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PDBsum entry 1k5l
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Cytokine PDB id
1k5l

 

 

 

 

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Contents
Protein chain
176 a.a.
Theoretical model
PDB id:
1k5l
Name: Cytokine
Title: Interleukin 1beta-sea bass
Structure: Interleukin-1 beta. Chain: a
Source: Dicentrarchus labrax l.. European sea bass
Authors: S.Costantini,A.Facchiano
Key ref: G.Scapigliati et al. (2004). Modelling of fish interleukin-1 and its receptor. Dev Comp Immunol, 28, 429-441. PubMed id: 15062642 DOI: 10.1016/j.dci.2003.09.014
Date:
11-Oct-01     Release date:   24-Jun-03    
PROCHECK
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 Headers
 References

Protein chain
No UniProt id for this chain
Struc: 176 a.a.
Key:    Secondary structure

 

 
DOI no: 10.1016/j.dci.2003.09.014 Dev Comp Immunol 28:429-441 (2004)
PubMed id: 15062642  
 
 
Modelling of fish interleukin-1 and its receptor.
G.Scapigliati, S.Costantini, G.Colonna, A.Facchiano, F.Buonocore, P.Bossù, C.Cunningham, J.W.Holland, C.J.Secombes.
 
  ABSTRACT  
 
This paper presents original data regarding: the three-dimensional modelling of rainbow trout (Oncorhynchus mykiss) and sea bass (Dicentrarchus labrax) IL-1beta, the modelling of trout IL-1 receptor type I (IL-1RI) and the modelling of trout IL-1beta bound to its receptor. The 3D models of trout and sea bass IL-1beta molecules were predicted by comparison with those already available of human and mouse, and, in both cases, a structure consisting of a beta-trefoil fold was obtained, a motif well conserved during evolution of IL-1beta-related proteins. Moreover, a model for the rainbow trout IL-1 receptor alone and complexed with IL-1beta was predicted and compared to the murine model. Both ligand-receptor complex models were compared with the known crystal structure of the human IL-1beta/IL-1R complex. A cross-interaction of trout IL-1beta with the mouse receptor was also simulated. Such analysis and the predicted interaction energies calculated from the models have helped to explain the different biological efficacies of mammalian and fish IL-1beta molecules in assays based on mammalian target cells. The obtained data are discussed on the basis of evolutionary and applied perspectives.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
17243169 A.Chambery, M.Pisante, A.Di Maro, E.Di Zazzo, M.Ruvo, S.Costantini, G.Colonna, and A.Parente (2007).
Invariant Ser211 is involved in the catalysis of PD-L4, type I RIP from Phytolacca dioica leaves.
  Proteins, 67, 209-218.  
16059754 F.Buonocore, M.Forlenza, E.Randelli, S.Benedetti, P.Bossù, S.Meloni, C.J.Secombes, M.Mazzini, and G.Scapigliati (2005).
Biological activity of sea bass (Dicentrarchus labrax L.) recombinant interleukin-1beta.
  Mar Biotechnol (NY), 7, 609-617.  
16047156 N.Romano, M.R.Baldassini, F.Buonocore, S.Picchietti, L.Mastrolia, and L.Abelli (2005).
In vivo allograft rejection in a bony fish Dicentrarchus labrax (L.): characterisation of effector lymphocytes.
  Cell Tissue Res, 321, 353-363.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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