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Nature
371:37-43
(1994)
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PubMed id:
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Structure of influenza haemagglutinin at the pH of membrane fusion.
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P.A.Bullough,
F.M.Hughson,
J.J.Skehel,
D.C.Wiley.
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ABSTRACT
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Low pH induces a conformational change in the influenza virus haemagglutinin,
which then mediates fusion of the viral and host cell membranes. The
three-dimensional structure of a fragment of the haemagglutinin in this
conformation reveals a major refolding of the secondary and tertiary structure
of the molecule. The apolar fusion peptide moves at least 100 A to one tip of
the molecule. At the other end a helical segment unfolds, a subdomain relocates
reversing the chain direction, and part of the structure becomes disordered.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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PDB code:
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PDB code:
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PDB codes:
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}
}
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