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Contents |
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* Residue conservation analysis
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Cell
76:39-50
(1994)
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PubMed id:
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The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection.
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A.C.Young,
W.Zhang,
J.C.Sacchettini,
S.G.Nathenson.
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ABSTRACT
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Solution at 2.4 A resolution of the structure of H-2Db with the influenza virus
peptide NP366-374 (ASNEN-METM) and comparison with the H-2Kb-VSV (RGY-VYQGL)
structure allow description of the molecular details of MHC class I peptide
binding interactions for mice of the H-2b haplotype, revealing a strategy that
maximizes the repertoire of peptides than can be presented. The H-2Db cleft has
a mouse-specific hydrophobic ridge that causes a compensatory arch in the
backbone of the peptide, exposing the arch residues to TCR contact and requiring
the peptide to be at least 9 residues. This ridge occurs in about 40% of the
known murine D and L allelic molecules, classifying them as a structural
subgroup.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.A.Valkenburg,
S.Gras,
C.Guillonneau,
N.L.La Gruta,
P.G.Thomas,
A.W.Purcell,
J.Rossjohn,
P.C.Doherty,
S.J.Turner,
and
K.Kedzierska
(2010).
Protective Efficacy of Cross-Reactive CD8 T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold.
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PLoS Pathog,
6,
0.
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PDB code:
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D.Schrama,
H.Voigt,
A.O.Eggert,
R.Xiang,
H.Zhou,
T.N.Schumacher,
M.H.Andersen,
P.thor Straten,
R.A.Reisfeld,
and
J.C.Becker
(2008).
Immunological tumor destruction in a murine melanoma model by targeted LTalpha independent of secondary lymphoid tissue.
|
| |
Cancer Immunol Immunother,
57,
85-95.
|
|
|
|
|
|
|
K.Kedzierska,
C.Guillonneau,
S.Gras,
L.A.Hatton,
R.Webby,
A.W.Purcell,
J.Rossjohn,
P.C.Doherty,
and
S.J.Turner
(2008).
Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy.
|
| |
Proc Natl Acad Sci U S A,
105,
19408-19413.
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PDB code:
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K.Kedzierska,
N.L.La Gruta,
J.Stambas,
S.J.Turner,
and
P.C.Doherty
(2008).
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.
|
| |
Mol Immunol,
45,
607-618.
|
|
|
|
|
|
|
N.L.La Gruta,
P.G.Thomas,
A.I.Webb,
M.A.Dunstone,
T.Cukalac,
P.C.Doherty,
A.W.Purcell,
J.Rossjohn,
and
S.J.Turner
(2008).
Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides.
|
| |
Proc Natl Acad Sci U S A,
105,
2034-2039.
|
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PDB code:
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A.Glithero,
J.Tormo,
K.Doering,
M.Kojima,
E.Y.Jones,
and
T.Elliott
(2006).
The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate.
|
| |
J Biol Chem,
281,
12699-12704.
|
|
|
PDB code:
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|
|
|
|
|
I.K.Egorov
(2006).
Mouse models of efficient and inefficient anti-tumor immunity, with emphasis on minimal residual disease and tumor escape.
|
| |
Cancer Immunol Immunother,
55,
1.
|
|
|
|
|
|
|
V.Mitaksov,
and
D.H.Fremont
(2006).
Structural definition of the H-2Kd peptide-binding motif.
|
| |
J Biol Chem,
281,
10618-10625.
|
|
|
PDB code:
|
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|
|
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K.Kedzierska,
N.L.La Gruta,
M.P.Davenport,
S.J.Turner,
and
P.C.Doherty
(2005).
Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses.
|
| |
Proc Natl Acad Sci U S A,
102,
11432-11437.
|
|
|
|
|
|
|
S.J.Turner,
K.Kedzierska,
H.Komodromou,
N.L.La Gruta,
M.A.Dunstone,
A.I.Webb,
R.Webby,
H.Walden,
W.Xie,
J.McCluskey,
A.W.Purcell,
J.Rossjohn,
and
P.C.Doherty
(2005).
Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations.
|
| |
Nat Immunol,
6,
382-389.
|
|
|
|
|
|
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T.Elliott,
and
A.Williams
(2005).
The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex.
|
| |
Immunol Rev,
207,
89-99.
|
|
|
|
|
|
|
T.Sandalova,
J.Michaëlsson,
R.A.Harris,
J.Odeberg,
G.Schneider,
K.Kärre,
and
A.Achour
(2005).
A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity.
|
| |
J Biol Chem,
280,
27069-27075.
|
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PDB code:
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K.Kedzierska,
S.J.Turner,
and
P.C.Doherty
(2004).
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope.
|
| |
Proc Natl Acad Sci U S A,
101,
4942-4947.
|
|
|
|
|
|
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R.J.Webby,
S.Andreansky,
J.Stambas,
J.E.Rehg,
R.G.Webster,
P.C.Doherty,
and
S.J.Turner
(2003).
Protection and compensation in the influenza virus-specific CD8+ T cell response.
|
| |
Proc Natl Acad Sci U S A,
100,
7235-7240.
|
|
|
|
|
|
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A.Achour,
J.Michaëlsson,
R.A.Harris,
J.Odeberg,
P.Grufman,
J.K.Sandberg,
V.Levitsky,
K.Kärre,
T.Sandalova,
and
G.Schneider
(2002).
A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.
|
| |
Immunity,
17,
757-768.
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PDB codes:
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M.G.Rudolph,
and
I.A.Wilson
(2002).
The specificity of TCR/pMHC interaction.
|
| |
Curr Opin Immunol,
14,
52-65.
|
|
|
|
|
|
|
A.M.Moody,
Y.Xiong,
H.C.Chang,
and
E.L.Reinherz
(2001).
The CD8alphabeta co-receptor on double-positive thymocytes binds with differing affinities to the products of distinct class I MHC loci.
|
| |
Eur J Immunol,
31,
2791-2799.
|
|
|
|
|
|
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D.Hudrisier,
J.Riond,
and
J.E.Gairin
(2001).
Molecular and functional dissection of the H-2Db-restricted subdominant cytotoxic T-cell response to lymphocytic choriomeningitis virus.
|
| |
J Virol,
75,
2468-2471.
|
|
|
|
|
|
|
A.Simon,
Z.Dosztányi,
E.Rajnavölgyi,
and
I.Simon
(2000).
Function-related regulation of the stability of MHC proteins.
|
| |
Biophys J,
79,
2305-2313.
|
|
|
|
|
|
|
C.Wingren,
M.P.Crowley,
M.Degano,
Y.Chien,
and
I.A.Wilson
(2000).
Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold.
|
| |
Science,
287,
310-314.
|
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PDB code:
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G.E.Price,
R.Ou,
H.Jiang,
L.Huang,
and
D.Moskophidis
(2000).
Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia.
|
| |
J Exp Med,
191,
1853-1867.
|
|
|
|
|
|
|
M.C.Nakamura,
S.Hayashi,
E.C.Niemi,
J.C.Ryan,
and
W.E.Seaman
(2000).
Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d).
|
| |
J Exp Med,
192,
447-454.
|
|
|
|
|
|
|
O.Schueler-Furman,
Y.Altuvia,
A.Sette,
and
H.Margalit
(2000).
Structure-based prediction of binding peptides to MHC class I molecules: application to a broad range of MHC alleles.
|
| |
Protein Sci,
9,
1838-1846.
|
|
|
|
|
|
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S.Tourdot,
A.Scardino,
E.Saloustrou,
D.A.Gross,
S.Pascolo,
P.Cordopatis,
F.A.Lemonnier,
and
K.Kosmatopoulos
(2000).
A general strategy to enhance immunogenicity of low-affinity HLA-A2. 1-associated peptides: implication in the identification of cryptic tumor epitopes.
|
| |
Eur J Immunol,
30,
3411-3421.
|
|
|
|
|
|
|
A.Achour,
R.A.Harris,
K.Persson,
J.Sundbäck,
C.L.Sentman,
G.Schneider,
Y.Lindqvist,
and
K.Kärre
(1999).
Murine class I major histocompatibility complex H-2Dd: expression, refolding and crystallization.
|
| |
Acta Crystallogr D Biol Crystallogr,
55,
260-262.
|
|
|
|
|
|
|
A.Glithero,
J.Tormo,
J.S.Haurum,
G.Arsequell,
G.Valencia,
J.Edwards,
S.Springer,
A.Townsend,
Y.L.Pao,
M.Wormald,
R.A.Dwek,
E.Y.Jones,
and
T.Elliott
(1999).
Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.
|
| |
Immunity,
10,
63-74.
|
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PDB codes:
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C.Stemmer,
A.Quesnel,
A.Prévost-Blondel,
C.Zimmermann,
S.Muller,
J.P.Briand,
and
H.Pircher
(1999).
Protection against lymphocytic choriomeningitis virus infection induced by a reduced peptide bond analogue of the H-2Db-restricted CD8(+) T cell epitope GP33.
|
| |
J Biol Chem,
274,
5550-5556.
|
|
|
|
|
|
|
D.Hudrisier,
J.Riond,
H.Mazarguil,
M.B.Oldstone,
and
J.E.Gairin
(1999).
Genetically encoded and post-translationally modified forms of a major histocompatibility complex class I-restricted antigen bearing a glycosylation motif are independently processed and co-presented to cytotoxic T lymphocytes.
|
| |
J Biol Chem,
274,
36274-36280.
|
|
|
|
|
|
|
J.A.Speir,
U.M.Abdel-Motal,
M.Jondal,
and
I.A.Wilson
(1999).
Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL.
|
| |
Immunity,
10,
51-61.
|
|
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PDB code:
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J.B.Haanen,
M.C.Wolkers,
A.M.Kruisbeek,
and
T.N.Schumacher
(1999).
Selective expansion of cross-reactive CD8(+) memory T cells by viral variants.
|
| |
J Exp Med,
190,
1319-1328.
|
|
|
|
|
|
|
J.B.Haanen,
M.Toebes,
T.A.Cordaro,
M.C.Wolkers,
A.M.Kruisbeek,
and
T.N.Schumacher
(1999).
Systemic T cell expansion during localized viral infection.
|
| |
Eur J Immunol,
29,
1168-1174.
|
|
|
|
|
|
|
J.C.Solheim
(1999).
Class I MHC molecules: assembly and antigen presentation.
|
| |
Immunol Rev,
172,
11-19.
|
|
|
|
|
|
|
K.C.Garcia,
L.Teyton,
and
I.A.Wilson
(1999).
Structural basis of T cell recognition.
|
| |
Annu Rev Immunol,
17,
369-397.
|
|
|
|
|
|
|
K.Hashimoto,
K.Okamura,
H.Yamaguchi,
M.Ototake,
T.Nakanishi,
and
Y.Kurosawa
(1999).
Conservation and diversification of MHC class I and its related molecules in vertebrates.
|
| |
Immunol Rev,
167,
81.
|
|
|
|
|
|
|
K.Maenaka,
and
E.Y.Jones
(1999).
MHC superfamily structure and the immune system.
|
| |
Curr Opin Struct Biol,
9,
745-753.
|
|
|
|
|
|
|
L.Pewe,
and
S.Perlman
(1999).
Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57Bl/6 mice.
|
| |
Virology,
255,
106-116.
|
|
|
|
|
|
|
N.R.Glover,
and
A.S.Tracey
(1999).
Nuclear magnetic resonance and restrained molecular dynamics studies of the interaction of an epidermal growth factor-derived peptide with protein tyrosine phosphatase 1B.
|
| |
Biochemistry,
38,
5256-5271.
|
|
|
|
|
|
|
Q.R.Fan,
and
D.C.Wiley
(1999).
Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor.
|
| |
J Exp Med,
190,
113-123.
|
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PDB code:
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R.Zhao,
D.J.Loftus,
E.Appella,
and
E.J.Collins
(1999).
Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry.
|
| |
J Exp Med,
189,
359-370.
|
|
|
PDB codes:
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A.R.Zuberi,
G.J.Christianson,
L.M.Mendoza,
N.Shastri,
and
D.C.Roopenian
(1998).
Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex.
|
| |
Immunity,
9,
687-698.
|
|
|
|
|
|
|
I.B.Jakobsen,
X.Gao,
S.Easteal,
and
G.Chelvanayagam
(1998).
Correlating sequence variation with HLA-A allelic families: implications for T cell receptor binding specificities.
|
| |
Immunol Cell Biol,
76,
135-142.
|
|
|
|
|
|
|
J.A.Speir,
K.C.Garcia,
A.Brunmark,
M.Degano,
P.A.Peterson,
L.Teyton,
and
I.A.Wilson
(1998).
Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes.
|
| |
Immunity,
8,
553-562.
|
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PDB code:
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M.H.Johansson,
E.Höglund,
M.C.Nakamura,
J.C.Ryan,
and
P.Höglund
(1998).
Alpha1/alpha2 domains of H-2D(d), but not H-2L(d), induce "missing self" reactivity in vivo--no effect of H-2L(d) on protection against NK cells expressing the inhibitory receptor Ly49G2.
|
| |
Eur J Immunol,
28,
4198-4206.
|
|
|
|
|
|
|
M.J.Shields,
and
R.K.Ribaudo
(1998).
Mapping of the monoclonal antibody W6/32: sensitivity to the amino terminus of beta2-microglobulin.
|
| |
Tissue Antigens,
51,
567-570.
|
|
|
|
|
|
|
M.Waldenström,
J.Sundbäck,
M.Y.Olsson-Alheim,
A.Achour,
and
K.Kärre
(1998).
Impaired MHC class I (H-2Dd)-mediated protection against Ly-49A+ NK cells after amino acid substitutions in the antigen binding cleft.
|
| |
Eur J Immunol,
28,
2872-2881.
|
|
|
|
|
|
|
P.J.Fairchild
(1998).
Presentation of antigenic peptides by products of the major histocompatibility complex.
|
| |
J Pept Sci,
4,
182-194.
|
|
|
|
|
|
|
S.Springer,
K.Doring,
J.C.Skipper,
A.R.Townsend,
and
V.Cerundolo
(1998).
Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding.
|
| |
Biochemistry,
37,
3001-3012.
|
|
|
|
|
|
|
V.Apostolopoulos,
S.A.Lofthouse,
V.Popovski,
G.Chelvanayagam,
M.S.Sandrin,
and
I.F.McKenzie
(1998).
Peptide mimics of a tumor antigen induce functional cytotoxic T cells.
|
| |
Nat Biotechnol,
16,
276-280.
|
|
|
|
|
|
|
D.Housset,
G.Mazza,
C.Grégoire,
C.Piras,
B.Malissen,
and
J.C.Fontecilla-Camps
(1997).
The three-dimensional structure of a T-cell antigen receptor V alpha V beta heterodimer reveals a novel arrangement of the V beta domain.
|
| |
EMBO J,
16,
4205-4216.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
E.Y.Jones
(1997).
MHC class I and class II structures.
|
| |
Curr Opin Immunol,
9,
75-79.
|
|
|
|
|
|
|
G.K.Balendiran,
J.C.Solheim,
A.C.Young,
T.H.Hansen,
S.G.Nathenson,
and
J.C.Sacchettini
(1997).
The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.
|
| |
Proc Natl Acad Sci U S A,
94,
6880-6885.
|
|
|
PDB code:
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|
|
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|
|
J.L.Seibel,
N.Wilson,
H.Kozono,
P.Marrack,
and
J.W.Kappler
(1997).
Influence of the NH2-terminal amino acid of the T cell receptor alpha chain on major histocompatibility complex (MHC) class II + peptide recognition.
|
| |
J Exp Med,
185,
1919-1927.
|
|
|
|
|
|
|
K.D.Smith,
Z.B.Kurago,
and
C.T.Lutz
(1997).
Conformational changes in MHC class I molecules. Antibody, T-cell receptor, and NK cell recognition in an HLA-B7 model system.
|
| |
Immunol Res,
16,
243-259.
|
|
|
|
|
|
|
L.M.Mendoza,
P.Paz,
A.Zuberi,
G.Christianson,
D.Roopenian,
and
N.Shastri
(1997).
Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex.
|
| |
Immunity,
7,
461-472.
|
|
|
|
|
|
|
L.Pewe,
S.Xue,
and
S.Perlman
(1997).
Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.
|
| |
J Virol,
71,
7640-7647.
|
|
|
|
|
|
|
M.A.Batalia,
and
E.J.Collins
(1997).
Peptide binding by class I and class II MHC molecules.
|
| |
Biopolymers,
43,
281-302.
|
|
|
|
|
|
|
M.P.Crowley,
Z.Reich,
N.Mavaddat,
J.D.Altman,
and
Y.Chien
(1997).
The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the gammadelta T cell, G8.
|
| |
J Exp Med,
185,
1223-1230.
|
|
|
|
|
|
|
M.Wang,
S.M.Stepkowski,
J.Yu,
M.Wang,
and
B.D.Kahan
(1997).
Localization of cryptic tolerogenic epitopes in the alpha1-helical region of the RT1.Au alloantigen.
|
| |
Transplantation,
63,
1373-1379.
|
|
|
|
|
|
|
N.D.Borson,
C.Paul,
X.Lin,
W.K.Nevala,
M.A.Strausbauch,
M.Rodriguez,
and
P.J.Wettstein
(1997).
Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue.
|
| |
J Virol,
71,
5244-5250.
|
|
|
|
|
|
|
P.Goulder,
D.Price,
M.Nowak,
S.Rowland-Jones,
R.Phillips,
and
A.McMichael
(1997).
Co-evolution of human immunodeficiency virus and cytotoxic T-lymphocyte responses.
|
| |
Immunol Rev,
159,
17-29.
|
|
|
|
|
|
|
P.Zheng,
and
Y.Liu
(1997).
Costimulation by B7 modulates specificity of cytotoxic T lymphocytes: a missing link that explains some bystander T cell activation.
|
| |
J Exp Med,
186,
1787-1791.
|
|
|
|
|
|
|
Q.Hu,
C.R.Bazemore Walker,
C.Girao,
J.T.Opferman,
J.Sun,
J.Shabanowitz,
D.F.Hunt,
and
P.G.Ashton-Rickardt
(1997).
Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes.
|
| |
Immunity,
7,
221-231.
|
|
|
|
|
|
|
V.Apostolopoulos,
J.S.Haurum,
and
I.F.McKenzie
(1997).
MUC1 peptide epitopes associated with five different H-2 class I molecules.
|
| |
Eur J Immunol,
27,
2579-2587.
|
|
|
|
|
|
|
Y.Reiter,
A.Di Carlo,
L.Fugger,
J.Engberg,
and
I.Pastan
(1997).
Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity.
|
| |
Proc Natl Acad Sci U S A,
94,
4631-4636.
|
|
|
|
|
|
|
Z.Zeng,
A.R.Castaño,
B.W.Segelke,
E.A.Stura,
P.A.Peterson,
and
I.A.Wilson
(1997).
Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove.
|
| |
Science,
277,
339-345.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Stryhn,
L.O.Pedersen,
T.Romme,
C.B.Holm,
A.Holm,
and
S.Buus
(1996).
Peptide binding specificity of major histocompatibility complex class I resolved into an array of apparently independent subspecificities: quantitation by peptide libraries and improved prediction of binding.
|
| |
Eur J Immunol,
26,
1911-1918.
|
|
|
|
|
|
|
C.Perreault,
J.Jutras,
D.C.Roy,
J.G.Filep,
and
S.Brochu
(1996).
Identification of an immunodominant mouse minor histocompatibility antigen (MiHA). T cell response to a single dominant MiHA causes graft-versus-host disease.
|
| |
J Clin Invest,
98,
622-628.
|
|
|
|
|
|
|
D.B.Williams,
A.Vassilakos,
and
W.K.Suh
(1996).
Peptide presentation by MHC class I molecules.
|
| |
Trends Cell Biol,
6,
267-273.
|
|
|
|
|
|
|
D.H.Fremont,
W.A.Rees,
and
H.Kozono
(1996).
Biophysical studies of T-cell receptors and their ligands.
|
| |
Curr Opin Immunol,
8,
93.
|
|
|
|
|
|
|
D.Hudrisier,
H.Mazarguil,
F.Laval,
M.B.Oldstone,
and
J.E.Gairin
(1996).
Binding of viral antigens to major histocompatibility complex class I H-2Db molecules is controlled by dominant negative elements at peptide non-anchor residues. Implications for peptide selection and presentation.
|
| |
J Biol Chem,
271,
17829-17836.
|
|
|
|
|
|
|
D.McCormick,
H.J.Stauss,
C.Thorpe,
P.Travers,
and
P.J.Dyson
(1996).
Major histocompatibility complex and T cell receptor interaction of the P91A tum- peptide.
|
| |
Eur J Immunol,
26,
2895-2902.
|
|
|
|
|
|
|
E.Sebzda,
T.M.Kündig,
C.T.Thomson,
K.Aoki,
S.Y.Mak,
J.P.Mayer,
T.Zamborelli,
S.G.Nathenson,
and
P.S.Ohashi
(1996).
Mature T cell reactivity altered by peptide agonist that induces positive selection.
|
| |
J Exp Med,
183,
1093-1104.
|
|
|
|
|
|
|
K.J.Smith,
S.W.Reid,
D.I.Stuart,
A.J.McMichael,
E.Y.Jones,
and
J.I.Bell
(1996).
An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501.
|
| |
Immunity,
4,
203-213.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.J.Smith,
S.W.Reid,
K.Harlos,
A.J.McMichael,
D.I.Stuart,
J.I.Bell,
and
E.Y.Jones
(1996).
Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53.
|
| |
Immunity,
4,
215-228.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.R.Taylor,
J.A.Peterson,
R.L.Ceriani,
and
J.R.Couto
(1996).
Cloning and sequence analysis of human butyrophilin reveals a potential receptor function.
|
| |
Biochim Biophys Acta,
1306,
1-4.
|
|
|
|
|
|
|
O.Williams,
Y.Tanaka,
M.Bix,
M.Murdjeva,
D.R.Littman,
and
D.Kioussis
(1996).
Inhibition of thymocyte negative selection by T cell receptor antagonist peptides.
|
| |
Eur J Immunol,
26,
532-538.
|
|
|
|
|
|
|
P.S.Andersen,
A.Stryhn,
B.E.Hansen,
L.Fugger,
J.Engberg,
and
S.Buus
(1996).
A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells.
|
| |
Proc Natl Acad Sci U S A,
93,
1820-1824.
|
|
|
|
|
|
|
R.E.Toes,
W.M.Kast,
R.J.Blom,
S.C.Bakker,
R.Offringa,
and
C.J.Melief
(1996).
Efficient tumor eradication by adoptively transferred cytotoxic T-cell clones in allogeneic hosts.
|
| |
Int J Cancer,
66,
686-691.
|
|
|
|
|
|
|
R.R.Ghobrial,
T.Hamashima,
M.E.Wang,
M.Wang,
S.M.Stepkowski,
and
B.D.Kahan
(1996).
Induction of transplantation tolerance by chimeric donor/recipient class I RT1.Aa molecules.
|
| |
Transplantation,
62,
1002-1010.
|
|
|
|
|
|
|
S.Joyce,
and
S.G.Nathenson
(1996).
Alloreactivity, antigen recognition and T-cell selection: three diverse T-cell recognition problems with a common solution.
|
| |
Immunol Rev,
154,
59.
|
|
|
|
|
|
|
S.W.Reid,
S.McAdam,
K.J.Smith,
P.Klenerman,
C.A.O'Callaghan,
K.Harlos,
B.K.Jakobsen,
A.J.McMichael,
J.I.Bell,
D.I.Stuart,
and
E.Y.Jones
(1996).
Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
|
| |
J Exp Med,
184,
2279-2286.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
U.M.Abdel-Motal,
L.Berg,
A.Rosén,
M.Bengtsson,
C.J.Thorpe,
J.Kihlberg,
J.Dahmén,
G.Magnusson,
K.A.Karlsson,
and
M.Jondal
(1996).
Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells.
|
| |
Eur J Immunol,
26,
544-551.
|
|
|
|
|
|
|
Y.Itoh,
K.Kajino,
K.Ogasawara,
M.Katoh,
K.Namba,
K.Takami,
K.Iwabuchi,
N.S.Braunstein,
and
K.Onoé
(1996).
Determination of the allele-specific antigen-binding site on I-Ak and I-Ab molecules.
|
| |
Eur J Immunol,
26,
1314-1321.
|
|
|
|
|
|
|
C.R.Wang,
A.R.Castaño,
P.A.Peterson,
C.Slaughter,
K.F.Lindahl,
and
J.Deisenhofer
(1995).
Nonclassical binding of formylated peptide in crystal structure of the MHC class Ib molecule H2-M3.
|
| |
Cell,
82,
655-664.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.H.Fremont,
E.A.Stura,
M.Matsumura,
P.A.Peterson,
and
I.A.Wilson
(1995).
Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove.
|
| |
Proc Natl Acad Sci U S A,
92,
2479-2483.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
E.J.Collins,
D.N.Garboczi,
M.N.Karpusas,
and
D.C.Wiley
(1995).
The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain.
|
| |
Proc Natl Acad Sci U S A,
92,
1218-1221.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.Guichard,
S.Calbo,
S.Muller,
P.Kourilsky,
J.P.Briand,
and
J.P.Abastado
(1995).
Efficient binding of reduced peptide bond pseudopeptides to major histocompatibility complex class I molecule.
|
| |
J Biol Chem,
270,
26057-26059.
|
|
|
|
|
|
|
G.Siligardi,
and
A.F.Drake
(1995).
The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides.
|
| |
Biopolymers,
37,
281-292.
|
|
|
|
|
|
|
H.Isobe,
T.Moran,
S.Li,
A.Young,
S.Nathenson,
P.Palese,
and
C.Bona
(1995).
Presentation by a major histocompatibility complex class I molecule of nucleoprotein peptide expressed in two different genes of an influenza virus transfectant.
|
| |
J Exp Med,
181,
203-213.
|
|
|
|
|
|
|
J.D.Lippolis,
L.M.Mylin,
D.T.Simmons,
and
S.S.Tevethia
(1995).
Functional analysis of amino acid residues encompassing and surrounding two neighboring H-2Db-restricted cytotoxic T-lymphocyte epitopes in simian virus 40 tumor antigen.
|
| |
J Virol,
69,
3134-3146.
|
|
|
|
|
|
|
J.E.Gairin,
H.Mazarguil,
D.Hudrisier,
and
M.B.Oldstone
(1995).
Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes.
|
| |
J Virol,
69,
2297-2305.
|
|
|
|
|
|
|
J.S.Haurum,
L.Tan,
G.Arsequell,
P.Frodsham,
A.C.Lellouch,
P.A.Moss,
R.A.Dwek,
A.J.McMichael,
and
T.Elliott
(1995).
Peptide anchor residue glycosylation: effect on class I major histocompatibility complex binding and cytotoxic T lymphocyte recognition.
|
| |
Eur J Immunol,
25,
3270-3276.
|
|
|
|
|
|
|
K.C.Parker,
M.Shields,
M.DiBrino,
A.Brooks,
and
J.E.Coligan
(1995).
Peptide binding to MHC class I molecules: implications for antigenic peptide prediction.
|
| |
Immunol Res,
14,
34-57.
|
|
|
|
|
|
|
L.M.Mylin,
R.H.Bonneau,
J.D.Lippolis,
and
S.S.Tevethia
(1995).
Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.
|
| |
J Virol,
69,
6665-6677.
|
|
|
|
|
|
|
M.B.Oldstone,
H.Lewicki,
P.Borrow,
D.Hudrisier,
and
J.E.Gairin
(1995).
Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection.
|
| |
J Virol,
69,
7423-7429.
|
|
|
|
|
|
|
R.L.Stanfield,
and
I.A.Wilson
(1995).
Protein-peptide interactions.
|
| |
Curr Opin Struct Biol,
5,
103-113.
|
|
|
|
|
|
|
R.Sun,
S.E.Shepherd,
S.S.Geier,
C.T.Thomson,
J.M.Sheil,
and
S.G.Nathenson
(1995).
Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule.
|
| |
Immunity,
3,
573-582.
|
|
|
|
|
|
|
S.R.Burrows,
S.L.Silins,
D.J.Moss,
R.Khanna,
I.S.Misko,
and
V.P.Argaet
(1995).
T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen.
|
| |
J Exp Med,
182,
1703-1715.
|
|
|
|
|
|
|
U.Zügel,
B.Schoel,
S.Yamamoto,
H.Hengel,
B.Morein,
and
S.H.Kaufmann
(1995).
Crossrecognition by CD8 T cell receptor alpha beta cytotoxic T lymphocytes of peptides in the self and the mycobacterial hsp60 which share intermediate sequence homology.
|
| |
Eur J Immunol,
25,
451-458.
|
|
|
|
|
|
|
B.Schoel,
U.Zügel,
T.Ruppert,
and
S.H.Kaufmann
(1994).
Elongated peptides, not the predicted nonapeptide stimulate a major histocompatibility complex class I-restricted cytotoxic T lymphocyte clone with specificity for a bacterial heat shock protein.
|
| |
Eur J Immunol,
24,
3161-3169.
|
|
|
|
|
|
|
J.Roelse,
M.Grommé,
F.Momburg,
G.Hämmerling,
and
J.Neefjes
(1994).
Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.
|
| |
J Exp Med,
180,
1591-1597.
|
|
|
|
|
|
|
K.L.Hilyard,
H.Reyburn,
S.Chung,
J.I.Bell,
and
J.L.Strominger
(1994).
Binding of soluble natural ligands to a soluble human T-cell receptor fragment produced in Escherichia coli.
|
| |
Proc Natl Acad Sci U S A,
91,
9057-9061.
|
|
|
|
|
|
|
L.J.Stern,
and
D.C.Wiley
(1994).
Antigenic peptide binding by class I and class II histocompatibility proteins.
|
| |
Structure,
2,
245-251.
|
|
|
|
|
|
|
L.J.Stern,
J.H.Brown,
T.S.Jardetzky,
J.C.Gorga,
R.G.Urban,
J.L.Strominger,
and
D.C.Wiley
(1994).
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.
|
| |
Nature,
368,
215-221.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.A.Gavin,
B.Dere,
A.G.Grandea,
K.A.Hogquist,
and
M.J.Bevan
(1994).
Major histocompatibility complex class I allele-specific peptide libraries: identification of peptides that mimic an H-Y T cell epitope.
|
| |
Eur J Immunol,
24,
2124-2133.
|
|
|
|
|
|
|
M.Tanaka,
and
W.Herr
(1994).
Reconstitution of transcriptional activation domains by reiteration of short peptide segments reveals the modular organization of a glutamine-rich activation domain.
|
| |
Mol Cell Biol,
14,
6056-6067.
|
|
|
|
|
|
|
P.J.Bjorkman,
and
W.P.Burmeister
(1994).
Structures of two classes of MHC molecules elucidated: crucial differences and similarities.
|
| |
Curr Opin Struct Biol,
4,
852-856.
|
|
|
|
|
|
|
S.Joyce,
K.Kuzushima,
G.Kepecs,
R.H.Angeletti,
and
S.G.Nathenson
(1994).
Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation.
|
| |
Proc Natl Acad Sci U S A,
91,
4145-4149.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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 |
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