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Complex (gtp-binding/transducer) PDB id
1gp2
Jmol
Contents
Protein chains
344 a.a. *
339 a.a. *
54 a.a. *
Ligands
GDP
Waters ×390
* Residue conservation analysis
PDB id:
1gp2
Name: Complex (gtp-binding/transducer)
Title: G protein heterotrimer gi_alpha_1 beta_1 gamma_2 with gdp bound
Structure: G protein gi alpha 1. Chain: a. Fragment: alpha 1. Engineered: yes. G protein gi beta 1. Chain: b. Fragment: beta 1. Engineered: yes. G protein gi gamma 2.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.
Biol. unit: Trimer (from PQS)
Resolution:
2.30Å     R-factor:   0.226     R-free:   0.307
Authors: M.A.Wall,S.R.Sprang
Key ref: M.A.Wall et al. (1995). The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell, 83, 1047-1058. PubMed id: 8521505 DOI: 10.1016/0092-8674(95)90220-1
Date:
13-Nov-96     Release date:   12-Feb-97    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P10824  (GNAI1_RAT) -  Guanine nucleotide-binding protein G(i) subunit alpha-1
Seq:
Struc: 		354 a.a.
344 a.a.
Protein chain
Pfam   ArchSchema ?
P62871  (GBB1_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Seq:
Struc: 		340 a.a.
339 a.a.
Protein chain
Pfam   ArchSchema ?
P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Seq:
Struc: 		71 a.a.
54 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   14 terms 
  Biological process     cell cycle   11 terms 
  Biochemical function     nucleotide binding     10 terms  

 

 
DOI no: 10.1016/0092-8674(95)90220-1 Cell 83:1047-1058 (1995)
PubMed id: 8521505  
 
 
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
M.A.Wall, D.E.Coleman, E.Lee, J.A.Iñiguez-Lluhi, B.A.Posner, A.G.Gilman, S.R.Sprang.
 
  ABSTRACT  
 
The crystallographic structure of the G protein heterotrimer Gi alpha 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of contact between alpha and beta, an extended interface between beta and nearly all of gamma, and limited interaction of alpha with gamma. The major alpha/beta interface covers switch II of alpha, and GTP-induced rearrangement of switch II causes subunit dissociation during signaling. Alterations in GDP binding in the heterotrimer (compared with alpha-GDP) explain stabilization of the inactive conformation of alpha by beta gamma. Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21468892 C.Xu, and J.Min (2011).
Structure and function of WD40 domain proteins.
  Protein Cell, 2, 202-214.
PDB codes: 3e0c 3fm0 3i2n 3ow8
21337626 L.M.Simpson, I.D.Wall, F.E.Blaney, and C.A.Reynolds (2011).
Modeling GPCR active state conformations: The β(2) -adrenergic receptor.
  Proteins, 79, 1441-1457.  
21064128 M.S.Park, A.V.Smrcka, and H.A.Stern (2011).
Conformational flexibility and binding interactions of the G protein βγ heterodimer.
  Proteins, 79, 518-527.  
20639466 A.Nishimura, K.Kitano, J.Takasaki, M.Taniguchi, N.Mizuno, K.Tago, T.Hakoshima, and H.Itoh (2010).
Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule.
  Proc Natl Acad Sci U S A, 107, 13666-13671.
PDB code: 3ah8
20119640 A.Strasser, and H.J.Wittmann (2010).
Distinct interactions between the human adrenergic beta(2) receptor and Galpha(s)--an in silico study.
  J Mol Model, 16, 1307-1318.  
20018744 A.V.Smrcka, N.Kichik, T.Tarragó, M.Burroughs, M.S.Park, N.K.Itoga, H.A.Stern, B.M.Willardson, and E.Giralt (2010).
NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.
  Proc Natl Acad Sci U S A, 107, 639-644.  
20976244 B.R.Temple, C.D.Jones, and A.M.Jones (2010).
Evolution of a signaling nexus constrained by protein interfaces and conformational States.
  PLoS Comput Biol, 6, e1000962.  
20451393 C.U.Stirnimann, E.Petsalaki, R.B.Russell, and C.W.Müller (2010).
WD40 proteins propel cellular networks.
  Trends Biochem Sci, 35, 565-574.  
20974918 C.Xu, C.Bian, W.Yang, M.Galka, H.Ouyang, C.Chen, W.Qiu, H.Liu, A.E.Jones, F.MacKenzie, P.Pan, S.S.Li, H.Wang, and J.Min (2010).
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
  Proc Natl Acad Sci U S A, 107, 19266-19271.
PDB codes: 3jpx 3jzg 3jzh 3jzn 3k26 3k27
20520658 J.J.Tesmer (2010).
The quest to understand heterotrimeric G protein signaling.
  Nat Struct Mol Biol, 17, 650-652.  
20529362 K.A.Gonçalves, J.C.Borges, J.C.Silva, P.F.Papa, G.C.Bressan, I.L.Torriani, and J.Kobarg (2010).
Solution structure of the human signaling protein RACK1.
  BMC Struct Biol, 10, 15.  
20383734 M.Ambrosio, F.Fanelli, S.Brocchetti, F.Raimondi, M.Mauri, G.E.Rovati, and V.Capra (2010).
Superactive mutants of thromboxane prostanoid receptor: functional and computational analysis of an active form alternative to constitutively active mutants.
  Cell Mol Life Sci, 67, 2979-2989.  
20016006 R.Navarro-Olmos, L.Kawasaki, L.Domínguez-Ramírez, L.Ongay-Larios, R.Pérez-Molina, and R.Coria (2010).
The beta subunit of the heterotrimeric G protein triggers the Kluyveromyces lactis pheromone response pathway in the absence of the gamma subunit.
  Mol Biol Cell, 21, 489-498.  
19927323 X.H.Wu, H.Zhang, and Y.D.Wu (2010).
Is Asp-His-Ser/Thr-Trp tetrad hydrogen-bond network important to WD40-repeat proteins: a statistical and theoretical study.
  Proteins, 78, 1186-1194.  
19456859 A.Faussner, G.Wennerberg, S.Schüssler, J.Feierler, C.Seidl, M.Jochum, and D.Proud (2009).
Alanine screening of the intracellular loops of the human bradykinin B receptor--effects on receptor maintenance, G protein activation and internalization.
  FEBS J, 276, 3491-3503.  
19629046 A.Guilfoyle, M.J.Maher, M.Rapp, R.Clarke, S.Harrop, and M.Jormakka (2009).
Structural basis of GDP release and gating in G protein coupled Fe2+ transport.
  EMBO J, 28, 2677-2685.
PDB codes: 3hyr 3hyt
18834311 D.J.Dupré, M.Robitaille, R.V.Rebois, and T.E.Hébert (2009).
The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.
  Annu Rev Pharmacol Toxicol, 49, 31-56.  
19521673 G.R.Anderson, E.Posokhova, and K.A.Martemyanov (2009).
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.
  Cell Biochem Biophys, 54, 33-46.  
19760664 H.E.Hamm, S.M.Meier, G.Liao, and A.M.Preininger (2009).
Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.
  Protein Sci, 18, 2326-2335.  
19369247 J.Wang, P.Sengupta, Y.Guo, U.Golebiewska, and S.Scarlata (2009).
Evidence for a Second, High Affinity G{beta}{gamma} Binding Site on G{alpha}i1(GDP) Subunits.
  J Biol Chem, 284, 16906-16913.  
19361438 J.Wang, U.Golebiewska, and S.Scarlata (2009).
A self-scaffolding model for G protein signaling.
  J Mol Biol, 387, 92.  
19437048 K.Khafizov (2009).
GoLoco motif proteins binding to Galpha(i1): insights from molecular simulations.
  J Mol Model, 15, 1491-1499.  
19211784 M.Garcia-Marcos, P.Ghosh, and M.G.Farquhar (2009).
GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.
  Proc Natl Acad Sci U S A, 106, 3178-3183.  
19806206 R.Prasobh, and N.Manoj (2009).
The repertoire of heterotrimeric G proteins and RGS proteins in Ciona intestinalis.
  PLoS One, 4, e7349.  
19783621 R.Sadana, N.Dascal, and C.W.Dessauer (2009).
N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer.
  Mol Pharmacol, 76, 1256-1264.  
19306928 S.Ye, K.T.Nguyen, S.V.Le Clair, and Z.Chen (2009).
In situ molecular level studies on membrane related peptides and proteins in real time using sum frequency generation vibrational spectroscopy.
  J Struct Biol, 168, 61-77.  
19212142 W.E.McIntire (2009).
Structural determinants involved in the formation and activation of G protein betagamma dimers.
  Neurosignals, 17, 82-99.  
18975915 A.Goc, T.E.Angel, B.Jastrzebska, B.Wang, P.L.Wintrode, and K.Palczewski (2008).
Different properties of the native and reconstituted heterotrimeric G protein transducin.
  Biochemistry, 47, 12409-12419.  
18771287 A.M.Preininger, J.Parello, S.M.Meier, G.Liao, and H.E.Hamm (2008).
Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins.
  Biochemistry, 47, 10281-10293.  
18258741 A.R.Zurita, and L.Birnbaumer (2008).
The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits.
  Proc Natl Acad Sci U S A, 105, 2363-2368.  
18488142 A.V.Smrcka (2008).
G protein betagamma subunits: central mediators of G protein-coupled receptor signaling.
  Cell Mol Life Sci, 65, 2191-2214.  
18537559 A.V.Smrcka, D.M.Lehmann, and A.L.Dessal (2008).
G protein betagamma subunits as targets for small molecule therapeutic development.
  Comb Chem High Throughput Screen, 11, 382-395.  
18373982 B.T.Layden, W.Saengsawang, R.J.Donati, S.Yang, D.C.Mulhearn, M.E.Johnson, and M.M.Rasenick (2008).
Structural model of a complex between the heterotrimeric G protein, Gsalpha, and tubulin.
  Biochim Biophys Acta, 1783, 964-973.  
18537558 C.A.Johnston, F.S.Willard, J.K.Ramer, R.Blaesius, C.N.Roques, and D.P.Siderovski (2008).
State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.
  Comb Chem High Throughput Screen, 11, 370-381.  
18541531 C.J.Thomas, G.G.Tall, A.Adhikari, and S.R.Sprang (2008).
Ric-8A Catalyzes Guanine Nucleotide Exchange on G{alpha}i1 Bound to the GPR/GoLoco Exchange Inhibitor AGS3.
  J Biol Chem, 283, 23150-23160.  
  18302803 D.Rakotobe, S.Violot, S.S.Hong, P.Gouet, and P.Boulanger (2008).
Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED.
  Virol J, 5, 32.  
18984596 F.S.Willard, Z.Zheng, J.Guo, G.J.Digby, A.J.Kimple, J.M.Conley, C.A.Johnston, D.Bosch, M.D.Willard, V.J.Watts, N.A.Lambert, S.R.Ikeda, Q.Du, and D.P.Siderovski (2008).
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
  J Biol Chem, 283, 36698-36710.  
18715992 H.Ullah, E.L.Scappini, A.F.Moon, L.V.Williams, D.L.Armstrong, and L.C.Pedersen (2008).
Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana.
  Protein Sci, 17, 1771-1780.
PDB code: 3dm0
18454845 K.Sayar, O.UÄŸur, T.Liu, V.J.Hilser, and O.Onaran (2008).
Exploring allosteric coupling in the alpha-subunit of Heterotrimeric G proteins using evolutionary and ensemble-based approaches.
  BMC Struct Biol, 8, 23.  
18611861 M.Buscarlet, A.Perin, A.Laing, J.M.Brickman, and S.Stifani (2008).
Inhibition of Cortical Neuron Differentiation by Groucho/TLE1 Requires Interaction with WRPW, but Not Eh1, Repressor Peptides.
  J Biol Chem, 283, 24881-24888.  
18647648 M.Crouthamel, M.M.Thiyagarajan, D.S.Evanko, and P.B.Wedegaertner (2008).
N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).
  Cell Signal, 20, 1900-1910.  
18636747 M.Katadae, K.Hagiwara, A.Wada, M.Ito, M.Umeda, P.J.Casey, and Y.Fukada (2008).
Interacting targets of the farnesyl of transducin gamma-subunit.
  Biochemistry, 47, 8424-8433.  
18782760 M.Kosloff, E.Alexov, V.Y.Arshavsky, and B.Honig (2008).
Electrostatic and Lipid Anchor Contributions to the Interaction of Transducin with Membranes: MECHANISTIC IMPLICATIONS FOR ACTIVATION AND TRANSLOCATION.
  J Biol Chem, 283, 31197-31207.  
  19025606 M.Y.Yu, M.K.Ho, A.M.Liu, and Y.H.Wong (2008).
Mutations on the Switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectors.
  J Mol Signal, 3, 17.  
18769712 N.Iwanami, T.Higuchi, Y.Sasano, T.Fujiwara, V.Q.Hoa, M.Okada, S.R.Talukder, S.Kunimatsu, J.Li, F.Saito, C.Bhattacharya, A.Matin, T.Sasaki, N.Shimizu, H.Mitani, H.Himmelbauer, A.Momoi, H.Kondoh, M.Furutani-Seiki, and Y.Takahama (2008).
WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development.
  PLoS Genet, 4, e1000171.  
18842000 R.A.Edwards, M.S.Lee, S.E.Tsutakawa, R.S.Williams, J.A.Tainer, and J.N.Glover (2008).
The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.
  Biochemistry, 47, 11446-11456.  
17978098 S.C.Strickfaden, and P.M.Pryciak (2008).
Distinct Roles for Two G{alpha} G Interfaces in Cell Polarity Control by a Yeast Heterotrimeric G Protein.
  Mol Biol Cell, 19, 181-197.  
17989959 S.Massaro, T.Zlateva, V.Torre, and L.Quaroni (2008).
Detection of molecular processes in the intact retina by ATR-FTIR spectromicroscopy.
  Anal Bioanal Chem, 390, 317-322.  
18483215 T.Suganuma, S.G.Pattenden, and J.L.Workman (2008).
Diverse functions of WD40 repeat proteins in histone recognition.
  Genes Dev, 22, 1265-1268.  
  18209068 V.Gupta, J.L.Alonso, T.Sugimori, M.Essafi, M.Issafi, J.P.Xiong, and M.A.Arnaout (2008).
Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function.
  J Immunol, 180, 1713-1718.  
18043707 W.M.Oldham, and H.E.Hamm (2008).
Heterotrimeric G protein activation by G-protein-coupled receptors.
  Nat Rev Mol Cell Biol, 9, 60-71.  
18922469 Y.Xu, Y.Chen, P.Zhang, P.D.Jeffrey, and Y.Shi (2008).
Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
  Mol Cell, 31, 873-885.
PDB code: 3dw8
17962409 A.F.Neuwald (2007).
Galpha Gbetagamma dissociation may be due to retraction of a buried lysine and disruption of an aromatic cluster by a GTP-sensing Arg Trp pair.
  Protein Sci, 16, 2570-2577.  
  17971232 A.V.Andreeva, M.A.Kutuzov, and T.A.Voyno-Yasenetskaya (2007).
Scaffolding proteins in G-protein signaling.
  J Mol Signal, 2, 13.  
17684011 E.N.Nikolov, and T.T.Ivanova-Nikolova (2007).
Dynamic integration of alpha-adrenergic and cholinergic signals in the atria: role of G protein-regulated inwardly rectifying K+ channels.
  J Biol Chem, 282, 28669-28682.  
17882334 F.Mancia, and W.A.Hendrickson (2007).
Expression of recombinant G-protein coupled receptors for structural biology.
  Mol Biosyst, 3, 723-734.  
17973867 H.G.Zhang, X.H.Li, J.Z.Zhou, Y.Liu, Y.Jia, and Z.B.Yuan (2007).
G(alphaq)-protein carboxyl terminus imitation polypeptide GCIP-27 attenuates cardiac hypertrophy in vitro and in vivo.
  Clin Exp Pharmacol Physiol, 34, 1276-1281.  
17240454 J.B.Blumer, A.V.Smrcka, and S.M.Lanier (2007).
Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling.
  Pharmacol Ther, 113, 488-506.  
17242511 J.Bosch, T.Tamura, N.Tamura, W.Baumeister, and L.O.Essen (2007).
The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology.
  Acta Crystallogr D Biol Crystallogr, 63, 179-187.
PDB code: 2gop
17264208 J.Napetschnig, G.Blobel, and A.Hoelz (2007).
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN.
  Proc Natl Acad Sci U S A, 104, 1783-1788.
PDB code: 2oit
17588669 L.S.Weinstein, T.Xie, Q.H.Zhang, and M.Chen (2007).
Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.
  Pharmacol Ther, 115, 271-291.  
17708769 M.Tanaka-Kunishima, Y.Ishida, K.Takahashi, M.Honda, and T.Oonuma (2007).
Ancient intron insertion sites and palindromic genomic duplication evolutionally shapes an elementally functioning membrane protein family.
  BMC Evol Biol, 7, 143.  
17984965 S.D.Taverna, H.Li, A.J.Ruthenburg, C.D.Allis, and D.J.Patel (2007).
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.
  Nat Struct Mol Biol, 14, 1025-1040.  
17584745 T.Niranjan, X.Guo, J.Victor, A.Lu, and J.P.Hirsch (2007).
Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange.
  J Biol Chem, 282, 24231-24238.  
17200862 T.Wieland (2007).
Interaction of nucleoside diphosphate kinase B with heterotrimeric G protein betagamma dimers: consequences on G protein activation and stability.
  Naunyn Schmiedebergs Arch Pharmacol, 374, 373-383.  
17937914 V.Srinivasan, D.J.Netz, H.Webert, J.Mascarenhas, A.J.Pierik, H.Michel, and R.Lill (2007).
Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.
  Structure, 15, 1246-1257.
PDB code: 2hes
17463080 W.M.Oldham, N.Van Eps, A.M.Preininger, W.L.Hubbell, and H.E.Hamm (2007).
Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins.
  Proc Natl Acad Sci U S A, 104, 7927-7932.  
17216128 X.Xie, Z.Wang, and Y.Chen (2007).
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.
  Mol Cell Biochem, 301, 115-122.  
17094082 Y.Zheng, D.Xu, and X.Gu (2007).
Functional divergence after gene duplication and sequence-structure relationship: a case study of G-protein alpha subunits.
  J Exp Zoolog B Mol Dev Evol, 308, 85-96.  
17937919 Z.Han, X.Xing, M.Hu, Y.Zhang, P.Liu, and J.Chai (2007).
Structural basis of EZH2 recognition by EED.
  Structure, 15, 1306-1315.
PDB code: 2qxv
16407068 B.A.Appleton, P.Wu, and C.Wiesmann (2006).
The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes.
  Structure, 14, 87-96.
PDB codes: 2aq5 2b4e
16762837 B.H.Jennings, L.M.Pickles, S.M.Wainwright, S.M.Roe, L.H.Pearl, and D.Ish-Horowicz (2006).
Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor.
  Mol Cell, 22, 645-655.
PDB codes: 2ce8 2ce9
16388592 B.Kreutz, D.M.Yau, M.R.Nance, S.Tanabe, J.J.Tesmer, and T.Kozasa (2006).
A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
  Biochemistry, 45, 167-174.
PDB codes: 1zca 1zcb
16698293 C.Hill, A.Goddard, J.Davey, and G.Ladds (2006).
Investigating RGS proteins in yeast.
  Semin Cell Dev Biol, 17, 352-362.  
16457939 E.H.Sklan, E.Podoly, and H.Soreq (2006).
RACK1 has the nerve to act: structure meets function in the nervous system.
  Prog Neurobiol, 78, 117-134.  
16704413 E.H.Wu, B.H.Tam, and Y.H.Wong (2006).
Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade.
  FEBS J, 273, 2388-2398.  
16957986 H.J.Hippe, and T.Wieland (2006).
High energy phosphate transfer by NDPK B/Gbetagammacomplexes--an alternative signaling pathway involved in the regulation of basal cAMP production.
  J Bioenerg Biomembr, 38, 197-203.  
16839886 J.E.Slessareva, S.M.Routt, B.Temple, V.A.Bankaitis, and H.G.Dohlman (2006).
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome.
  Cell, 126, 191-203.  
16683034 K.Fitzgerald, S.Tertyshnikova, L.Moore, L.Bjerke, B.Burley, J.Cao, P.Carroll, R.Choy, S.Doberstein, Y.Dubaquie, Y.Franke, J.Kopczynski, H.Korswagen, S.R.Krystek, N.J.Lodge, R.Plasterk, J.Starrett, T.Stouch, G.Thalody, H.Wayne, A.van der Linden, Y.Zhang, S.G.Walker, M.Cockett, J.Wardwell-Swanson, P.Ross-Macdonald, and R.M.Kindt (2006).
Chemical genetics reveals an RGS/G-protein role in the action of a compound.
  PLoS Genet, 2, e57.  
16754659 L.Dowal, P.Provitera, and S.Scarlata (2006).
Stable association between G alpha(q) and phospholipase C beta 1 in living cells.
  J Biol Chem, 281, 23999-24014.  
16537908 L.Wang, N.Jahren, M.L.Vargas, E.F.Andersen, J.Benes, J.Zhang, E.L.Miller, R.S.Jones, and J.A.Simon (2006).
Alternative ESC and ESC-like subunits of a polycomb group histone methyltransferase complex are differentially deployed during Drosophila development.
  Mol Cell Biol, 26, 2637-2647.  
17177891 M.A.Anderson, B.Ogbay, O.G.Kisselev, D.P.Cistola, and G.R.Marshall (2006).
Alternate binding mode of C-terminal phenethylamine analogs of G(t)alpha(340-350) to photoactivated rhodopsin.
  Chem Biol Drug Des, 68, 295-307.  
16498633 M.Waragai, S.Nagamitsu, W.Xu, Y.J.Li, X.Lin, and T.Ashizawa (2006).
Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit.
  J Neurosci Res, 83, 1170-1178.  
17053066 N.Van Eps, W.M.Oldham, H.E.Hamm, and W.L.Hubbell (2006).
Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway.
  Proc Natl Acad Sci U S A, 103, 16194-16199.  
16630274 R.Coria, L.Kawasaki, F.Torres-Quiroz, L.Ongay-Larios, E.Sánchez-Paredes, N.Velázquez-Zavala, R.Navarro-Olmos, M.Rodríguez-González, R.Aguilar-Corachán, and G.Coello (2006).
The pheromone response pathway of Kluyveromyces lactis.
  FEMS Yeast Res, 6, 336-344.  
16964240 S.Angers, T.Li, X.Yi, M.J.MacCoss, R.T.Moon, and N.Zheng (2006).
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
  Nature, 443, 590-593.
PDB code: 2hye
16888629 S.C.Lo, X.Li, M.T.Henzl, L.J.Beamer, and M.Hannink (2006).
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
  EMBO J, 25, 3605-3617.
PDB code: 2flu
16371464 S.K.Gibson, and A.G.Gilman (2006).
Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.
  Proc Natl Acad Sci U S A, 103, 212-217.  
17040904 S.Mukai, and Y.Fujiki (2006).
Molecular mechanisms of import of peroxisome-targeting signal type 2 (PTS2) proteins by PTS2 receptor Pex7p and PTS1 receptor Pex5pL.
  J Biol Chem, 281, 37311-37320.  
16980371 S.Zhong, J.M.Moix, S.Quirk, and R.Hernandez (2006).
Dihedral-angle information entropy as a gauge of secondary structure propensity.
  Biophys J, 91, 4014-4023.  
16413485 T.Li, X.Chen, K.C.Garbutt, P.Zhou, and N.Zheng (2006).
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
  Cell, 124, 105-117.
PDB codes: 2b5l 2b5m 2b5n
16627746 T.M.Bonacci, J.L.Mathews, C.Yuan, D.M.Lehmann, S.Malik, D.Wu, J.L.Font, J.M.Bidlack, and A.V.Smrcka (2006).
Differential targeting of Gbetagamma-subunit signaling with small molecules.
  Science, 312, 443-446.  
16428273 T.Mirshahi, D.E.Logothetis, and A.Rosenhouse-Dantsker (2006).
Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation.
  Biophys J, 90, 2776-2785.  
16407229 U.Hopfer, H.Hopfer, K.Jablonski, R.A.Stahl, and G.Wolf (2006).
The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3).
  J Biol Chem, 281, 8645-8655.  
16460808 V.V.Gurevich, and E.V.Gurevich (2006).
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors.
  Pharmacol Ther, 110, 465-502.  
16892066 W.M.Oldham, N.Van Eps, A.M.Preininger, W.L.Hubbell, and H.E.Hamm (2006).
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.
  Nat Struct Mol Biol, 13, 772-777.  
16382134 W.Zhang, C.S.Zong, U.Hermanto, P.Lopez-Bergami, Z.Ronai, and L.H.Wang (2006).
RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.
  Mol Cell Biol, 26, 413-424.  
16004878 C.A.Johnston, F.S.Willard, M.R.Jezyk, Z.Fredericks, E.T.Bodor, M.B.Jones, R.Blaesius, V.J.Watts, T.K.Harden, J.Sondek, J.K.Ramer, and D.P.Siderovski (2005).
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.
  Structure, 13, 1069-1080.
PDB code: 1y3a
16225870 C.A.Johnston, J.K.Ramer, R.Blaesius, Z.Fredericks, V.J.Watts, and D.P.Siderovski (2005).
A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity.
  FEBS Lett, 579, 5746-5750.  
15747061 C.R.McCudden, M.D.Hains, R.J.Kimple, D.P.Siderovski, and F.S.Willard (2005).
G-protein signaling: back to the future.
  Cell Mol Life Sci, 62, 551-577.  
15644329 D.K.Wilson, D.Cerna, and E.Chew (2005).
The 1.1-angstrom structure of the spindle checkpoint protein Bub3p reveals functional regions.
  J Biol Chem, 280, 13944-13951.
PDB code: 1yfq
16314508 J.Balk, D.J.Aguilar Netz, K.Tepper, A.J.Pierik, and R.Lill (2005).
The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly.
  Mol Cell Biol, 25, 10833-10841.  
15953547 L.Hennig, R.Bouveret, and W.Gruissem (2005).
MSI1-like proteins: an escort service for chromatin assembly and remodeling complexes.
  Trends Cell Biol, 15, 295-302.  
15866880 M.Frank, L.Thümer, M.J.Lohse, and M.Bünemann (2005).
G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region.
  J Biol Chem, 280, 24584-24590.  
16043514 M.Hölzel, M.Rohrmoser, M.Schlee, T.Grimm, T.Harasim, A.Malamoussi, A.Gruber-Eber, E.Kremmer, W.Hiddemann, G.W.Bornkamm, and D.Eick (2005).
Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation.
  J Cell Biol, 170, 367-378.  
16249682 M.W.Hollmann, D.Strumper, S.Herroeder, and M.E.Durieux (2005).
Receptors, G proteins, and their interactions.
  Anesthesiology, 103, 1066-1078.  
16041481 N.G.Abdulaev, C.Zhang, A.Dinh, T.Ngo, P.N.Bryan, D.M.Brabazon, J.P.Marino, and K.D.Ridge (2005).
Bacterial expression and one-step purification of an isotope-labeled heterotrimeric G-protein alpha-subunit.
  J Biomol NMR, 32, 31-40.  
16129667 N.G.Abdulaev, T.Ngo, C.Zhang, A.Dinh, D.M.Brabazon, K.D.Ridge, and J.P.Marino (2005).
Heterotrimeric G-protein alpha-subunit adopts a "preactivated" conformation when associated with betagamma-subunits.
  J Biol Chem, 280, 38071-38080.  
16230528 N.G.Kolev, and J.A.Steitz (2005).
Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs.
  Genes Dev, 19, 2583-2592.  
16103122 R.Pereira, and R.A.Cerione (2005).
A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor.
  J Biol Chem, 280, 35696-35703.  
16207360 R.Riley, C.Lee, C.Sabatti, and D.Eisenberg (2005).
Inferring protein domain interactions from databases of interacting proteins.
  Genome Biol, 6, R89.  
15665133 S.Scarlata (2005).
Determination of the activation volume of PLCbeta by Gbeta gamma-subunits through the use of high hydrostatic pressure.
  Biophys J, 88, 2867-2874.  
16287855 T.D.Miles, J.Jakovljevic, E.W.Horsey, P.Harnpicharnchai, L.Tang, and J.L.Woolford (2005).
Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes.
  Mol Cell Biol, 25, 10419-10432.  
16030250 T.Harashima, and J.Heitman (2005).
Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae.
  Mol Biol Cell, 16, 4557-4571.  
15611108 T.M.Bonacci, M.Ghosh, S.Malik, and A.V.Smrcka (2005).
Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.
  J Biol Chem, 280, 10174-10181.  
16339447 V.M.Tesmer, T.Kawano, A.Shankaranarayanan, T.Kozasa, and J.J.Tesmer (2005).
Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.
  Science, 310, 1686-1690.
PDB code: 2bcj
16373322 W.R.Leifert, A.L.Aloia, O.Bucco, and E.J.McMurchie (2005).
GPCR-induced dissociation of G-protein subunits in early stage signal transduction.
  Mol Membr Biol, 22, 507-517.  
15824105 X.Li, A.Hümmer, J.Han, M.Xie, K.Melnik-Martinez, R.L.Moreno, M.Buck, M.D.Mark, and S.Herlitze (2005).
G protein beta2 subunit-derived peptides for inhibition and induction of G protein pathways. Examination of voltage-gated Ca2+ and G protein inwardly rectifying K+ channels.
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14699056 A.Eugster, G.Frigerio, M.Dale, and R.Duden (2004).
The alpha- and beta'-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs.
  Mol Biol Cell, 15, 1011-1023.  
15282312 A.Kobayashi, M.I.Kang, H.Okawa, M.Ohtsuji, Y.Zenke, T.Chiba, K.Igarashi, and M.Yamamoto (2004).
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
  Mol Cell Biol, 24, 7130-7139.  
14593110 A.V.Skurat, and A.D.Dietrich (2004).
Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.
  J Biol Chem, 279, 2490-2498.  
15152089 A.Y.Madrona, and D.K.Wilson (2004).
The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure.
  Protein Sci, 13, 1557-1565.
PDB code: 1sq9
15105422 C.J.Doering, A.E.Kisilevsky, Z.P.Feng, M.I.Arnot, J.Peloquin, J.Hamid, W.Barr, A.Nirdosh, B.Simms, R.J.Winkfein, and G.W.Zamponi (2004).
A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels.
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15572112 C.Tarricone, F.Perrina, S.Monzani, L.Massimiliano, M.H.Kim, Z.S.Derewenda, S.Knapp, L.H.Tsai, and A.Musacchio (2004).
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.
  Neuron, 44, 809-821.
PDB code: 1vyh
15033976 J.D.Topp, N.W.Gray, R.D.Gerard, and B.F.Horazdovsky (2004).
Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.
  J Biol Chem, 279, 24612-24623.  
15006348 J.Dai, J.Liu, Y.Deng, T.M.Smith, and M.Lu (2004).
Structure and protein design of a human platelet function inhibitor.
  Cell, 116, 649-659.
PDB codes: 1s18 1s1d
15193154 J.H.Shin, J.W.Yang, M.Le Pecheur, J.London, H.Hoeger, and G.Lubec (2004).
Altered expression of hypothetical proteins in hippocampus of transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1.
  Proteome Sci, 2, 2.  
15539076 J.Moyersoen, J.Choe, E.Fan, W.G.Hol, and P.A.Michels (2004).
Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target.
  FEMS Microbiol Rev, 28, 603-643.  
15039343 K.Campbell, V.Popov, and L.Soong (2004).
Identification and molecular characterization of a gene encoding a protective Leishmania amazonensis Trp-Asp (WD) protein.
  Infect Immun, 72, 2194-2202.  
15280373 M.Goto, and E.M.Eddy (2004).
Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20.
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15471870 P.W.Day, J.J.Tesmer, R.Sterne-Marr, L.C.Freeman, J.L.Benovic, and P.B.Wedegaertner (2004).
Characterization of the GRK2 binding site of Galphaq.
  J Biol Chem, 279, 53643-53652.  
15007073 R.Herrmann, M.Heck, P.Henklein, P.Henklein, C.Kleuss, K.P.Hofmann, and O.P.Ernst (2004).
Sequence of interactions in receptor-G protein coupling.
  J Biol Chem, 279, 24283-24290.  
15271992 S.Majumdar, S.Ramachandran, and R.A.Cerione (2004).
Perturbing the linker regions of the alpha-subunit of transducin: a new class of constitutively active GTP-binding proteins.
  J Biol Chem, 279, 40137-40145.  
15273299 S.Y.Reddy, and T.C.Bruice (2004).
Determination of enzyme mechanisms by molecular dynamics: studies on quinoproteins, methanol dehydrogenase, and soluble glucose dehydrogenase.
  Protein Sci, 13, 1965-1978.  
15469982 T.W.Hendrickson, C.A.Perrone, P.Griffin, K.Wuichet, J.Mueller, P.Yang, M.E.Porter, and W.S.Sale (2004).
IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bending.
  Mol Biol Cell, 15, 5431-5442.  
15340168 Z.Cheng, Y.Liu, C.Wang, R.Parker, and H.Song (2004).
Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination.
  Protein Sci, 13, 2673-2684.
PDB code: 1s4u
15173184 Z.Zhang, T.J.Melia, F.He, C.Yuan, A.McGough, M.F.Schmid, and T.G.Wensel (2004).
How a G protein binds a membrane.
  J Biol Chem, 279, 33937-33945.  
12857859 A.Gloss, F.Rivero, N.Khaire, R.Müller, W.F.Loomis, M.Schleicher, and A.A.Noegel (2003).
Villidin, a novel WD-repeat and villin-related protein from Dictyostelium, is associated with membranes and the cytoskeleton.
  Mol Biol Cell, 14, 2716-2727.  
12551930 A.M.Rojkova, G.E.Woodard, T.C.Huang, C.A.Combs, J.H.Zhang, and W.F.Simonds (2003).
Ggamma subunit-selective G protein beta 5 mutant defines regulators of G protein signaling protein binding requirement for nuclear localization.
  J Biol Chem, 278, 12507-12512.  
  14704167 C.A.Bastiani, S.Gharib, M.I.Simon, and P.W.Sternberg (2003).
Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle.
  Genetics, 165, 1805-1822.  
12958590 C.A.Love, K.Harlos, N.Mavaddat, S.J.Davis, D.I.Stuart, E.Y.Jones, and R.M.Esnouf (2003).
The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D.
  Nat Struct Biol, 10, 843-848.
PDB code: 1olz
12795688 D.G.Cole (2003).
The intraflagellar transport machinery of Chlamydomonas reinhardtii.
  Traffic, 4, 435-442.  
12764189 D.T.Lodowski, J.A.Pitcher, W.D.Capel, R.J.Lefkowitz, and J.J.Tesmer (2003).
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
  Science, 300, 1256-1262.
PDB code: 1omw
12777817 D.T.Lodowski, J.F.Barnhill, J.A.Pitcher, W.D.Capel, R.J.Lefkowitz, and J.J.Tesmer (2003).
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.
  Acta Crystallogr D Biol Crystallogr, 59, 936-939.  
12486123 F.Cuello, R.A.Schulze, F.Heemeyer, H.E.Meyer, S.Lutz, K.H.Jakobs, F.Niroomand, and T.Wieland (2003).
Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.
  J Biol Chem, 278, 7220-7226.  
12649269 F.Goubaeva, M.Ghosh, S.Malik, J.Yang, P.M.Hinkle, K.K.Griendling, R.R.Neubig, and A.V.Smrcka (2003).
Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.
  J Biol Chem, 278, 19634-19641.  
12820959 G.Wu, G.Xu, B.A.Schulman, P.D.Jeffrey, J.W.Harper, and N.P.Pavletich (2003).
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
  Mol Cell, 11, 1445-1456.
PDB code: 1p22
  12771191 H.L.Agler, J.Evans, H.M.Colecraft, and D.T.Yue (2003).
Custom distinctions in the interaction of G-protein beta subunits with N-type (CaV2.2) versus P/Q-type (CaV2.1) calcium channels.
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12517447 J.Cherfils, and M.Chabre (2003).
Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta and Galpha-Ggamma interactions.
  Trends Biochem Sci, 28, 13-17.  
14525988 J.E.Slessareva, H.Ma, K.M.Depree, L.A.Flood, H.Bae, T.M.Cabrera-Vera, H.E.Hamm, and S.G.Graber (2003).
Closely related G-protein-coupled receptors use multiple and distinct domains on G-protein alpha-subunits for selective coupling.
  J Biol Chem, 278, 50530-50536.  
12871301 J.P.Xiong, T.Stehle, S.L.Goodman, and M.A.Arnaout (2003).
Integrins, cations and ligands: making the connection.
  J Thromb Haemost, 1, 1642-1654.  
14517324 K.L.Cerveny, and R.E.Jensen (2003).
The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria.
  Mol Biol Cell, 14, 4126-4139.  
14673086 M.Bünemann, M.Frank, and M.J.Lohse (2003).
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation.
  Proc Natl Acad Sci U S A, 100, 16077-16082.  
12700354 M.H.Hamilton, L.A.Cook, T.R.McRackan, K.L.Schey, and J.D.Hildebrandt (2003).
Gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate.
  Proc Natl Acad Sci U S A, 100, 5081-5086.  
12665529 S.L.Chinault, and K.J.Blumer (2003).
The C-terminal tail preceding the CAAX box of a yeast G protein gamma subunit is dispensable for receptor-mediated G protein activation in vivo.
  J Biol Chem, 278, 20638-20644.  
14680630 S.M.Daganzo, J.P.Erzberger, W.M.Lam, E.Skordalakes, R.Zhang, A.A.Franco, S.J.Brill, P.D.Adams, J.M.Berger, and P.D.Kaufman (2003).
Structure and function of the conserved core of histone deposition protein Asf1.
  Curr Biol, 13, 2148-2158.
PDB code: 1roc
14621980 S.Ono (2003).
Regulation of actin filament dynamics by actin depolymerizing factor/cofilin and actin-interacting protein 1: new blades for twisted filaments.
  Biochemistry, 42, 13363-13370.  
14672542 S.van Nocker, and P.Ludwig (2003).
The WD-repeat protein superfamily in Arabidopsis: conservation and divergence in structure and function.
  BMC Genomics, 4, 50.  
12717455 T.Häder, S.Müller, M.Aguilera, K.G.Eulenberg, A.Steuernagel, T.Ciossek, R.P.Kühnlein, L.Lemaire, R.Fritsch, C.Dohrmann, I.R.Vetter, H.Jäckle, W.W.Doane, and G.Brönner (2003).
Control of triglyceride storage by a WD40/TPR-domain protein.
  EMBO Rep, 4, 511-516.  
12807914 W.C.Voegtli, A.Y.Madrona, and D.K.Wilson (2003).
The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
  J Biol Chem, 278, 34373-34379.
PDB codes: 1pgu 1pi6
11889140 C.Y.Tai, D.L.Dujardin, N.E.Faulkner, and R.B.Vallee (2002).
Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.
  J Cell Biol, 156, 959-968.  
  12019224 E.Espagne, P.Balhadère, M.L.Penin, C.Barreau, and B.Turcq (2002).
HET-E and HET-D belong to a new subfamily of WD40 proteins involved in vegetative incompatibility specificity in the fungus Podospora anserina.
  Genetics, 161, 71-81.  
  12193273 G.B.Bolger, A.McCahill, S.J.Yarwood, M.R.Steele, J.Warwicker, and M.D.Houslay (2002).
Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.
  BMC Biochem, 3, 24.  
12101406 H.J.Choi, S.Park-Snyder, L.T.Pascoe, K.J.Green, and W.I.Weis (2002).
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.
  Nat Struct Biol, 9, 612-620.
PDB codes: 1lm5 1lm7
11979595 J.Navarro, E.M.Landau, and K.Fahmy (2002).
Receptor-dependent G-protein activation in lipidic cubic phase.
  Biopolymers, 67, 167-177.  
12196293 J.Park, B.S.Lee, J.K.Choi, R.E.Means, J.Choe, and J.U.Jung (2002).
Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression.
  Immunity, 17, 221-233.  
  12057191 L.M.Pickles, S.M.Roe, E.J.Hemingway, S.Stifani, and L.H.Pearl (2002).
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.
  Structure, 10, 751-761.
PDB code: 1gxr
12234368 M.A.Arnaout (2002).
Integrin structure: new twists and turns in dynamic cell adhesion.
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12231361 M.A.Arnaout, S.L.Goodman, and J.P.Xiong (2002).
Coming to grips with integrin binding to ligands.
  Curr Opin Cell Biol, 14, 641-651.  
11914377 M.Akgoz, I.Azpiazu, V.Kalyanaraman, and N.Gautam (2002).
Role of the G protein gamma subunit in beta gamma complex modulation of phospholipase Cbeta function.
  J Biol Chem, 277, 19573-19578.  
12169104 M.Fathallah, G.Sandoz, K.Mabrouk, S.Geib, J.Urbani, M.Villaz, M.Ronjat, J.M.Sabatier, and M.De Waard (2002).
Modelling of the III-IV loop, a domain involved in calcium channel Ca(v)2.1 inactivation, highlights a structural homology with the gamma subunit of G proteins.
  Eur J Neurosci, 16, 219-228.  
12146960 M.Medkova, A.M.Preininger, N.J.Yu, W.L.Hubbell, and H.E.Hamm (2002).
Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation.
  Biochemistry, 41, 9962-9972.  
12325024 N.Braverman, L.Chen, P.Lin, C.Obie, G.Steel, P.Douglas, P.K.Chakraborty, J.T.Clarke, A.Boneh, A.Moser, H.Moser, and D.Valle (2002).
Mutation analysis of PEX7 in 60 probands with rhizomelic chondrodysplasia punctata and functional correlations of genotype with phenotype.
  Hum Mutat, 20, 284-297.  
12057015 P.B.Wedegaertner (2002).
Characterization of subcellular localization and stability of a splice variant of G alpha i2.
  BMC Cell Biol, 3, 12.  
11967380 S.J.King, M.Bonilla, M.E.Rodgers, and T.A.Schroer (2002).
Subunit organization in cytoplasmic dynein subcomplexes.
  Protein Sci, 11, 1239-1250.  
11741937 S.Lee, J.H.Kim, C.S.Lee, J.H.Kim, Y.Kim, K.Heo, Y.Ihara, Y.Goshima, P.G.Suh, and S.H.Ryu (2002).
Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction.
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11994281 S.Liu, J.J.Carrillo, J.D.Pediani, and G.Milligan (2002).
Effective information transfer from the alpha 1b-adrenoceptor to Galpha 11 requires both beta/gamma interactions and an aromatic group four amino acids from the C terminus of the G protein.
  J Biol Chem, 277, 25707-25714.  
12150916 T.Harashima, and J.Heitman (2002).
The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits.
  Mol Cell, 10, 163-173.  
11707461 T.Mirshahi, L.Robillard, H.Zhang, T.E.Hébert, and D.E.Logothetis (2002).
Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels.
  J Biol Chem, 277, 7348-7355.  
12124391 T.Mirshahi, V.Mittal, H.Zhang, M.E.Linder, and D.E.Logothetis (2002).
Distinct sites on G protein beta gamma subunits regulate different effector functions.
  J Biol Chem, 277, 36345-36350.  
11756452 W.J.Friesen, A.Wyce, S.Paushkin, L.Abel, J.Rappsilber, M.Mann, and G.Dreyfuss (2002).
A novel WD repeat protein component of the methylosome binds Sm proteins.
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  11937049 Z.Jawad, and M.Paoli (2002).
Novel sequences propel familiar folds.
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11242542 C.Gross, E.De Baere, A.Lo, W.Chang, and L.Messiaen (2001).
Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis.
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11264536 C.Janetopoulos, T.Jin, and P.Devreotes (2001).
Receptor-mediated activation of heterotrimeric G-proteins in living cells.
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Cell cycle: Waiters serving the Destruction machinery.
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Crystal structure of the extracellular segment of integrin alpha Vbeta3.
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PDB code: 1jv2
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Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta.
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Interaction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55k.
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RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
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Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.
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FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis.
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Site-directed mutagenesis of the magB gene affects growth and development in Magnaporthe grisea.
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A groovy new structure.
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GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.
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Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.
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PDB code: 1erj
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Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin.
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The kelch repeat superfamily of proteins: propellers of cell function.
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A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC.
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The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function.
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RNA location and modeling of a WD40 repeat domain within the vault.
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