa, T.Selwood, D.Woo, C.Lin, N.M.Schechter, and J.R.Stanley (2003).
Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin.
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12397616 A.M.DeLise, and R.S.Tuan (2002).
Alterations in the spatiotemporal expression pattern and function of N-cadherin inhibit cellular condensation and chondrogenesis of limb mesenchymal cells in vitro.
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11790800 C.M.Niessen, and B.M.Gumbiner (2002).
Cadherin-mediated cell sorting not determined by binding or adhesion specificity.
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12032067 E.Perret, A.M.Benoliel, P.Nassoy, A.Pierres, V.Delmas, J.P.Thiery, P.Bongrand, and H.Feracci (2002).
Fast dissociation kinetics between individual E-cadherin fragments revealed by flow chamber analysis.
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11726665 G.Williams, E.J.Williams, and P.Doherty (2002).
Dimeric versions of two short N-cadherin binding motifs (HAVDI and INPISG) function as N-cadherin agonists.
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11856755 I.T.Makagiansar, P.D.Nguyen, A.Ikesue, K.Kuczera, W.Dentler, J.L.Urbauer, N.Galeva, M.Alterman, and T.J.Siahaan (2002).
Disulfide bond formation promotes the cis- and trans-dimerization of the E-cadherin-derived first repeat.
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12370292 J.Klingelhöfer, O.Y.Laur, R.B.Troyanovsky, and S.M.Troyanovsky (2002).
Dynamic interplay between adhesive and lateral E-cadherin dimers.
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12210736 M.Bagchi, M.Katar, J.Lewis, and H.Maisel (2002).
Associated proteins of lens adherens junction.
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11970959 M.Lambert, D.Choquet, and R.M.Mège (2002).
Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton.
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11916976 M.Ozawa (2002).
Lateral dimerization of the E-cadherin extracellular domain is necessary but not sufficient for adhesive activity.
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12154084 M.Renaud-Young, and W.J.Gallin (2002).
In the first extracellular domain of E-cadherin, heterophilic interactions, but not the conserved His-Ala-Val motif, are required for adhesion.
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12884975 N.J.Bray, G.Kirov, R.J.Owen, N.J.Jacobsen, L.Georgieva, H.J.Williams, N.Norton, G.Spurlock, S.Jones, S.Zammit, M.C.O'Donovan, and M.J.Owen (2002).
Screening the human protocadherin 8 (PCDH8) gene in schizophrenia.
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12234928 R.Nawroth, G.Poell, A.Ranft, S.Kloep, U.Samulowitz, G.Fachinger, M.Golding, D.T.Shima, U.Deutsch, and D.Vestweber (2002).
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts.
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11821414 S.Bibert, M.Jaquinod, E.Concord, C.Ebel, E.Hewat, C.Vanbelle, P.Legrand, M.Weidenhaupt, T.Vernet, and D.Gulino-Debrac (2002).
Synergy between extracellular modules of vascular endothelial cadherin promotes homotypic hexameric interactions.
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11900554 S.Gorlatov, and L.Medved (2002).
Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains.
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11909859 T.Ahrens, O.Pertz, D.Haussinger, C.Fauser, T.Schulthess, and J.Engel (2002).
Analysis of heterophilic and homophilic interactions of cadherins using the c-Jun/c-Fos dimerization domains.
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11964443 T.J.Boggon, J.Murray, S.Chappuis-Flament, E.Wong, B.M.Gumbiner, and L.Shapiro (2002).
C-cadherin ectodomain structure and implications for cell adhesion mechanisms.
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PDB code: 1l3w
11953402 W.C.Prozialeck, M.J.Fay, P.C.Lamar, C.A.Pearson, I.Sigar, and K.H.Ramsey (2002).
Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequesters beta-catenin in human cervical epithelial cells.
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12125071 W.Shan, M.Yoshida, X.R.Wu, G.W.Huntley, and D.R.Colman (2002).
Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure.
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11514671 A.E.Kister, M.A.Roytberg, C.Chothia, J.M.Vasiliev, and I.M.Gelfand (2001).
The sequence determinants of cadherin molecules.
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11439369 A.S.Rocha, P.Soares, R.Seruca, V.Máximo, X.Matias-Guiu, J.Cameselle-Teijeiro, and M.Sobrinho-Simões (2001).
Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant.
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11564756 A.Stockinger, A.Eger, J.Wolf, H.Beug, and R.Foisner (2001).
E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity.
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11710914 C.D.Andl, and J.R.Stanley (2001).
Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes.
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11500366 D.Kostrewa, M.Brockhaus, A.D'Arcy, G.E.Dale, P.Nelboeck, G.Schmid, F.Mueller, G.Bazzoni, E.Dejana, T.Bartfai, F.K.Winkler, and M.Hennig (2001).
X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif.
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PDB code: 1f97
11571292 E.J.Williams, G.Williams, F.V.Howell, S.D.Skaper, F.S.Walsh, and P.Doherty (2001).
Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth.
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11204426 J.Kawaguchi, I.Kii, Y.Sugiyama, S.Takeshita, and A.Kudo (2001).
The transition of cadherin expression in osteoblast differentiation from mesenchymal cells: consistent expression of cadherin-11 in osteoblast lineage.
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11447106 J.Yang, P.Dokurno, N.K.Tonks, and D.Barford (2001).
Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion.
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PDB code: 1h6g
11458036 K.Tryggvason, and J.Wartiovaara (2001).
Molecular basis of glomerular permselectivity.
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11259604 M.Balzar, I.H.Briaire-de Bruijn, H.A.Rees-Bakker, F.A.Prins, W.Helfrich, L.de Leij, G.Riethmüller, S.Alberti, S.O.Warnaar, G.J.Fleuren, and S.V.Litvinov (2001).
Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions.
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11523031 M.Ohgaki, T.Kizuki, M.Katsura, and K.Yamashita (2001).
Manipulation of selective cell adhesion and growth by surface charges of electrically polarized hydroxyapatite.
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Single molecule imaging of green fluorescent proteins in living cells: E-cadherin forms oligomers on the free cell surface.
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11449003 S.Chappuis-Flament, E.Wong, L.D.Hicks, C.M.Kay, and B.M.Gumbiner (2001).
Multiple cadherin extracellular repeats mediate homophilic binding and adhesion.
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11259289 S.Sivasankar, B.Gumbiner, and D.Leckband (2001).
Direct measurements of multiple adhesive alignments and unbinding trajectories between cadherin extracellular domains.
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FAT is a component of glomerular slit diaphragms.
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11526210 Y.Liu, C.M.Ogata, and W.A.Hendrickson (2001).
Multiwavelength anomalous diffraction analysis at the M absorption edges of uranium.
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10741417 B.Cox, A.K.Hadjantonakis, J.E.Collins, and A.I.Magee (2000).
Cloning and expression throughout mouse development of mfat1, a homologue of the Drosophila tumour suppressor gene fat.
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11087873 B.Kachar, M.Parakkal, M.Kurc, Y.Zhao, and P.G.Gillespie (2000).
High-resolution structure of hair-cell tip links.
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10685062 D.Vestweber (2000).
Molecular mechanisms that control endothelial cell contacts.
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10660557 E.Williams, G.Williams, B.J.Gour, O.W.Blaschuk, and P.Doherty (2000).
A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motif.
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11036563 H.H.Chen, and G.W.Brodland (2000).
Cell-level finite element studies of viscous cells in planar aggregates.
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HYR, an extracellular module involved in cellular adhesion and related to the immunoglobulin-like fold.
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N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility.
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10790430 K.S.Taraszka, J.M.Higgins, K.Tan, D.A.Mandelbrot, J.H.Wang, and M.B.Brenner (2000).
Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin.
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10974003 K.Tachibana, H.Nakanishi, K.Mandai, K.Ozaki, W.Ikeda, Y.Yamamoto, A.Nagafuchi, S.Tsukita, and Y.Takai (2000).
Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins.
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10792570 M.Bernards, and B.P.Korge (2000).
Desmosome assembly and keratin network formation after Ca2+/serum induction and UVB radiation in Hailey-Hailey keratinocytes.
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Interaction of nectin with afadin is necessary for its clustering at cell-cell contact sites but not for its cis dimerization or trans interaction.
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Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes.
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10759550 W.Baumgartner, P.Hinterdorfer, W.Ness, A.Raab, D.Vestweber, H.Schindler, and D.Drenckhahn (2000).
Cadherin interaction probed by atomic force microscopy.
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10662782 W.S.Shan, H.Tanaka, G.R.Phillips, K.Arndt, M.Yoshida, D.R.Colman, and L.Shapiro (2000).
Functional cis-heterodimers of N- and R-cadherins.
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10234805 A.R.Haas, and R.S.Tuan (1999).
Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: II. Stimulation by bone morphogenetic protein-2 requires modulation of N-cadherin expression and function.
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10408833 A.U.Jawhari, M.Noda, M.J.Farthing, and M.Pignatelli (1999).
Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines.
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9988734 B.A.Fox, V.C.Yee, L.C.Pedersen, I.Le Trong, P.D.Bishop, R.E.Stenkamp, and D.C.Teller (1999).
Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography.
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PDB codes: 1bl2 1ggu 1ggy
10584868 C.Huiping, J.R.Sigurgeirsdottir, J.G.Jonasson, G.Eiriksdottir, J.T.Johannsdottir, V.Egilsson, and S.Ingvarsson (1999).
Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer.
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10097129 G.A.Snyder, A.G.Brooks, and P.D.Sun (1999).
Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2.
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PDB codes: 2dl2 2dli
10089396 G.Evans, and K.S.Wilson (1999).
A MAD experiment performed at the white line of the iridium LIII absorption edge in lysozyme.
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10064578 H.K.Song, S.H.Sohn, and S.W.Suh (1999).
Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex.
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PDB codes: 1b49 1b5d 1b5e
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Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?
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10098927 K.Kawamura, and Y.M.Sugino (1999).
Cell adhesion in the process of asexual reproduction of tunicates.
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Cadherins and tissue formation: integrating adhesion and signaling.
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A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes.
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10545506 M.T.Nieman, R.S.Prudoff, K.R.Johnson, and M.J.Wheelock (1999).
N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression.
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10202138 O.Pertz, D.Bozic, A.W.Koch, C.Fauser, A.Brancaccio, and J.Engel (1999).
A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation.
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PDB code: 1ff5
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Alpha E beta 7.
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10092601 R.Gurezka, R.Laage, B.Brosig, and D.Langosch (1999).
A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments.
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Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains.
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Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context.
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Small GTPases and regulation of cadherin dependent cell-cell adhesion.
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Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion.
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10037790 Y.T.Chen, D.B.Stewart, and W.J.Nelson (1999).
Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells.
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IQGAP1 and calmodulin modulate E-cadherin function.
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Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease.
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Experimental study of the interaction range and association rate of surface-attached cadherin 11.
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Expression of rat target of the antiproliferative antibody (TAPA) in the developing brain.
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Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein.
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MAD phasing grows up.
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Desmosomal adhesion inhibits invasive behavior.
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Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelium cadherin.
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The binding of calcium to the B-repeat segment of SdrD, a cell surface protein of Staphylococcus aureus.
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Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin.
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Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses.
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E-cadherin and catenins: molecules with versatile roles in normal and neoplastic epithelial cell biology.
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Effects of forced expression of an NH2-terminal truncated beta-Catenin on mouse intestinal epithelial homeostasis.
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The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity.
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Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation.
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Regulation of chondrocyte differentiation and maturation.
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A new DNA-binding motif in the Skn-1 binding domain-DNA complex.
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PDB code: 1skn
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Direct involvement of N-cadherin-mediated signaling in muscle differentiation.
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Intracellular pathogens and the actin cytoskeleton.
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The role of charged residues mediating low affinity protein-protein recognition at the cell surface by CD2.
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Crystal structure of hemolin: a horseshoe shape with implications for homophilic adhesion.
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PDB code: 1bih
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Cytoplasmic regulation of the movement of E-cadherin on the free cell surface as studied by optical tweezers and single particle tracking: corralling and tethering by the membrane skeleton.
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Projection structure of a gap junction membrane channel at 7 A resolution.