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PDBsum entry 1g4o

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protein ligands metals links
Lyase PDB id
1g4o
Jmol
Contents
Protein chain
258 a.a. *
Ligands
BSB
Metals
_ZN
_HG
Waters ×132
* Residue conservation analysis
PDB id:
1g4o
Name: Lyase
Title: Carbonic anhydrase ii (f131v) complexed with 4- (aminosulfonyl)-n-phenylmethylbenzamide
Structure: Carbonic anhydrase ii. Chain: a. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.96Å     R-factor:   0.197     R-free:   0.284
Authors: C.-Y.Kim,J.S.Chang,J.B.Doyon,T.T.Baird Jr.,C.A.Fierke, A.Jain,D.W.Christianson
Key ref: C.-Y.Kim et al. (2000). Contribution of flourine to protein-Ligand affinity in the binding of flouroaromatic inhibitors to carbonic anhydrase ii. J.Am.Chem.Soc., 122, 12125-12134.
Date:
27-Oct-00     Release date:   08-Nov-00    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
258 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zinc
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   9 terms 
  Biological process     angiotensin-mediated signaling pathway   20 terms 
  Biochemical function     protein binding     5 terms