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40 a.a.
_ZN
Key reference
DOI no: 10.1021/bi026988m Biochemistry 42:217-221 (2003) PubMed id: 12515557
A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure. B.T.Amann, M.T.Worthington, J.M.Berg. ABSTRACT
Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.
Literature references that cite this PDB file's key reference
PubMed id Reference
19672455 M.Baou, A.Jewell, and J.J.Murphy (2009).
TIS11 family proteins and their roles in posttranscriptional gene regulation.J Biomed Biotechnol, 2009, 634520.
18467502 R.M.Rowlett, C.A.Chrestensen, M.J.Schroeder, M.G.Harp, J.W.Pelo, J.Shabanowitz, R.DeRose, D.F.Hunt, T.W.Sturgill, and M.T.Worthington (2008).
Inhibition of tristetraprolin deadenylation by poly(A) binding protein.Am J Physiol Gastrointest Liver Physiol, 295, G421-G430.
17558470 J.A.Vila, M.E.Villegas, H.A.Baldoni, and H.A.Scheraga (2007).
Predicting 13Calpha chemical shifts for validation of protein structures.J Biomol NMR, 38, 221-235.
17785455 M.Saravanan, K.Vasu, S.Ghosh, and V.Nagaraja (2007).
Dual role for Zn2+ in maintaining structural integrity and inducing DNA sequence specificity in a promiscuous endonuclease.J Biol Chem, 282, 32320-32326.
14981510 B.P.Hudson, M.A.Martinez-Yamout, H.J.Dyson, and P.E.Wright (2004).
Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d.Nat Struct Mol Biol, 11, 257-264.
PDB code: 1rgo
14688255 C.A.Chrestensen, M.J.Schroeder, J.Shabanowitz, D.F.Hunt, J.W.Pelo, M.T.Worthington, and T.W.Sturgill (2004).
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.J Biol Chem, 279, 10176-10184.
12844493 C.R.Cook, G.Kung, F.C.Peterson, B.F.Volkman, and M.Lei (2003).
A novel zinc finger is required for Mcm10 homocomplex assembly.J Biol Chem, 278, 36051-36058.
12639954 P.J.Blackshear, W.S.Lai, E.A.Kennington, G.Brewer, G.M.Wilson, X.Guan, and P.Zhou (2003).
Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates.J Biol Chem, 278, 19947-19955. The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.
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