PDBsum entry: 1kmc

Apoptosis/hydrolase

PDB id: 1kmc

Contents

Protein chains

234 a.a. *

17 a.a. *

Waters ×25

* Residue conservation analysis

PDB id:

1kmc

Name:

Apoptosis/hydrolase

Title:

Crystal structure of the caspase-7 / xiap-bir2 complex

Structure:

Caspase-7. Chain: a, b. Engineered: yes. Mutation: yes. X-linked inhibitor of apoptosis protein. Chain: c, d. Fragment: xiap-bir2. Synonym: xiap. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Tetramer (from PQS)

Resolution:

2.90Å R-factor: 0.234 R-free: 0.275

Authors:

S.J.Riedl,G.S.Salvesen,W.Bode

Key ref:

S.J.Riedl et al. Crystal structure of the caspase-7 / xiap-Bir2 complex. To be published,

Date:

14-Dec-01 Release date: 16-Jan-02

Protein chains

P55210  (CASP7_HUMAN) -  Caspase-7

Seq: 303 a.a.

Struc: 234 a.a.*

Protein chains

P98170  (XIAP_HUMAN) -  Baculoviral IAP repeat-containing protein 4

Seq: 497 a.a.

Struc: 17 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.22.60 - Caspase-7.

 Gene Ontology (GO) functional annotation 

• Cellular component: intracellular (8 terms)
• Biological process: aging (12 terms)
• Biochemical function: protein binding (6 terms)