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Cell adhesion protein
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PDB id
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1ncg
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Cell adhesion protein
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Title:
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Structural basis of cell-cell adhesion by cadherins
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Structure:
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N-cadherin. Chain: a. Engineered: yes. Mutation: yes
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Source:
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Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Biol. unit:
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Dimer (from
)
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Resolution:
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2.10Å
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R-factor:
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0.217
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R-free:
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0.201
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Authors:
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L.Shapiro,A.M.Fannon,P.D.Kwong,A.Thompson,M.S.Lehmann, G.Grubel,J.-F.Legrand,J.Als-Nielsen,D.R.Colman, W.A.Hendrickson
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Key ref:
|
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L.Shapiro
et al.
(1995).
Structural basis of cell-cell adhesion by cadherins.
Nature,
374,
327-337.
PubMed id:
DOI:
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Date:
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23-Mar-95
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Release date:
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10-Jul-95
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PROCHECK
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Headers
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References
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P15116
(CADH2_MOUSE) -
Cadherin-2
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Seq:
Struc:
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906 a.a.
99 a.a.*
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Key: |
 |
PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Gene Ontology (GO) functional annotation
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Cellular component
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membrane
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2 terms
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Biological process
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cell adhesion
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2 terms
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Biochemical function
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calcium ion binding
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1 term
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| |
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DOI no:
|
Nature
374:327-337
(1995)
|
|
PubMed id:
|
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|
| |
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Structural basis of cell-cell adhesion by cadherins.
|
|
L.Shapiro,
A.M.Fannon,
P.D.Kwong,
A.Thompson,
M.S.Lehmann,
G.Grübel,
J.F.Legrand,
J.Als-Nielsen,
D.R.Colman,
W.A.Hendrickson.
|
|
|
|
|
| |
ABSTRACT
|
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| |
|
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Crystal structures of the amino-terminal domain of N-cadherin provide a picture
at the atomic level of a specific adhesive contact between cells. A repeated set
of dimer interfaces is common to the structure in three lattices. These
interactions combine to form a linear zipper of molecules that mirrors the
linear structure of the intracellular filaments with which cadherins associate.
This cell-adhesion zipper may provide a mechanism to marshal individual
molecular adhesive interactions into strong bonds between cells.
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 |
 |
 |
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Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
G.S.Brigidi,
and
S.X.Bamji
(2011).
Cadherin-catenin adhesion complexes at the synapse.
|
| |
Curr Opin Neurobiol, 21,
208-214.
|
|
|
|
|
|
|
J.Brasch,
O.J.Harrison,
G.Ahlsen,
S.M.Carnally,
R.M.Henderson,
B.Honig,
and
L.Shapiro
(2011).
Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin.
|
| |
J Mol Biol, 408,
57-73.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
L.D.Nagaprashantha,
R.Vatsyayan,
P.C.Lelsani,
S.Awasthi,
and
S.S.Singhal
(2011).
The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors.
|
| |
Int J Cancer, 128,
743-752.
|
|
|
|
|
|
|
S.Hong,
R.B.Troyanovsky,
and
S.M.Troyanovsky
(2011).
Cadherin exits the junction by switching its adhesive bond.
|
| |
J Cell Biol, 192,
1073-1083.
|
|
|
|
|
|
|
B.Bartelt-Kirbach,
K.Langer-Fischer,
and
N.Golenhofen
(2010).
Different regulation of N-cadherin and cadherin-11 in rat hippocampus.
|
| |
Cell Commun Adhes, 17,
75-82.
|
|
|
|
|
|
|
C.Ciatto,
F.Bahna,
N.Zampieri,
H.C.VanSteenhouse,
P.S.Katsamba,
G.Ahlsen,
O.J.Harrison,
J.Brasch,
X.Jin,
S.Posy,
J.Vendome,
B.Ranscht,
T.M.Jessell,
B.Honig,
and
L.Shapiro
(2010).
T-cadherin structures reveal a novel adhesive binding mechanism.
|
| |
Nat Struct Mol Biol, 17,
339-347.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.Ozaki,
S.Obata,
H.Yamanaka,
S.Tominaga,
and
S.T.Suzuki
(2010).
The extracellular domains of E- and N-cadherin determine the scattered punctate localization in epithelial cells and the cytoplasmic domains modulate the localization.
|
| |
J Biochem, 147,
415-425.
|
|
|
|
|
|
|
D.Garrod
(2010).
Desmosomes in vivo.
|
| |
Dermatol Res Pract, 2010,
212439.
|
|
|
|
|
|
|
G.R.Owen,
and
D.L.Stokes
(2010).
Exploring the Nature of Desmosomal Cadherin Associations in 3D.
|
| |
Dermatol Res Pract, 2010,
930401.
|
|
|
|
|
|
|
H.M.Elledge,
P.Kazmierczak,
P.Clark,
J.S.Joseph,
A.Kolatkar,
P.Kuhn,
and
U.Müller
(2010).
Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.
|
| |
Proc Natl Acad Sci U S A, 107,
10708-10712.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Yamagami,
A.S.Payne,
S.Kacir,
K.Ishii,
D.L.Siegel,
and
J.R.Stanley
(2010).
Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity.
|
| |
J Clin Invest, 120,
4111-4117.
|
|
|
|
|
|
|
K.J.Green,
S.Getsios,
S.Troyanovsky,
and
L.M.Godsel
(2010).
Intercellular junction assembly, dynamics, and homeostasis.
|
| |
Cold Spring Harb Perspect Biol, 2,
a000125.
|
|
|
|
|
|
|
L.A.Chtcheglova,
L.Wildling,
J.Waschke,
D.Drenckhahn,
and
P.Hinterdorfer
(2010).
AFM functional imaging on vascular endothelial cells.
|
| |
J Mol Recognit, 23,
589-596.
|
|
|
|
|
|
|
L.Hong,
H.Sun,
X.Lv,
D.Yang,
J.Zhang,
and
Y.Shi
(2010).
Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro.
|
| |
Mol Biol Rep, 37,
2285-2293.
|
|
|
|
|
|
|
M.A.Craig,
M.W.McBride,
G.Smith,
S.J.George,
and
A.Baker
(2010).
Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat.
|
| |
J Mol Cell Cardiol, 48,
1121-1128.
|
|
|
|
|
|
|
M.Amagai
(2010).
Autoimmune and infectious skin diseases that target desmogleins.
|
| |
Proc Jpn Acad Ser B Phys Biol Sci, 86,
524-537.
|
|
|
|
|
|
|
M.Fernández-Monreal,
T.Oung,
H.H.Hanson,
R.O'Leary,
W.G.Janssen,
G.Dolios,
R.Wang,
and
G.R.Phillips
(2010).
Gamma-protocadherins are enriched and transported in specialized vesicles associated with the secretory pathway in neurons.
|
| |
Eur J Neurosci, 32,
921-931.
|
|
|
|
|
|
|
N.T.Georgopoulos,
L.A.Kirkwood,
D.C.Walker,
and
J.Southgate
(2010).
Differential regulation of growth-promoting signalling pathways by E-cadherin.
|
| |
PLoS One, 5,
e13621.
|
|
|
|
|
|
|
O.J.Harrison,
F.Bahna,
P.S.Katsamba,
X.Jin,
J.Brasch,
J.Vendome,
G.Ahlsen,
K.J.Carroll,
S.R.Price,
B.Honig,
and
L.Shapiro
(2010).
Two-step adhesive binding by classical cadherins.
|
| |
Nat Struct Mol Biol, 17,
348-357.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Q.Zhou,
M.Kapoor,
M.Guo,
R.Belani,
X.Xu,
W.B.Kiosses,
M.Hanan,
C.Park,
E.Armour,
M.H.Do,
L.A.Nangle,
P.Schimmel,
and
X.L.Yang
(2010).
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality.
|
| |
Nat Struct Mol Biol, 17,
57-61.
|
|
|
|
|
|
|
S.R.Grossman,
I.Shylakhter,
E.K.Karlsson,
E.H.Byrne,
S.Morales,
G.Frieden,
E.Hostetter,
E.Angelino,
M.Garber,
O.Zuk,
E.S.Lander,
S.F.Schaffner,
and
P.C.Sabeti
(2010).
A composite of multiple signals distinguishes causal variants in regions of positive selection.
|
| |
Science, 327,
883-886.
|
|
|
|
|
|
|
C.Banh,
C.Fugère,
and
L.Brossay
(2009).
Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling.
|
| |
Blood, 114,
5299-5306.
|
|
|
|
|
|
|
C.Qi,
Y.T.Zhu,
L.Hu,
and
Y.J.Zhu
(2009).
Identification of Fat4 as a candidate tumor suppressor gene in breast cancers.
|
| |
Int J Cancer, 124,
793-798.
|
|
|
|
|
|
|
C.Rollenhagen,
T.Wöllert,
G.M.Langford,
and
P.Sundstrom
(2009).
Stimulation of cell motility and expression of late markers of differentiation in human oral keratinocytes by Candida albicans.
|
| |
Cell Microbiol, 11,
946-966.
|
|
|
|
|
|
|
D.Osumi,
M.Takahashi,
E.Miyoshi,
S.Yokoe,
S.H.Lee,
K.Noda,
S.Nakamori,
J.Gu,
Y.Ikeda,
Y.Kuroki,
K.Sengoku,
M.Ishikawa,
and
N.Taniguchi
(2009).
Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells.
|
| |
Cancer Sci, 100,
888-895.
|
|
|
|
|
|
|
D.Yeh,
C.Chen,
M.Z.Sun,
S.Shao,
L.Hao,
Y.Song,
L.Gong,
J.Hu,
and
Q.Wang
(2009).
Caveolin-1 is an important factor for the metastasis and proliferation of human small cell lung cancer NCI-H446 cell.
|
| |
Anat Rec (Hoboken), 292,
1584-1592.
|
|
|
|
|
|
|
E.H.Lee,
J.Hsin,
M.Sotomayor,
G.Comellas,
and
K.Schulten
(2009).
Discovery through the computational microscope.
|
| |
Structure, 17,
1295-1306.
|
|
|
|
|
|
|
G.S.Marrs,
C.S.Theisen,
and
J.L.Brusés
(2009).
N-cadherin modulates voltage activated calcium influx via RhoA, p120-catenin, and myosin-actin interaction.
|
| |
Mol Cell Neurosci, 40,
390-400.
|
|
|
|
|
|
|
K.A.Syed,
S.Beyhan,
N.Correa,
J.Queen,
J.Liu,
F.Peng,
K.J.Satchell,
F.Yildiz,
and
K.E.Klose
(2009).
The Vibrio cholerae flagellar regulatory hierarchy controls expression of virulence factors.
|
| |
J Bacteriol, 191,
6555-6570.
|
|
|
|
|
|
|
L.Shapiro,
and
W.I.Weis
(2009).
Structure and biochemistry of cadherins and catenins.
|
| |
Cold Spring Harbor Perspect Biol, 1,
a003053.
|
|
|
|
|
|
|
M.A.Westhoff,
and
S.Fulda
(2009).
Adhesion-mediated apoptosis resistance in cancer.
|
| |
Drug Resist Updat, 12,
127-136.
|
|
|
|
|
|
|
M.Trivedi,
R.A.Davis,
Y.Shabaik,
A.Roy,
G.Verkhivker,
J.S.Laurence,
C.R.Middaugh,
and
T.J.Siahaan
(2009).
The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin.
|
| |
J Pharm Sci, 98,
3562-3574.
|
|
|
|
|
|
|
P.Hulpiau,
and
F.van Roy
(2009).
Molecular evolution of the cadherin superfamily.
|
| |
Int J Biochem Cell Biol, 41,
349-369.
|
|
|
|
|
|
|
P.Katsamba,
K.Carroll,
G.Ahlsen,
F.Bahna,
J.Vendome,
S.Posy,
M.Rajebhosale,
S.Price,
T.M.Jessell,
A.Ben-Shaul,
L.Shapiro,
and
B.H.Honig
(2009).
Linking molecular affinity and cellular specificity in cadherin-mediated adhesion.
|
| |
Proc Natl Acad Sci U S A, 106,
11594-11599.
|
|
|
|
|
|
|
S.Nakamura,
K.Kuroki,
I.Ohki,
K.Sasaki,
M.Kajikawa,
T.Maruyama,
M.Ito,
Y.Kameda,
M.Ikura,
K.Yamamoto,
N.Matsumoto,
and
K.Maenaka
(2009).
Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1).
|
| |
J Biol Chem, 284,
27327-27335.
|
|
|
|
|
|
|
W.M.Heupel,
T.Müller,
A.Efthymiadis,
E.Schmidt,
D.Drenckhahn,
and
J.Waschke
(2009).
Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus.
|
| |
J Biol Chem, 284,
8589-8595.
|
|
|
|
|
|
|
Y.Zhang,
S.Sivasankar,
W.J.Nelson,
and
S.Chu
(2009).
Resolving cadherin interactions and binding cooperativity at the single-molecule level.
|
| |
Proc Natl Acad Sci U S A, 106,
109-114.
|
|
|
|
|
|
|
A.M.Sokac,
and
E.Wieschaus
(2008).
Zygotically controlled F-actin establishes cortical compartments to stabilize furrows during Drosophila cellularization.
|
| |
J Cell Sci, 121,
1815-1824.
|
|
|
|
|
|
|
C.B.Lira,
K.Chu,
Y.C.Lee,
M.C.Hu,
and
S.H.Lin
(2008).
Expression of the extracellular domain of OB-cadherin as an Fc fusion protein using bicistronic retroviral expression vector.
|
| |
Protein Expr Purif, 61,
220-226.
|
|
|
|
|
|
|
D.Studer,
B.M.Humbel,
and
M.Chiquet
(2008).
Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution.
|
| |
Histochem Cell Biol, 130,
877-889.
|
|
|
|
|
|
|
I.H.Bekirov,
V.Nagy,
A.Svoronos,
G.W.Huntley,
and
D.L.Benson
(2008).
Cadherin-8 and N-cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway.
|
| |
Hippocampus, 18,
349-363.
|
|
|
|
|
|
|
J.S.Yu,
S.Koujak,
S.Nagase,
C.M.Li,
T.Su,
X.Wang,
M.Keniry,
L.Memeo,
A.Rojtman,
M.Mansukhani,
H.Hibshoosh,
B.Tycko,
and
R.Parsons
(2008).
PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer.
|
| |
Oncogene, 27,
4657-4665.
|
|
|
|
|
|
|
J.Waschke
(2008).
The desmosome and pemphigus.
|
| |
Histochem Cell Biol, 130,
21-54.
|
|
|
|
|
|
|
K.J.Rosenberg,
J.L.Ross,
H.E.Feinstein,
S.C.Feinstein,
and
J.Israelachvili
(2008).
Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis.
|
| |
Proc Natl Acad Sci U S A, 105,
7445-7450.
|
|
|
|
|
|
|
L.A.Taneyhill
(2008).
To adhere or not to adhere: the role of Cadherins in neural crest development.
|
| |
Cell Adh Migr, 2,
223-230.
|
|
|
|
|
|
|
L.Da Silva,
S.Parry,
L.Reid,
P.Keith,
N.Waddell,
M.Kossai,
C.Clarke,
S.R.Lakhani,
and
P.T.Simpson
(2008).
Aberrant expression of E-cadherin in lobular carcinomas of the breast.
|
| |
Am J Surg Pathol, 32,
773-783.
|
|
|
|
|
|
|
M.Auer,
A.J.Koster,
U.Ziese,
C.Bajaj,
N.Volkmann,
d.a. .N.Wang,
and
A.J.Hudspeth
(2008).
Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography.
|
| |
J Assoc Res Otolaryngol, 9,
215-224.
|
|
|
|
|
|
|
M.P.Stemmler
(2008).
Cadherins in development and cancer.
|
| |
Mol Biosyst, 4,
835-850.
|
|
|
|
|
|
|
M.Sotomayor,
and
K.Schulten
(2008).
The allosteric role of the Ca2+ switch in adhesion and elasticity of C-cadherin.
|
| |
Biophys J, 94,
4621-4633.
|
|
|
|
|
|
|
N.A.Gloushankova
(2008).
Changes in regulation of cell-cell adhesion during tumor transformation.
|
| |
Biochemistry (Mosc), 73,
742-750.
|
|
|
|
|
|
|
P.Xia,
S.Wang,
Z.Guo,
and
X.Yao
(2008).
Emperipolesis, entosis and beyond: dance with fate.
|
| |
Cell Res, 18,
705-707.
|
|
|
|
|
|
|
Q.Shi,
Y.H.Chien,
and
D.Leckband
(2008).
Biophysical properties of cadherin bonds do not predict cell sorting.
|
| |
J Biol Chem, 283,
28454-28463.
|
|
|
|
|
|
|
S.A.Dames,
E.Bang,
D.Haüssinger,
T.Ahrens,
J.Engel,
and
S.Grzesiek
(2008).
Insights into the Low Adhesive Capacity of Human T-cadherin from the NMR Structure of Its N-terminal Extracellular Domain.
|
| |
J Biol Chem, 283,
23485-23495.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.Bibert,
H.Ayari,
D.Riveline,
E.Concord,
B.Hermant,
T.Vernet,
and
D.Gulino-Debrac
(2008).
Establishment of cell-cell junctions depends on the oligomeric states of VE-cadherin.
|
| |
J Biochem, 143,
821-832.
|
|
|
|
|
|
|
S.Posy,
L.Shapiro,
and
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