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DNA binding protein/DNA
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PDB id
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1hcr
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Contents |
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* Residue conservation analysis
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DOI no:
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Science
263:348-355
(1994)
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PubMed id:
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Hin recombinase bound to DNA: the origin of specificity in major and minor groove interactions.
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J.A.Feng,
R.C.Johnson,
R.E.Dickerson.
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ABSTRACT
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The structure of the 52-amino acid DNA-binding domain of the prokaryotic Hin
recombinase, complexed with a DNA recombination half-site, has been solved by
x-ray crystallography at 2.3 angstrom resolution. The Hin domain consists of a
three-alpha-helix bundle, with the carboxyl-terminal helix inserted into the
major groove of DNA, and two flanking extended polypeptide chains that contact
bases in the minor groove. The overall structure displays features resembling
both a prototypical bacterial helix-turn-helix and the eukaryotic homeodomain,
and in many respects is an intermediate between these two DNA-binding motifs. In
addition, a new structural motif is seen: the six-amino acid carboxyl-terminal
peptide of the Hin domain runs along the minor groove at the edge of the
recombination site, with the peptide backbone facing the floor of the groove and
side chains extending away toward the exterior. The x-ray structure provides an
almost complete explanation for DNA mutant binding studies in the Hin system and
for DNA specificity observed in the Hin-related family of DNA invertases.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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F.F.Yin,
S.Bailey,
C.A.Innis,
M.Ciubotaru,
S.Kamtekar,
T.A.Steitz,
and
D.G.Schatz
(2009).
Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
|
| |
Nat Struct Mol Biol, 16,
499-508.
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PDB codes:
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Y.Yonetani,
and
H.Kono
(2009).
Sequence dependencies of DNA deformability and hydration in the minor groove.
|
| |
Biophys J, 97,
1138-1147.
|
|
|
|
|
|
|
B.Brillet,
B.Benjamin,
Y.Bigot,
B.Yves,
C.Augé-Gouillou,
and
A.G.Corinne
(2007).
Assembly of the Tc1 and mariner transposition initiation complexes depends on the origins of their transposase DNA binding domains.
|
| |
Genetica, 130,
105-120.
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|
|
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|
|
F.Spyrakis,
P.Cozzini,
C.Bertoli,
A.Marabotti,
G.E.Kellogg,
and
A.Mozzarelli
(2007).
Energetics of the protein-DNA-water interaction.
|
| |
BMC Struct Biol, 7,
4.
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|
H.Takinowaki,
Y.Matsuda,
T.Yoshida,
Y.Kobayashi,
and
T.Ohkubo
(2006).
The solution structure of the methylated form of the N-terminal 16-kDa domain of Escherichia coli Ada protein.
|
| |
Protein Sci, 15,
487-497.
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|
|
PDB code:
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J.Seetharaman,
D.Kumaran,
J.B.Bonanno,
S.K.Burley,
and
S.Swaminathan
(2006).
Crystal structure of a putative HTH-type transcriptional regulator yxaF from Bacillus subtilis.
|
| |
Proteins, 63,
1087-1091.
|
|
|
PDB code:
|
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|
|
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K.Kutsukake,
H.Nakashima,
A.Tominaga,
and
T.Abo
(2006).
Two DNA invertases contribute to flagellar phase variation in Salmonella enterica serovar Typhimurium strain LT2.
|
| |
J Bacteriol, 188,
950-957.
|
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|
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|
P.Prabakaran,
J.G.Siebers,
S.Ahmad,
M.M.Gromiha,
M.G.Singarayan,
and
A.Sarai
(2006).
Classification of protein-DNA complexes based on structural descriptors.
|
| |
Structure, 14,
1355-1367.
|
|
|
|
|
|
|
S.H.Bae,
S.H.Yun,
D.Sun,
H.M.Lim,
and
B.S.Choi
(2006).
Structural and dynamic basis of a supercoiling-responsive DNA element.
|
| |
Nucleic Acids Res, 34,
254-261.
|
|
|
PDB codes:
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|
P.C.Swanson
(2004).
The bounty of RAGs: recombination signal complexes and reaction outcomes.
|
| |
Immunol Rev, 200,
90.
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A.I.Lee,
S.D.Fugmann,
L.G.Cowell,
L.M.Ptaszek,
G.Kelsoe,
and
D.G.Schatz
(2003).
A functional analysis of the spacer of V(D)J recombination signal sequences.
|
| |
PLoS Biol, 1,
E1.
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|
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C.Lours,
O.Bardot,
D.Godt,
F.A.Laski,
and
J.L.Couderc
(2003).
The Drosophila melanogaster BTB proteins bric à brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif.
|
| |
Nucleic Acids Res, 31,
5389-5398.
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|
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J.B.Blanco,
M.E.Vázquez,
J.Martinez-Costas,
L.Castedo,
and
J.L.Mascareñas
(2003).
A synthetic miniprotein that binds specific DNA sequences by contacting both the major and the minor groove.
|
| |
Chem Biol, 10,
713-722.
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|
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|
|
J.Huang,
Q.Zhang,
and
T.Schlick
(2003).
Effect of DNA superhelicity and bound proteins on mechanistic aspects of the Hin-mediated and Fis-enhanced inversion.
|
| |
Biophys J, 85,
804-817.
|
|
|
|
|
|
|
T.K.Chiu,
C.Sohn,
R.E.Dickerson,
and
R.C.Johnson
(2002).
Testing water-mediated DNA recognition by the Hin recombinase.
|
| |
EMBO J, 21,
801-814.
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|
|
PDB codes:
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Z.Morávek,
S.Neidle,
and
B.Schneider
(2002).
Protein and drug interactions in the minor groove of DNA.
|
| |
Nucleic Acids Res, 30,
1182-1191.
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|
|
|
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|
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M.E.Vázquez,
A.M.Caamaño,
J.Martínez-Costas,
L.Castedo,
and
J.L.Mascareñas
(2001).
Design and Synthesis of a Peptide That Binds Specific DNA Sequences through Simultaneous Interaction in the Major and in the Minor Groove This work was supported by the Spanish M.E.C. (PB97-0524) and the Xunta de Galicia (PGIDT00PXI20912PR). M.E.V. and A.M.C. thank the Xunta de Galicia and the University of Santiago for their predoctoral fellowships. We are very grateful to Prof. G. L. Verdine for his input and support in the early phases of this work. We also thank Prof. J. Benavente for allowing us to use the radioactivity facilities and Prof. C. Abell for critical reading of the manuscript.
|
| |
Angew Chem Int Ed Engl, 40,
4723-4725.
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|
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M.Thompson,
and
N.W.Woodbury
(2001).
Thermodynamics of specific and nonspecific DNA binding by two DNA-binding domains conjugated to fluorescent probes.
|
| |
Biophys J, 81,
1793-1804.
|
|
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|
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|
|
W.Ross,
A.Ernst,
and
R.L.Gourse
(2001).
Fine structure of E. coli RNA polymerase-promoter interactions: alpha subunit binding to the UP element minor groove.
|
| |
Genes Dev, 15,
491-506.
|
|
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|
|
|
E.d'Alençon,
and
S.D.Ehrlich
(2000).
A study of the CopF repressor of plasmid pAMbeta1 by phage display.
|
| |
J Bacteriol, 182,
2973-2977.
|
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|
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|
|
L.Jen-Jacobson,
L.E.Engler,
and
L.A.Jacobson
(2000).
Structural and thermodynamic strategies for site-specific DNA binding proteins.
|
| |
Structure, 8,
1015-1023.
|
|
|
|
|
|
|
L.Tang,
J.Li,
D.S.Katz,
and
J.A.Feng
(2000).
Determining the DNA bending angle induced by non-specific high mobility group-1 (HMG-1) proteins: a novel method.
|
| |
Biochemistry, 39,
3052-3060.
|
|
|
|
|
|
|
N.M.Luscombe,
S.E.Austin,
H.M.Berman,
and
J.M.Thornton
(2000).
An overview of the structures of protein-DNA complexes.
|
| |
Genome Biol, 1,
REVIEWS001.
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|
|
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|
A.A.Vaguine,
J.Richelle,
and
S.J.Wodak
(1999).
SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model.
|
| |
Acta Crystallogr D Biol Crystallogr, 55,
191-205.
|
|
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|
|
|
|
H.E.Xu,
M.A.Rould,
W.Xu,
J.A.Epstein,
R.L.Maas,
and
C.O.Pabo
(1999).
Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding.
|
| |
Genes Dev, 13,
1263-1275.
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PDB code:
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R.H.Plasterk,
Z.Izsvák,
and
Z.Ivics
(1999).
Resident aliens: the Tc1/mariner superfamily of transposable elements.
|
| |
Trends Genet, 15,
326-332.
|
|
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|
|
|
|
S.M.Lewis
(1999).
Evolution of immunoglobulin and T-cell receptor gene assembly.
|
| |
Ann N Y Acad Sci, 870,
58-67.
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|
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|
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|
|
T.Kophengnavong,
A.S.Carroll,
and
T.K.Blackwell
(1999).
The SKN-1 amino-terminal arm is a DNA specificity segment.
|
| |
Mol Cell Biol, 19,
3039-3050.
|
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|
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U.Zügel,
and
S.H.Kaufmann
(1999).
Role of heat shock proteins in protection from and pathogenesis of infectious diseases.
|
| |
Clin Microbiol Rev, 12,
19-39.
|
|
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|
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|
|
W.S.Tzou,
and
M.J.Hwang
(1999).
Modeling helix-turn-helix protein-induced DNA bending with knowledge-based distance restraints.
|
| |
Biophys J, 77,
1191-1205.
|
|
|
|
|
|
|
Y.Komeiji,
and
M.Uebayasi
(1999).
Change in conformation by DNA-peptide association: molecular dynamics of the Hin-recombinase-hixL complex.
|
| |
Biophys J, 77,
123-138.
|
|
|
|
|
|
|
A.C.Martin,
C.A.Orengo,
E.G.Hutchinson,
S.Jones,
M.Karmirantzou,
R.A.Laskowski,
J.B.Mitchell,
C.Taroni,
and
J.M.Thornton
(1998).
Protein folds and functions.
|
| |
Structure, 6,
875-884.
|
|
|
|
|
|
|
C.R.Robinson,
and
S.G.Sligar
(1998).
Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease.
|
| |
Proc Natl Acad Sci U S A, 95,
2186-2191.
|
|
|
|
|
|
|
F.Nagawa,
K.Ishiguro,
A.Tsuboi,
T.Yoshida,
A.Ishikawa,
T.Takemori,
A.J.Otsuka,
and
H.Sakano
(1998).
Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.
|
| |
Mol Cell Biol, 18,
655-663.
|
|
|
|
|
|
|
J.P.Schneider,
A.Lombardi,
and
W.F.DeGrado
(1998).
Analysis and design of three-stranded coiled coils and three-helix bundles.
|
| |
Fold Des, 3,
R29-R40.
|
|
|
|
|
|
|
O.Z.Nanassy,
and
K.T.Hughes
(1998).
In vivo identification of intermediate stages of the DNA inversion reaction catalyzed by the Salmonella Hin recombinase.
|
| |
Genetics, 149,
1649-1663.
|
|
|
|
|
|
|
P.C.Swanson,
and
S.Desiderio
(1998).
V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.
|
| |
Immunity, 9,
115-125.
|
|
|
|
|
|
|
R.E.Bremer,
E.E.Baird,
and
P.B.Dervan
(1998).
Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch.
|
| |
Chem Biol, 5,
119-133.
|
|
|
|
|
|
|
S.K.Merickel,
M.J.Haykinson,
and
R.C.Johnson
(1998).
Communication between Hin recombinase and Fis regulatory subunits during coordinate activation of Hin-catalyzed site-specific DNA inversion.
|
| |
Genes Dev, 12,
2803-2816.
|
|
|
|
|
|
|
B.Hallet,
and
D.J.Sherratt
(1997).
Transposition and site-specific recombination: adapting DNA cut-and-paste mechanisms to a variety of genetic rearrangements.
|
| |
FEMS Microbiol Rev, 21,
157-178.
|
|
|
|
|
|
|
D.E.Wemmer,
and
P.B.Dervan
(1997).
Targeting the minor groove of DNA.
|
| |
Curr Opin Struct Biol, 7,
355-361.
|
|
|
|
|
|
|
D.Kosztin,
T.C.Bishop,
and
K.Schulten
(1997).
Binding of the estrogen receptor to DNA. The role of waters.
|
| |
Biophys J, 73,
557-570.
|
|
|
|
|
|
|
G.van Pouderoyen,
R.F.Ketting,
A.Perrakis,
R.H.Plasterk,
and
T.K.Sixma
(1997).
Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.
|
| |
EMBO J, 16,
6044-6054.
|
|
|
PDB code:
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|
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|
|
|
H.Bahl,
H.Scholz,
N.Bayan,
M.Chami,
G.Leblon,
T.Gulik-Krzywicki,
E.Shechter,
A.Fouet,
S.Mesnage,
E.Tosi-Couture,
P.Gounon,
M.Mock,
E.Conway de Macario,
A.J.Macario,
L.A.Fernández-Herrero,
G.Olabarría,
J.Berenguer,
M.J.Blaser,
B.Kuen,
W.Lubitz,
M.Sára,
P.H.Pouwels,
C.P.Kolen,
H.J.Boot,
and
S.Resch
(1997).
Molecular biology of S-layers.
|
| |
FEMS Microbiol Rev, 20,
47-98.
|
|
|
|
|
|
|
R.E.Dickerson,
and
T.K.Chiu
(1997).
Helix bending as a factor in protein/DNA recognition.
|
| |
Biopolymers, 44,
361-403.
|
|
|
|
|
|
|
S.M.Lewis,
and
G.E.Wu
(1997).
The origins of V(D)J recombination.
|
| |
Cell, 88,
159-162.
|
|
|
|
|
|
|
Z.Kozmik,
T.Czerny,
and
M.Busslinger
(1997).
Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8.
|
| |
EMBO J, 16,
6793-6803.
|
|
|
|
|
|
|
C.R.Robinson,
and
S.G.Sligar
(1996).
Participation of water in Hin recombinase--DNA recognition.
|
| |
Protein Sci, 5,
2119-2124.
|
|
|
|
|
|
|
E.Spanopoulou,
F.Zaitseva,
F.H.Wang,
S.Santagata,
D.Baltimore,
and
G.Panayotou
(1996).
The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination.
|
| |
Cell, 87,
263-276.
|
|
|
|
|
|
|
J.C.Alonso,
S.Ayora,
I.Canosa,
F.Weise,
and
F.Rojo
(1996).
Site-specific recombination in gram-positive theta-replicating plasmids.
|
| |
FEMS Microbiol Lett, 142,
1.
|
|
|
|
|
|
|
K.J.Vogan,
D.A.Underhill,
and
P.Gros
(1996).
An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity.
|
| |
Mol Cell Biol, 16,
6677-6686.
|
|
|
|
|
|
|
L.J.Donald,
I.V.Chernushevich,
J.Zhou,
A.Verentchikov,
N.Poppe-Schriemer,
D.J.Hosfield,
J.B.Westmore,
W.Ens,
H.W.Duckworth,
and
K.G.Standing
(1996).
Preparation and properties of pure, full-length IclR protein of Escherichia coli. Use of time-of-flight mass spectrometry to investigate the problems encountered.
|
| |
Protein Sci, 5,
1613-1624.
|
|
|
|
|
|
|
M.J.Difilippantonio,
C.J.McMahan,
Q.M.Eastman,
E.Spanopoulou,
and
D.G.Schatz
(1996).
RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.
|
| |
Cell, 87,
253-262.
|
|
|
|
|
|
|
M.J.Haykinson,
L.M.Johnson,
J.Soong,
and
R.C.Johnson
(1996).
The Hin dimer interface is critical for Fis-mediated activation of the catalytic steps of site-specific DNA inversion.
|
| |
Curr Biol, 6,
163-177.
|
|
|
|
|
|
|
T.Härd,
and
T.Lundbäck
(1996).
Thermodynamics of sequence-specific protein-DNA interactions.
|
| |
Biophys Chem, 62,
121-139.
|
|
|
|
|
|
|
A.P.Eijkelenboom,
R.A.Lutzke,
R.Boelens,
R.H.Plasterk,
R.Kaptein,
and
K.Hård
(1995).
The DNA-binding domain of HIV-1 integrase has an SH3-like fold.
|
| |
Nat Struct Biol, 2,
807-810.
|
|
|
|
|
|
|
C.R.Robinson,
and
S.G.Sligar
(1995).
Heterogeneity in molecular recognition by restriction endonucleases: osmotic and hydrostatic pressure effects on BamHI, Pvu II, and EcoRV specificity.
|
| |
Proc Natl Acad Sci U S A, 92,
3444-3448.
|
|
|
|
|
|
|
F.Rojo,
and
J.C.Alonso
(1995).
The beta recombinase of plasmid pSM19035 binds to two adjacent sites, making different contacts at each of them.
|
| |
Nucleic Acids Res, 23,
3181-3188.
|
|
|
|
|
|
|
F.W.Rozsa,
P.Viollier,
M.Fussenegger,
R.Hiestand-Nauer,
and
W.Arber
(1995).
Cin-mediated recombination at secondary crossover sites on the Escherichia coli chromosome.
|
| |
J Bacteriol, 177,
1159-1168.
|
|
|
|
|
|
|
G.Siligardi,
and
A.F.Drake
(1995).
The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides.
|
| |
Biopolymers, 37,
281-292.
|
|
|
|
|
|
|
J.E.Mueller,
D.Smith,
M.Bryk,
and
M.Belfort
(1995).
Intron-encoded endonuclease I-TevI binds as a monomer to effect sequential cleavage via conformational changes in the td homing site.
|
| |
EMBO J, 14,
5724-5735.
|
|
|
|
|
|
|
J.Janin
(1995).
Elusive affinities.
|
| |
Proteins, 21,
30-39.
|
|
|
|
|
|
|
K.E.Sanderson,
A.Hessel,
and
K.E.Rudd
(1995).
Genetic map of Salmonella typhimurium, edition VIII.
|
| |
Microbiol Rev, 59,
241-303.
|
|
|
|
|
|
|
L.Spaeny-Dekking,
E.Schlicher,
K.Franken,
P.van de Putte,
and
N.Goosen
(1995).
Gin mutants that can be suppressed by a Fis-independent mutation.
|
| |
J Bacteriol, 177,
222-228.
|
|
|
|
|
|
|
M.Oram,
M.D.Szczelkun,
and
S.E.Halford
(1995).
Recombination. Pieces of the site-specific recombination puzzle.
|
| |
Curr Biol, 5,
1106-1109.
|
|
|
|
|
|
|
M.Suzuki,
and
M.Gerstein
(1995).
Binding geometry of alpha-helices that recognize DNA.
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| |
Proteins, 23,
525-535.
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M.Suzuki,
and
N.Yagi
(1995).
Stereochemical basis of DNA bending by transcription factors.
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| |
Nucleic Acids Res, 23,
2083-2091.
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R.T.Sauer
(1995).
Minor groove DNA-recognition by alpha-helices.
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| |
Nat Struct Biol, 2,
7-9.
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|
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W.Yang,
and
T.A.Steitz
(1995).
Crystal structure of the site-specific recombinase gamma delta resolvase complexed with a 34 bp cleavage site.
|
| |
Cell, 82,
193-207.
|
|
|
PDB code:
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C.E.Pritchard,
J.A.Grasby,
F.Hamy,
A.M.Zacharek,
M.Singh,
J.Karn,
and
M.J.Gait
(1994).
Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins.
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| |
Nucleic Acids Res, 22,
2592-2600.
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|
D.A.Erlanson,
and
G.L.Verdine
(1994).
Falling out of the fold: tumorigenic mutations and p53.
|
| |
Chem Biol, 1,
79-84.
|
|
|
|
|
|
|
E.Liepinsh,
W.Leupin,
and
G.Otting
(1994).
Hydration of DNA in aqueous solution: NMR evidence for a kinetic destabilization of the minor groove hydration of d-(TTAA)2 versus d-(AATT)2 segments.
|
| |
Nucleic Acids Res, 22,
2249-2254.
|
|
|
|
|
|
|
F.F.Damberger,
J.G.Pelton,
C.J.Harrison,
H.C.Nelson,
and
D.E.Wemmer
(1994).
Solution structure of the DNA-binding domain of the heat shock transcription factor determined by multidimensional heteronuclear magnetic resonance spectroscopy.
|
| |
Protein Sci, 3,
1806-1821.
|
|
|
PDB code:
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|
|
G.W.Blakely,
and
D.J.Sherratt
(1994).
Interactions of the site-specific recombinases XerC and XerD with the recombination site dif.
|
| |
Nucleic Acids Res, 22,
5613-5620.
|
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|
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H.Sandmeier
(1994).
Acquisition and rearrangement of sequence motifs in the evolution of bacteriophage tail fibres.
|
| |
Mol Microbiol, 12,
343-350.
|
|
|
|
|
|
|
J.Fukushima,
T.Ishiwata,
M.Kurata,
Z.You,
and
K.Okuda
(1994).
Intracellular receptor-type transcription factor, LasR, contains a highly conserved amphipathic region which precedes the putative helix-turn-helix DNA binding motif.
|
| |
Nucleic Acids Res, 22,
3706-3707.
|
|
|
|
|
|
|
J.Pfau,
D.N.Arvidson,
and
P.Youderian
(1994).
Mutants of Escherichia coli Trp repressor with changes of conserved, helix-turn-helix residue threonine 81 have altered DNA-binding specificities.
|
| |
Mol Microbiol, 13,
1001-1012.
|
|
|
|
|
|
|
K.Ogata,
S.Morikawa,
H.Nakamura,
A.Sekikawa,
T.Inoue,
H.Kanai,
A.Sarai,
S.Ishii,
and
Y.Nishimura
(1994).
Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices.
|
| |
Cell, 79,
639-648.
|
|
|
PDB codes:
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|
|
M.Suzuki,
and
N.Yagi
(1994).
DNA recognition code of transcription factors in the helix-turn-helix, probe helix, hormone receptor, and zinc finger families.
|
| |
Proc Natl Acad Sci U S A, 91,
12357-12361.
|
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|
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R.T.Clubb,
J.G.Omichinski,
H.Savilahti,
K.Mizuuchi,
A.M.Gronenborn,
and
G.M.Clore
(1994).
A novel class of winged helix-turn-helix protein: the DNA-binding domain of Mu transposase.
|
| |
Structure, 2,
1041-1048.
|
|
|
PDB codes:
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T.Liu,
E.F.DeRose,
and
G.P.Mullen
(1994).
Determination of the structure of the DNA binding domain of gamma delta resolvase in solution.
|
| |
Protein Sci, 3,
1286-1295.
|
|
|
PDB codes:
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V.Gindilis,
M.Banikazemi,
A.Vyasankin,
O.Verlinsky,
I.Matveyev,
and
Y.Verlinsky
(1994).
Review: borders, patterns, and distinctive families of homeodomains.
|
| |
J Assist Reprod Genet, 11,
244-269.
|
|
|
|
|
|
|
W.J.Gehring,
Y.Q.Qian,
M.Billeter,
K.Furukubo-Tokunaga,
A.F.Schier,
D.Resendez-Perez,
M.Affolter,
G.Otting,
and
K.Wüthrich
(1994).
Homeodomain-DNA recognition.
|
| |
Cell, 78,
211-223.
|
|
|
|
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|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
