PDBsum entry 1fsz

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Cell-division protein PDB id
Protein chain
334 a.a. *
Waters ×116
* Residue conservation analysis
PDB id:
Name: Cell-division protein
Title: Crystal structure of the cell-division protein ftsz at 2.8a resolution
Structure: Ftsz. Chain: a. Synonym: sulb. Engineered: yes
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Atcc: 43067. Cellular_location: cytoplasm-membrane. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: dsm 2661 methanococcus jannaschii
Biol. unit: Trimer (from PQS)
2.80Å     R-factor:   0.199     R-free:   0.282
Authors: J.Lowe,L.A.Amos
Key ref:
J.Löwe and L.A.Amos (1998). Crystal structure of the bacterial cell-division protein FtsZ. Nature, 391, 203-206. PubMed id: 9428770 DOI: 10.1038/34472
24-Jun-97     Release date:   24-Jun-98    
Go to PROCHECK summary

Protein chain
Pfam   ArchSchema ?
Q57816  (FTSZ1_METJA) -  Cell division protein FtsZ 1
364 a.a.
334 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     protein complex   3 terms 
  Biological process     metabolic process   6 terms 
  Biochemical function     nucleotide binding     3 terms  


DOI no: 10.1038/34472 Nature 391:203-206 (1998)
PubMed id: 9428770  
Crystal structure of the bacterial cell-division protein FtsZ.
J.Löwe, L.A.Amos.
Bacterial cell division ends with septation, the constriction of the cell wall and cell membranes that leads to the formation of two daughter cells. During septation, FtsZ, a protein of relative molecular mass 40,000 which is ubiquitous in eubacteria and is also found in archaea and chloroplasts, localizes early at the division site to form a ring-shaped septum. This septum is required for the mechanochemical process of membrane constriction. FtsZ is a GTPase with weak sequence homology to tubulins. The nature of FtsZ polymers in vivo is unknown, but FtsZ can form tubules, sheets and minirings in vitro. Here we report the crystal structure at 2.8 A resolution of recombinant FtsZ from the hyperthermophilic methanogen Methanococcus jannaschii. FtsZ has two domains, one of which is a GTPase domain with a fold related to one found in the proteins p21ras and elongation factor EF-Tu. The carboxy-terminal domain, whose function is unknown, is a four-stranded beta-sheet tilted by 90 degrees against the beta-sheet of the GTPase domain. The two domains are arranged around a central helix. GDP binding is different from that typically found in GTPases and involves four phosphate-binding loops and a sugar-binding loop in the first domain, with guanine being recognized by residues in the central connecting helix. The three-dimensional structure of FtsZ is similar to the structure of alpha- and beta-tubulin.
  Selected figure(s)  
Figure 1.
Figure 1 Ribbon drawings of FtsZ (residues 23-356) from M.jannaschii. a, View showing the GTPase domain in blue/green, the C-terminal domain in red/orange, and the connecting helix H5 in yellow. GDP is represented by a space-filling model. b, View of FtsZ rotated by 90 from that in a. GDP is represented by a ball-and-stick model. Figures were prepared with POVSCRIPT (D. Peisach, personal communication)28.
Figure 3.
Figure 3 Stereo plot of the active site of FtsZ. Superimposed is the final 2F [0]-F [c] electron density map for the nucleotide contoured at 1 .Prepared with MOLSCRIPT28.
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (1998, 391, 203-206) copyright 1998.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
20847002 C.Fraipont, S.Alexeeva, B.Wolf, R.van der Ploeg, M.Schloesser, T.den Blaauwen, and M.Nguyen-Distèche (2011).
The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex in Escherichia coli.
  Microbiology, 157, 251-259.  
21413908 D.Awasthi, K.Kumar, and I.Ojima (2011).
Therapeutic potential of FtsZ inhibition: a patent perspective.
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Many ways to build an actin filament.
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21276094 D.W.Adams, L.J.Wu, L.G.Czaplewski, and J.Errington (2011).
Multiple effects of benzamide antibiotics on FtsZ function.
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21321206 H.Cho, H.R.McManus, S.L.Dove, and T.G.Bernhardt (2011).
Nucleoid occlusion factor SlmA is a DNA-activated FtsZ polymerization antagonist.
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21336930 K.Voigt, and P.M.Kirk (2011).
Recent developments in the taxonomic affiliation and phylogenetic positioning of fungi: impact in applied microbiology and environmental biotechnology.
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The domain organization of the bacterial intermediate filament-like protein crescentin is important for assembly and function.
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Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties.
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Electron cryotomography.
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Characterization of ftsZ mutations that render Bacillus subtilis resistant to MinC.
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20559630 J.Hritz, T.Läppchen, and C.Oostenbrink (2010).
Calculations of binding affinity between C8-substituted GTP analogs and the bacterial cell-division protein FtsZ.
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The metabolic enzyme CTP synthase forms cytoskeletal filaments.
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A metabolic assembly line in bacteria.
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The bacterial cytoskeleton.
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Synchronization of chromosome dynamics and cell division in bacteria.
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Mycobacterium tuberculosis FtsZ requires at least one arginine residue at the C-terminal end for polymerization in vitro.
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21050804 R.Bernander, and T.J.Ettema (2010).
FtsZ-less cell division in archaea and bacteria.
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20571565 R.V.Ulijn, and P.F.Caponi (2010).
Bioinspired chemistry: rewiring nanostructures.
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19995726 A.J.Schmitz, J.M.Glynn, B.J.Olson, K.D.Stokes, and K.W.Osteryoung (2009).
Arabidopsis FtsZ2-1 and FtsZ2-2 Are Functionally Redundant, But FtsZ-Based Plastid Division Is Not Essential for Chloroplast Partitioning or Plant Growth and Development.
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  19946616 A.Martin, D.Lang, S.T.Hanke, S.J.Mueller, E.Sarnighausen, M.Vervliet-Scheebaum, and R.Reski (2009).
Targeted Gene Knockouts Reveal Overlapping Functions of the Five Physcomitrella patens FtsZ Isoforms in Chloroplast Division, Chloroplast Shaping, Cell Patterning, Plant Development, and Gravity Sensing.
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19845632 A.Niehl, and M.Heinlein (2009).
Impact of RNA virus infection on plant cell function and evolution.
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Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
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PDB codes: 2rhh 2rhj 2rhl 2rho
19415799 B.Shen, and J.Lutkenhaus (2009).
The conserved C-terminal tail of FtsZ is required for the septal localization and division inhibitory activity of MinC(C)/MinD.
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19680248 D.W.Adams, and J.Errington (2009).
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
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Evidence for a distinct ligand binding site on tubulin discovered through inhibition by GDP of paclitaxel-induced tubulin assembly in the absence of exogenous GTP.
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19210726 I.Inoue, R.Ino, and A.Nishimura (2009).
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Cellular polarity in prokaryotic organisms.
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Two-step assembly dynamics of the Bacillus subtilis divisome.
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Dynamics of bacterial cytoskeletal elements.
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PDB code: 3cm1
19565362 R.H.Wade (2009).
On and around microtubules: an overview.
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19453278 R.Reski (2009).
Challenges to our current view on chloroplasts.
  Biol Chem, 390, 731-738.  
19583568 T.K.Beuria, P.Singh, A.Surolia, and D.Panda (2009).
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19582221 V.Norris, and R.Root-Bernstein (2009).
The eukaryotic cell originated in the integration and redistribution of hyperstructures from communities of prokaryotic cells based on molecular complementarity.
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Sculpting the bacterial cell.
  Curr Biol, 19, R812-R822.  
18363795 D.Claessen, R.Emmins, L.W.Hamoen, R.A.Daniel, J.Errington, and D.H.Edwards (2008).
Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis.
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18801997 D.J.Haydon, N.R.Stokes, R.Ure, G.Galbraith, J.M.Bennett, D.R.Brown, P.J.Baker, V.V.Barynin, D.W.Rice, S.E.Sedelnikova, J.R.Heal, J.M.Sheridan, S.T.Aiwale, P.K.Chauhan, A.Srivastava, A.Taneja, I.Collins, J.Errington, and L.G.Czaplewski (2008).
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.
  Science, 321, 1673-1675.
PDB code: 2vxy
18502809 E.R.Miraldi, P.J.Thomas, and L.Romberg (2008).
Allosteric models for cooperative polymerization of linear polymers.
  Biophys J, 95, 2470-2486.  
18312270 F.van den Ent, T.M.Vinkenvleugel, A.Ind, P.West, D.Veprintsev, N.Nanninga, T.den Blaauwen, and J.Löwe (2008).
Structural and mutational analysis of the cell division protein FtsQ.
  Mol Microbiol, 68, 110-123.
PDB codes: 2vh1 2vh2
18394147 G.Ebersbach, E.Galli, J.Møller-Jensen, J.Löwe, and K.Gerdes (2008).
Novel coiled-coil cell division factor ZapB stimulates Z ring assembly and cell division.
  Mol Microbiol, 68, 720-735.
PDB code: 2jee
18621825 G.Lan, A.Dajkovic, D.Wirtz, and S.X.Sun (2008).
Polymerization and bundling kinetics of FtsZ filaments.
  Biophys J, 95, 4045-4056.  
19033202 I.K.Cann (2008).
Cell sorting protein homologs reveal an unusual diversity in archaeal cell division.
  Proc Natl Acad Sci U S A, 105, 18653-18654.  
18243677 J.Pogliano (2008).
The bacterial cytoskeleton.
  Curr Opin Cell Biol, 20, 19-27.  
18503198 K.Kanoh, K.Adachi, S.Matsuda, Y.Shizuri, K.Yasumoto, T.Kusumi, K.Okumura, and T.Kirikae (2008).
New sulfoalkylresorcinol from marine-derived fungus, Zygosporium sp. KNC52.
  J Antibiot (Tokyo), 61, 192-194.  
18388201 L.M.Rice, E.A.Montabana, and D.A.Agard (2008).
The lattice as allosteric effector: structural studies of alphabeta- and gamma-tubulin clarify the role of GTP in microtubule assembly.
  Proc Natl Acad Sci U S A, 105, 5378-5383.
PDB code: 3cb2
18390602 L.Niu, and J.Yu (2008).
Investigating intracellular dynamics of FtsZ cytoskeleton with photoactivation single-molecule tracking.
  Biophys J, 95, 2009-2016.  
18310338 M.Pilhofer, K.Rappl, C.Eckl, A.P.Bauer, W.Ludwig, K.H.Schleifer, and G.Petroni (2008).
Characterization and evolution of cell division and cell wall synthesis genes in the bacterial phyla Verrucomicrobia, Lentisphaerae, Chlamydiae, and Planctomycetes and phylogenetic comparison with rRNA genes.
  J Bacteriol, 190, 3192-3202.  
18059290 M.Thanbichler, and L.Shapiro (2008).
Getting organized--how bacterial cells move proteins and DNA.
  Nat Rev Microbiol, 6, 28-40.  
18436955 R.Jaiswal, and D.Panda (2008).
Cysteine 155 plays an important role in the assembly of Mycobacterium tuberculosis FtsZ.
  Protein Sci, 17, 846-854.  
18323848 R.L.Lock, and E.J.Harry (2008).
Cell-division inhibitors: new insights for future antibiotics.
  Nat Rev Drug Discov, 7, 324-338.  
18593876 R.Srinivasan, M.Mishra, L.Wu, Z.Yin, and M.K.Balasubramanian (2008).
The bacterial cell division protein FtsZ assembles into cytoplasmic rings in fission yeast.
  Genes Dev, 22, 1741-1746.  
18291323 T.Läppchen, V.A.Pinas, A.F.Hartog, G.J.Koomen, C.Schaffner-Barbero, J.M.Andreu, D.Trambaiolo, J.Löwe, A.Juhem, A.V.Popov, and T.den Blaauwen (2008).
Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites.
  Chem Biol, 15, 189-199.
PDB code: 2r75
18679172 T.O.Yeates, C.A.Kerfeld, S.Heinhorst, G.C.Cannon, and J.M.Shively (2008).
Protein-based organelles in bacteria: carboxysomes and related microcompartments.
  Nat Rev Microbiol, 6, 681-691.  
18291311 W.Vollmer (2008).
Targeting the bacterial Z-ring.
  Chem Biol, 15, 93-94.  
18515385 Y.Gebremichael, J.W.Chu, and G.A.Voth (2008).
Intrinsic bending and structural rearrangement of tubulin dimer: molecular dynamics simulations and coarse-grained analysis.
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17873883 A.Orlova, E.C.Garner, V.E.Galkin, J.Heuser, R.D.Mullins, and E.H.Egelman (2007).
The structure of bacterial ParM filaments.
  Nat Struct Mol Biol, 14, 921-926.
PDB code: 2qu4
17349062 B.Yee, F.F.Lafi, B.Oakley, J.T.Staley, and J.A.Fuerst (2007).
A canonical FtsZ protein in Verrucomicrobium spinosum, a member of the Bacterial phylum Verrucomicrobia that also includes tubulin-producing Prosthecobacter species.
  BMC Evol Biol, 7, 37.  
17468127 D.W.Yoder, D.Kadirjan-Kalbach, B.J.Olson, S.Y.Miyagishima, S.L.Deblasio, R.P.Hangarter, and K.W.Osteryoung (2007).
Effects of mutations in Arabidopsis FtsZ1 on plastid division, FtsZ ring formation and positioning, and FtsZ filament morphology in vivo.
  Plant Cell Physiol, 48, 775-791.  
17932487 E.Magnani, J.Fan, L.Gasparini, M.Golding, M.Williams, G.Schiavo, M.Goedert, L.A.Amos, and M.G.Spillantini (2007).
Interaction of tau protein with the dynactin complex.
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17239231 G.Jékely (2007).
Origin of phagotrophic eukaryotes as social cheaters in microbial biofilms.
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17563102 H.P.Erickson (2007).
Evolution of the cytoskeleton.
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17326815 I.Barák, and A.J.Wilkinson (2007).
Division site recognition in Escherichia coli and Bacillus subtilis.
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17138581 J.Maple, and S.G.Møller (2007).
Plastid division: evolution, mechanism and complexity.
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17043359 K.M.Chung, H.H.Hsu, H.Y.Yeh, and B.Y.Chang (2007).
Mechanism of regulation of prokaryotic tubulin-like GTPase FtsZ by membrane protein EzrA.
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18095085 K.Zomorodian, U.Uthman, B.Tarazooie, and S.Rezaie (2007).
The effect of griseofulvin on the gene regulation of beta-tubulin in the dermatophyte pathogen Trichophyton rubrum.
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Nanoscale dewetting transition in protein complex folding.
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Structural biology of plasmid segregation proteins.
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Acid-induced loss of functional properties of bacterial cell division protein FtsZ: evidence for an alternative conformation at acidic pH.
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Cytoskeletal elements in bacteria.
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17981078 R.Carballido-López, and A.Formstone (2007).
Shape determination in Bacillus subtilis.
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17276920 R.Srinivasan, M.Mishra, M.Murata-Hori, and M.K.Balasubramanian (2007).
Filament formation of the Escherichia coli actin-related protein, MreB, in fission yeast.
  Curr Biol, 17, 266-272.  
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Bacterial cell division protein FtsZ is stable against degradation by AAA family protease FtsH in Escherichia coli cells.
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17347523 V.Norris, T.den Blaauwen, A.Cabin-Flaman, R.H.Doi, R.Harshey, L.Janniere, A.Jimenez-Sanchez, D.J.Jin, P.A.Levin, E.Mileykovskaya, A.Minsky, M.Saier, and K.Skarstad (2007).
Functional taxonomy of bacterial hyperstructures.
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17896876 V.Norris, T.den Blaauwen, R.H.Doi, R.M.Harshey, L.Janniere, A.Jiménez-Sánchez, D.J.Jin, P.A.Levin, E.Mileykovskaya, A.Minsky, G.Misevic, C.Ripoll, M.Saier, K.Skarstad, and M.Thellier (2007).
Toward a hyperstructure taxonomy.
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17178455 Z.Gitai (2007).
Diversification and specialization of the bacterial cytoskeleton.
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17948052 Z.Li, M.J.Trimble, Y.V.Brun, and G.J.Jensen (2007).
The structure of FtsZ filaments in vivo suggests a force-generating role in cell division.
  EMBO J, 26, 4694-4708.  
16713943 C.Stephens (2006).
Bacterial cell biology: managing magnetosomes.
  Curr Biol, 16, R363-R365.  
16549346 E.Nogales, and H.W.Wang (2006).
Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives.
  Curr Opin Struct Biol, 16, 221-229.  
16585744 E.Tinsley, and S.A.Khan (2006).
A novel FtsZ-like protein is involved in replication of the anthrax toxin-encoding pXO1 plasmid in Bacillus anthracis.
  J Bacteriol, 188, 2829-2835.  
16756499 K.A.Michie, and J.Löwe (2006).
Dynamic filaments of the bacterial cytoskeleton.
  Annu Rev Biochem, 75, 467-492.  
16484179 K.A.Michie, L.G.Monahan, P.L.Beech, and E.J.Harry (2006).
Trapping of a spiral-like intermediate of the bacterial cytokinetic protein FtsZ.
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16936026 L.S.Thompson, P.L.Beech, G.Real, A.O.Henriques, and E.J.Harry (2006).
Requirement for the cell division protein DivIB in polar cell division and engulfment during sporulation in Bacillus subtilis.
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17064283 M.Vicente, J.Hodgson, O.Massidda, T.Tonjum, B.Henriques-Normark, and E.Z.Ron (2006).
The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time?
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Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
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17158703 R.Carballido-López (2006).
The bacterial actin-like cytoskeleton.
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Domain architecture and structure of the bacterial cell division protein DivIB.
  Proc Natl Acad Sci U S A, 103, 6700-6705.
PDB codes: 1yr1 2alj
17024474 W.Vollmer (2006).
The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?
  Appl Microbiol Biotechnol, 73, 37-47.  
16959967 Y.L.Shih, and L.Rothfield (2006).
The bacterial cytoskeleton.
  Microbiol Mol Biol Rev, 70, 729-754.  
15943810 A.Mukherjee, M.K.Santra, T.K.Beuria, and D.Panda (2005).
A natural osmolyte trimethylamine N-oxide promotes assembly and bundling of the bacterial cell division protein, FtsZ and counteracts the denaturing effects of urea.
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15967998 D.Schlieper, M.A.Oliva, J.M.Andreu, and J.Löwe (2005).
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Dynamic localization of bacterial and plasmid chromosomes.
  Annu Rev Genet, 34, 21-59.  
10978550 W.Margolin (2000).
Themes and variations in prokaryotic cell division.
  FEMS Microbiol Rev, 24, 531-548.  
10801435 W.Margolin (2000).
Organelle division: Self-assembling GTPase caught in the middle.
  Curr Biol, 10, R328-R330.  
  9922245 A.Mukherjee, and J.Lutkenhaus (1999).
Analysis of FtsZ assembly by light scattering and determination of the role of divalent metal cations.
  J Bacteriol, 181, 823-832.  
  10542160 B.Gullbrand, T.Akerlund, and K.Nordström (1999).
On the origin of branches in Escherichia coli.
  J Bacteriol, 181, 6607-6614.  
15216884 C.Lu, and H.P.Erickson (1999).
The straight and curved conformation of FtsZ protofilaments-evidence for rapid exchange of GTP into the curved protofilament.
  Cell Struct Funct, 24, 285-290.  
10228152 D.RayChaudhuri (1999).
ZipA is a MAP-Tau homolog and is essential for structural integrity of the cytokinetic FtsZ ring during bacterial cell division.
  EMBO J, 18, 2372-2383.  
10047529 E.Mandelkow, and A.Hoenger (1999).
Structures of kinesin and kinesin-microtubule interactions.
  Curr Opin Cell Biol, 11, 34-44.  
10231484 G.Di Lallo, D.Anderluzzi, P.Ghelardini, and L.Paolozzi (1999).
FtsZ dimerization in vivo.
  Mol Microbiol, 32, 265-274.  
10572304 I.B.Holland, H.E.Jones, A.K.Campbell, and A.Jacq (1999).
An assessment of the role of intracellular free Ca2+ in E. coli.
  Biochimie, 81, 901-907.  
  9882666 J.C.Chen, D.S.Weiss, J.M.Ghigo, and J.Beckwith (1999).
Septal localization of FtsQ, an essential cell division protein in Escherichia coli.
  J Bacteriol, 181, 521-530.  
10228151 J.Löwe, and L.A.Amos (1999).
Tubulin-like protofilaments in Ca2+-induced FtsZ sheets.
  EMBO J, 18, 2364-2371.  
  10508003 J.M.Ghuysen, and C.Goffin (1999).
Lack of cell wall peptidoglycan versus penicillin sensitivity: new insights into the chlamydial anomaly.
  Antimicrob Agents Chemother, 43, 2339-2344.  
15216882 K.H.Downing, and E.Nogales (1999).
Crystallographic structure of tubulin: implications for dynamics and drug binding.
  Cell Struct Funct, 24, 269-275.  
  10595546 K.Volz (1999).
A test case for structure-based functional assignment: the 1.2 A crystal structure of the yjgF gene product from Escherichia coli.
  Protein Sci, 8, 2428-2437.
PDB code: 1qu9
10074470 L.A.Amos, and J.Löwe (1999).
How Taxol stabilises microtubule structure.
  Chem Biol, 6, R65-R69.  
10690414 L.Rothfield, S.Justice, and J.García-Lara (1999).
Bacterial cell division.
  Annu Rev Genet, 33, 423-448.  
10580983 M.M.Heck (1999).
Dr. Dolittle and the making of the mitotic spindle.
  Bioessays, 21, 985-990.  
10545099 M.Yamazoe, T.Onogi, Y.Sunako, H.Niki, K.Yamanaka, T.Ichimura, and S.Hiraga (1999).
Complex formation of MukB, MukE and MukF proteins involved in chromosome partitioning in Escherichia coli.
  EMBO J, 18, 5873-5884.  
10449747 P.A.Levin, I.G.Kurtser, and A.D.Grossman (1999).
Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilis.
  Proc Natl Acad Sci U S A, 96, 9642-9647.  
10322543 R.G.Anthony, and P.J.Hussey (1999).
Dinitroaniline herbicide resistance and the microtubule cytoskeleton.
  Trends Plant Sci, 4, 112-116.  
  10464184 T.Den Blaauwen, N.Buddelmeijer, M.E.Aarsman, C.M.Hameete, and N.Nanninga (1999).
Timing of FtsZ assembly in Escherichia coli.
  J Bacteriol, 181, 5167-5175.  
10411886 X.Chen, D.L.Court, and X.Ji (1999).
Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif.
  Proc Natl Acad Sci U S A, 96, 8396-8401.
PDB code: 1ega
  10601211 X.Ma, and W.Margolin (1999).
Genetic and functional analyses of the conserved C-terminal core domain of Escherichia coli FtsZ.
  J Bacteriol, 181, 7531-7544.  
  9973366 Y.Ohashi, Y.Chijiiwa, K.Suzuki, K.Takahashi, H.Nanamiya, T.Sato, Y.Hosoya, K.Ochi, and F.Kawamura (1999).
The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.
  J Bacteriol, 181, 1348-1351.  
10611296 Z.Hu, A.Mukherjee, S.Pichoff, and J.Lutkenhaus (1999).
The MinC component of the division site selection system in Escherichia coli interacts with FtsZ to prevent polymerization.
  Proc Natl Acad Sci U S A, 96, 14819-14824.  
10209756 Z.Liu, A.Mukherjee, and J.Lutkenhaus (1999).
Recruitment of ZipA to the division site by interaction with FtsZ.
  Mol Microbiol, 31, 1853-1861.  
9722999 A.Desai, and T.J.Mitchison (1998).
Tubulin and FtsZ structures: functional and therapeutic implications.
  Bioessays, 20, 523-527.  
10447379 A.P.Pugsley, and T.J.Silhavy (1998).
Cell regulation: continually redefining the rules.
  Curr Opin Microbiol, 1, 141-144.  
  9841666 C.Goffin, and J.M.Ghuysen (1998).
Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs.
  Microbiol Mol Biol Rev, 62, 1079-1093.  
9605973 C.Lu, J.Stricker, and H.P.Erickson (1998).
FtsZ from Escherichia coli, Azotobacter vinelandii, and Thermotoga maritima--quantitation, GTP hydrolysis, and assembly.
  Cell Motil Cytoskeleton, 40, 71-86.  
9601632 D.M.Faguy, and W.F.Doolittle (1998).
Cytoskeletal proteins: the evolution of cell division.
  Curr Biol, 8, R338-R341.  
  9683493 D.Trusca, S.Scott, C.Thompson, and D.Bramhill (1998).
Bacterial SOS checkpoint protein SulA inhibits polymerization of purified FtsZ cell division protein.
  J Bacteriol, 180, 3946-3953.  
9628483 E.Nogales, K.H.Downing, L.A.Amos, and J.Löwe (1998).
Tubulin and FtsZ form a distinct family of GTPases.
  Nat Struct Biol, 5, 451-458.  
9704406 F.J.Kull, and R.J.Fletterick (1998).
Is the tubulin/FtsZ fold related to the G-protein fold?
  Trends Cell Biol, 8, 306-307.  
9742393 J.Lutkenhaus (1998).
Organelle division: from coli to chloroplasts.
  Curr Biol, 8, R619-R621.  
9914260 K.H.Downing, and E.Nogales (1998).
Tubulin structure: insights into microtubule properties and functions.
  Curr Opin Struct Biol, 8, 785-791.  
9821287 K.Mikulík (1998).
The role of GTP-binding proteins in mechanochemical movements of microorganisms and their potential to form filamentous structures.
  Folia Microbiol (Praha), 43, 339-352.  
9687500 K.Scheffzek, M.R.Ahmadian, L.Wiesmüller, W.Kabsch, P.Stege, F.Schmitz, and A.Wittinghofer (1998).
Structural analysis of the GAP-related domain from neurofibromin and its implications.
  EMBO J, 17, 4313-4327.
PDB code: 1nf1
10066635 K.W.Osteryoung, and K.A.Pyke (1998).
Plastid division: evidence for a prokaryotically derived mechanism.
  Curr Opin Plant Biol, 1, 475-479.  
9723913 L.Wang, and J.Lutkenhaus (1998).
FtsK is an essential cell division protein that is localized to the septum and induced as part of the SOS response.
  Mol Microbiol, 29, 731-740.  
  9603865 L.Wang, M.K.Khattar, W.D.Donachie, and J.Lutkenhaus (1998).
FtsI and FtsW are localized to the septum in Escherichia coli.
  J Bacteriol, 180, 2810-2816.  
9628027 M.Heinlein, M.R.Wood, T.Thiel, and R.N.Beachy (1998).
Targeting and modification of prokaryotic cell-cell junctions by tobacco mosaic virus cell-to-cell movement protein.
  Plant J, 14, 345-351.  
10066540 P.A.Levin, and A.D.Grossman (1998).
Cell cycle and sporulation in Bacillus subtilis.
  Curr Opin Microbiol, 1, 630-635.  
  9811667 P.A.Levin, J.J.Shim, and A.D.Grossman (1998).
Effect of minCD on FtsZ ring position and polar septation in Bacillus subtilis.
  J Bacteriol, 180, 6048-6051.  
  9841676 P.Giesbrecht, T.Kersten, H.Maidhof, and J.Wecke (1998).
Staphylococcal cell wall: morphogenesis and fatal variations in the presence of penicillin.
  Microbiol Mol Biol Rev, 62, 1371-1414.  
  9555885 Q.Sun, and W.Margolin (1998).
FtsZ dynamics during the division cycle of live Escherichia coli cells.
  J Bacteriol, 180, 2050-2056.  
9720867 Q.Sun, X.C.Yu, and W.Margolin (1998).
Assembly of the FtsZ ring at the central division site in the absence of the chromosome.
  Mol Microbiol, 29, 491-503.  
9675800 W.Margolin (1998).
A green light for the bacterial cytoskeleton.
  Trends Microbiol, 6, 233-238.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.