|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
Chains A, B:
E.C.3.4.22.36
- Caspase-1.
|
|
|
|
|
|
|
Reaction:
|
|
Release of interleukin 1-beta by specific cleavage at 116-Asp-|-Ala-117 and 27-Asp-|-Gly-28 bonds in precursor. Also hydrolyzes the small- molecule substrate, Ac-Tyr-Val-Ala-Asp-|-NHMec.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Gene Ontology (GO) functional annotation
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Biological process
|
apoptosis
|
2 terms
|
|
|
Biochemical function
|
cysteine-type peptidase activity
|
2 terms
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
DOI no:
|
Nature
370:270-275
(1994)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Structure and mechanism of interleukin-1 beta converting enzyme.
|
|
K.P.Wilson,
J.A.Black,
J.A.Thomson,
E.E.Kim,
J.P.Griffith,
M.A.Navia,
M.A.Murcko,
S.P.Chambers,
R.A.Aldape,
S.A.Raybuck.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to
the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed
cell death in neuronal cells. The high-resolution structure of human ICE in
complex with an inhibitor has been determined by X-ray diffraction. The
structure confirms the relationship between human ICE and cell-death proteins in
other organisms. The active site spans both the 10 and 20K subunits, which
associate to form a tetramer, suggesting a mechanism for ICE autoactivation.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
A.Romero,
N.Estévez-Calvar,
S.Dios,
A.Figueras,
and
B.Novoa
(2011).
New Insights into the Apoptotic Process in Mollusks: Characterization of Caspase Genes in Mytilus galloprovincialis.
|
| |
PLoS One, 6,
e17003.
|
|
|
|
|
|
|
F.Bauernfeind,
A.Ablasser,
E.Bartok,
S.Kim,
J.Schmid-Burgk,
T.Cavlar,
and
V.Hornung
(2011).
Inflammasomes: current understanding and open questions.
|
| |
Cell Mol Life Sci, 68,
765-783.
|
|
|
|
|
|
|
B.B.Mishra,
P.Moura-Alves,
A.Sonawane,
N.Hacohen,
G.Griffiths,
L.F.Moita,
and
E.Anes
(2010).
Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.
|
| |
Cell Microbiol, 12,
1046-1063.
|
|
|
|
|
|
|
J.Chen,
L.Li,
and
L.S.Chin
(2010).
Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage.
|
| |
Hum Mol Genet, 19,
2395-2408.
|
|
|
|
|
|
|
M.B.Boxer,
A.M.Quinn,
M.Shen,
A.Jadhav,
W.Leister,
A.Simeonov,
D.S.Auld,
and
C.J.Thomas
(2010).
A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety.
|
| |
ChemMedChem, 5,
730-738.
|
|
|
|
|
|
|
M.Egerer,
and
K.J.Satchell
(2010).
Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins.
|
| |
PLoS Pathog, 6,
e1000942.
|
|
|
|
|
|
|
M.G.Netea,
A.Simon,
F.van de Veerdonk,
B.J.Kullberg,
J.W.Van der Meer,
and
L.A.Joosten
(2010).
IL-1beta processing in host defense: beyond the inflammasomes.
|
| |
PLoS Pathog, 6,
e1000661.
|
|
|
|
|
|
|
M.Marí,
A.Colell,
A.Morales,
C.von Montfort,
C.Garcia-Ruiz,
and
J.C.Fernández-Checa
(2010).
Redox control of liver function in health and disease.
|
| |
Antioxid Redox Signal, 12,
1295-1331.
|
|
|
|
|
|
|
R.Sengupta,
T.R.Billiar,
V.E.Kagan,
and
D.A.Stoyanovsky
(2010).
Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells.
|
| |
Biochem Biophys Res Commun, 391,
1127-1130.
|
|
|
|
|
|
|
S.Rosales-Corral,
R.J.Reiter,
D.X.Tan,
G.G.Ortiz,
and
G.Lopez-Armas
(2010).
Functional aspects of redox control during neuroinflammation.
|
| |
Antioxid Redox Signal, 13,
193-247.
|
|
|
|
|
|
|
A.Stutz,
D.T.Golenbock,
and
E.Latz
(2009).
Inflammasomes: too big to miss.
|
| |
J Clin Invest, 119,
3502-3511.
|
|
|
|
|
|
|
C.R.McIntire,
G.Yeretssian,
and
M.Saleh
(2009).
Inflammasomes in infection and inflammation.
|
| |
Apoptosis, 14,
522-535.
|
|
|
|
|
|
|
J.M.Elliott,
L.Rouge,
C.Wiesmann,
and
J.M.Scheer
(2009).
Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation.
|
| |
J Biol Chem, 284,
6546-6553.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.Prochazkova,
L.A.Shuvalova,
G.Minasov,
Z.Voburka,
W.F.Anderson,
and
K.J.Satchell
(2009).
Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites.
|
| |
J Biol Chem, 284,
26557-26568.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
L.A.Joosten,
M.G.Netea,
G.Fantuzzi,
M.I.Koenders,
M.M.Helsen,
H.Sparrer,
C.T.Pham,
J.W.van der Meer,
C.A.Dinarello,
and
W.B.van den Berg
(2009).
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
|
| |
Arthritis Rheum, 60,
3651-3662.
|
|
|
|
|
|
|
M.G.Netea,
C.A.Nold-Petry,
M.F.Nold,
L.A.Joosten,
B.Opitz,
J.H.van der Meer,
F.L.van de Veerdonk,
G.Ferwerda,
B.Heinhuis,
I.Devesa,
C.J.Funk,
R.J.Mason,
B.J.Kullberg,
A.Rubartelli,
J.W.van der Meer,
and
C.A.Dinarello
(2009).
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.
|
| |
Blood, 113,
2324-2335.
|
|
|
|
|
|
|
M.Lamkanfi,
and
V.M.Dixit
(2009).
Inflammasomes: guardians of cytosolic sanctity.
|
| |
Immunol Rev, 227,
95.
|
|
|
|
|
|
|
R.Baumgartner,
G.Meder,
C.Briand,
A.Decock,
A.D'arcy,
U.Hassiepen,
R.Morse,
and
M.Renatus
(2009).
The crystal structure of caspase-6, a selective effector of axonal degeneration.
|
| |
Biochem J, 423,
429-439.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
W.A.Witkowski,
and
J.A.Hardy
(2009).
L2' loop is critical for caspase-7 active site formation.
|
| |
Protein Sci, 18,
1459-1468.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
W.Jeong,
Y.Jung,
H.Kim,
S.J.Park,
and
S.G.Rhee
(2009).
Thioredoxin-related protein 14, a new member of the thioredoxin family with disulfide reductase activity: implication in the redox regulation of TNF-alpha signaling.
|
| |
Free Radic Biol Med, 47,
1294-1303.
|
|
|
|
|
|
|
G.Fu,
A.A.Chumanevich,
J.Agniswamy,
B.Fang,
R.W.Harrison,
and
I.T.Weber
(2008).
Structural basis for executioner caspase recognition of P5 position in substrates.
|
| |
Apoptosis, 13,
1291-1302.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
G.N.Schroeder,
and
H.Hilbi
(2008).
Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.
|
| |
Clin Microbiol Rev, 21,
134-156.
|
|
|
|
|
|
|
K.E.Wickliffe,
S.H.Leppla,
and
M.Moayeri
(2008).
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome.
|
| |
Cell Microbiol, 10,
332-343.
|
|
|
|
|
|
|
L.Dorstyn,
and
S.Kumar
(2008).
A biochemical analysis of the activation of the Drosophila caspase DRONC.
|
| |
Cell Death Differ, 15,
461-470.
|
|
|
|
|
|
|
M.G.Netea,
F.L.van de Veerdonk,
B.J.Kullberg,
J.W.Van der Meer,
and
L.A.Joosten
(2008).
The role of NLRs and TLRs in the activation of the inflammasome.
|
| |
Expert Opin Biol Ther, 8,
1867-1872.
|
|
|
|
|
|
|
A.Piekarska,
R.Kubiak,
A.Omulecka,
W.Szymczak,
and
J.Piekarski
(2007).
Expression of tumour necrosis factor-related apoptosis-inducing ligand and caspase-3 in relation to grade of inflammation and stage of fibrosis in chronic hepatitis C.
|
| |
Histopathology, 51,
597-604.
|
|
|
|
|
|
|
C.Adlbrecht,
K.Hoetzenecker,
M.Posch,
S.Steiner,
C.Kopp,
S.Hacker,
J.Auer,
R.Horvath,
B.Moser,
G.Roth,
E.Wolner,
I.M.Lang,
and
H.J.Ankersmit
(2007).
Elevated levels of interleukin-1beta-converting enzyme and caspase-cleaved cytokeratin-18 in acute myocardial infarction.
|
| |
Eur J Clin Invest, 37,
372-380.
|
|
|
|
|
|
|
N.Rozwadowska,
D.Fiszer,
P.Jedrzejczak,
W.Kosicki,
and
M.Kurpisz
(2007).
Interleukin-1 superfamily genes expression in normal or impaired human spermatogenesis.
|
| |
Genes Immun, 8,
100-107.
|
|
|
|
|
|
|
A.J.Henzing,
H.Dodson,
J.M.Reid,
S.H.Kaufmann,
R.L.Baxter,
and
W.C.Earnshaw
(2006).
Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo.
|
| |
J Med Chem, 49,
7636-7645.
|
|
|
|
|
|
|
A.K.Mitra,
and
D.K.Agrawal
(2006).
In stent restenosis: bane of the stent era.
|
| |
J Clin Pathol, 59,
232-239.
|
|
|
|
|
|
|
D.Twiddy,
G.M.Cohen,
M.Macfarlane,
and
K.Cain
(2006).
Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.
|
| |
J Biol Chem, 281,
3876-3888.
|
|
|
|
|
|
|
G.Wagner,
and
S.Laufer
(2006).
Small molecular anti-cytokine agents.
|
| |
Med Res Rev, 26,
1.
|
|
|
|
|
|
|
J.Dobó,
R.Swanson,
G.S.Salvesen,
S.T.Olson,
and
P.G.Gettins
(2006).
Cytokine response modifier a inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer.
|
| |
J Biol Chem, 281,
38781-38790.
|
|
|
|
|
|
|
J.J.Chae,
G.Wood,
S.L.Masters,
K.Richard,
G.Park,
B.J.Smith,
and
D.L.Kastner
(2006).
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.
|
| |
Proc Natl Acad Sci U S A, 103,
9982-9987.
|
|
|
|
|
|
|
N.Hatsugai,
M.Kuroyanagi,
M.Nishimura,
and
I.Hara-Nishimura
(2006).
A cellular suicide strategy of plants: vacuole-mediated cell death.
|
| |
Apoptosis, 11,
905-911.
|
|
|
|
|
|
|
S.Zhang,
A.Yanaka,
M.Tauchi,
H.Suzuki,
T.Shibahara,
H.Matsui,
A.Nakahara,
and
N.Tanaka
(2006).
Hyperosmotic stress enhances interleukin-1beta expression in Helicobacter pylori-infected murine gastric epithelial cells in vitro.
|
| |
J Gastroenterol Hepatol, 21,
759-766.
|
|
|
|
|
|
|
T.Ravizza,
S.M.Lucas,
S.Balosso,
L.Bernardino,
G.Ku,
F.Noé,
J.Malva,
J.C.Randle,
S.Allan,
and
A.Vezzani
(2006).
Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy.
|
| |
Epilepsia, 47,
1160-1168.
|
|
|
|
|
|
|
C.L.Le Maitre,
A.J.Freemont,
and
J.A.Hoyland
(2005).
The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration.
|
| |
Arthritis Res Ther, 7,
R732-R745.
|
|
|
|
|
|
|
G.Kim,
and
R.L.Levine
(2005).
Molecular determinants of S-glutathionylation of carbonic anhydrase 3.
|
| |
Antioxid Redox Signal, 7,
849-854.
|
|
|
|
|
|
|
I.Hara-Nishimura,
N.Hatsugai,
S.Nakaune,
M.Kuroyanagi,
and
M.Nishimura
(2005).
Vacuolar processing enzyme: an executor of plant cell death.
|
| |
Curr Opin Plant Biol, 8,
404-408.
|
|
|
|
|
|
|
I.N.Lavrik,
A.Golks,
and
P.H.Krammer
(2005).
Caspases: pharmacological manipulation of cell death.
|
| |
J Clin Invest, 115,
2665-2672.
|
|
|
|
|
|
|
M.S.Willis,
J.K.Hogan,
P.Prabhakar,
X.Liu,
K.Tsai,
Y.Wei,
and
T.Fox
(2005).
Investigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactions.
|
| |
Protein Sci, 14,
1818-1826.
|
|
|
|
|
|
|
N.Yan,
and
Y.Shi
(2005).
Mechanisms of apoptosis through structural biology.
|
| |
Annu Rev Cell Dev Biol, 21,
35-56.
|
|
|
|
|
|
|
S.L.Fink,
and
B.T.Cookson
(2005).
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells.
|
| |
Infect Immun, 73,
1907-1916.
|
|
|
|
|
|
|
T.O'Brien,
B.T.Fahr,
M.M.Sopko,
J.W.Lam,
N.D.Waal,
B.C.Raimundo,
H.E.Purkey,
P.Pham,
and
M.J.Romanowski
(2005).
Structural analysis of caspase-1 inhibitors derived from Tethering.
|
| |
Acta Crystallogr Sect F Struct Biol Cryst Commun, 61,
451-458.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.J.Pollard,
A.Currie,
C.M.Rosenberger,
J.P.Heale,
B.B.Finlay,
and
D.P.Speert
(2004).
Differential post-transcriptional activation of human phagocytes by different Pseudomonas aeruginosa isolates.
|
| |
Cell Microbiol, 6,
639-650.
|
|
|
|
|
|
|
A.Yoshimori,
R.Takasawa,
and
S.Tanuma
(2004).
A novel method for evaluation and screening of caspase inhibitory peptides by the amino acid positional fitness score.
|
| |
BMC Pharmacol, 4,
7.
|
|
|
|
|
|
|
C.M.Forsyth,
D.Lemongello,
D.J.LaCount,
P.D.Friesen,
and
A.J.Fisher
(2004).
Crystal structure of an invertebrate caspase.
|
| |
J Biol Chem, 279,
7001-7008.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.A.Olzmann,
K.Brown,
K.D.Wilkinson,
H.D.Rees,
Q.Huai,
H.Ke,
A.I.Levey,
L.Li,
and
L.S.Chin
(2004).
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.
|
| |
J Biol Chem, 279,
8506-8515.
|
|
|
|
|
|
|
K.Watanabe,
Y.Hasegawa,
H.Yamashita,
K.Shimizu,
Y.Ding,
M.Abe,
H.Ohta,
K.Imagawa,
K.Hojo,
H.Maki,
H.Sonoda,
and
Y.Sato
(2004).
Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis.
|
| |
J Clin Invest, 114,
898-907.
|
|
|
|
|
|
|
M.J.Romanowski,
J.M.Scheer,
T.O'Brien,
and
R.S.McDowell
(2004).
Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.
|
| |
Structure, 12,
1361-1371.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.J.Riedl,
and
Y.Shi
(2004).
Molecular mechanisms of caspase regulation during apoptosis.
|
| |
Nat Rev Mol Cell Biol, 5,
897-907.
|
|
|
|
|
|
|
S.Lippens,
M.Kockx,
G.Denecker,
M.Knaapen,
A.Verheyen,
R.Christiaen,
E.Tschachler,
P.Vandenabeele,
and
W.Declercq
(2004).
Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.
|
| |
Am J Pathol, 165,
833-841.
|
|
|
|
|
|
|
S.Piana,
and
U.Rothlisberger
(2004).
Molecular dynamics simulations of structural changes during procaspase 3 activation.
|
| |
Proteins, 55,
932-941.
|
|
|
|
|
|
|
W.Jeong,
T.S.Chang,
E.S.Boja,
H.M.Fales,
and
S.G.Rhee
(2004).
Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.
|
| |
J Biol Chem, 279,
3151-3159.
|
|
|
|
|
|
|
X.Jiang,
and
X.Wang
(2004).
Cytochrome C-mediated apoptosis.
|
| |
Annu Rev Biochem, 73,
87.
|
|
|
|
|
|
|
Y.Zong,
S.K.Mazmanian,
O.Schneewind,
and
S.V.Narayana
(2004).
The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.
|
| |
Structure, 12,
105-112.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.K.Liou,
R.S.Clark,
D.C.Henshall,
X.M.Yin,
and
J.Chen
(2003).
To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways.
|
| |
Prog Neurobiol, 69,
103-142.
|
|
|
|
|
|
|
A.Schweizer,
C.Briand,
and
M.G.Grutter
(2003).
Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.
|
| |
J Biol Chem, 278,
42441-42447.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.T.Supuran,
A.Casini,
and
A.Scozzafava
(2003).
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.
|
| |
Med Res Rev, 23,
535-558.
|
|
|
|
|
|
|
J.Masumoto,
W.Zhou,
F.F.Chen,
F.Su,
J.Y.Kuwada,
E.Hidaka,
T.Katsuyama,
J.Sagara,
S.Taniguchi,
P.Ngo-Hazelett,
J.H.Postlethwait,
G.Núñez,
and
N.Inohara
(2003).
Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development.
|
| |
J Biol Chem, 278,
4268-4276.
|
|
|
|
|
|
|
M.Donepudi,
A.Mac Sweeney,
C.Briand,
and
M.G.Grütter
(2003).
Insights into the regulatory mechanism for caspase-8 activation.
|
| |
Mol Cell, 11,
543-549.
|
|
|
|
|
|
|
M.Sulpizi,
A.Laio,
J.VandeVondele,
A.Cattaneo,
U.Rothlisberger,
and
P.Carloni
(2003).
Reaction mechanism of caspases: insights from QM/MM Car-Parrinello simulations.
|
| |
Proteins, 52,
212-224.
|
|
|
|
|
|
|
M.Sulpizi,
U.Rothlisberger,
and
P.Carloni
(2003).
Molecular dynamics studies of caspase-3.
|
| |
Biophys J, 84,
2207-2215.
|
|
|
|
|
|
|
S.Lakhani,
and
R.A.Flavell
(2003).
Caspases and T lymphocytes: a flip of the coin?
|
| |
Immunol Rev, 193,
22-30.
|
|
|
|
|
|
|
W.M.Boedefeld,
K.I.Bland,
and
M.J.Heslin
(2003).
Recent insights into angiogenesis, apoptosis, invasion, and metastasis in colorectal carcinoma.
|
| |
Ann Surg Oncol, 10,
839-851.
|
|
|
|
|
|
|
W.Nickel
(2003).
The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes.
|
| |
Eur J Biochem, 270,
2109-2119.
|
|
|
|
|
|
|
Y.Ibuki,
and
R.Goto
(2003).
The antiapoptotic effect of low-dose UVB irradiation in NIH3T3 cells involves caspase inhibitions.
|
| |
Photochem Photobiol, 77,
276-283.
|
|
|
|
|
|
|
A.S.Paszkowski,
B.Rau,
J.M.Mayer,
P.Möller,
and
H.G.Beger
(2002).
Therapeutic application of caspase 1/interleukin-1beta-converting enzyme inhibitor decreases the death rate in severe acute experimental pancreatitis.
|
| |
Ann Surg, 235,
68-76.
|
|
|
|
|
|
|
B.J.Shenker,
L.Pankoski,
A.Zekavat,
and
I.M.Shapiro
(2002).
Mercury-induced apoptosis in human lymphocytes: caspase activation is linked to redox status.
|
| |
Antioxid Redox Signal, 4,
379-389.
|
|
|
|
|
|
|
C.Boileau,
J.Martel-Pelletier,
F.Moldovan,
J.Y.Jouzeau,
P.Netter,
P.T.Manning,
and
J.P.Pelletier
(2002).
The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide.
|
| |
Arthritis Rheum, 46,
2637-2647.
|
|
|
|
|
|
|
H.R.Stennicke,
C.A.Ryan,
and
G.S.Salvesen
(2002).
Reprieval from execution: the molecular basis of caspase inhibition.
|
| |
Trends Biochem Sci, 27,
94.
|
|
|
|
|
|
|
J.Salgado,
A.J.García-Sáez,
G.Malet,
I.Mingarro,
and
E.Pérez-Payá
(2002).
Peptides in apoptosis research.
|
| |
J Pept Sci, 8,
543-560.
|
|
|
|
|
|
|
K.W.Kang,
R.F.Novak,
C.H.Lee,
and
S.G.Kim
(2002).
Induction of microsomal epoxide hydrolase by sulfur amino acid deprivation via the pathway of C-Jun N-terminal kinase and its extracellular exposure during cell death.
|
| |
Free Radic Biol Med, 32,
1017-1032.
|
|
|
|
|
|
|
L.Aravind,
and
E.V.Koonin
(2002).
Classification of the caspase-hemoglobinase fold: detection of new families and implications for the origin of the eukaryotic separins.
|
| |
Proteins, 46,
355-367.
|
|
|
|
|
|
|
L.B.Maggi,
J.M.Moran,
A.L.Scarim,
D.A.Ford,
J.W.Yoon,
J.McHowat,
R.M.Buller,
and
J.A.Corbett
(2002).
Novel role for calcium-independent phospholipase A(2) in the macrophage antiviral response of inducible nitric-oxide synthase expression.
|
| |
J Biol Chem, 277,
38449-38455.
|
|
|
|
|
|
|
M.Chen,
A.Orozco,
D.M.Spencer,
and
J.Wang
(2002).
Activation of initiator caspases through a stable dimeric intermediate.
|
| |
J Biol Chem, 277,
50761-50767.
|
|
|
|
|
|
|
N.Morishima,
K.Nakanishi,
H.Takenouchi,
T.Shibata,
and
Y.Yasuhiko
(2002).
An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12.
|
| |
J Biol Chem, 277,
34287-34294.
|
|
|
|
|
|
|
S.Ueda,
H.Masutani,
H.Nakamura,
T.Tanaka,
M.Ueno,
and
J.Yodoi
(2002).
Redox control of cell death.
|
| |
Antioxid Redox Signal, 4,
405-414.
|
|
|
|
|
|
|
Y.Shi
(2002).
Mechanisms of caspase activation and inhibition during apoptosis.
|
| |
Mol Cell, 9,
459-470.
|
|
|
|
|
|
|
B.Siegmund,
H.A.Lehr,
G.Fantuzzi,
and
C.A.Dinarello
(2001).
IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation.
|
| |
Proc Natl Acad Sci U S A, 98,
13249-13254.
|
|
|
|
|
|
|
D.Blum,
S.Torch,
N.Lambeng,
M.Nissou,
A.L.Benabid,
R.Sadoul,
and
J.M.Verna
(2001).
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease.
|
| |
Prog Neurobiol, 65,
135-172.
|
|
|
|
|
|
|
J.C.Reed
(2001).
Apoptosis-regulating proteins as targets for drug discovery.
|
| |
Trends Mol Med, 7,
314-319.
|
|
|
|
|
|
|
J.Chai,
E.Shiozaki,
S.M.Srinivasula,
Q.Wu,
P.Datta,
E.S.Alnemri,
Y.Shi,
and
P.Dataa
(2001).
Structural basis of caspase-7 inhibition by XIAP.
|
| |
Cell, 104,
769-780.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Chai,
Q.Wu,
E.Shiozaki,
S.M.Srinivasula,
E.S.Alnemri,
and
Y.Shi
(2001).
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
|
| |
Cell, 107,
399-407.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Rotonda,
M.Garcia-Calvo,
H.G.Bull,
W.M.Geissler,
B.M.McKeever,
C.A.Willoughby,
N.A.Thornberry,
and
J.W.Becker
(2001).
The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.
|
| |
Chem Biol, 8,
357-368.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.C.Zimmermann,
C.Bonzon,
and
D.R.Green
(2001).
The machinery of programmed cell death.
|
| |
Pharmacol Ther, 92,
57-70.
|
|
|
|
|
|
|
M.Buck,
V.Poli,
T.Hunter,
and
M.Chojkier
(2001).
C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.
|
| |
Mol Cell, 8,
807-816.
|
|
|
|
|
|
|
M.Renatus,
H.R.Stennicke,
F.L.Scott,
R.C.Liddington,
and
G.S.Salvesen
(2001).
Dimer formation drives the activation of the cell death protease caspase 9.
|
| |
Proc Natl Acad Sci U S A, 98,
14250-14255.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Zörnig,
A.Hueber,
W.Baum,
and
G.Evan
(2001).
Apoptosis regulators and their role in tumorigenesis.
|
| |
Biochim Biophys Acta, 1551,
F1-37.
|
|
|
|
|
|
|
N.Chauvet,
K.Palin,
D.Verrier,
S.Poole,
R.Dantzer,
and
J.Lestage
(2001).
Rat microglial cells secrete predominantly the precursor of interleukin-1beta in response to lipopolysaccharide.
|
| |
Eur J Neurosci, 14,
609-617.
|
|
|
|
|
|
|
N.Majeux,
M.Scarsi,
and
A.Caflisch
(2001).
Efficient electrostatic solvation model for protein-fragment docking.
|
| |
Proteins, 42,
256-268.
|
|
|
|
|
|
|
S.J.Riedl,
M.Renatus,
R.Schwarzenbacher,
Q.Zhou,
C.Sun,
S.W.Fesik,
R.C.Liddington,
and
G.S.Salvesen
(2001).
Structural basis for the inhibition of caspase-3 by XIAP.
|
| |
Cell, 104,
791-800.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.J.Riedl,
P.Fuentes-Prior,
M.Renatus,
N.Kairies,
S.Krapp,
R.Huber,
G.S.Salvesen,
and
W.Bode
(2001).
Structural basis for the activation of human procaspase-7.
|
| |
Proc Natl Acad Sci U S A, 98,
14790-14795.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
T.M.Ross
(2001).
Using death to one's advantage: HIV modulation of apoptosis.
|
| |
Leukemia, 15,
332-341.
|
|
|
|
|
|
|
U.Sartorius,
I.Schmitz,
and
P.H.Krammer
(2001).
Molecular mechanisms of death-receptor-mediated apoptosis.
|
| |
Chembiochem, 2,
20-29.
|
|
|
|
|
|
|
Y.Wang,
and
X.Gu
(2001).
Functional divergence in the caspase gene family and altered functional constraints: statistical analysis and prediction.
|
| |
Genetics, 158,
1311-1320.
|
|
|
|
|
|
|
A.Strasser,
L.O'Connor,
and
V.M.Dixit
(2000).
Apoptosis signaling.
|
| |
Annu Rev Biochem, 69,
217-245.
|
|
|
|
|
|
|
E.W.Humke,
S.K.Shriver,
M.A.Starovasnik,
W.J.Fairbrother,
and
V.M.Dixit
(2000).
ICEBERG: a novel inhibitor of interleukin-1beta generation.
|
| |
Cell, 103,
99.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.S.Park,
S.H.Huh,
Y.Kim,
J.Shim,
S.H.Lee,
I.S.Park,
Y.K.Jung,
I.Y.Kim,
and
E.J.Choi
(2000).
Selenite negatively regulates caspase-3 through a redox mechanism.
|
| |
J Biol Chem, 275,
8487-8491.
|
|
|
|
|
|
|
H.Y.Chang,
and
X.Yang
(2000).
Proteases for cell suicide: functions and regulation of caspases.
|
| |
Microbiol Mol Biol Rev, 64,
821-846.
|
|
|
|
|
|
|
J.C.Reed,
and
K.J.Tomaselli
(2000).
Drug discovery opportunities from apoptosis research.
|
| |
Curr Opin Biotechnol, 11,
586-592.
|
|
|
|
|
|
|
J.L.Young,
G.K.Sukhova,
D.Foster,
W.Kisiel,
P.Libby,
and
U.Schönbeck
(2000).
The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells.
|
| |
J Exp Med, 191,
1535-1544.
|
|
|
|
|
|
|
K.J.Banasiak,
Y.Xia,
and
G.G.Haddad
(2000).
Mechanisms underlying hypoxia-induced neuronal apoptosis.
|
| |
Prog Neurobiol, 62,
215-249.
|
|
|
|
|
|
|
K.Nakajima,
A.Takahashi,
and
Y.Yaoita
(2000).
Structure, expression, and function of the Xenopus laevis caspase family.
|
| |
J Biol Chem, 275,
10484-10491.
|
|
|
|
|
|
|
M.G.Grütter
(2000).
Caspases: key players in programmed cell death.
|
| |
Curr Opin Struct Biol, 10,
649-655.
|
|
|
|
|
|
|
P.Meier,
J.Silke,
S.J.Leevers,
and
G.I.Evan
(2000).
The Drosophila caspase DRONC is regulated by DIAP1.
|
| |
EMBO J, 19,
598-611.
|
|
|
|
|
|
|
S.Koga,
S.Hirohata,
Y.Kondo,
T.Komata,
M.Takakura,
M.Inoue,
S.Kyo,
and
S.Kondo
(2000).
A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter.
|
| |
Hum Gene Ther, 11,
1397-1406.
|
|
|
|
|
|
|
S.W.Fesik
(2000).
Insights into programmed cell death through structural biology.
|
| |
Cell, 103,
273-282.
|
|
|
|
|
|
|
T.F.Kagawa,
J.C.Cooney,
H.M.Baker,
S.McSweeney,
M.Liu,
S.Gubba,
J.M.Musser,
and
E.N.Baker
(2000).
Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease.
|
| |
Proc Natl Acad Sci U S A, 97,
2235-2240.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Y.J.Lee,
and
E.Shacter
(2000).
Hydrogen peroxide inhibits activation, not activity, of cellular caspase-3 in vivo.
|
| |
Free Radic Biol Med, 29,
684-692.
|
|
|
|
|
|
|
Y.Wei,
T.Fox,
S.P.Chambers,
J.Sintchak,
J.T.Coll,
J.M.Golec,
L.Swenson,
K.P.Wilson,
and
P.S.Charifson
(2000).
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
|
| |
Chem Biol, 7,
423-432.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Z.Song,
B.Guan,
A.Bergman,
D.W.Nicholson,
N.A.Thornberry,
E.P.Peterson,
and
H.Steller
(2000).
Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim.
|
| |
Mol Cell Biol, 20,
2907-2914.
|
|
|
|
|
|
|
A.Eichinger,
H.G.Beisel,
U.Jacob,
R.Huber,
F.J.Medrano,
A.Banbula,
J.Potempa,
J.Travis,
and
W.Bode
(1999).
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
|
| |
EMBO J, 18,
5453-5462.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
B.B.Wolf,
and
D.R.Green
(1999).
Suicidal tendencies: apoptotic cell death by caspase family proteinases.
|
| |
J Biol Chem, 274,
20049-20052.
|
|
|
|
|
|
|
D.K.Miller
(1999).
Activation of apoptosis and its inhibition.
|
| |
Ann N Y Acad Sci, 886,
132-157.
|
|
|
|
|
|
|
D.W.Seol,
and
T.R.Billiar
(1999).
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis.
|
| |
J Biol Chem, 274,
2072-2076.
|
|
|
|
|
|
|
F.S.Shihab,
T.F.Andoh,
A.M.Tanner,
H.Yi,
and
W.M.Bennett
(1999).
Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis.
|
| |
Kidney Int, 56,
2147-2159.
|
|
|
|
|
|
|
G.S.Salvesen
(1999).
Caspase 8: igniting the death machine.
|
| |
Structure, 7,
R225-R229.
|
|
|
|
|
|
|
H.Blanchard,
L.Kodandapani,
P.R.Mittl,
S.D.Marco,
J.F.Krebs,
J.C.Wu,
K.J.Tomaselli,
and
M.G.Grütter
(1999).
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
|
| |
Structure, 7,
1125-1133.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.C.Rathmell,
and
C.B.Thompson
(1999).
The central effectors of cell death in the immune system.
|
| |
Annu Rev Immunol, 17,
781-828.
|
|
|
|
|
|
|
J.S.Braun,
E.I.Tuomanen,
and
J.L.Cleveland
(1999).
Neuroprotection by caspase inhibitors.
|
| |
Expert Opin Investig Drugs, 8,
1599-1610.
|
|
|
|
|
|
|
J.Y.Matroule,
A.C.Hellin,
P.Morlière,
A.S.Fabiano,
R.Santus,
M.P.Merville,
and
J.Piette
(1999).
Role of nuclear factor-kappa B in colon cancer cell apoptosis mediated by aminopyropheophorbide photosensitization.
|
| |
Photochem Photobiol, 70,
540-548.
|
|
|
|
|
|
|
K.Cain,
D.G.Brown,
C.Langlais,
and
G.M.Cohen
(1999).
Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex.
|
| |
J Biol Chem, 274,
22686-22692.
|
|
|
|
|
|
|
K.L.Johnson,
D.R.Grubb,
and
A.Lawen
(1999).
Unspecific activation of caspases during the induction of apoptosis by didemnin B in human cell lines.
|
| |
J Cell Biochem, 72,
269-278.
|
|
|
|
|
|
|
K.M.Edwards,
J.E.Davis,
K.A.Browne,
V.R.Sutton,
and
J.A.Trapani
(1999).
Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.
|
| |
Immunol Cell Biol, 77,
76-89.
|
|
|
|
|
|
|
M.K.Squier,
A.J.Sehnert,
K.S.Sellins,
A.M.Malkinson,
E.Takano,
and
J.J.Cohen
(1999).
Calpain and calpastatin regulate neutrophil apoptosis.
|
| |
J Cell Physiol, 178,
311-319.
|
|
|
|
|
|
|
M.Los,
S.Wesselborg,
and
K.Schulze-Osthoff
(1999).
The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
|
| |
Immunity, 10,
629-639.
|
|
|
|
|
|
|
N.Saha,
F.Moldovan,
G.Tardif,
J.P.Pelletier,
J.M.Cloutier,
and
J.Martel-Pelletier
(1999).
Interleukin-1beta-converting enzyme/caspase-1 in human osteoarthritic tissues: localization and role in the maturation of interleukin-1beta and interleukin-18.
|
| |
Arthritis Rheum, 42,
1577-1587.
|
|
|
|
|
|
|
P.W.Ng,
A.G.Porter,
and
R.U.Jänicke
(1999).
Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10.
|
| |
J Biol Chem, 274,
10301-10308.
|
|
|
|
|
|
|
R.E.Laliberte,
J.Eggler,
and
C.A.Gabel
(1999).
ATP treatment of human monocytes promotes caspase-1 maturation and externalization.
|
| |
J Biol Chem, 274,
36944-36951.
|
|
|
|
|
|
|
R.H.Arch,
and
C.B.Thompson
(1999).
Lymphocyte survival--the struggle against death.
|
| |
Annu Rev Cell Dev Biol, 15,
113-140.
|
|
|
|
|
|
|
S.Bajusz,
I.Fauszt,
K.Németh,
E.Barabás,
A.Juhász,
M.Patthy,
and
P.I.Bauer
(1999).
Peptidyl beta-homo-aspartals (3-amino-4-carboxybutyraldehydes): new specific inhibitors of caspases.
|
| |
Biopolymers, 51,
109-118.
|
|
|
|
|
|
|
S.J.Zoog,
J.Bertin,
and
P.D.Friesen
(1999).
Caspase inhibition by baculovirus P35 requires interaction between the reactive site loop and the beta-sheet core.
|
| |
J Biol Chem, 274,
25995-26002.
|
|
|
|
|
|
|
S.Shaham,
P.W.Reddien,
B.Davies,
and
H.R.Horvitz
(1999).
Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3.
|
| |
Genetics, 153,
1655-1671.
|
|
|
|
|
|
|
T.Rudel
(1999).
Caspase inhibitors in prevention of apoptosis.
|
| |
Herz, 24,
236-241.
|
|
|
|
|
|
|
W.C.Earnshaw,
L.M.Martins,
and
S.H.Kaufmann
(1999).
Mammalian caspases: structure, activation, substrates, and functions during apoptosis.
|
| |
Annu Rev Biochem, 68,
383-424.
|
|
|
|
|
|
|
W.Watt,
K.A.Koeplinger,
A.M.Mildner,
R.L.Heinrikson,
A.G.Tomasselli,
and
K.D.Watenpaugh
(1999).
The atomic-resolution structure of human caspase-8, a key activator of apoptosis.
|
| |
Structure, 7,
1135-1143.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Kawahara,
M.Enari,
R.V.Talanian,
W.W.Wong,
and
S.Nagata
(1998).
Fas-induced DNA fragmentation and proteolysis of nuclear proteins.
|
| |
Genes Cells, 3,
297-306.
|
|
|
|
|
|
|
A.M.Jelaso,
S.Acevedo,
T.Dang,
A.Lepere,
and
C.F.Ide
(1998).
Interleukin-1beta and its type 1 receptor are expressed in developing neural circuits in the frog, Xenopus laevis.
|
| |
J Comp Neurol, 394,
242-251.
|
|
|
|
|
|
|
C.A.Dinarello
(1998).
Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme.
|
| |
Ann N Y Acad Sci, 856,
1.
|
|
|
|
|
|
|
C.A.Dinarello
(1998).
Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
|
| |
Int Rev Immunol, 16,
457-499.
|
|
|
|
|
|
|
C.Schick,
P.A.Pemberton,
G.P.Shi,
Y.Kamachi,
S.Cataltepe,
A.J.Bartuski,
E.R.Gornstein,
D.Brömme,
H.A.Chapman,
and
G.A.Silverman
(1998).
Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.
|
| |
Biochemistry, 37,
5258-5266.
|
|
|
|
|
|
|
E.S.Woodle,
and
S.Kulkarni
(1998).
Programmed cell death.
|
| |
Transplantation, 66,
681-691.
|
|
|
|
|
|
|
E.W.Humke,
J.Ni,
and
V.M.Dixit
(1998).
ERICE, a novel FLICE-activatable caspase.
|
| |
J Biol Chem, 273,
15702-15707.
|
|
|
|
|
|
|
I.C.Chikanza,
S.Jawed,
D.Naughton,
and
D.R.Blake
(1998).
Why do we need new treatments for rheumatoid arthritis?
|
| |
J Pharm Pharmacol, 50,
357-369.
|
|
|
|
|
|
|
L.F.Lincz
(1998).
Deciphering the apoptotic pathway: all roads lead to death.
|
| |
Immunol Cell Biol, 76,
1.
|
|
|
|
|
|
|
M.Centola,
X.Chen,
R.Sood,
Z.Deng,
I.Aksentijevich,
T.Blake,
D.O.Ricke,
X.Chen,
G.Wood,
N.Zaks,
N.Richards,
D.Krizman,
E.Mansfield,
S.Apostolou,
J.Liu,
N.Shafran,
A.Vedula,
M.Hamon,
A.Cercek,
T.Kahan,
D.Gumucio,
D.F.Callen,
R.I.Richards,
R.K.Moyzis,
and
D.L.Kastner
(1998).
Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3.
|
| |
Genome Res, 8,
1172-1191.
|
|
|
|
|
|
|
M.E.McAlindon,
C.J.Hawkey,
and
Y.R.Mahida
(1998).
Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease.
|
| |
Gut, 42,
214-219.
|
|
|
|
|
|
|
M.Garcia-Calvo,
E.P.Peterson,
B.Leiting,
R.Ruel,
D.W.Nicholson,
and
N.A.Thornberry
(1998).
Inhibition of human caspases by peptide-based and macromolecular inhibitors.
|
| |
J Biol Chem, 273,
32608-32613.
|
|
|
|
|
|
|
N.A.Thornberry,
and
Y.Lazebnik
(1998).
Caspases: enemies within.
|
| |
Science, 281,
1312-1316.
|
|
|
|
|
|
|
P.Pasinelli,
D.R.Borchelt,
M.K.Houseweart,
D.W.Cleveland,
and
R.H.Brown
(1998).
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.
|
| |
Proc Natl Acad Sci U S A, 95,
15763-15768.
|
|
|
|
|
|
|
Q.Zhou,
J.F.Krebs,
S.J.Snipas,
A.Price,
E.S.Alnemri,
K.J.Tomaselli,
and
G.S.Salvesen
(1998).
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
|
| |
Biochemistry, 37,
10757-10765.
|
|
|
|
|
|
|
S.A.Loddick,
C.Liu,
T.Takao,
K.Hashimoto,
and
E.B.De Souza
(1998).
Interleukin-1 receptors: cloning studies and role in central nervous system disorders.
|
| |
Brain Res Brain Res Rev, 26,
306-319.
|
|
|
|
|
|
|
S.Andjelic,
and
H.C.Liou
(1998).
Antigen receptor-induced B lymphocyte apoptosis mediated via a protease of the caspase family.
|
| |
Eur J Immunol, 28,
570-581.
|
|
|
|
|
|
|
S.Hu,
S.J.Snipas,
C.Vincenz,
G.Salvesen,
and
V.M.Dixit
(1998).
Caspase-14 is a novel developmentally regulated protease.
|
| |
J Biol Chem, 273,
29648-29653.
|
|
|
|
|
|
|
S.Kamada,
H.Kusano,
H.Fujita,
M.Ohtsu,
R.C.Koya,
N.Kuzumaki,
and
Y.Tsujimoto
(1998).
A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin.
|
| |
Proc Natl Acad Sci U S A, 95,
8532-8537.
|
|
|
|
|
|
|
S.Ubol,
C.Sukwattanapan,
and
P.Utaisincharoen
(1998).
Rabies virus replication induces Bax-related, caspase dependent apoptosis in mouse neuroblastoma cells.
|
| |
Virus Res, 56,
207-215.
|
|
|
|
|
|
|
S.Wang,
M.Miura,
Y.K.Jung,
H.Zhu,
E.Li,
and
J.Yuan
(1998).
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.
|
| |
Cell, 92,
501-509.
|
|
|
|
|
|
|
T.M.LaVallee,
F.Tarantini,
S.Gamble,
C.Mouta Carreira,
A.Jackson,
and
T.Maciag
(1998).
Synaptotagmin-1 is required for fibroblast growth factor-1 release.
|
| |
J Biol Chem, 273,
22217-22223.
|
|
|
|
|
|
|
T.Takahashi,
M.Ogo,
and
T.Hibino
(1998).
Partial purification and characterization of two distinct types of caspases from human epidermis.
|
| |
J Invest Dermatol, 111,
367-372.
|
|
|
|
|
|
|
V.J.Kidd
(1998).
Proteolytic activities that mediate apoptosis.
|
| |
Annu Rev Physiol, 60,
533-573.
|
|
|
|
|
|
|
A.Strasser,
D.C.Huang,
and
D.L.Vaux
(1997).
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy.
|
| |
Biochim Biophys Acta, 1333,
F151-F178.
|
|
|
|
|
|
|
B.Elangovan,
and
G.Chinnadurai
(1997).
Functional dissection of the pro-apoptotic protein Bik. Heterodimerization with anti-apoptosis proteins is insufficient for induction of cell death.
|
| |
J Biol Chem, 272,
24494-24498.
|
|
|
|
|
|
|
C.A.Dinarello
(1997).
Interleukin-1.
|
| |
Cytokine Growth Factor Rev, 8,
253-265.
|
|
|
|
|
|
|
C.Miossec,
V.Dutilleul,
F.Fassy,
and
A.Diu-Hercend
(1997).
Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation.
|
| |
J Biol Chem, 272,
13459-13462.
|
|
|
|
|
|
|
C.Rocher,
C.Faucheu,
A.M.Blanchet,
M.Claudon,
F.Hervé,
L.Durand,
M.Harnois,
A.Diu-Hercend,
and
J.L.Lalanne
(1997).
Identification of five new genes, closely related to the interleukin-1beta converting enzyme gene, that do not encode functional proteases.
|
| |
Eur J Biochem, 246,
394-400.
|
|
|
|
|
|
|
C.Vincenz,
and
V.M.Dixit
(1997).
Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling.
|
| |
J Biol Chem, 272,
6578-6583.
|
|
|
|
|
|
|
D.A.Giegel
(1997).
ICE processing and kinetic mechanism.
|
| |
J Cell Biochem, 64,
11-18.
|
|
|
|
|
|
|
D.A.Norris,
K.Whang,
K.David-Bajar,
and
S.D.Bennion
(1997).
The influence of ultraviolet light on immunological cytotoxicity in the skin.
|
| |
Photochem Photobiol, 65,
636-646.
|
|
|
|
|
|
|
D.Ferrari,
S.Wesselborg,
M.K.Bauer,
and
K.Schulze-Osthoff
(1997).
Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65.
|
| |
J Cell Biol, 139,
1635-1643.
|
|
|
|
|
|
|
D.J.Livingston
(1997).
In vitro and in vivo studies of ICE inhibitors.
|
| |
J Cell Biochem, 64,
19-26.
|
|
|
|
|
|
|
D.K.Miller,
J.Myerson,
and
J.W.Becker
(1997).
The interleukin-1 beta converting enzyme family of cysteine proteases.
|
| |
J Cell Biochem, 64,
2.
|
|
|
|
|
|
|
D.W.Nicholson,
and
N.A.Thornberry
(1997).
Caspases: killer proteases.
|
| |
Trends Biochem Sci, 22,
299-306.
|
|
|
|
|
|
|
H.B.Shu,
D.R.Halpin,
and
D.V.Goeddel
(1997).
Casper is a FADD- and caspase-related inducer of apoptosis.
|
| |
Immunity, 6,
751-763.
|
|
|
|
|
|
|
H.Eichholtz-Wirth,
O.Stoetzer,
and
K.Marx
(1997).
Reduced expression of the ICE-related protease CPP32 is associated with radiation-induced cisplatin resistance in HeLa cells.
|
| |
Br J Cancer, 76,
1322-1327.
|
|
|
|
|
|
|
H.R.Stennicke,
and
G.S.Salvesen
(1997).
Biochemical characteristics of caspases-3, -6, -7, and -8.
|
| |
J Biol Chem, 272,
25719-25723.
|
|
|
|
|
|
|
J.Norman,
J.Yang,
G.Fink,
G.Carter,
G.Ku,
W.Denham,
and
D.Livingston
(1997).
Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE).
|
| |
J Interferon Cytokine Res, 17,
113-118.
|
|
|
|
|
|
|
K.Akita,
T.Ohtsuki,
Y.Nukada,
T.Tanimoto,
M.Namba,
T.Okura,
R.Takakura-Yamamoto,
K.Torigoe,
Y.Gu,
M.S.Su,
M.Fujii,
M.Satoh-Itoh,
K.Yamamoto,
K.Kohno,
M.Ikeda,
and
M.Kurimoto
(1997).
Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.
|
| |
J Biol Chem, 272,
26595-26603.
|
|
|
|
|
|
|
K.Hayakawa,
Y.S.Li,
R.Wasserman,
S.Sauder,
S.Shinton,
and
R.R.Hardy
(1997).
B lymphocyte developmental lineages.
|
| |
Ann N Y Acad Sci, 815,
15-29.
|
|
|
|
|
|
|
L.K.Clayton,
Y.Ghendler,
E.Mizoguchi,
R.J.Patch,
T.D.Ocain,
K.Orth,
A.K.Bhan,
V.M.Dixit,
and
E.L.Reinherz
(1997).
T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.
|
| |
EMBO J, 16,
2282-2293.
|
|
|
|
|
|
|
M.Van de Craen,
I.Van den Brande,
W.Declercq,
M.Irmler,
R.Beyaert,
J.Tschopp,
W.Fiers,
and
P.Vandenabeele
(1997).
Cleavage of caspase family members by granzyme B: a comparative study in vitro.
|
| |
Eur J Immunol, 27,
1296-1299.
|
|
|
|
|
|
|
N.A.Thornberry,
T.A.Rano,
E.P.Peterson,
D.M.Rasper,
T.Timkey,
M.Garcia-Calvo,
V.M.Houtzager,
P.A.Nordstrom,
S.Roy,
J.P.Vaillancourt,
K.T.Chapman,
and
D.W.Nicholson
(1997).
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.
|
| |
J Biol Chem, 272,
17907-17911.
|
|
|
|
|
|
|
N.Inohara,
T.Koseki,
Y.Hu,
S.Chen,
and
G.Núñez
(1997).
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.
|
| |
Proc Natl Acad Sci U S A, 94,
10717-10722.
|
|
|
|
|
|
|
N.L.Harvey,
A.J.Butt,
and
S.Kumar
(1997).
Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis.
|
| |
J Biol Chem, 272,
13134-13139.
|
|
|
|
|
|
|
N.Roy,
Q.L.Deveraux,
R.Takahashi,
G.S.Salvesen,
and
J.C.Reed
(1997).
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.
|
| |
EMBO J, 16,
6914-6925.
|
|
|
|
|
|
|
P.Li,
H.Allen,
S.Banerjee,
and
T.Seshadri
(1997).
Characterization of mice deficient in interleukin-1 beta converting enzyme.
|
| |
J Cell Biochem, 64,
27-32.
|
|
|
|
|
|
|
P.R.Mittl,
S.Di Marco,
J.F.Krebs,
X.Bai,
D.S.Karanewsky,
J.P.Priestle,
K.J.Tomaselli,
and
M.G.Grütter
(1997).
Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone.
|
| |
J Biol Chem, 272,
6539-6547.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.M.Friedlander,
V.Gagliardini,
H.Hara,
K.B.Fink,
W.Li,
G.MacDonald,
M.C.Fishman,
A.H.Greenberg,
M.A.Moskowitz,
and
J.Yuan
(1997).
Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury.
|
| |
J Exp Med, 185,
933-940.
|
|
|
|
|
|
|
R.V.Talanian,
C.Quinlan,
S.Trautz,
M.C.Hackett,
J.A.Mankovich,
D.Banach,
T.Ghayur,
K.D.Brady,
and
W.W.Wong
(1997).
Substrate specificities of caspase family proteases.
|
| |
J Biol Chem, 272,
9677-9682.
|
|
|
|
|
|
|
R.W.Keane,
A.Srinivasan,
L.M.Foster,
M.P.Testa,
T.Ord,
D.Nonner,
H.G.Wang,
J.C.Reed,
D.E.Bredesen,
and
C.Kayalar
(1997).
Activation of CPP32 during apoptosis of neurons and astrocytes.
|
| |
J Neurosci Res, 48,
168-180.
|
|
|
|
|
|
|
S.Hu,
C.Vincenz,
J.Ni,
R.Gentz,
and
V.M.Dixit
(1997).
I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.
|
| |
J Biol Chem, 272,
17255-17257.
|
|
|
|
|
|
|
S.Murakami,
Y.Shimabukuro,
T.Saho,
E.Hino,
D.Kasai,
T.Hashikawa,
H.Hirano,
and
H.Okada
(1997).
Immunoregulatory roles of adhesive interactions between lymphocytes and gingival fibroblasts.
|
| |
J Periodontal Res, 32,
110-114.
|
|
|
|
|
|
|
S.Pinitglang,
A.B.Watts,
M.Patel,
J.D.Reid,
M.A.Noble,
S.Gul,
A.Bokth,
A.Naeem,
H.Patel,
E.W.Thomas,
S.K.Sreedharan,
C.Verma,
and
K.Brocklehurst
(1997).
A classical enzyme active center motif lacks catalytic competence until modulated electrostatically.
|
| |
Biochemistry, 36,
9968-9982.
|
|
|
|
|
|
|
T.A.Rano,
T.Timkey,
E.P.Peterson,
J.Rotonda,
D.W.Nicholson,
J.W.Becker,
K.T.Chapman,
and
N.A.Thornberry
(1997).
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).
|
| |
Chem Biol, 4,
149-155.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
U.Schönbeck,
F.Mach,
J.Y.Bonnefoy,
H.Loppnow,
H.D.Flad,
and
P.Libby
(1997).
Ligation of CD40 activates interleukin 1beta-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1beta.
|
| |
J Biol Chem, 272,
19569-19574.
|
|
|
|
|
|
|
U.Schönbeck,
M.Herzberg,
A.Petersen,
C.Wohlenberg,
J.Gerdes,
H.D.Flad,
and
H.Loppnow
(1997).
Human vascular smooth muscle cells express interleukin-1beta-converting enzyme (ICE), but inhibit processing of the interleukin-1beta precursor by ICE.
|
| |
J Exp Med, 185,
1287-1294.
|
|
|
|
|
|
|
Y.V.Goltsev,
A.V.Kovalenko,
E.Arnold,
E.E.Varfolomeev,
V.M.Brodianskii,
and
D.Wallach
(1997).
CASH, a novel caspase homologue with death effector domains.
|
| |
J Biol Chem, 272,
19641-19644.
|
|
|
|
|
|
|
Z.Song,
K.McCall,
and
H.Steller
(1997).
DCP-1, a Drosophila cell death protease essential for development.
|
| |
Science, 275,
536-540.
|
|
|
|
|
|
|
A.Fraser,
N.McCarthy,
and
G.I.Evan
(1996).
Biochemistry of cell death.
|
| |
Curr Opin Neurobiol, 6,
71-80.
|
|
|
|
|
|
|
A.G.Uren,
and
D.L.Vaux
(1996).
Molecular and clinical aspects of apoptosis.
|
| |
Pharmacol Ther, 72,
37-50.
|
|
|
|
|
|
|
A.G.Uren,
M.Pakusch,
C.J.Hawkins,
K.L.Puls,
and
D.L.Vaux
(1996).
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.
|
| |
Proc Natl Acad Sci U S A, 93,
4974-4978.
|
|
|
|
|
|
|
A.J.Beveridge
(1996).
A theoretical study of the active sites of papain and S195C rat trypsin: implications for the low reactivity of mutant serine proteinases.
|
| |
Protein Sci, 5,
1355-1365.
|
|
|
|
|
|
|
A.J.Hale,
C.A.Smith,
L.C.Sutherland,
V.E.Stoneman,
V.L.Longthorne,
A.C.Culhane,
and
G.T.Williams
(1996).
Apoptosis: molecular regulation of cell death.
|
| |
Eur J Biochem, 236,
1.
|
|
|
|
|
|
|
A.Takahashi,
and
W.C.Earnshaw
(1996).
ICE-related proteases in apoptosis.
|
| |
Curr Opin Genet Dev, 6,
50-55.
|
|
|
|
|
|
|
B.Allet,
A.Hochmann,
I.Martinou,
A.Berger,
M.Missotten,
B.Antonsson,
R.Sadoul,
J.C.Martinou,
and
L.Bernasconi
(1996).
Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis.
|
| |
J Cell Biol, 135,
479-486.
|
|
|
|
|
|
|
B.Henderson,
S.Poole,
and
M.Wilson
(1996).
Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis.
|
| |
Microbiol Rev, 60,
316-341.
|
|
|
|
|
|
|
C.Faucheu,
A.M.Blanchet,
V.Collard-Dutilleul,
J.L.Lalanne,
and
A.Diu-Hercend
(1996).
Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme.
|
| |
Eur J Biochem, 236,
207-213.
|
|
|
|
|
|
|
C.J.Hawkins,
A.G.Uren,
G.Häcker,
R.L.Medcalf,
and
D.L.Vaux
(1996).
Inhibition of interleukin 1 beta-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP.
|
| |
Proc Natl Acad Sci U S A, 93,
13786-13790.
|
|
|
|
|
|
|
C.Miossec,
M.C.Decoen,
L.Durand,
F.Fassy,
and
A.Diu-Hercend
(1996).
Use of monoclonal antibodies to study interleukin-1 beta-converting enzyme expression: only precursor forms are detected in interleukin-1 beta-secreting cells.
|
| |
Eur J Immunol, 26,
1032-1042.
|
|
|
|
|
|
|
D.W.Nicholson
(1996).
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis.
|
| |
Nat Biotechnol, 14,
297-301.
|
|
|
|
|
|
|
H.Duan,
A.M.Chinnaiyan,
P.L.Hudson,
J.P.Wing,
W.W.He,
and
V.M.Dixit
(1996).
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.
|
| |
J Biol Chem, 271,
1621-1625.
|
|
|
|
|
|
|
H.Duan,
K.Orth,
A.M.Chinnaiyan,
G.G.Poirier,
C.J.Froelich,
W.W.He,
and
V.M.Dixit
(1996).
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
|
| |
J Biol Chem, 271,
16720-16724.
|
|
|
|
|
|
|
H.R.Stennicke,
J.J.Birktoft,
and
K.Breddam
(1996).
Characterization of the S1 binding site of the glutamic acid-specific protease from Streptomyces griseus.
|
| |
Protein Sci, 5,
2266-2275.
|
|
|
|
|
|
|
J.A.Lippke,
Y.Gu,
C.Sarnecki,
P.R.Caron,
and
M.S.Su
(1996).
Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32.
|
| |
J Biol Chem, 271,
1825-1828.
|
|
|
|
|
|
|
J.Rotonda,
D.W.Nicholson,
K.M.Fazil,
M.Gallant,
Y.Gareau,
M.Labelle,
E.P.Peterson,
D.M.Rasper,
R.Ruel,
J.P.Vaillancourt,
N.A.Thornberry,
and
J.W.Becker
(1996).
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.
|
| |
Nat Struct Biol, 3,
619-625.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Schlegel,
I.Peters,
S.Orrenius,
D.K.Miller,
N.A.Thornberry,
T.T.Yamin,
and
D.W.Nicholson
(1996).
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis.
|
| |
J Biol Chem, 271,
1841-1844.
|
|
|
|
|
|
|
L.C.Dang,
R.V.Talanian,
D.Banach,
M.C.Hackett,
J.L.Gilmore,
S.J.Hays,
J.A.Mankovich,
and
K.D.Brady
(1996).
Preparation of an autolysis-resistant interleukin-1 beta converting enzyme mutant.
|
| |
Biochemistry, 35,
14910-14916.
|
|
|
|
|
|
|
L.M.Grimm,
A.L.Goldberg,
G.G.Poirier,
L.M.Schwartz,
and
B.A.Osborne
(1996).
Proteasomes play an essential role in thymocyte apoptosis.
|
| |
EMBO J, 15,
3835-3844.
|
|
|
|
|
|
|
L.M.Schwartz,
and
C.E.Milligan
(1996).
Cold thoughts of death: the role of ICE proteases in neuronal cell death.
|
| |
Trends Neurosci, 19,
555-562.
|
|
|
|
|
|
|
M.H.Werner
(1996).
Stopping death cold.
|
| |
Structure, 4,
879-883.
|
|
|
|
|
|
|
M.R.Hall,
and
W.Gibson
(1996).
Cytomegalovirus assemblin: the amino and carboxyl domains of the proteinase form active enzyme when separately cloned and coexpressed in eukaryotic cells.
|
| |
J Virol, 70,
5395-5404.
|
|
|
|
|
|
|
M.Whyte
(1996).
ICE/CED-3 proteasesin apoptosis.
|
| |
Trends Cell Biol, 6,
245-248.
|
|
|
|
|
|
|
P.A.Henkart
(1996).
ICE family proteases: mediators of all apoptotic cell death?
|
| |
Immunity, 4,
195-201.
|
|
|
|
|
|
|
S.M.Srinivasula,
T.Fernandes-Alnemri,
J.Zangrilli,
N.Robertson,
R.C.Armstrong,
L.Wang,
J.A.Trapani,
K.J.Tomaselli,
G.Litwack,
and
E.S.Alnemri
(1996).
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
|
| |
J Biol Chem, 271,
27099-27106.
|
|
|
|
|
|
|
S.Wang,
M.Miura,
Y.Jung,
H.Zhu,
V.Gagliardini,
L.Shi,
A.H.Greenberg,
and
J.Yuan
(1996).
Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.
|
| |
J Biol Chem, 271,
20580-20587.
|
|
|
|
|
|
|
T.T.Yamin,
J.M.Ayala,
and
D.K.Miller
(1996).
Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme.
|
| |
J Biol Chem, 271,
13273-13282.
|
|
|
|
|
|
|
W.Van Criekinge,
R.
| |
Links
