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Protein transport PDB id
1mn3
Jmol
Contents
Protein chain
54 a.a. *
Waters ×31
* Residue conservation analysis
PDB id:
1mn3
Name: Protein transport
Title: Cue domain of yeast vps9p
Structure: Vacuolar protein sorting-associated protein vps9. Chain: a. Fragment: cue domain (residues 398-451). Engineered: yes. Mutation: yes
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: vps9. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PQS)
Resolution:
2.30Å     R-factor:   0.244     R-free:   0.266
Authors: G.Prag,S.Misra,E.Jones,R.Ghirlando,B.A.Davies,B.F.Horazdovsk J.H.Hurley
Key ref:
G.Prag et al. (2003). Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell, 113, 609-620. PubMed id: 12787502 DOI: 10.1016/S0092-8674(03)00364-7
Date:
04-Sep-02     Release date:   10-Jun-03    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P54787  (VPS9_YEAST) -  Vacuolar protein sorting-associated protein 9
Seq:
Struc: 		451 a.a.
54 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     protein binding     1 term  

 

 
DOI no: 10.1016/S0092-8674(03)00364-7 Cell 113:609-620 (2003)
PubMed id: 12787502  
 
 
Mechanism of ubiquitin recognition by the CUE domain of Vps9p.
G.Prag, S.Misra, E.A.Jones, R.Ghirlando, B.A.Davies, B.F.Horazdovsky, J.H.Hurley.
 
  ABSTRACT  
 
Coupling of ubiquitin conjugation to ER degradation (CUE) domains are approximately 50 amino acid monoubiquitin binding motifs found in proteins of trafficking and ubiquitination pathways. The 2.3 A structure of the Vps9p-CUE domain is a dimeric domain-swapped variant of the ubiquitin binding UBA domain. The 1.7 A structure of the CUE:ubiquitin complex shows that one CUE dimer binds one ubiquitin molecule. The bound CUE dimer is kinked relative to the unbound CUE dimer and wraps around ubiquitin. The CUE monomer contains two ubiquitin binding surfaces on opposite faces of the molecule that cannot bind simultaneously to a single ubiquitin molecule. Dimerization of the CUE domain allows both surfaces to contact a single ubiquitin molecule, providing a mechanism for high-affinity binding to monoubiquitin.
 
  Selected figure(s)  
 
Figure 2.
Figure 2. Structure of the CUE Dimer:Ubiqui- tin Complex 		Figure 3.
Figure 3. Conformational Changes in the CUE Domain
 
  The above figures are reprinted by permission from Cell Press: Cell (2003, 113, 609-620) copyright 2003.  
  Figures were selected by the author.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
21294713 G.Ankem, S.Mitra, F.Sun, A.C.Moreno, B.Chutvirasakul, H.F.Azurmendi, L.Li, and D.G.Capelluto (2011).
The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides.
  Biochem J, 435, 597-608.  
21460442 Z.S.Derewenda (2011).
It's all in the crystals….
  Acta Crystallogr D Biol Crystallogr, 67, 243-248.  
20949063 A.X.Song, C.J.Zhou, Y.Peng, X.C.Gao, Z.R.Zhou, Q.S.Fu, J.Hong, D.H.Lin, and H.Y.Hu (2010).
Structural transformation of the tandem ubiquitin-interacting motifs in ataxin-3 and their cooperative interactions with ubiquitin chains.
  PLoS One, 5, e13202.  
20957454 H.F.Azurmendi, S.Mitra, I.Ayala, L.Li, C.V.Finkielstein, and D.G.Capelluto (2010).
Backbone (1)H, (15)N, and (13)C resonance assignments and secondary structure of the tollip CUE domain.
  Mol Cells, 30, 581-585.  
20126661 H.Yang, C.Liu, Y.Zhong, S.Luo, M.J.Monteiro, and S.Fang (2010).
Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.
  PLoS One, 5, e8905.  
19828134 P.Ballar, A.U.Ors, H.Yang, and S.Fang (2010).
Differential regulation of CFTRDeltaF508 degradation by ubiquitin ligases gp78 and Hrd1.
  Int J Biochem Cell Biol, 42, 167-173.  
20541997 R.Anindya, P.O.Mari, U.Kristensen, H.Kool, G.Giglia-Mari, L.H.Mullenders, M.Fousteri, W.Vermeulen, J.M.Egly, and J.Q.Svejstrup (2010).
A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.
  Mol Cell, 38, 637-648.  
19956593 A.Neves-Costa, W.R.Will, A.T.Vetter, J.R.Miller, and P.Varga-Weisz (2009).
The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci.
  PLoS One, 4, e8111.  
20064473 H.B.Kamadurai, J.Souphron, D.C.Scott, D.M.Duda, D.J.Miller, D.Stringer, R.C.Piper, and B.A.Schulman (2009).
Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.
  Mol Cell, 36, 1095-1102.  
19773779 I.Dikic, S.Wakatsuki, and K.J.Walters (2009).
Ubiquitin-binding domains - from structures to functions.
  Nat Rev Mol Cell Biol, 10, 659-671.  
19620964 J.J.Sims, A.Haririnia, B.C.Dickinson, D.Fushman, and R.E.Cohen (2009).
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains.
  Nat Struct Mol Biol, 16, 883-889.  
19366730 Z.Kostova, J.Mariano, S.Scholz, C.Koenig, and A.M.Weissman (2009).
A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation.
  J Cell Sci, 122, 1374-1381.  
18216283 D.Morito, K.Hirao, Y.Oda, N.Hosokawa, F.Tokunaga, D.M.Cyr, K.Tanaka, K.Iwai, and A.K.Nagata (2008).
Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.
  Mol Biol Cell, 19, 1328-1336.  
18083707 J.Long, T.R.Gallagher, J.R.Cavey, P.W.Sheppard, S.H.Ralston, R.Layfield, and M.S.Searle (2008).
Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch.
  J Biol Chem, 283, 5427-5440.
PDB codes: 2jy7 2jy8
18321851 O.A.Bazirgan, and R.Y.Hampton (2008).
Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo.
  J Biol Chem, 283, 12797-12810.  
18083189 Y.C.Kim, and G.Hummer (2008).
Coarse-grained models for simulations of multiprotein complexes: application to ubiquitin binding.
  J Mol Biol, 375, 1416-1433.  
17919899 A.D.Capili, and C.D.Lima (2007).
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways.
  Curr Opin Struct Biol, 17, 726-735.  
17368669 A.Haririnia, M.D'Onofrio, and D.Fushman (2007).
Mapping the interactions between Lys48 and Lys63-linked di-ubiquitins and a ubiquitin-interacting motif of S5a.
  J Mol Biol, 368, 753-766.  
17242378 B.C.Dickinson, R.Varadan, and D.Fushman (2007).
Effects of cyclization on conformational dynamics and binding properties of Lys48-linked di-ubiquitin.
  Protein Sci, 16, 369-378.  
17452789 D.R.Cooper, T.Boczek, K.Grelewska, M.Pinkowska, M.Sikorska, M.Zawadzki, and Z.Derewenda (2007).
Protein crystallization by surface entropy reduction: optimization of the SER strategy.
  Acta Crystallogr D Biol Crystallogr, 63, 636-645.
PDB codes: 2bxw 2jhs 2jht 2jhu 2jhv 2jhw 2jhx 2jhy 2jhz 2ji0
17897937 G.Kozlov, L.Nguyen, T.Lin, G.De Crescenzo, M.Park, and K.Gehring (2007).
Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD.
  J Biol Chem, 282, 35787-35795.
PDB code: 2qho
17681147 J.Cao, J.Wang, W.Qi, H.H.Miao, J.Wang, L.Ge, R.A.DeBose-Boyd, J.J.Tang, B.L.Li, and B.L.Song (2007).
Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase.
  Cell Metab, 6, 115-128.  
17656576 L.Goldschmidt, D.R.Cooper, Z.S.Derewenda, and D.Eisenberg (2007).
Toward rational protein crystallization: A Web server for the design of crystallizable protein variants.
  Protein Sci, 16, 1569-1576.  
17567738 N.B.de la Cruz, F.C.Peterson, B.L.Lytle, and B.F.Volkman (2007).
Solution structure of a membrane-anchored ubiquitin-fold (MUB) protein from Homo sapiens.
  Protein Sci, 16, 1479-1484.
PDB code: 2gow
17679095 P.Peschard, G.Kozlov, T.Lin, I.A.Mirza, A.M.Berghuis, S.Lipkowitz, M.Park, and K.Gehring (2007).
Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b.
  Mol Cell, 27, 474-485.
PDB codes: 2ooa 2oob
17192413 W.Wimuttisuk, and J.D.Singer (2007).
The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer.
  Mol Biol Cell, 18, 899-909.  
17950636 Z.Kostova, Y.C.Tsai, and A.M.Weissman (2007).
Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation.
  Semin Cell Dev Biol, 18, 770-779.  
16407162 B.Chen, J.Mariano, Y.C.Tsai, A.H.Chan, M.Cohen, and A.M.Weissman (2006).
The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site.
  Proc Natl Acad Sci U S A, 103, 341-346.  
16901703 C.Raiborg, T.Slagsvold, and H.Stenmark (2006).
A new side to ubiquitin.
  Trends Biochem Sci, 31, 541-544.  
16330212 D.S.Carney, B.A.Davies, and B.F.Horazdovsky (2006).
Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons.
  Trends Cell Biol, 16, 27-35.  
16421449 E.D.Lowe, N.Hasan, J.F.Trempe, L.Fonso, M.E.Noble, J.A.Endicott, L.N.Johnson, and N.R.Brown (2006).
Structures of the Dsk2 UBL and UBA domains and their complex.
  Acta Crystallogr D Biol Crystallogr, 62, 177-188.
PDB codes: 2bwb 2bwe 2bwf
16564012 F.E.Reyes-Turcu, J.R.Horton, J.E.Mullally, A.Heroux, X.Cheng, and K.D.Wilkinson (2006).
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.
  Cell, 124, 1197-1208.
PDB codes: 2g43 2g45
16499958 L.Penengo, M.Mapelli, A.G.Murachelli, S.Confalonieri, L.Magri, A.Musacchio, P.P.Di Fiore, S.Polo, and T.R.Schneider (2006).
Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.
  Cell, 124, 1183-1195.
PDB codes: 2c7m 2c7n
16518696 M.J.Lewis, L.F.Saltibus, D.D.Hau, W.Xiao, and L.Spyracopoulos (2006).
Structural basis for non-covalent interaction between ubiquitin and the ubiquitin conjugating enzyme variant human MMS2.
  J Biomol NMR, 34, 89.
PDB code: 1zgu
16407276 R.Mattera, Y.C.Tsai, A.M.Weissman, and J.S.Bonifacino (2006).
The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain.
  J Biol Chem, 281, 6874-6883.  
16462748 S.Hirano, M.Kawasaki, H.Ura, R.Kato, C.Raiborg, H.Stenmark, and S.Wakatsuki (2006).
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting.
  Nat Struct Mol Biol, 13, 272-277.
PDB code: 2d3g
16518384 S.L.Alam, and W.I.Sundquist (2006).
Two new structures of Ub-receptor complexes. U2.
  Nat Struct Mol Biol, 13, 186-188.  
16462746 S.Lee, Y.C.Tsai, R.Mattera, W.J.Smith, M.S.Kostelansky, A.M.Weissman, J.S.Bonifacino, and J.H.Hurley (2006).
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.
  Nat Struct Mol Biol, 13, 264-271.
PDB codes: 2fid 2fif
16897495 Y.Tsumoto, T.Yoshizumi, H.Kuroda, M.Kawashima, T.Ichikawa, M.Nakazawa, N.Yamamoto, and M.Matsui (2006).
Light-dependent polyploidy control by a CUE protein variant in Arabidopsis.
  Plant Mol Biol, 61, 817-828.  
16369101 Z.S.Derewenda, and P.G.Vekilov (2006).
Entropy and surface engineering in protein crystallization.
  Acta Crystallogr D Biol Crystallogr, 62, 116-124.  
15837191 A.Ohno, J.Jee, K.Fujiwara, T.Tenno, N.Goda, H.Tochio, H.Kobayashi, H.Hiroaki, and M.Shirakawa (2005).
Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition.
  Structure, 13, 521-532.
PDB code: 1wr1
  16511237 D.M.Anstrom, L.Colip, B.Moshofsky, E.Hatcher, and S.J.Remington (2005).
Systematic replacement of lysine with glutamine and alanine in Escherichia coli malate synthase G: effect on crystallization.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 61, 1069-1074.  
15694336 D.T.Huang, A.Paydar, M.Zhuang, M.B.Waddell, J.M.Holton, and B.A.Schulman (2005).
Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
  Mol Cell, 17, 341-350.
PDB code: 1y8x
15701688 G.Prag, S.Lee, R.Mattera, C.N.Arighi, B.M.Beach, J.S.Bonifacino, and J.H.Hurley (2005).
Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins.
  Proc Natl Acad Sci U S A, 102, 2334-2339.
PDB code: 1yd8
16138082 J.F.Trempe, N.R.Brown, E.D.Lowe, C.Gordon, I.D.Campbell, M.E.Noble, and J.A.Endicott (2005).
Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain.
  EMBO J, 24, 3178-3189.
PDB code: 1z96
16049008 J.R.Bayrer, W.Zhang, and M.A.Weiss (2005).
Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation.
  J Biol Chem, 280, 32989-32996.
PDB code: 1zv1
15765181 J.R.Cavey, S.H.Ralston, L.J.Hocking, P.W.Sheppard, B.Ciani, M.S.Searle, and R.Layfield (2005).
Loss of ubiquitin-binding associated with Paget's disease of bone p62 (SQSTM1) mutations.
  J Bone Miner Res, 20, 619-624.  
16064137 L.Hicke, H.L.Schubert, and C.P.Hill (2005).
Ubiquitin-binding domains.
  Nat Rev Mol Cell Biol, 6, 610-621.  
15898057 M.Biel, V.Wascholowski, and A.Giannis (2005).
Epigenetics--an epicenter of gene regulation: histones and histone-modifying enzymes.
  Angew Chem Int Ed Engl, 44, 3186-3216.  
15966896 M.Kawasaki, T.Shiba, Y.Shiba, Y.Yamaguchi, N.Matsugaki, N.Igarashi, M.Suzuki, R.Kato, K.Kato, K.Nakayama, and S.Wakatsuki (2005).
Molecular mechanism of ubiquitin recognition by GGA3 GAT domain.
  Genes Cells, 10, 639-654.
PDB code: 1wr6
15780906 R.Farràs, G.Bossis, E.Andermarcher, I.Jariel-Encontre, and M.Piechaczyk (2005).
Mechanisms of delivery of ubiquitylated proteins to the proteasome: new target for anti-cancer therapy?
  Crit Rev Oncol Hematol, 54, 31-51.  
15949443 R.Varadan, M.Assfalg, S.Raasi, C.Pickart, and D.Fushman (2005).
Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.
  Mol Cell, 18, 687-698.
PDB code: 1zo6
15836773 S.Kishida, H.Sanjo, S.Akira, K.Matsumoto, and J.Ninomiya-Tsuji (2005).
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.
  Genes Cells, 10, 447-454.  
16007098 S.Raasi, R.Varadan, D.Fushman, and C.M.Pickart (2005).
Diverse polyubiquitin interaction properties of ubiquitin-associated domains.
  Nat Struct Mol Biol, 12, 708-714.  
16212605 T.Kawasaki, J.Nam, D.C.Boyes, B.F.Holt, D.A.Hubert, A.Wiig, and J.L.Dangl (2005).
A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response.
  Plant J, 44, 258-270.  
15869391 X.Cheng, R.E.Collins, and X.Zhang (2005).
Structural and sequence motifs of protein (histone) methylation enzymes.
  Annu Rev Biophys Biomol Struct, 34, 267-294.  
15556404 C.M.Pickart, and D.Fushman (2004).
Polyubiquitin chains: polymeric protein signals.
  Curr Opin Chem Biol, 8, 610-616.  
15473838 D.J.Owen, B.M.Collins, and P.R.Evans (2004).
Adaptors for clathrin coats: structure and function.
  Annu Rev Cell Dev Biol, 20, 153-191.  
15044434 H.Teo, D.B.Veprintsev, and R.L.Williams (2004).
Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins.
  J Biol Chem, 279, 28689-28696.
PDB code: 1uzx
14747703 J.Czepas, Y.Devedjiev, D.Krowarsch, U.Derewenda, J.Otlewski, and Z.S.Derewenda (2004).
The impact of Lys-->Arg surface mutations on the crystallization of the globular domain of RhoGDI.
  Acta Crystallogr D Biol Crystallogr, 60, 275-280.
PDB code: 1qvy
15292170 K.Sawada, Z.Yang, J.R.Horton, R.E.Collins, X.Zhang, and X.Cheng (2004).
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase.
  J Biol Chem, 279, 43296-43306.
PDB code: 1u2z
14997574 N.Chim, W.E.Gall, J.Xiao, M.P.Harris, T.R.Graham, and A.M.Krezel (2004).
Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae.
  Proteins, 54, 784-793.
PDB code: 1pgy
15082787 P.Feng, C.W.Scott, N.H.Cho, H.Nakamura, Y.H.Chung, M.J.Monteiro, and J.U.Jung (2004).
Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation.
  Mol Cell Biol, 24, 3938-3948.  
15149598 P.L.Kannouche, J.Wing, and A.R.Lehmann (2004).
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.
  Mol Cell, 14, 491-500.  
  15209385 R.Hartmann-Petersen, and C.Gordon (2004).
Integral UBL domain proteins: a family of proteasome interacting proteins.
  Semin Cell Dev Biol, 15, 247-259.  
15365659 R.Layfield, and L.J.Hocking (2004).
SQSTM1 and Paget's disease of bone.
  Calcif Tissue Int, 75, 347-357.  
15039775 R.Puertollano, and J.S.Bonifacino (2004).
Interactions of GGA3 with the ubiquitin sorting machinery.
  Nat Cell Biol, 6, 244-251.  
15029239 S.L.Alam, J.Sun, M.Payne, B.D.Welch, B.K.Blake, D.R.Davis, H.H.Meyer, S.D.Emr, and W.I.Sundquist (2004).
Ubiquitin interactions of NZF zinc fingers.
  EMBO J, 23, 1411-1421.
PDB code: 1q5w
14707125 T.D.Mueller, M.Kamionka, and J.Feigon (2004).
Specificity of the interaction between ubiquitin-associated domains and ubiquitin.
  J Biol Chem, 279, 11926-11936.  
15461659 T.Tenno, K.Fujiwara, H.Tochio, K.Iwai, E.H.Morita, H.Hayashi, S.Murata, H.Hiroaki, M.Sato, K.Tanaka, and M.Shirakawa (2004).
Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.
  Genes Cells, 9, 865-875.  
14962390 U.Derewenda, A.Mateja, Y.Devedjiev, K.M.Routzahn, A.G.Evdokimov, Z.S.Derewenda, and D.S.Waugh (2004).
The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague.
  Structure, 12, 301-306.
PDB code: 1r6f
15053872 W.I.Sundquist, H.L.Schubert, B.N.Kelly, G.C.Hill, J.M.Holton, and C.P.Hill (2004).
Ubiquitin recognition by the human TSG101 protein.
  Mol Cell, 13, 783-789.
PDB code: 1s1q
15029246 X.Yuan, P.Simpson, C.McKeown, H.Kondo, K.Uchiyama, R.Wallis, I.Dreveny, C.Keetch, X.Zhang, C.Robinson, P.Freemont, and S.Matthews (2004).
Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97.
  EMBO J, 23, 1463-1473.
PDB codes: 1v92 1vaz
15331598 X.Zhong, Y.Shen, P.Ballar, A.Apostolou, R.Agami, and S.Fang (2004).
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation.
  J Biol Chem, 279, 45676-45684.  
14660606 Y.Shiba, Y.Katoh, T.Shiba, K.Yoshino, H.Takatsu, H.Kobayashi, H.W.Shin, S.Wakatsuki, and K.Nakayama (2004).
GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination.
  J Biol Chem, 279, 7105-7111.  
15062076 Z.S.Derewenda (2004).
Rational protein crystallization by mutational surface engineering.
  Structure, 12, 529-535.  
12787494 C.D.Lima (2003).
CUE'd up for Monoubiquitin.
  Cell, 113, 554-556.  
14690597 H.Walden, M.S.Podgorski, D.T.Huang, D.W.Miller, R.J.Howard, D.L.Minor, J.M.Holton, and B.A.Schulman (2003).
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
  Mol Cell, 12, 1427-1437.
PDB codes: 1r4m 1r4n
12860974 J.D.Schnell, and L.Hicke (2003).
Non-traditional functions of ubiquitin and ubiquitin-binding proteins.
  J Biol Chem, 278, 35857-35860.  
12970172 K.A.Swanson, R.S.Kang, S.D.Stamenova, L.Hicke, and I.Radhakrishnan (2003).
Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation.
  EMBO J, 22, 4597-4606.
PDB codes: 1q0v 1q0w
14745136 K.Umebayashi (2003).
The roles of ubiquitin and lipids in protein sorting along the endocytic pathway.
  Cell Struct Funct, 28, 443-453.  
14570567 L.Hicke, and R.Dunn (2003).
Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.
  Annu Rev Cell Dev Biol, 19, 141-172.  
14592861 O.Cremona, C.Collesi, and E.Raiteri (2003).
Protein ubiquitylation and synaptic function.
  Ann N Y Acad Sci, 998, 33-40.  
14621999 Q.Wang, A.M.Goh, P.M.Howley, and K.J.Walters (2003).
Ubiquitin recognition by the DNA repair protein hHR23a.
  Biochemistry, 42, 13529-13535.  
12970176 T.D.Mueller, and J.Feigon (2003).
Structural determinants for the binding of ubiquitin-like domains to the proteasome.
  EMBO J, 22, 4634-4645.
PDB codes: 1p98 1p9c 1p9d
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.