PDBsum entry: 1kkk

Hydrolase/hydrolase inhibitor

PDB id: 1kkk

Contents

Protein chain

316 a.a. *

Ligands

PHQ-ASP

Metals

_CA ×4

_ZN

Waters ×189

* Residue conservation analysis

PDB id:

1kkk

Name:

Hydrolase/hydrolase inhibitor

Title:

Thermolysin complexed with z-l-aspartic acid (benzyloxycarbo aspartic acid)

Structure:

Thermolysin. Chain: a. Ec: 3.4.24.27

Source:

Bacillus thermoproteolyticus. Organism_taxid: 1427

Biol. unit:

Dimer (from PQS)

Resolution:

1.60Å R-factor: 0.169 R-free: 0.189

Authors:

M.Senda,T.Senda,S.Kidokoro

Key ref:

M.Senda et al. Crystal structure analyses of thermolysin in complex with its inhibitors.. To be published,

Date:

10-Dec-01 Release date: 10-Dec-02

Protein chain

P00800  (THER_BACTH) -  Thermolysin

Seq: 548 a.a.

Struc: 316 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.24.27 - Thermolysin.
• Reaction: Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
• Cofactor: Calcium; Zinc

 Gene Ontology (GO) functional annotation 

• Biological process: proteolysis (1 term)
• Biochemical function: metalloendopeptidase activity (1 term)