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Transcription/DNA
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PDB id
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1glu
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* Residue conservation analysis
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Gene Ontology (GO) functional annotation
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Cellular component
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nucleus
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1 term
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Biological process
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regulation of transcription, DNA-dependent
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1 term
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Biochemical function
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DNA binding
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5 terms
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DOI no:
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Nature
352:497-505
(1991)
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PubMed id:
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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.
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B.F.Luisi,
W.X.Xu,
Z.Otwinowski,
L.P.Freedman,
K.R.Yamamoto,
P.B.Sigler.
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ABSTRACT
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Two crystal structures of the glucocorticoid receptor DNA-binding domain
complexed with DNA are reported. The domain has a globular fold which contains
two Zn-nucleated substructures of distinct conformation and function. When it
binds DNA, the domain dimerizes, placing the subunits in adjacent major grooves.
In one complex, the DNA has the symmetrical consensus target sequence; in the
second, the central spacing between the target's half-sites is larger by one
base pair. This results in one subunit interacting specifically with the
consensus target half-site and the other nonspecifically with a noncognate
element. The DNA-induced dimer fixes the separation of the subunits' recognition
surfaces so that the spacing between the half-sites becomes a critical feature
of the target sequence's identity.
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Literature references that cite this PDB file's key reference
|
|
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| |
PubMed id
|
|
Reference
|
|
|
|
|
|
A.K.Hinz,
Y.Wang,
and
M.J.Smerdon
(2010).
Base excision repair in a glucocorticoid response element: effect of glucocorticoid receptor binding.
|
| |
J Biol Chem, 285,
28683-28690.
|
|
|
|
|
|
|
D.M.Chenoweth,
and
P.B.Dervan
(2010).
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.
|
| |
J Am Chem Soc, 132,
14521-14529.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
I.E.Sánchez,
D.U.Ferreiro,
M.Dellarole,
and
G.de Prat-Gay
(2010).
Experimental snapshots of a protein-DNA binding landscape.
|
| |
Proc Natl Acad Sci U S A, 107,
7751-7756.
|
|
|
|
|
|
|
J.D.Ballin,
J.P.Prevas,
C.R.Ross,
E.A.Toth,
G.M.Wilson,
and
M.T.Record
(2010).
Contributions of the histidine side chain and the N-terminal alpha-amino group to the binding thermodynamics of oligopeptides to nucleic acids as a function of pH.
|
| |
Biochemistry, 49,
2018-2030.
|
|
|
|
|
|
|
J.M.D'Antonio,
D.J.Vander Griend,
L.Antony,
G.Ndikuyeze,
S.L.Dalrymple,
S.Koochekpour,
and
J.T.Isaacs
(2010).
Loss of androgen receptor-dependent growth suppression by prostate cancer cells can occur independently from acquiring oncogenic addiction to androgen receptor signaling.
|
| |
PLoS One, 5,
e11475.
|
|
|
|
|
|
|
L.E.Shipp,
J.V.Lee,
C.Y.Yu,
M.Pufall,
P.Zhang,
D.K.Scott,
and
J.C.Wang
(2010).
Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids.
|
| |
PLoS One, 5,
e13754.
|
|
|
|
|
|
|
R.Newton,
R.Leigh,
and
M.A.Giembycz
(2010).
Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases.
|
| |
Pharmacol Ther, 125,
286-327.
|
|
|
|
|
|
|
R.Rohs,
X.Jin,
S.M.West,
R.Joshi,
B.Honig,
and
R.S.Mann
(2010).
Origins of specificity in protein-DNA recognition.
|
| |
Annu Rev Biochem, 79,
233-269.
|
|
|
|
|
|
|
T.Kino,
D.E.Hurt,
T.Ichijo,
N.Nader,
and
G.P.Chrousos
(2010).
Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor.
|
| |
Sci Signal, 3,
ra8.
|
|
|
|
|
|
|
Y.Xing,
X.Fan,
and
D.Ying
(2010).
Liver X receptor agonist treatment promotes the migration of granule neurons during cerebellar development.
|
| |
J Neurochem, 115,
1486-1494.
|
|
|
|
|
|
|
A.A.George,
R.L.Schiltz,
and
G.L.Hager
(2009).
Dynamic access of the glucocorticoid receptor to response elements in chromatin.
|
| |
Int J Biochem Cell Biol, 41,
214-224.
|
|
|
|
|
|
|
L.R.Stow,
M.L.Gumz,
I.J.Lynch,
M.M.Greenlee,
A.Rudin,
B.D.Cain,
and
C.S.Wingo
(2009).
Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1).
|
| |
J Biol Chem, 284,
30087-30096.
|
|
|
|
|
|
|
M.S.Flaherty,
J.Zavadil,
L.A.Ekas,
and
E.A.Bach
(2009).
Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway.
|
| |
Dev Dyn, 238,
2235-2253.
|
|
|
|
|
|
|
S.H.Meijsing,
M.A.Pufall,
A.Y.So,
D.L.Bates,
L.Chen,
and
K.R.Yamamoto
(2009).
DNA binding site sequence directs glucocorticoid receptor structure and activity.
|
| |
Science, 324,
407-410.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.K.Koliwad,
T.Kuo,
L.E.Shipp,
N.E.Gray,
F.Backhed,
A.Y.So,
R.V.Farese,
and
J.C.Wang
(2009).
Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
|
| |
J Biol Chem, 284,
25593-25601.
|
|
|
|
|
|
|
A.Morani,
M.Warner,
and
J.A.Gustafsson
(2008).
Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues.
|
| |
J Intern Med, 264,
128-142.
|
|
|
|
|
|
|
A.Y.So,
S.B.Cooper,
B.J.Feldman,
M.Manuchehri,
and
K.R.Yamamoto
(2008).
Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes.
|
| |
Proc Natl Acad Sci U S A, 105,
5745-5749.
|
|
|
|
|
|
|
F.Claessens,
S.Denayer,
N.Van Tilborgh,
S.Kerkhofs,
C.Helsen,
and
A.Haelens
(2008).
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling.
|
| |
Nucl Recept Signal, 6,
e008.
|
|
|
|
|
|
|
H.Reinke,
C.Saini,
F.Fleury-Olela,
C.Dibner,
I.J.Benjamin,
and
U.Schibler
(2008).
Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor.
|
| |
Genes Dev, 22,
331-345.
|
|
|
|
|
|
|
L.A.Ponguta,
C.W.Gregory,
F.S.French,
and
E.M.Wilson
(2008).
Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer.
|
| |
J Biol Chem, 283,
20989-21001.
|
|
|
|
|
|
|
R.Kumar,
and
W.J.Calhoun
(2008).
Differential regulation of the transcriptional activity of the glucocorticoid receptor through site-specific phosphorylation.
|
| |
Biologics, 2,
845-854.
|
|
|
|
|
|
|
S.R.Holmstrom,
S.Chupreta,
A.Y.So,
and
J.A.Iñiguez-Lluhí
(2008).
SUMO-mediated inhibition of glucocorticoid receptor synergistic activity depends on stable assembly at the promoter but not on DAXX.
|
| |
Mol Endocrinol, 22,
2061-2075.
|
|
|
|
|
|
|
A.Carrigan,
R.F.Walther,
H.A.Salem,
D.Wu,
E.Atlas,
Y.A.Lefebvre,
and
R.J.Haché
(2007).
An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation.
|
| |
J Biol Chem, 282,
10963-10971.
|
|
|
|
|
|
|
A.Marabotti,
G.Colonna,
and
A.Facchiano
(2007).
New computational strategy to analyze the interactions of ERalpha and ERbeta with different ERE sequences.
|
| |
J Comput Chem, 28,
1031-1041.
|
|
|
|
|
|
|
A.Y.So,
C.Chaivorapol,
E.C.Bolton,
H.Li,
and
K.R.Yamamoto
(2007).
Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor.
|
| |
PLoS Genet, 3,
e94.
|
|
|
|
|
|
|
D.L.Bain,
A.F.Heneghan,
K.D.Connaghan-Jones,
and
M.T.Miura
(2007).
Nuclear receptor structure: implications for function.
|
| |
Annu Rev Physiol, 69,
201-220.
|
|
|
|
|
|
|
D.Nguyen,
M.Bail,
G.Pesant,
V.N.Dupont,
E.Rouault,
J.Deschênes,
W.Rocha,
G.Melançon,
S.V.Steinberg,
and
S.Mader
(2007).
Rational design of an estrogen receptor mutant with altered DNA-binding specificity.
|
| |
Nucleic Acids Res, 35,
3465-3477.
|
|
|
|
|
|
|
K.Schauwaers,
K.De Gendt,
P.T.Saunders,
N.Atanassova,
A.Haelens,
L.Callewaert,
U.Moehren,
J.V.Swinnen,
G.Verhoeven,
G.Verrijdt,
and
F.Claessens
(2007).
Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model.
|
| |
Proc Natl Acad Sci U S A, 104,
4961-4966.
|
|
|
|
|
|
|
L.Pujo,
J.Fagart,
F.Gary,
D.T.Papadimitriou,
A.Claës,
X.Jeunemaître,
and
M.C.Zennaro
(2007).
Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism.
|
| |
Hum Mutat, 28,
33-40.
|
|
|
|
|
|
|
M.M.McGrane
(2007).
Vitamin A regulation of gene expression: molecular mechanism of a prototype gene.
|
| |
J Nutr Biochem, 18,
497-508.
|
|
|
|
|
|
|
N.G.Nickols,
and
P.B.Dervan
(2007).
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide.
|
| |
Proc Natl Acad Sci U S A, 104,
10418-10423.
|
|
|
|
|
|
|
R.P.Metpally,
R.Vigneshwar,
and
R.Sowdhamini
(2007).
Genome inventory and analysis of nuclear hormone receptors in Tetraodon nigroviridis.
|
| |
J Biosci, 32,
43-50.
|
|
|
|
|
|
|
S.A.Townson,
J.C.Samuelson,
Y.Bao,
S.Y.Xu,
and
A.K.Aggarwal
(2007).
BstYI bound to noncognate DNA reveals a "hemispecific" complex: implications for DNA scanning.
|
| |
Structure, 15,
449-459.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
T.Bawa-Khalfe,
J.Cheng,
Z.Wang,
and
E.T.Yeh
(2007).
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
|
| |
J Biol Chem, 282,
37341-37349.
|
|
|
|
|
|
|
A.V.Fedorova,
I.S.Chan,
and
J.A.Shin
(2006).
The GCN4 bZIP can bind to noncognate gene regulatory sequences.
|
| |
Biochim Biophys Acta, 1764,
1252-1259.
|
|
|
|
|
|
|
C.Xu,
M.E.Call,
and
K.W.Wucherpfennig
(2006).
A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.
|
| |
J Biol Chem, 281,
36977-36984.
|
|
|
|
|
|
|
I.H.Chan,
and
M.L.Privalsky
(2006).
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs.
|
| |
Oncogene, 25,
3576-3588.
|
|
|
|
|
|
|
J.T.Moore,
J.L.Collins,
and
K.H.Pearce
(2006).
The nuclear receptor superfamily and drug discovery.
|
| |
ChemMedChem, 1,
504-523.
|
|
|
|
|
|
|
M.D.Sam,
M.A.Abbani,
D.Cascio,
R.C.Johnson,
and
R.T.Clubb
(2006).
Crystallization, dehydration and preliminary X-ray analysis of excisionase (Xis) proteins cooperatively bound to DNA.
|
| |
Acta Crystallogr Sect F Struct Biol Cryst Commun, 62,
825-828.
|
|
|
|
|
|
|
M.J.Herold,
K.G.McPherson,
and
H.M.Reichardt
(2006).
Glucocorticoids in T cell apoptosis and function.
|
| |
Cell Mol Life Sci, 63,
60-72.
|
|
|
|
|
|
|
S.C.Roemer,
D.C.Donham,
L.Sherman,
V.H.Pon,
D.P.Edwards,
and
M.E.Churchill
(2006).
Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements.
|
| |
Mol Endocrinol, 20,
3042-3052.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Y.Chen,
T.J.Nickola,
N.L.DiFronzo,
A.M.Colberg-Poley,
and
M.C.Rose
(2006).
Dexamethasone-mediated repression of MUC5AC gene expression in human lung epithelial cells.
|
| |
Am J Respir Cell Mol Biol, 34,
338-347.
|
|
|
|
|
|
|
Z.Orbak
(2006).
Glucocorticoid resistance.
|
| |
Biochemistry (Mosc), 71,
1073-1081.
|
|
|
|
|
|
|
A.M.Zimeri,
O.P.Dhankher,
B.McCaig,
and
R.B.Meagher
(2005).
The plant MT1 metallothioneins are stabilized by binding cadmiums and are required for cadmium tolerance and accumulation.
|
| |
Plant Mol Biol, 58,
839-855.
|
|
|
|
|
|
|
A.Sarai,
and
H.Kono
(2005).
Protein-DNA recognition patterns and predictions.
|
| |
Annu Rev Biophys Biomol Struct, 34,
379-398.
|
|
|
|
|
|
|
C.He,
J.C.Hus,
L.J.Sun,
P.Zhou,
D.P.Norman,
V.Dötsch,
H.Wei,
J.D.Gross,
W.S.Lane,
G.Wagner,
and
G.L.Verdine
(2005).
A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.
|
| |
Mol Cell, 20,
117-129.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.E.Donald,
and
E.I.Shakhnovich
(2005).
Predicting specificity-determining residues in two large eukaryotic transcription factor families.
|
| |
Nucleic Acids Res, 33,
4455-4465.
|
|
|
|
|
|
|
M.Fuxreiter,
M.Mezei,
I.Simon,
and
R.Osman
(2005).
Interfacial water as a "hydration fingerprint" in the noncognate complex of BamHI.
|
| |
Biophys J, 89,
903-911.
|
|
|
|
|
|
|
Y.Shostak,
and
K.R.Yamamoto
(2005).
Overlapping but separable determinants of DNA binding and nuclear localization map to the C-terminal end of the Caenorhabditis elegans DAF-12 DNA binding domain.
|
| |
J Biol Chem, 280,
6554-6560.
|
|
|
|
|
|
|
B.M.Necela,
and
J.A.Cidlowski
(2004).
A single amino acid change in the first zinc finger of the DNA binding domain of the glucocorticoid receptor regulates differential promoter selectivity.
|
| |
J Biol Chem, 279,
39279-39288.
|
|
|
|
|
|
|
M.Grabacka,
W.Placha,
P.M.Plonka,
S.Pajak,
K.Urbanska,
P.Laidler,
and
A.Slominski
(2004).
Inhibition of melanoma metastases by fenofibrate.
|
| |
Arch Dermatol Res, 296,
54-58.
|
|
|
|
|
|
|
M.Welin,
U.Kosinska,
N.E.Mikkelsen,
C.Carnrot,
C.Zhu,
L.Wang,
S.Eriksson,
B.Munch-Petersen,
and
H.Eklund
(2004).
Structures of thymidine kinase 1 of human and mycoplasmic origin.
|
| |
Proc Natl Acad Sci U S A, 101,
17970-17975.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
N.Z.Lu,
and
J.A.Cidlowski
(2004).
The origin and functions of multiple human glucocorticoid receptor isoforms.
|
| |
Ann N Y Acad Sci, 1024,
102-123.
|
|
|
|
|
|
|
P.L.Shaffer,
A.Jivan,
D.E.Dollins,
F.Claessens,
and
D.T.Gewirth
(2004).
Structural basis of androgen receptor binding to selective androgen response elements.
|
| |
Proc Natl Acad Sci U S A, 101,
4758-4763.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.Kumar,
D.E.Volk,
J.Li,
J.C.Lee,
D.G.Gorenstein,
and
E.B.Thompson
(2004).
TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain.
|
| |
Proc Natl Acad Sci U S A, 101,
16425-16430.
|
|
|
|
|
|
|
S.Belikov,
C.Astrand,
P.H.Holmqvist,
and
O.Wrange
(2004).
Chromatin-mediated restriction of nuclear factor 1/CTF binding in a repressed and hormone-activated promoter in vivo.
|
| |
Mol Cell Biol, 24,
3036-3047.
|
|
|
|
|
|
|
V.S.Melvin,
C.Harrell,
J.S.Adelman,
W.L.Kraus,
M.Churchill,
and
D.P.Edwards
(2004).
The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGB.
|
| |
J Biol Chem, 279,
14763-14771.
|
|
|
|
|
|
|
Y.Umemura,
T.Ishiduka,
R.Yamamoto,
and
M.Esaka
(2004).
The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain.
|
| |
Plant J, 37,
741-749.
|
|
|
|
|
|
|
B.M.Necela,
and
J.A.Cidlowski
(2003).
Crystallization of the human glucocorticoid receptor ligand binding domain: a step towards selective glucocorticoids.
|
| |
Trends Pharmacol Sci, 24,
58-61.
|
|
|
|
|
|
|
I.Rogatsky,
J.C.Wang,
M.K.Derynck,
D.F.Nonaka,
D.B.Khodabakhsh,
C.M.Haqq,
B.D.Darimont,
M.J.Garabedian,
and
K.R.Yamamoto
(2003).
Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor.
|
| |
Proc Natl Acad Sci U S A, 100,
13845-13850.
|
|
|
|
|
|
|
J.C.Payne,
B.W.Rous,
A.L.Tenderholt,
and
H.A.Godwin
(2003).
Spectroscopic determination of the binding affinity of zinc to the DNA-binding domains of nuclear hormone receptors.
|
| |
Biochemistry, 42,
14214-14224.
|
|
|
|
|
|
|
J.Sun,
H.Viadiu,
A.K.Aggarwal,
and
H.Weinstein
(2003).
Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex.
|
| |
Biophys J, 84,
3317-3325.
|
|
|
|
|
|
|
M.E.Colosimo,
S.Tran,
and
P.Sengupta
(2003).
The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron gene expression via multiple mechanisms in Caenorhabditis elegans.
|
| |
Genetics, 165,
1779-1791.
|
|
|
|
|
|
|
N.Shibusawa,
A.N.Hollenberg,
and
F.E.Wondisford
(2003).
Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation.
|
| |
J Biol Chem, 278,
732-738.
|
|
|
|
|
|
|
R.Jauch,
G.P.Bourenkov,
H.R.Chung,
H.Urlaub,
U.Reidt,
H.Jäckle,
and
M.C.Wahl
(2003).
The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module.
|
| |
Structure, 11,
1393-1402.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.Devarakonda,
J.M.Harp,
Y.Kim,
A.Ozyhar,
and
F.Rastinejad
(2003).
Structure of the heterodimeric ecdysone receptor DNA-binding complex.
|
| |
EMBO J, 22,
5827-5840.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.G.Kalodimos,
A.M.Bonvin,
R.K.Salinas,
R.Wechselberger,
R.Boelens,
and
R.Kaptein
(2002).
Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain.
|
| |
EMBO J, 21,
2866-2876.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.Verrijdt,
K.Schauwaers,
A.Haelens,
W.Rombauts,
and
F.Claessens
(2002).
Functional interplay between two response elements with distinct binding characteristics dictates androgen specificity of the mouse sex-limited protein enhancer.
|
| |
J Biol Chem, 277,
35191-35201.
|
|
|
|
|
|
|
J.Bredenberg,
and
L.Nilsson
(2002).
Conformational states of the glucocorticoid receptor DNA-binding domain from molecular dynamics simulations.
|
| |
Proteins, 49,
24-36.
|
|
|
|
|
|
|
J.Chen,
S.Kaul,
and
S.S.Simons
(2002).
Structure/activity elements of the multifunctional protein, GMEB-1. Characterization of domains relevant for the modulation of glucocorticoid receptor transactivation properties.
|
| |
J Biol Chem, 277,
22053-22062.
|
|
|
|
|
|
|
K.Mitsouras,
B.Wong,
C.Arayata,
R.C.Johnson,
and
M.Carey
(2002).
The DNA architectural protein HMGB1 displays two distinct modes of action that promote enhanceosome assembly.
|
| |
Mol Cell Biol, 22,
4390-4401.
|
|
|
|
|
|
|
P.L.Shaffer,
and
D.T.Gewirth
(2002).
Structural basis of VDR-DNA interactions on direct repeat response elements.
|
| |
EMBO J, 21,
2242-2252.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.W.Jurutka,
P.N.MacDonald,
S.Nakajima,
J.C.Hsieh,
P.D.Thompson,
G.K.Whitfield,
M.A.Galligan,
C.A.Haussler,
and
M.R.Haussler
(2002).
Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor.
|
| |
J Cell Biochem, 85,
435-457.
|
|
|
|
|
|
|
R.Sanchez,
D.Nguyen,
W.Rocha,
J.H.White,
and
S.Mader
(2002).
Diversity in the mechanisms of gene regulation by estrogen receptors.
|
| |
Bioessays, 24,
244-254.
|
|
|
|
|
|
|
X.Gao,
D.J.Rowley,
X.Gai,
and
D.F.Voytas
(2002).
Ty5 gag mutations increase retrotransposition and suggest a role for hydrogen bonding in the function of the nucleocapsid zinc finger.
|
| |
J Virol, 76,
3240-3247.
|
|
|
|
|
|
|
Y.S.Ji,
B.H.Johnson,
M.S.Webb,
and
E.B.Thompson
(2002).
Mutational analysis of DBD*--a unique antileukemic gene sequence.
|
| |
Neoplasia, 4,
417-423.
|
|
|
|
|
|
|
F.Rastinejad
(2001).
Retinoid X receptor and its partners in the nuclear receptor family.
|
| |
Curr Opin Struct Biol, 11,
33-38.
|
|
|
|
|
|
|
H.Hauksdóttir,
and
M.L.Privalsky
(2001).
DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia.
|
| |
Cell Growth Differ, 12,
85-98.
|
|
|
|
|
|
|
J.G.Savory,
G.G.Préfontaine,
C.Lamprecht,
M.Liao,
R.F.Walther,
Y.A.Lefebvre,
and
R.J.Haché
(2001).
Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces.
|
| |
Mol Cell Biol, 21,
781-793.
|
|
|
|
|
|
|
K.Pettersson,
and
J.A.Gustafsson
(2001).
Role of estrogen receptor beta in estrogen action.
|
| |
Annu Rev Physiol, 63,
165-192.
|
|
|
|
|
|
|
M.Ruiz,
U.Lind,
M.Gåfvels,
G.Eggertsen,
J.Carlstedt-Duke,
L.Nilsson,
M.Holtmann,
P.Stierna,
A.C.Wikström,
and
S.Werner
(2001).
Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance.
|
| |
Clin Endocrinol (Oxf), 55,
363-371.
|
|
|
|
|
|
|
M.Wang,
J.S.You,
and
S.H.Lee
(2001).
Role of zinc-finger motif in redox regulation of human replication protein A.
|
| |
Antioxid Redox Signal, 3,
657-669.
|
|
|
|
|
|
|
N.V.Grishin
(2001).
Treble clef finger--a functionally diverse zinc-binding structural motif.
|
| |
Nucleic Acids Res, 29,
1703-1714.
|
|
|
|
|
|
|
O.Littlefield,
and
H.C.Nelson
(2001).
Crystal packing interaction that blocks crystallization of a site-specific DNA binding protein-DNA complex.
|
| |
Proteins, 45,
219-228.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Khorasanizadeh,
and
F.Rastinejad
(2001).
Nuclear-receptor interactions on DNA-response elements.
|
| |
Trends Biochem Sci, 26,
384-390.
|
|
|
|
|
|
|
S.Plaza,
F.Prince,
J.Jaeger,
U.Kloter,
S.Flister,
C.Benassayag,
D.Cribbs,
and
W.J.Gehring
(2001).
Molecular basis for the inhibition of Drosophila eye development by Antennapedia.
|
| |
EMBO J, 20,
802-811.
|
|
|
|
|
|
|
A.Antebi,
W.H.Yeh,
D.Tait,
E.M.Hedgecock,
and
D.L.Riddle
(2000).
daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans.
|
| |
Genes Dev, 14,
1512-1527.
|
|
|
|
|
|
|
A.Sapone,
J.M.Peters,
S.Sakai,
S.Tomita,
S.S.Papiha,
R.Dai,
F.K.Friedman,
and
F.J.Gonzalez
(2000).
The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.
|
| |
Pharmacogenetics, 10,
321-333.
|
|
|
|
|
|
|
C.Castagné,
H.Terenzi,
M.M.Zakin,
and
M.Delepierre
(2000).
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*.
|
| |
Biochimie, 82,
739-748.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.B.Defranco
(2000).
Role of molecular chaperones in subnuclear trafficking of glucocorticoid receptors.
|
| |
Kidney Int, 57,
1241-1249.
|
|
|
|
|
|
|
D.J.Segal,
and
C.F.Barbas
(2000).
Design of novel sequence-specific DNA-binding proteins.
|
| |
Curr Opin Chem Biol, 4,
34-39.
|
|
|
|
|
|
|
E.Schoenmakers,
G.Verrijdt,
B.Peeters,
G.Verhoeven,
W.Rombauts,
and
F.Claessens
(2000).
Differences in DNA binding characteristics of the androgen and glucocorticoid receptors can determine hormone-specific responses.
|
| |
J Biol Chem, 275,
12290-12297.
|
|
|
|
|
|
|
F.Rastinejad,
T.Wagner,
Q.Zhao,
and
S.Khorasanizadeh
(2000).
Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.
|
| |
EMBO J, 19,
1045-1054.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.Poukka,
P.Aarnisalo,
H.Santti,
O.A.Jänne,
and
J.J.Palvimo
(2000).
Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms.
|
| |
J Biol Chem, 275,
571-579.
|
|
|
|
|
|
|
I.Anderson,
and
J.Gorski
(2000).
Estrogen receptor alpha interaction with estrogen response element half-sites from the rat prolactin gene.
|
| |
Biochemistry, 39,
3842-3847.
|
|
|
|
|
|
|
J.A.Iñiguez-Lluhí,
and
D.Pearce
(2000).
A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy.
|
| |
Mol Cell Biol, 20,
6040-6050.
|
|
|
|
|
|
|
J.S.You,
M.Wang,
and
S.H.Lee
(2000).
Functional characterization of zinc-finger motif in redox regulation of RPA-ssDNA interaction.
|
| |
Biochemistry, 39,
12953-12958.
|
|
|
|
|
|
|
J.Zhang,
and
M.A.Lazar
(2000).
The mechanism of action of thyroid hormones.
|
| |
Annu Rev Physiol, 62,
439-466.
|
|
|
|
|
|
|
L.M.Lima,
D.Foguel,
and
J.L.Silva
(2000).
DNA tightens the dimeric DNA-binding domain of human papillomavirus E2 protein without changes in volume.
|
| |
Proc Natl Acad Sci U S A, 97,
14289-14294.
|
|
|
|
|
|
|
M.Ruff,
M.Gangloff,
J.M.Wurtz,
and
D.Moras
(2000).
Estrogen receptor transcription and transactivation: Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors.
|
| |
Breast Cancer Res, 2,
353-359.
|
|
|
|
|
|
|
M.Thompson,
and
N.W.Woodbury
(2000).
Fluorescent and photochemical properties of a single zinc finger conjugated to a fluorescent DNA-binding probe.
|
| |
Biochemistry, 39,
4327-4338.
|
|
|
|
|
|
|
N.Radoja,
M.Komine,
S.H.Jho,
M.Blumenberg,
and
M.Tomic-Canic
(2000).
Novel mechanism of steroid action in skin through glucocorticoid receptor monomers.
|
| |
Mol Cell Biol, 20,
4328-4339.
|
|
|
|
|
|
|
P.J.van Tilborg,
M.Czisch,
F.A.Mulder,
G.E.Folkers,
A.M.Bonvin,
M.Nair,
R.Boelens,
and
R.Kaptein
(2000).
Changes in dynamical behavior of the retinoid X receptor DNA-binding domain upon binding to a 14 base-pair DNA half site.
|
| |
Biochemistry, 39,
8747-8757.
|
|
|
|
|
|
|
R.M.Nissen,
and
K.R.Yamamoto
(2000).
The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain.
|
| |
Genes Dev, 14,
2314-2329.
|
|
|
|
|
|
|
R.Mohana-Borges,
A.B.Pacheco,
F.J.Sousa,
D.Foguel,
D.F.Almeida,
and
J.L.Silva
(2000).
LexA repressor forms stable dimers in solution. The role of specific dna in tightening protein-protein interactions.
|
| |
J Biol Chem, 275,
4708-4712.
|
|
|
|
|
|
|
T.Lundbäck,
S.van Den Berg,
and
T.Härd
(2000).
Sequence-specific DNA binding by the glucocorticoid receptor DNA-binding domain is linked to a salt-dependent histidine protonation.
|
| |
Biochemistry, 39,
8909-8916.
|
|
|
|
|
|
|
T.M.Fletcher,
B.W.Ryu,
C.T.Baumann,
B.S.Warren,
G.Fragoso,
S.John,
and
G.L.Hager
(2000).
Structure and dynamic properties of a glucocorticoid receptor-induced chromatin transition.
|
| |
Mol Cell Biol, 20,
6466-6475.
|
|
|
|
|
|
|
B.Xiao,
G.Shi,
X.Chen,
H.Yan,
and
X.Ji
(1999).
Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents.
|
| |
Structure, 7,
489-496.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.Huang,
N.Kohno,
H.Inufusa,
K.Kodama,
T.Taki,
and
M.Miyake
(1999).
Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53.
|
| |
Am J Pathol, 155,
955-965.
|
|
|
|
|
|
|
C.M.Falcon,
and
K.S.Matthews
(1999).
Glycine insertion in the hinge region of lactose repressor protein alters DNA binding.
|
| |
J Biol Chem, 274,
30849-30857.
|
|
|
|
|
|
|
C.Wolberger
(1999).
Multiprotein-DNA complexes in transcriptional regulation.
|
| |
Annu Rev Biophys Biomol Struct, 28,
29-56.
|
|
|
|
|
|
|
D.B.DeFranco
(1999).
Regulation of steroid receptor subcellular trafficking.
|
| |
Cell Biochem Biophys, 30,
1.
|
|
|
|
|
|
|
F.H.Allain,
Y.M.Yen,
J.E.Masse,
P.Schultze,
T.Dieckmann,
R.C.Johnson,
and
J.Feigon
(1999).
Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific binding.
|
| |
EMBO J, 18,
2563-2579.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.Schweizer-Groyer,
N.Jibard,
E.Neau,
D.Fortin,
F.Cadepond,
E.E.Baulieu,
and
A.Groyer
(1999).
The glucocorticoid response element II is functionally homologous in rat and human insulin-like growth factor-binding protein-1 promoters.
|
| |
J Biol Chem, 274,
11679-11686.
|
|
|
|
|
|
|
H.J.Berkovits,
and
J.M.Berg
(1999).
Metal and DNA binding properties of a two-domain fragment of neural zinc finger factor 1, a CCHC-type zinc binding protein.
|
| |
Biochemistry, 38,
16826-16830.
|
|
|
|
|
|
|
H.Kono,
and
A.Sarai
(1999).
Structure-based prediction of DNA target sites by regulatory proteins.
|
| |
Proteins, 35,
114-131.
|
|
|
|
|
|
|
H.Tanaka,
Y.Makino,
K.Okamoto,
T.Iida,
K.Yan,
and
N.Yoshikawa
(1999).
Redox regulation of the glucocorticoid receptor.
|
| |
Antioxid Redox Signal, 1,
403-423.
|
|
|
|
|
|
|
I.Rogatsky,
A.B.Hittelman,
D.Pearce,
and
M.J.Garabedian
(1999).
Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids.
|
| |
Mol Cell Biol, 19,
5036-5049.
|
|
|
|
|
|
|
I.V.Baskakov,
R.Kumar,
G.Srinivasan,
Y.S.Ji,
D.W.Bolen,
and
E.B.Thompson
(1999).
Trimethylamine N-oxide-induced cooperative folding of an intrinsically unfolded transcription-activating fragment of human glucocorticoid receptor.
|
| |
J Biol Chem, 274,
10693-10696.
|
|
|
|
|
|
|
J.F.Schildbach,
A.W.Karzai,
B.E.Raumann,
and
R.T.Sauer
(1999).
Origins of DNA-binding specificity: role of protein contacts with the DNA backbone.
|
| |
Proc Natl Acad Sci U S A, 96,
811-817.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.P.Charles,
T.Shinoda,
and
Y.Chinzei
(1999).
Characterization and DNA-binding properties of GRF, a novel monomeric binding orphan receptor related to GCNF and betaFTZ-F1.
|
| |
Eur J Biochem, 266,
181-190.
|
|
|
|
|
|
|
J.S.Park,
M.Wang,
S.J.Park,
and
S.H.Lee
(1999).
Zinc finger of replication protein A, a non-DNA binding element, regulates its DNA binding activity through redox.
|
| |
J Biol Chem, 274,
29075-29080.
|
|
|
|
|
|
|
K.E.Hightower,
and
C.A.Fierke
(1999).
Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase.
|
| |
Curr Opin Chem Biol, 3,
176-181.
|
|
|
|
|
|
|
K.Nadassy,
S.J.Wodak,
and
J.Janin
(1999).
Structural features of protein-nucleic acid recognition sites.
|
| |
Biochemistry, 38,
1999-2017.
|
|
|
|
|
|
|
P.J.van Tilborg,
F.A.Mulder,
M.M.de Backer,
M.Nair,
E.C.van Heerde,
G.Folkers,
P.T.van der Saag,
Y.Karimi-Nejad,
R.Boelens,
and
R.Kaptein
(1999).
Millisecond to microsecond time scale dynamics of the retinoid X and retinoic acid receptor DNA-binding domains and dimeric complex formation.
|
| |
Biochemistry, 38,
1951-1956.
|
|
|
|
|
|
|
R.Kumar,
I.V.Baskakov,
G.Srinivasan,
D.W.Bolen,
J.C.Lee,
and
E.B.Thompson
(1999).
Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor.
|
| |
J Biol Chem, 274,
24737-24741.
|
|
|
|
|
|
|
R.V.Weatherman,
R.J.Fletterick,
and
T.S.Scanlan
(1999).
Nuclear-receptor ligands and ligand-binding domains.
|
| |
Annu Rev Biochem, 68,
559-581.
|
|
|
|
|
|
|
S.Chen,
C.H.Costa,
K.Nakamura,
R.C.Ribeiro,
and
D.G.Gardner
(1999).
Vitamin D-dependent suppression of human atrial natriuretic peptide gene promoter activity requires heterodimer assembly.
|
| |
J Biol Chem, 274,
11260-11266.
|
|
|
|
|
|
|
S.Chusacultanachai,
K.A.Glenn,
A.O.Rodriguez,
E.K.Read,
J.F.Gardner,
B.S.Katzenellenbogen,
and
D.J.Shapiro
(1999).
Analysis of estrogen response element binding by genetically selected steroid receptor DNA binding domain mutants exhibiting altered specificity and enhanced affinity.
|
| |
J Biol Chem, 274,
23591-23598.
|
|
|
|
|
|
|
S.Sen,
and
L.Nilsson
(1999).
Structure, interaction, dynamics and solvent effects on the DNA-EcoRI complex in aqueous solution from molecular dynamics simulation.
|
| |
Biophys J, 77,
1782-1800.
|
|
|
|
|
|
|
T.Uz,
Y.Dwivedi,
P.D.Savani,
F.Impagnatiello,
G.Pandey,
and
H.Manev
(1999).
Glucocorticoids stimulate inflammatory 5-lipoxygenase gene expression and protein translocation in the brain.
|
| |
J Neurochem, 73,
693-699.
|
|
|
|
|
|
|
X.Yao,
G.C.Pérez-Alvarado,
H.A.Louis,
P.Pomiès,
C.Hatt,
M.F.Summers,
and
M.C.Beckerle
(1999).
Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation.
|
| |
Biochemistry, 38,
5701-5713.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.W.Norman
(1998).
Receptors for 1alpha,25(OH)2D3: past, present, and future.
|
| |
J Bone Miner Res, 13,
1360-1369.
|
|
|
|
|
|
|
C.Massaad,
X.Coumoul,
M.Sabbah,
M.Garlatti,
G.Redeuilh,
and
R.Barouki
(1998).
Properties of overlapping EREs: synergistic activation of transcription and cooperative binding of ER.
|
| |
Biochemistry, 37,
6023-6032.
|
|
|
|
|
|
|
C.R.Robinson,
and
S.G.Sligar
(1998).
Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease.
|
| |
Proc Natl Acad Sci U S A, 95,
2186-2191.
|
|
|
|
|
|
|
C.Tzagarakis-Foster,
and
M.L.Privalsky
(1998).
Phosphorylation of thyroid hormone receptors by protein kinase A regulates DNA recognition by specific inhibition of receptor monomer binding.
|
| |
J Biol Chem, 273,
10926-10932.
|
|
|
|
|
|
|
D.Rabinovich,
H.Rozenberg,
and
Z.Shakked
(1998).
Molecular replacement: the revival of the molecular Fourier transform method.
|
| |
Acta Crystallogr D Biol Crystallogr, 54,
1336-1342.
|
|
|
|
|
|
|
E.Carosa,
A.Fanelli,
S.Ulisse,
R.Di Lauro,
J.E.Rall,
and
E.A.Jannini
(1998).
Ciona intestinalis nuclear receptor 1: a member of steroid/thyroid hormone receptor family.
|
| |
Proc Natl Acad Sci U S A, 95,
11152-11157.
|
|
|
|
|
|
|
F.Tronche,
C.Kellendonk,
H.M.Reichardt,
and
G.Schütz
(1998).
Genetic dissection of glucocorticoid receptor function in mice.
|
| |
Curr Opin Genet Dev, 8,
532-538.
|
|
|
|
|
|
|
G.B.Koudelka
(1998).
Recognition of DNA structure by 434 repressor.
|
| |
Nucleic Acids Res, 26,
669-675.
|
|
|
|
|
|
|
G.G.Préfontaine,
M.E.Lemieux,
W.Giffin,
C.Schild-Poulter,
L.Pope,
E.LaCasse,
P.Walker,
and
R.J.Haché
(1998).
Recruitment of octamer transcription factors to DNA by glucocorticoid receptor.
|
| |
Mol Cell Biol, 18,
3416-3430.
|
|
|
|
|
|
|
H.M.Reichardt,
and
G.Schütz
(1998).
Glucocorticoid signalling--multiple variations of a common theme.
|
| |
Mol Cell Endocrinol, 146,
1-6.
|
|
|
|
|
|
|
H.M.Reichardt,
K.H.Kaestner,
J.Tuckermann,
O.Kretz,
O.Wessely,
R.Bock,
P.Gass,
W.Schmid,
P.Herrlich,
P.Angel,
and
G.Schütz
(1998).
DNA binding of the glucocorticoid receptor is not essential for survival.
|
| |
Cell, 93,
531-541.
|
|
|
|
|
|
|
H.Terenzi,
P.M.Alzari,
and
M.M.Zakin
(1998).
Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites.
|
| |
Biochemistry, 37,
11488-11495.
|
|
|
|
|
|
|
J.C.Corton,
E.Moreno,
and
S.A.Johnston
(1998).
Alterations in the GAL4 DNA-binding domain can affect transcriptional activation independent of DNA binding.
|
| |
J Biol Chem, 273,
13776-13780.
|
|
|
|
|
|
|
J.D.Klemm,
S.L.Schreiber,
and
G.R.Crabtree
(1998).
Dimerization as a regulatory mechanism in signal transduction.
|
| |
Annu Rev Immunol, 16,
569-592.
|
|
|
|
|
|
|
J.R.Wood,
G.L.Greene,
and
A.M.Nardulli
(1998).
Estrogen response elements function as allosteric modulators of estrogen receptor conformation.
|
| |
Mol Cell Biol, 18,
1927-1934.
|
|
|
|
|
|
|
K.D.Finley,
P.T.Edeen,
M.Foss,
E.Gross,
N.Ghbeish,
R.H.Palmer,
B.J.Taylor,
and
M.McKeown
(1998).
Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior.
|
| |
Neuron, 21,
1363-1374.
|
|
|
|
|
|
|
L.Howe,
and
J.Ausió
(1998).
Nucleosome translational position, not histone acetylation, determines TFIIIA binding to nucleosomal Xenopus laevis 5S rRNA genes.
|
| |
Mol Cell Biol, 18,
1156-1162.
|
|
|
|
|
|
|
M.H.Hsu,
C.N.Palmer,
W.Song,
K.J.Griffin,
and
E.F.Johnson
(1998).
A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding.
|
| |
J Biol Chem, 273,
27988-27997.
|
|
|
|
|
|
|
M.Li,
X.Ye,
R.N.Woodward,
C.Zhu,
L.A.Nichols,
and
L.J.Holland
(1998).
Analysis of the DNA-binding site for Xenopus glucocorticoid receptor accessory factor. Critical nucleotides for binding specificity in vitro and for amplification of steroid-induced fibrinogen gene transcription.
|
| |
J Biol Chem, 273,
9790-9796.
|
|
|
|
|
|
|
M.Vögtli,
C.Elke,
M.O.Imhof,
and
M.Lezzi
(1998).
High level transactivation by the ecdysone receptor complex at the core recognition motif.
|
| |
Nucleic Acids Res, 26,
2407-2414.
|
|
|
|
|
|
|
Q.Zhao,
S.Khorasanizadeh,
Y.Miyoshi,
M.A.Lazar,
and
F.Rastinejad
(1998).
Structural elements of an orphan nuclear receptor-DNA complex.
|
| |
Mol Cell, 1,
849-861.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.A.Albright,
M.C.Mossing,
and
B.W.Matthews
(1998).
Crystal structure of an engineered Cro monomer bound nonspecifically to DNA: possible implications for nonspecific binding by the wild-type protein.
|
| |
Protein Sci, 7,
1485-1494.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.Konrat,
B.Kräutler,
R.Weiskirchen,
and
K.Bister
(1998).
Structure of cysteine- and glycine-rich protein CRP2. Backbone dynamics reveal motional freedom and independent spatial orientation of the lim domains.
|
| |
J Biol Chem, 273,
23233-23240.
|
|
|
|
|
|
|
S.Xiao,
S.R.Nalabolu,
J.C.Aster,
J.Ma,
L.Abruzzo,
E.S.Jaffe,
R.Stone,
S.M.Weissman,
T.J.Hudson,
and
J.A.Fletcher
(1998).
FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome.
|
| |
Nat Genet, 18,
84-87.
|
|
|
|
|
|
|
V.H.van der Velden
(1998).
Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma.
|
| |
Mediators Inflamm, 7,
229-237.
|
|
|
|
|
|
|
V.M.Christoffels,
T.Grange,
K.H.Kaestner,
T.J.Cole,
G.J.Darlington,
C.M.Croniger,
and
W.H.Lamers
(1998).
Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.
|
| |
Mol Cell Biol, 18,
6305-6315.
|
|
|
|
|
|
|
Y.G.Kim,
J.Smith,
M.Durgesha,
and
S.Chandrasegaran
(1998).
Chimeric restriction enzyme: Gal4 fusion to FokI cleavage domain.
|
| |
Biol Chem, 379,
489-495.
|
|
|
|
|
|
|
A.K.Ostlund Farrants,
P.Blomquist,
H.Kwon,
and
O.Wrange
(1997).
Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex.
|
| |
Mol Cell Biol, 17,
895-905.
|
|
|
|
|
|
|
B.A.Lieberman,
and
S.K.Nordeen
(1997).
DNA intersegment transfer, how steroid receptors search for a target site.
|
| |
J Biol Chem, 272,
1061-1068.
|
|
|
|
|
|
|
D.Kosztin,
T.C.Bishop,
and
K.Schulten
(1997).
Binding of the estrogen receptor to DNA. The role of waters.
|
| |
Biophys J, 73,
557-570.
|
|
|
|
|
|
|
D.S.Sem,
D.R.Casimiro,
S.A.Kliewer,
J.Provencal,
R.M.Evans,
and
P.E.Wright
(1997).
NMR spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2. The carboxyl-terminal extension to the zinc-finger region is unstructured in the free form of the protein.
|
| |
J Biol Chem, 272,
18038-18043.
|
|
|
|
|
|
|
E.Hatzivassiliou,
P.Cardot,
V.I.Zannis,
and
S.A.Mitsialis
(1997).
Ultraspiracle, a Drosophila retinoic X receptor alpha homologue, can mobilize the human thyroid hormone receptor to transactivate a human promoter.
|
| |
Biochemistry, 36,
9221-9231.
|
|
|
|
|
|
|
G.E.Carney,
A.A.Wade,
R.Sapra,
E.S.Goldstein,
and
M.Bender
(1997).
DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis.
|
| |
Proc Natl Acad Sci U S A, 94,
12024-12029.
|
|
|
|
|
|
|
G.Jiang,
and
F.M.Sladek
(1997).
The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha.
|
| |
J Biol Chem, 272,
1218-1225.
|
|
|
|
|
|
|
G.Jiang,
U.Lee,
and
F.M.Sladek
(1997).
Proposed mechanism for the stabilization of nuclear receptor DNA binding via protein dimerization.
|
| |
Mol Cell Biol, 17,
6546-6554.
|
|
|
|
|
|
|
G.Patikoglou,
and
S.K.Burley
(1997).
Eukaryotic transcription factor-DNA complexes.
|
| |
Annu Rev Biophys Biomol Struct, 26,
289-325.
|
|
|
|
|
|
|
H.Berglund,
M.Wolf-Watz,
T.Lundbäck,
S.van den Berg,
and
T.Härd
(1997).
Structure and dynamics of the glucocorticoid receptor DNA-binding domain: comparison of wild type and a mutant with altered specificity.
|
| |
Biochemistry, 36,
11188-11197.
|
|
|
|
|
|
|
H.T.Brüggenwirth,
A.L.Boehmer,
S.Ramnarain,
M.C.Verleun-Mooijman,
D.P.Satijn,
J.Trapman,
J.A.Grootegoed,
and
A.O.Brinkmann
(1997).
Molecular analysis of the androgen-receptor gene in a family with receptor-positive partial androgen insensitivity: an unusual type of intronic mutation.
|
| |
Am J Hum Genet, 61,
1067-1077.
|
|
|
|
|
|
|
J.A.Subirana,
and
T.Faria
(1997).
Influence of sequence on the conformation of the B-DNA helix.
|
| |
Biophys J, 73,
333-338.
|
|
|
|
|
|
|
J.D.Spahn,
D.Y.Leung,
and
S.J.Szefler
(1997).
New insights into the pathogenesis and management of steroid-resistant asthma.
|
| |
J Asthma, 34,
177-194.
|
|
|
|
|
|
|
J.G.Omichinski,
P.V.Pedone,
G.Felsenfeld,
A.M.Gronenborn,
and
G.M.Clore
(1997).
The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode.
|
| |
Nat Struct Biol, 4,
122-132.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Liden,
F.Delaunay,
I.Rafter,
J.Gustafsson,
and
S.Okret
(1997).
A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation.
|
| |
J Biol Chem, 272,
21467-21472.
|
|
|
|
|
|
|
J.P.Kahlen,
and
C.Carlberg
(1997).
Allosteric interaction of the 1alpha,25-dihydroxyvitamin D3 receptor and the retinoid X receptor on DNA.
|
| |
Nucleic Acids Res, 25,
4307-4313.
|
|
|
|
|
|
|
J.R.Wilkinson,
and
H.C.Towle
(1997).
Identification and characterization of the AF-1 transactivation domain of thyroid hormone receptor beta1.
|
| |
J Biol Chem, 272,
23824-23832.
|
|
|
|
|
|
|
J.S.Albert,
M.W.Peczuh,
and
A.D.Hamilton
(1997).
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an alpha-helical conformation.
|
| |
Bioorg Med Chem, 5,
1455-1467.
|
|
|
|
|
|
|
J.W.Schwabe
(1997).
The role of water in protein-DNA interactions.
|
| |
Curr Opin Struct Biol, 7,
126-134.
|
|
|
|
|
|
|
K.Grandien,
A.Berkenstam,
and
J.A.Gustafsson
(1997).
The estrogen receptor gene: promoter organization and expression.
|
| |
Int J Biochem Cell Biol, 29,
1343-1369.
|
|
|
|
|
|
|
K.L.Schmeichel,
and
M.C.Beckerle
(1997).
Molecular dissection of a LIM domain.
|
| |
Mol Biol Cell, 8,
219-230.
|
|
|
|
|
|
|
L.Jen-Jacobson
(1997).
Protein-DNA recognition complexes: conservation of structure and binding energy in the transition state.
|
| |
Biopolymers, 44,
153-180.
|
|
|
|
|
|
|
L.Li,
and
K.S.Matthews
(1997).
Differences in water release with DNA binding by ultrabithorax and deformed homeodomains.
|
| |
Biochemistry, 36,
7003-7011.
|
|
|
|
|
|
|
M.A.Kuntz,
and
D.J.Shapiro
(1997).
Dimerizing the estrogen receptor DNA binding domain enhances binding to estrogen response elements.
|
| |
J Biol Chem, 272,
27949-27956.
|
|
|
|
|
|
|
M.Beato,
and
K.Eisfeld
(1997).
Transcription factor access to chromatin.
|
| |
Nucleic Acids Res, 25,
3559-3563.
|
|
|
|
|
|
|
M.K.Bhat,
P.McPhie,
and
S.Cheng
(1997).
Critical role of glutamine 252 in the hormone-dependent transcriptional activity of the thyroid hormone beta1 nuclear receptor.
|
| |
Biochemistry, 36,
4233-4239.
|
|
|
|
|
|
|
M.S.Finnin,
M.P.Cicero,
C.Davies,
S.J.Porter,
S.W.White,
and
K.N.Kreuzer
(1997).
The activation domain of the MotA transcription factor from bacteriophage T4.
|
| |
EMBO J, 16,
1992-2003.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
P.Doesburg,
C.W.Kuil,
C.A.Berrevoets,
K.Steketee,
P.W.Faber,
E.Mulder,
A.O.Brinkmann,
and
J.Trapman
(1997).
Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor.
|
| |
Biochemistry, 36,
1052-1064.
|
|
|
|
|
|
|
P.Pace,
J.Taylor,
S.Suntharalingam,
R.C.Coombes,
and
S.Ali
(1997).
Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.
|
| |
J Biol Chem, 272,
25832-25838.
|
|
|
|
|
|
|
S.Aliau,
D.El Garrouj,
A.Yasri,
B.S.Katzenellenbogen,
and
J.L.Borgna
(1997).
17 alpha (haloacetamidoalkyl) estradiols alkylate the human estrogen receptor at cysteine residues 417 and 530.
|
| |
Biochemistry, 36,
5861-5867.
|
|
|
|
|
|
|
S.Taraviras,
G.Schütz,
and
G.Kelsey
(1997).
Generation of inhibitory mutants of hepatocyte nuclear factor 4.
|
| |
Eur J Biochem, 244,
883-889.
|
|
|
|
|
|
|
T.C.Bishop,
D.Kosztin,
and
K.Schulten
(1997).
How hormone receptor-DNA binding affects nucleosomal DNA: the role of symmetry.
|
| |
Biophys J, 72,
2056-2067.
|
|
|
|
|
|
|
T.Meyer,
D.B.Starr,
and
J.Carlstedt-Duke
(1997).
The rat glucocorticoid receptor mutant K461A differentiates between two different mechanisms of transrepression.
|
| |
J Biol Chem, 272,
21090-21095.
|
|
|
|
|
|
|
Y.Tang,
C.Ramakrishnan,
J.Thomas,
and
D.B.DeFranco
(1997).
A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression defects of a glucocorticoid receptor zinc finger mutant.
|
| |
Mol Biol Cell, 8,
795-809.
|
|
|
|
|
|
|
Y.Z.Chen,
J.W.Powell,
and
E.W.Prohofsky
(1997).
Vibrational normal modes and dynamical stability of DNA triplex poly(dA). 2poly(dT): S-type structure is more stable and in better agreement with observations in solution.
|
| |
Biophys J, 72,
1327-1334.
|
|
|
|
|
|
|
A.G.Elefanty,
M.Antoniou,
N.Custodio,
M.Carmo-Fonseca,
and
F.G.Grosveld
(1996).
GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.
|
| |
EMBO J, 15,
319-333.
|
|
|
|
|
|
|
A.Hammarström,
K.D.Berndt,
R.Sillard,
K.Adermann,
and
G.Otting
(1996).
Solution structure of a naturally-occurring zinc-peptide complex demonstrates that the N-terminal zinc-binding module of the Lasp-1 LIM domain is an independent folding unit.
|
| |
Biochemistry, 35,
12723-12732.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
B.D.Lemon,
and
L.P.Freedman
(1996).
Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo.
|
| |
Mol Cell Biol, 16,
1006-1016.
|
|
|
|
|
|
|
C.Brostjan,
J.Anrather,
V.Csizmadia,
D.Stroka,
M.Soares,
F.H.Bach,
and
H.Winkler
(1996).
Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis.
|
| |
J Biol Chem, 271,
19612-19616.
|
|
|
|
|
|
|
C.C.Nelson,
S.C.Hendy,
J.S.Faris,
and
P.J.Romaniuk
(1996).
Retinoid X receptor alters the determination of DNA binding specificity by the P-box amino acids of the thyroid hormone receptor.
|
| |
J Biol Chem, 271,
19464-19474.
|
|
|
|
|
|
|
C.Rachez,
P.Sautière,
P.Formstecher,
and
P.Lefebvre
(1996).
Identification of amino acids critical for the DNA binding and dimerization properties of the human retinoic acid receptor alpha. Importance of lysine 360, lysine 365, and valine 361.
|
| |
J Biol Chem, 271,
17996-18006.
|
|
|
|
|
|
|
C.Wenz,
A.Jeltsch,
and
A.Pingoud
(1996).
Probing the indirect readout of the restriction enzyme EcoRV. Mutational analysis of contacts to the DNA backbone.
|
| |
J Biol Chem, 271,
5565-5573.
|
|
|
|
|
|
|
D.A.Erlanson,
M.Chytil,
and
G.L.Verdine
(1996).
The leucine zipper domain controls the orientation of AP-1 in the NFAT.AP-1.DNA complex.
|
| |
Chem Biol, 3,
981-991.
|
|
|
|
|
|
|
D.G.Mottershead,
P.Polly,
R.J.Lyons,
R.L.Sutherland,
and
C.K.Watts
(1996).
High activity, soluble, bacterially expressed human vitamin D receptor and its ligand binding domain.
|
| |
J Cell Biochem, 61,
325-337.
|
|
|
|
|
|
|
I.Segard-Maurel,
K.Rajkowski,
N.Jibard,
G.Schweizer-Groyer,
E.E.Baulieu,
and
F.Cadepond
(1996).
Glucocorticosteroid receptor dimerization investigated by analysis of receptor binding to glucocorticosteroid responsive elements using a monomer-dimer equilibrium model.
|
| |
Biochemistry, 35,
1634-1642.
|
|
|
|
|
|
|
I.Tzameli,
and
V.I.Zannis
(1996).
Binding specificity and modulation of the ApoA-I promoter activity by homo- and heterodimers of nuclear receptors.
|
| |
J Biol Chem, 271,
8402-8415.
|
|
|
|
|
|
|
J.H.Pinter,
C.Deep,
and
O.K.Park-Sarge
(1996).
Progesterone receptors: expression and regulation in the mammalian ovary.
|
| |
Clin Obstet Gynecol, 39,
424-435.
|
|
|
|
|
|
|
J.P.Aumais,
H.S.Lee,
C.DeGannes,
J.Horsford,
and
J.H.White
(1996).
Function of directly repeated half-sites as response elements for steroid hormone receptors.
|
| |
J Biol Chem, 271,
12568-12577.
|
|
|
|
|
|
|
J.S.Hanas,
and
C.G.Gunn
(1996).
Inhibition of transcription factor IIIA-DNA interactions by xenobiotic metal ions.
|
| |
Nucleic Acids Res, 24,
924-930.
|
|
|
|
|
|
|
J.W.Schwabe
(1996).
Transcriptional control: how nuclear receptors get turned on.
|
| |
Curr Biol, 6,
372-374.
|
|
|
|
|
|
|
K.Baysal,
and
D.W.Losordo
(1996).
Oestrogen receptors and cardiovascular disease.
|
| |
Clin Exp Pharmacol Physiol, 23,
537-548.
|
|
|
|
|
|
|
M.Balbín,
and
C.López-Otín
(1996).
Hormonal regulation of the human pepsinogen C gene in breast cancer cells. Identification of a cis-acting element mediating its induction by androgens, glucocorticoids, and progesterone.
|
| |
J Biol Chem, 271,
15175-15181.
|
|
|
|
|
|
|
M.Beato,
M.Truss,
and
S.Chávez
(1996).
Control of transcription by steroid hormones.
|
| |
Ann N Y Acad Sci, 784,
93.
|
|
|
|
|
|
|
M.E.Saks,
and
J.R.Sampson
(1996).
Variant minihelix RNAs reveal sequence-specific recognition of the helical tRNA(Ser) acceptor stem by E.coli seryl-tRNA synthetase.
|
| |
EMBO J, 15,
2843-2849.
|
|
|
|
|
|
|
M.K.Agarwai
(1996).
The antiglucocorticoid action of mifepristone.
|
| |
Pharmacol Ther, 70,
183-213.
|
|
|
|
|
|
|
M.Suckow,
M.Lopata,
A.Seydel,
B.Kisters-Woike,
B.von Wilcken-Bergmann,
and
B.Müller-Hill
(1996).
Mutant bZip-DNA complexes with four quasi-identical protein-DNA interfaces.
|
| |
EMBO J, 15,
598-606.
|
|
|
|
|
|
|
M.Truss,
J.Bartsch,
C.Möws,
S.Chávez,
and
M.Beato
(1996).
Chromatin structure of the MMTV promoter and its changes during hormonal induction.
|
| |
Cell Mol Neurobiol, 16,
85.
|
|
|
|
|
|
|
M.Xu,
P.K.Chakraborti,
M.J.Garabedian,
K.R.Yamamoto,
and
S.S.Simons
(1996).
Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. Stability and activity of the steroid binding domain are controlled by sequences in separate domains.
|
| |
J Biol Chem, 271,
21430-21438.
|
|
|
|
|
|
|
P.Blomquist,
Q.Li,
and
O.Wrange
(1996).
The affinity of nuclear factor 1 for its DNA site is drastically reduced by nucleosome organization irrespective of its rotational or translational position.
|
| |
J Biol Chem, 271,
153-159.
|
|
|
|
|
|
|
S.R.Patel,
R.J.Koenig,
and
C.H.Hsu
(1996).
Effect of Schiff base formation on the function of the calcitriol receptor.
|
| |
Kidney Int, 50,
1539-1545.
|
|
|
|
|
|
|
T.Härd,
and
T.Lundbäck
(1996).
Thermodynamics of sequence-specific protein-DNA interactions.
|
| |
Biophys Chem, 62,
121-139.
|
|
|
|
|
|
|
T.Lemberger,
B.Desvergne,
and
W.Wahli
(1996).
Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.
|
| |
Annu Rev Cell Dev Biol, 12,
335-363.
|
|
|
|
|
|
|
T.Lundbäck,
and
T.Härd
(1996).
Sequence-specific DNA-binding dominated by dehydration.
|
| |
Proc Natl Acad Sci U S A, 93,
4754-4759.
|
|
|
|
|
|
|
X.Cao,
S.L.Teitelbaum,
H.J.Zhu,
L.Zhang,
X.Feng,
and
F.P.Ross
(1996).
Competition for a unique response element mediates retinoic acid inhibition of vitamin D3-stimulated transcription.
|
| |
J Biol Chem, 271,
20650-20654.
|
|
|
|
|
|
|
Y.Makino,
K.Okamoto,
N.Yoshikawa,
M.Aoshima,
K.Hirota,
J.Yodoi,
K.Umesono,
I.Makino,
and
H.Tanaka
(1996).
Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.
|
| |
J Clin Invest, 98,
2469-2477.
|
|
|
|
|
|
|
Y.Xue,
M.Murdjeva,
S.Okret,
D.McConkey,
D.Kiuossis,
and
M.Jondal
(1996).
Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice.
|
| |
Eur J Immunol, 26,
428-434.
|
|
|
|
|
|
|
Z.Dauter,
K.S.Wilson,
L.C.Sieker,
J.M.Moulis,
and
J.Meyer
(1996).
Zinc- and iron-rubredoxins from Clostridium pasteurianum at atomic resolution: a high-precision model of a ZnS4 coordination unit in a protein.
|
| |
Proc Natl Acad Sci U S A, 93,
8836-8840.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.H.Swirnoff,
and
J.Milbrandt
(1995).
DNA-binding specificity of NGFI-A and related zinc finger transcription factors.
|
| |
Mol Cell Biol, 15,
2275-2287.
|
|
|
|
|
|
|
A.K.Aggarwal
(1995).
A gripping end to NF-kappa B.
|
| |
Nat Struct Biol, 2,
184-186.
|
|
|
|
|
|
|
A.Klug
(1995).
Gene regulatory proteins and their interaction with DNA.
|
| |
Ann N Y Acad Sci, 758,
143-160.
|
|
|
|
|
|
|
A.M.Gronenborn,
and
G.M.Clore
(1995).
Structures of protein complexes by multidimensional heteronuclear magnetic resonance spectroscopy.
|
| |
Crit Rev Biochem Mol Biol, 30,
351-385.
|
|
|
|
|
|
|
B.E.Raumann,
K.L.Knight,
and
R.T.Sauer
(1995).
Dramatic changes in DNA-binding specificity caused by single residue substitutions in an Arc/Mnt hybrid repressor.
|
| |
Nat Struct Biol, 2,
1115-1122.
|
|
|
|
|
|
|
B.M.Forman,
and
R.M.Evans
(1995).
Nuclear hormone receptors activate direct, inverted, and everted repeats.
|
| |
Ann N Y Acad Sci, 761,
29-37.
|
|
|
|
|
|
|
C.C.Nelson,
S.C.Hendy,
and
P.J.Romaniuk
(1995).
Relationship between P-box amino acid sequence and DNA binding specificity of the thyroid hormone receptor. The effects of half-site sequence in everted repeats.
|
| |
J Biol Chem, 270,
16981-16987.
|
|
|
|
|
|
|
C.C.Nelson,
S.C.Hendy,
and
P.J.Romaniuk
(1995).
Relationship between P-box amino acid sequence and DNA binding specificity of the thyroid hormone receptor. The effects of sequences flanking half-sites in thyroid hormone response elements.
|
| |
J Biol Chem, 270,
16988-16994.
|
|
|
|
|
|
|
Cheng Sy
(1995).
New Insights into the Structure and Function of the Thyroid Hormone Receptor.
|
| |
J Biomed Sci, 2,
77-89.
|
|
|
|
|
| |
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