spacer
spacer

PDBsum entry 1fsz

Go to PDB code: 
protein ligands links
Cell-division protein PDB id
1fsz
Jmol
Contents
Protein chain
334 a.a. *
Ligands
GDP
Waters ×116
* Residue conservation analysis
PDB id:
1fsz
Name: Cell-division protein
Title: Crystal structure of the cell-division protein ftsz at 2.8a resolution
Structure: Ftsz. Chain: a. Synonym: sulb. Engineered: yes
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Atcc: 43067. Cellular_location: cytoplasm-membrane. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: dsm 2661 methanococcus jannaschii
Biol. unit: Trimer (from PQS)
Resolution:
2.80Å     R-factor:   0.199     R-free:   0.282
Authors: J.Lowe,L.A.Amos
Key ref:
J.Löwe and L.A.Amos (1998). Crystal structure of the bacterial cell-division protein FtsZ. Nature, 391, 203-206. PubMed id: 9428770 DOI: 10.1038/34472
Date:
24-Jun-97     Release date:   24-Jun-98    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q57816  (FTSZ1_METJA) -  Cell division protein FtsZ 1
Seq:
Struc:
364 a.a.
334 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     protein complex   3 terms 
  Biological process     metabolic process   6 terms 
  Biochemical function     nucleotide binding     3 terms  

 

 
DOI no: 10.1038/34472 Nature 391:203-206 (1998)
PubMed id: 9428770  
 
 
Crystal structure of the bacterial cell-division protein FtsZ.
J.Löwe, L.A.Amos.
 
  ABSTRACT  
 
Bacterial cell division ends with septation, the constriction of the cell wall and cell membranes that leads to the formation of two daughter cells. During septation, FtsZ, a protein of relative molecular mass 40,000 which is ubiquitous in eubacteria and is also found in archaea and chloroplasts, localizes early at the division site to form a ring-shaped septum. This septum is required for the mechanochemical process of membrane constriction. FtsZ is a GTPase with weak sequence homology to tubulins. The nature of FtsZ polymers in vivo is unknown, but FtsZ can form tubules, sheets and minirings in vitro. Here we report the crystal structure at 2.8 A resolution of recombinant FtsZ from the hyperthermophilic methanogen Methanococcus jannaschii. FtsZ has two domains, one of which is a GTPase domain with a fold related to one found in the proteins p21ras and elongation factor EF-Tu. The carboxy-terminal domain, whose function is unknown, is a four-stranded beta-sheet tilted by 90 degrees against the beta-sheet of the GTPase domain. The two domains are arranged around a central helix. GDP binding is different from that typically found in GTPases and involves four phosphate-binding loops and a sugar-binding loop in the first domain, with guanine being recognized by residues in the central connecting helix. The three-dimensional structure of FtsZ is similar to the structure of alpha- and beta-tubulin.
 
  Selected figure(s)  
 
Figure 1.
Figure 1 Ribbon drawings of FtsZ (residues 23-356) from M.jannaschii. a, View showing the GTPase domain in blue/green, the C-terminal domain in red/orange, and the connecting helix H5 in yellow. GDP is represented by a space-filling model. b, View of FtsZ rotated by 90 from that in a. GDP is represented by a ball-and-stick model. Figures were prepared with POVSCRIPT (D. Peisach, personal communication)28.
Figure 3.
Figure 3 Stereo plot of the active site of FtsZ. Superimposed is the final 2F [0]-F [c] electron density map for the nucleotide contoured at 1 .Prepared with MOLSCRIPT28.
 
  The above figures are reprinted by permission from Macmillan Publishers Ltd: Nature (1998, 391, 203-206) copyright 1998.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
20847002 C.Fraipont, S.Alexeeva, B.Wolf, R.van der Ploeg, M.Schloesser, T.den Blaauwen, and M.Nguyen-Distèche (2011).
The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex in Escherichia coli.
  Microbiology, 157, 251-259.  
21413908 D.Awasthi, K.Kumar, and I.Ojima (2011).
Therapeutic potential of FtsZ inhibition: a patent perspective.
  Expert Opin Ther Pat, 21, 657-679.  
  21362063 D.Popp, and R.C.Robinson (2011).
Many ways to build an actin filament.
  Mol Microbiol, 80, 300-308.  
21276094 D.W.Adams, L.J.Wu, L.G.Czaplewski, and J.Errington (2011).
Multiple effects of benzamide antibiotics on FtsZ function.
  Mol Microbiol, 80, 68-84.  
21321206 H.Cho, H.R.McManus, S.L.Dove, and T.G.Bernhardt (2011).
Nucleoid occlusion factor SlmA is a DNA-activated FtsZ polymerization antagonist.
  Proc Natl Acad Sci U S A, 108, 3773-3778.  
21336930 K.Voigt, and P.M.Kirk (2011).
Recent developments in the taxonomic affiliation and phylogenetic positioning of fungi: impact in applied microbiology and environmental biotechnology.
  Appl Microbiol Biotechnol, 90, 41-57.  
  21360832 M.T.Cabeen, H.Herrmann, and C.Jacobs-Wagner (2011).
The domain organization of the bacterial intermediate filament-like protein crescentin is important for assembly and function.
  Cytoskeleton (Hoboken), 68, 205-219.  
20426423 D.J.Haydon, J.M.Bennett, D.Brown, I.Collins, G.Galbraith, P.Lancett, R.Macdonald, N.R.Stokes, P.K.Chauhan, J.K.Sutariya, N.Nayal, A.Srivastava, J.Beanland, R.Hall, V.Henstock, C.Noula, C.Rockley, and L.Czaplewski (2010).
Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties.
  J Med Chem, 53, 3927-3936.  
  20516135 E.I.Tocheva, Z.Li, and G.J.Jensen (2010).
Electron cryotomography.
  Cold Spring Harb Perspect Biol, 2, a003442.  
21059902 E.Nogales (2010).
When cytoskeletal worlds collide.
  Proc Natl Acad Sci U S A, 107, 19609-19610.  
20711458 I.F.de Oliveira, A.de Sousa Borges, V.Kooij, J.Bartosiak-Jentys, J.Luirink, and D.J.Scheffers (2010).
Characterization of ftsZ mutations that render Bacillus subtilis resistant to MinC.
  PLoS One, 5, e12048.  
20559630 J.Hritz, T.Läppchen, and C.Oostenbrink (2010).
Calculations of binding affinity between C8-substituted GTP analogs and the bacterial cell-division protein FtsZ.
  Eur Biophys J, 39, 1573-1580.  
20149104 J.Strömqvist, K.Skoog, D.O.Daley, J.Widengren, and G.von Heijne (2010).
Estimating Z-ring radius and contraction in dividing Escherichia coli.
  Mol Microbiol, 76, 151-158.  
20526791 K.Ksiazek (2010).
Bacterial aging: from mechanistic basis to evolutionary perspective.
  Cell Mol Life Sci, 67, 3131-3137.  
20639870 M.Ingerson-Mahar, A.Briegel, J.N.Werner, G.J.Jensen, and Z.Gitai (2010).
The metabolic enzyme CTP synthase forms cytoskeletal filaments.
  Nat Cell Biol, 12, 739-746.  
20680001 M.T.Cabeen, and C.Jacobs-Wagner (2010).
A metabolic assembly line in bacteria.
  Nat Cell Biol, 12, 731-733.  
21047262 M.T.Cabeen, and C.Jacobs-Wagner (2010).
The bacterial cytoskeleton.
  Annu Rev Genet, 44, 365-392.  
  20182599 M.Thanbichler (2010).
Synchronization of chromosome dynamics and cell division in bacteria.
  Cold Spring Harb Perspect Biol, 2, a000331.  
20043048 P.Gupta, H.Rajeswari, M.Arumugam, S.Mishra, R.Bhagavat, P.Anand, N.Chandra, R.Srinivasan, S.Indi, and P.Ajitkumar (2010).
Mycobacterium tuberculosis FtsZ requires at least one arginine residue at the C-terminal end for polymerization in vitro.
  Acta Biochim Biophys Sin (Shanghai), 42, 58-69.  
21050804 R.Bernander, and T.J.Ettema (2010).
FtsZ-less cell division in archaea and bacteria.
  Curr Opin Microbiol, 13, 747-752.  
20571565 R.V.Ulijn, and P.F.Caponi (2010).
Bioinspired chemistry: rewiring nanostructures.
  Nat Chem, 2, 521-523.  
19995726 A.J.Schmitz, J.M.Glynn, B.J.Olson, K.D.Stokes, and K.W.Osteryoung (2009).
Arabidopsis FtsZ2-1 and FtsZ2-2 Are Functionally Redundant, But FtsZ-Based Plastid Division Is Not Essential for Chloroplast Partitioning or Plant Growth and Development.
  Mol Plant, 2, 1211-1222.  
  19946616 A.Martin, D.Lang, S.T.Hanke, S.J.Mueller, E.Sarnighausen, M.Vervliet-Scheebaum, and R.Reski (2009).
Targeted Gene Knockouts Reveal Overlapping Functions of the Five Physcomitrella patens FtsZ Isoforms in Chloroplast Division, Chloroplast Shaping, Cell Patterning, Plant Development, and Gravity Sensing.
  Mol Plant, 2, 1359-1372.  
19845632 A.Niehl, and M.Heinlein (2009).
Impact of RNA virus infection on plant cell function and evolution.
  Ann N Y Acad Sci, 1178, 120-128.  
19383143 A.Raymond, S.Lovell, D.Lorimer, J.Walchli, M.Mixon, E.Wallace, K.Thompkins, K.Archer, A.Burgin, and L.Stewart (2009).
Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.
  BMC Biotechnol, 9, 37.
PDB codes: 2rhh 2rhj 2rhl 2rho
19415799 B.Shen, and J.Lutkenhaus (2009).
The conserved C-terminal tail of FtsZ is required for the septal localization and division inhibitory activity of MinC(C)/MinD.
  Mol Microbiol, 72, 410-424.  
19680248 D.W.Adams, and J.Errington (2009).
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
  Nat Rev Microbiol, 7, 642-653.  
19161972 E.Wilcox, C.McGrath, A.V.Blokhin, R.Gussio, and E.Hamel (2009).
Evidence for a distinct ligand binding site on tubulin discovered through inhibition by GDP of paclitaxel-induced tubulin assembly in the absence of exogenous GTP.
  Arch Biochem Biophys, 484, 55-62.  
19210726 I.Inoue, R.Ino, and A.Nishimura (2009).
New model for assembly dynamics of bacterial tubulin in relation to the stages of DNA replication.
  Genes Cells, 14, 435-444.  
  20457568 J.Dworkin (2009).
Cellular polarity in prokaryotic organisms.
  Cold Spring Harb Perspect Biol, 1, a003368.  
19210619 M.Kudryashev, M.Cyrklaff, W.Baumeister, M.M.Simon, R.Wallich, and F.Frischknecht (2009).
Comparative cryo-electron tomography of pathogenic Lyme disease spirochetes.
  Mol Microbiol, 71, 1415-1434.  
19429628 P.Gamba, J.W.Veening, N.J.Saunders, L.W.Hamoen, and R.A.Daniel (2009).
Two-step assembly dynamics of the Bacillus subtilis divisome.
  J Bacteriol, 191, 4186-4194.  
19466751 P.L.Graumann (2009).
Dynamics of bacterial cytoskeletal elements.
  Cell Motil Cytoskeleton, 66, 909-914.  
19567872 Q.Xu, B.A.Traag, J.Willemse, D.McMullan, M.D.Miller, M.A.Elsliger, P.Abdubek, T.Astakhova, H.L.Axelrod, C.Bakolitsa, D.Carlton, C.Chen, H.J.Chiu, M.Chruszcz, T.Clayton, D.Das, M.C.Deller, L.Duan, K.Ellrott, D.Ernst, C.L.Farr, J.Feuerhelm, J.C.Grant, A.Grzechnik, S.K.Grzechnik, G.W.Han, L.Jaroszewski, K.K.Jin, H.E.Klock, M.W.Knuth, P.Kozbial, S.S.Krishna, A.Kumar, D.Marciano, W.Minor, A.M.Mommaas, A.T.Morse, E.Nigoghossian, A.Nopakun, L.Okach, S.Oommachen, J.Paulsen, C.Puckett, R.Reyes, C.L.Rife, N.Sefcovic, H.J.Tien, C.B.Trame, H.van den Bedem, S.Wang, D.Weekes, K.O.Hodgson, J.Wooley, A.M.Deacon, A.Godzik, S.A.Lesley, I.A.Wilson, and G.P.van Wezel (2009).
Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes.
  J Biol Chem, 284, 25268-25279.
PDB code: 3cm1
19565362 R.H.Wade (2009).
On and around microtubules: an overview.
  Mol Biotechnol, 43, 177-191.  
19453278 R.Reski (2009).
Challenges to our current view on chloroplasts.
  Biol Chem, 390, 731-738.  
19583568 T.K.Beuria, P.Singh, A.Surolia, and D.Panda (2009).
Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs.
  Biochem J, 423, 61-69.  
19582221 V.Norris, and R.Root-Bernstein (2009).
The eukaryotic cell originated in the integration and redistribution of hyperstructures from communities of prokaryotic cells based on molecular complementarity.
  Int J Mol Sci, 10, 2611-2632.  
19906583 W.Margolin (2009).
Sculpting the bacterial cell.
  Curr Biol, 19, R812-R822.  
18363795 D.Claessen, R.Emmins, L.W.Hamoen, R.A.Daniel, J.Errington, and D.H.Edwards (2008).
Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis.
  Mol Microbiol, 68, 1029-1046.  
18801997 D.J.Haydon, N.R.Stokes, R.Ure, G.Galbraith, J.M.Bennett, D.R.Brown, P.J.Baker, V.V.Barynin, D.W.Rice, S.E.Sedelnikova, J.R.Heal, J.M.Sheridan, S.T.Aiwale, P.K.Chauhan, A.Srivastava, A.Taneja, I.Collins, J.Errington, and L.G.Czaplewski (2008).
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.
  Science, 321, 1673-1675.
PDB code: 2vxy
18502809 E.R.Miraldi, P.J.Thomas, and L.Romberg (2008).
Allosteric models for cooperative polymerization of linear polymers.
  Biophys J, 95, 2470-2486.  
18312270 F.van den Ent, T.M.Vinkenvleugel, A.Ind, P.West, D.Veprintsev, N.Nanninga, T.den Blaauwen, and J.Löwe (2008).
Structural and mutational analysis of the cell division protein FtsQ.
  Mol Microbiol, 68, 110-123.
PDB codes: 2vh1 2vh2
18394147 G.Ebersbach, E.Galli, J.Møller-Jensen, J.Löwe, and K.Gerdes (2008).
Novel coiled-coil cell division factor ZapB stimulates Z ring assembly and cell division.
  Mol Microbiol, 68, 720-735.
PDB code: 2jee
18621825 G.Lan, A.Dajkovic, D.Wirtz, and S.X.Sun (2008).
Polymerization and bundling kinetics of FtsZ filaments.
  Biophys J, 95, 4045-4056.  
19033202 I.K.Cann (2008).
Cell sorting protein homologs reveal an unusual diversity in archaeal cell division.
  Proc Natl Acad Sci U S A, 105, 18653-18654.  
18243677 J.Pogliano (2008).
The bacterial cytoskeleton.
  Curr Opin Cell Biol, 20, 19-27.  
18503198 K.Kanoh, K.Adachi, S.Matsuda, Y.Shizuri, K.Yasumoto, T.Kusumi, K.Okumura, and T.Kirikae (2008).
New sulfoalkylresorcinol from marine-derived fungus, Zygosporium sp. KNC52.
  J Antibiot (Tokyo), 61, 192-194.  
18388201 L.M.Rice, E.A.Montabana, and D.A.Agard (2008).
The lattice as allosteric effector: structural studies of alphabeta- and gamma-tubulin clarify the role of GTP in microtubule assembly.
  Proc Natl Acad Sci U S A, 105, 5378-5383.
PDB code: 3cb2
18390602 L.Niu, and J.Yu (2008).
Investigating intracellular dynamics of FtsZ cytoskeleton with photoactivation single-molecule tracking.
  Biophys J, 95, 2009-2016.  
18310338 M.Pilhofer, K.Rappl, C.Eckl, A.P.Bauer, W.Ludwig, K.H.Schleifer, and G.Petroni (2008).
Characterization and evolution of cell division and cell wall synthesis genes in the bacterial phyla Verrucomicrobia, Lentisphaerae, Chlamydiae, and Planctomycetes and phylogenetic comparison with rRNA genes.
  J Bacteriol, 190, 3192-3202.  
18059290 M.Thanbichler, and L.Shapiro (2008).
Getting organized--how bacterial cells move proteins and DNA.
  Nat Rev Microbiol, 6, 28-40.  
18436955 R.Jaiswal, and D.Panda (2008).
Cysteine 155 plays an important role in the assembly of Mycobacterium tuberculosis FtsZ.
  Protein Sci, 17, 846-854.  
18323848 R.L.Lock, and E.J.Harry (2008).
Cell-division inhibitors: new insights for future antibiotics.
  Nat Rev Drug Discov, 7, 324-338.  
18593876 R.Srinivasan, M.Mishra, L.Wu, Z.Yin, and M.K.Balasubramanian (2008).
The bacterial cell division protein FtsZ assembles into cytoplasmic rings in fission yeast.
  Genes Dev, 22, 1741-1746.  
18291323 T.Läppchen, V.A.Pinas, A.F.Hartog, G.J.Koomen, C.Schaffner-Barbero, J.M.Andreu, D.Trambaiolo, J.Löwe, A.Juhem, A.V.Popov, and T.den Blaauwen (2008).
Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites.
  Chem Biol, 15, 189-199.
PDB code: 2r75
18679172 T.O.Yeates, C.A.Kerfeld, S.Heinhorst, G.C.Cannon, and J.M.Shively (2008).
Protein-based organelles in bacteria: carboxysomes and related microcompartments.
  Nat Rev Microbiol, 6, 681-691.  
18291311 W.Vollmer (2008).
Targeting the bacterial Z-ring.
  Chem Biol, 15, 93-94.  
18515385 Y.Gebremichael, J.W.Chu, and G.A.Voth (2008).
Intrinsic bending and structural rearrangement of tubulin dimer: molecular dynamics simulations and coarse-grained analysis.
  Biophys J, 95, 2487-2499.  
17873883 A.Orlova, E.C.Garner, V.E.Galkin, J.Heuser, R.D.Mullins, and E.H.Egelman (2007).
The structure of bacterial ParM filaments.
  Nat Struct Mol Biol, 14, 921-926.
PDB code: 2qu4
17349062 B.Yee, F.F.Lafi, B.Oakley, J.T.Staley, and J.A.Fuerst (2007).
A canonical FtsZ protein in Verrucomicrobium spinosum, a member of the Bacterial phylum Verrucomicrobia that also includes tubulin-producing Prosthecobacter species.
  BMC Evol Biol, 7, 37.  
17468127 D.W.Yoder, D.Kadirjan-Kalbach, B.J.Olson, S.Y.Miyagishima, S.L.Deblasio, R.P.Hangarter, and K.W.Osteryoung (2007).
Effects of mutations in Arabidopsis FtsZ1 on plastid division, FtsZ ring formation and positioning, and FtsZ filament morphology in vivo.
  Plant Cell Physiol, 48, 775-791.  
17932487 E.Magnani, J.Fan, L.Gasparini, M.Golding, M.Williams, G.Schiavo, M.Goedert, L.A.Amos, and M.G.Spillantini (2007).
Interaction of tau protein with the dynactin complex.
  EMBO J, 26, 4546-4554.  
17239231 G.Jékely (2007).
Origin of phagotrophic eukaryotes as social cheaters in microbial biofilms.
  Biol Direct, 2, 3.  
17563102 H.P.Erickson (2007).
Evolution of the cytoskeleton.
  Bioessays, 29, 668-677.  
17326815 I.Barák, and A.J.Wilkinson (2007).
Division site recognition in Escherichia coli and Bacillus subtilis.
  FEMS Microbiol Rev, 31, 311-326.  
17138581 J.Maple, and S.G.Møller (2007).
Plastid division: evolution, mechanism and complexity.
  Ann Bot, 99, 565-579.  
17043359 K.M.Chung, H.H.Hsu, H.Y.Yeh, and B.Y.Chang (2007).
Mechanism of regulation of prokaryotic tubulin-like GTPase FtsZ by membrane protein EzrA.
  J Biol Chem, 282, 14891-14897.  
18095085 K.Zomorodian, U.Uthman, B.Tarazooie, and S.Rezaie (2007).
The effect of griseofulvin on the gene regulation of beta-tubulin in the dermatophyte pathogen Trichophyton rubrum.
  J Infect Chemother, 13, 373-379.  
17608515 L.Hua, X.Huang, P.Liu, R.Zhou, and B.J.Berne (2007).
Nanoscale dewetting transition in protein complex folding.
  J Phys Chem B, 111, 9069-9077.  
17161598 M.A.Schumacher (2007).
Structural biology of plasmid segregation proteins.
  Curr Opin Struct Biol, 17, 103-109.  
17243150 M.K.Santra, and D.Panda (2007).
Acid-induced loss of functional properties of bacterial cell division protein FtsZ: evidence for an alternative conformation at acidic pH.
  Proteins, 67, 177-188.  
17506674 P.L.Graumann (2007).
Cytoskeletal elements in bacteria.
  Annu Rev Microbiol, 61, 589-618.  
17981078 R.Carballido-López, and A.Formstone (2007).
Shape determination in Bacillus subtilis.
  Curr Opin Microbiol, 10, 611-616.  
17276920 R.Srinivasan, M.Mishra, M.Murata-Hori, and M.K.Balasubramanian (2007).
Filament formation of the Escherichia coli actin-related protein, MreB, in fission yeast.
  Curr Biol, 17, 266-272.  
17518418 R.Srinivasan, and P.Ajitkumar (2007).
Bacterial cell division protein FtsZ is stable against degradation by AAA family protease FtsH in Escherichia coli cells.
  J Basic Microbiol, 47, 251-259.  
17347523 V.Norris, T.den Blaauwen, A.Cabin-Flaman, R.H.Doi, R.Harshey, L.Janniere, A.Jimenez-Sanchez, D.J.Jin, P.A.Levin, E.Mileykovskaya, A.Minsky, M.Saier, and K.Skarstad (2007).
Functional taxonomy of bacterial hyperstructures.
  Microbiol Mol Biol Rev, 71, 230-253.  
17896876 V.Norris, T.den Blaauwen, R.H.Doi, R.M.Harshey, L.Janniere, A.Jiménez-Sánchez, D.J.Jin, P.A.Levin, E.Mileykovskaya, A.Minsky, G.Misevic, C.Ripoll, M.Saier, K.Skarstad, and M.Thellier (2007).
Toward a hyperstructure taxonomy.
  Annu Rev Microbiol, 61, 309-329.  
17178455 Z.Gitai (2007).
Diversification and specialization of the bacterial cytoskeleton.
  Curr Opin Cell Biol, 19, 5.  
17948052 Z.Li, M.J.Trimble, Y.V.Brun, and G.J.Jensen (2007).
The structure of FtsZ filaments in vivo suggests a force-generating role in cell division.
  EMBO J, 26, 4694-4708.  
16713943 C.Stephens (2006).
Bacterial cell biology: managing magnetosomes.
  Curr Biol, 16, R363-R365.  
16549346 E.Nogales, and H.W.Wang (2006).
Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives.
  Curr Opin Struct Biol, 16, 221-229.  
16585744 E.Tinsley, and S.A.Khan (2006).
A novel FtsZ-like protein is involved in replication of the anthrax toxin-encoding pXO1 plasmid in Bacillus anthracis.
  J Bacteriol, 188, 2829-2835.  
16756499 K.A.Michie, and J.Löwe (2006).
Dynamic filaments of the bacterial cytoskeleton.
  Annu Rev Biochem, 75, 467-492.  
16484179 K.A.Michie, L.G.Monahan, P.L.Beech, and E.J.Harry (2006).
Trapping of a spiral-like intermediate of the bacterial cytokinetic protein FtsZ.
  J Bacteriol, 188, 1680-1690.  
16936026 L.S.Thompson, P.L.Beech, G.Real, A.O.Henriques, and E.J.Harry (2006).
Requirement for the cell division protein DivIB in polar cell division and engulfment during sporulation in Bacillus subtilis.
  J Bacteriol, 188, 7677-7685.  
17064283 M.Vicente, J.Hodgson, O.Massidda, T.Tonjum, B.Henriques-Normark, and E.Z.Ron (2006).
The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time?
  FEMS Microbiol Rev, 30, 841-852.  
16824093 N.W.Goehring, M.D.Gonzalez, and J.Beckwith (2006).
Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
  Mol Microbiol, 61, 33-45.  
17158703 R.Carballido-López (2006).
The bacterial actin-like cytoskeleton.
  Microbiol Mol Biol Rev, 70, 888-909.  
16618922 S.A.Robson, and G.F.King (2006).
Domain architecture and structure of the bacterial cell division protein DivIB.
  Proc Natl Acad Sci U S A, 103, 6700-6705.
PDB codes: 1yr1 2alj
17024474 W.Vollmer (2006).
The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?
  Appl Microbiol Biotechnol, 73, 37-47.  
16959967 Y.L.Shih, and L.Rothfield (2006).
The bacterial cytoskeleton.
  Microbiol Mol Biol Rev, 70, 729-754.  
15943810 A.Mukherjee, M.K.Santra, T.K.Beuria, and D.Panda (2005).
A natural osmolyte trimethylamine N-oxide promotes assembly and bundling of the bacterial cell division protein, FtsZ and counteracts the denaturing effects of urea.
  FEBS J, 272, 2760-2772.  
15967998 D.Schlieper, M.A.Oliva, J.M.Andreu, and J.Löwe (2005).
Structure of bacterial tubulin BtubA/B: evidence for horizontal gene transfer.
  Proc Natl Acad Sci U S A, 102, 9170-9175.
PDB codes: 2bto 2btq
15738949 E.R.Angert (2005).
Alternatives to binary fission in bacteria.
  Nat Rev Microbiol, 3, 214-224.  
16043503 H.Liang, and L.F.Landweber (2005).
Molecular mimicry: quantitative methods to study structural similarity between protein and RNA.
  RNA, 11, 1167-1172.  
16146521 J.Maple, C.Aldridge, and S.G.Møller (2005).
Plastid division is mediated by combinatorial assembly of plastid division proteins.
  Plant J, 43, 811-823.  
15793307 J.Mingorance, M.Tadros, M.Vicente, J.M.González, G.Rivas, and M.Vélez (2005).
Visualization of single Escherichia coli FtsZ filament dynamics with atomic force microscopy.
  J Biol Chem, 280, 20909-20914.  
15844012 K.Ozawa, T.Harashina, R.Yatsunami, and S.Nakamura (2005).
Gene cloning, expression and partial characterization of cell division protein FtsZ1 from extremely halophilic archaeon Haloarcula japonica strain TR-1.
  Extremophiles, 9, 281-288.  
16322744 L.Rothfield, A.Taghbalout, and Y.L.Shih (2005).
Spatial control of bacterial division-site placement.
  Nat Rev Microbiol, 3, 959-968.  
15716374 M.Howard, and K.Kruse (2005).
Cellular organization by self-organization: mechanisms and models for Min protein dynamics.
  J Cell Biol, 168, 533-536.  
16245323 M.K.Santra, D.Dasgupta, and D.Panda (2005).
Deuterium oxide promotes assembly and bundling of FtsZ protofilaments.
  Proteins, 61, 1101-1110.  
16012516 M.T.Cabeen, and C.Jacobs-Wagner (2005).
Bacterial cell shape.
  Nat Rev Microbiol, 3, 601-610.  
15838050 N.Grantcharova, U.Lustig, and K.Flärdh (2005).
Dynamics of FtsZ assembly during sporulation in Streptomyces coelicolor A3(2).
  J Bacteriol, 187, 3227-3237.  
16174771 N.R.Stokes, J.Sievers, S.Barker, J.M.Bennett, D.R.Brown, I.Collins, V.M.Errington, D.Foulger, M.Hall, R.Halsey, H.Johnson, V.Rose, H.B.Thomaides, D.J.Haydon, L.G.Czaplewski, and J.Errington (2005).
Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay.
  J Biol Chem, 280, 39709-39715.  
15630023 N.W.Goehring, F.Gueiros-Filho, and J.Beckwith (2005).
Premature targeting of a cell division protein to midcell allows dissection of divisome assembly in Escherichia coli.
  Genes Dev, 19, 127-137.  
16005287 N.W.Goehring, and J.Beckwith (2005).
Diverse paths to midcell: assembly of the bacterial cell division machinery.
  Curr Biol, 15, R514-R526.  
15608376 R.A.Judge, K.Swift, and C.González (2005).
An ultraviolet fluorescence-based method for identifying and distinguishing protein crystals.
  Acta Crystallogr D Biol Crystallogr, 61, 60-66.  
15948963 R.B.Weart, S.Nakano, B.E.Lane, P.Zuber, and P.A.Levin (2005).
The ClpX chaperone modulates assembly of the tubulin-like protein FtsZ.
  Mol Microbiol, 57, 238-249.  
15805519 S.D.Redick, J.Stricker, G.Briscoe, and H.P.Erickson (2005).
Mutants of FtsZ targeting the protofilament interface: effects on cell division and GTPase activity.
  J Bacteriol, 187, 2727-2736.  
15601720 S.G.Addinall, E.Small, D.Whitaker, S.Sturrock, W.D.Donachie, and M.M.Khattar (2005).
New temperature-sensitive alleles of ftsZ in Escherichia coli.
  J Bacteriol, 187, 358-365.  
16143878 S.Y.Miyagishima (2005).
Origin and evolution of the chloroplast division machinery.
  J Plant Res, 118, 295-306.  
15897178 T.A.Leonard, J.Møller-Jensen, and J.Löwe (2005).
Towards understanding the molecular basis of bacterial DNA segregation.
  Philos Trans R Soc Lond B Biol Sci, 360, 523-535.  
15998306 T.Abe, and T.Hashimoto (2005).
Altered microtubule dynamics by expression of modified alpha-tubulin protein causes right-handed helical growth in transgenic Arabidopsis plants.
  Plant J, 43, 191-204.  
16227976 W.Margolin (2005).
FtsZ and the division of prokaryotic cells and organelles.
  Nat Rev Mol Cell Biol, 6, 862-871.  
15707892 Z.Gitai, N.A.Dye, A.Reisenauer, M.Wachi, and L.Shapiro (2005).
MreB actin-mediated segregation of a specific region of a bacterial chromosome.
  Cell, 120, 329-341.  
15766522 Z.Gitai (2005).
The new bacterial cell biology: moving parts and subcellular architecture.
  Cell, 120, 577-586.  
15866039 Z.Gitai, M.Thanbichler, and L.Shapiro (2005).
The choreographed dynamics of bacterial chromosomes.
  Trends Microbiol, 13, 221-228.  
15173579 A.Fiebig, and J.A.Theriot (2004).
Bacteria make tracks to the pole.
  Proc Natl Acad Sci U S A, 101, 8510-8511.  
15466024 A.Ursinus, F.van den Ent, S.Brechtel, M.de Pedro, J.V.Höltje, J.Löwe, and W.Vollmer (2004).
Murein (peptidoglycan) binding property of the essential cell division protein FtsN from Escherichia coli.
  J Bacteriol, 186, 6728-6737.  
14731269 C.M.Koppelman, M.E.Aarsman, J.Postmus, E.Pas, A.O.Muijsers, D.J.Scheffers, N.Nanninga, and T.den Blaauwen (2004).
R174 of Escherichia coli FtsZ is involved in membrane interaction and protofilament bundling, and is essential for cell division.
  Mol Microbiol, 51, 645-657.  
15317782 D.E.Anderson, F.J.Gueiros-Filho, and H.P.Erickson (2004).
Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins.
  J Bacteriol, 186, 5775-5781.  
15289600 D.N.Margalit, L.Romberg, R.B.Mets, A.M.Hebert, T.J.Mitchison, M.W.Kirschner, and D.RayChaudhuri (2004).
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality.
  Proc Natl Acad Sci U S A, 101, 11821-11826.  
15319781 J.Kiessling, A.Martin, L.Gremillon, S.A.Rensing, P.Nick, E.Sarnighausen, E.L.Decker, and R.Reski (2004).
Dual targeting of plastid division protein FtsZ to chloroplasts and the cytoplasm.
  EMBO Rep, 5, 889-894.  
15139810 J.Löwe, F.van den Ent, and L.A.Amos (2004).
Molecules of the bacterial cytoskeleton.
  Annu Rev Biophys Biomol Struct, 33, 177-198.  
15130131 K.Mazouni, F.Domain, C.Cassier-Chauvat, and F.Chauvat (2004).
Molecular analysis of the key cytokinetic components of cyanobacteria: FtsZ, ZipN and MinCDE.
  Mol Microbiol, 52, 1145-1158.  
15065662 K.Nasmyth, and A.Schleiffer (2004).
From a single double helix to paired double helices and back.
  Philos Trans R Soc Lond B Biol Sci, 359, 99.  
15558053 M.A.Oliva, S.C.Cordell, and J.Löwe (2004).
Structural insights into FtsZ protofilament formation.
  Nat Struct Mol Biol, 11, 1243-1250.
PDB codes: 1w58 1w59 1w5a 1w5b 1w5e 1w5f
15352321 M.C.Motta, G.F.Picchi, I.V.Palmié-Peixoto, M.R.Rocha, T.M.de Carvalho, J.Morgado-Diaz, W.de Souza, S.Goldenberg, and S.P.Fragoso (2004).
The microtubule analog protein, FtsZ, in the endosymbiont of trypanosomatid protozoa.
  J Eukaryot Microbiol, 51, 394-401.  
15458405 M.E.Martin, M.J.Trimble, and Y.V.Brun (2004).
Cell cycle-dependent abundance, stability and localization of FtsA and FtsQ in Caulobacter crescentus.
  Mol Microbiol, 54, 60-74.  
15039432 M.K.Santra, T.K.Beuria, A.Banerjee, and D.Panda (2004).
Ruthenium red-induced bundling of bacterial cell division protein, FtsZ.
  J Biol Chem, 279, 25959-25965.  
15303099 P.A.Coulombe, and P.Wong (2004).
Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds.
  Nat Cell Biol, 6, 699-706.  
15554957 P.J.Lewis (2004).
Bacterial subcellular architecture: recent advances and future prospects.
  Mol Microbiol, 54, 1135-1150.  
14967825 P.L.Ferguson, and G.S.Shaw (2004).
Human S100B protein interacts with the Escherichia coli division protein FtsZ in a calcium-sensitive manner.
  J Biol Chem, 279, 18806-18813.  
15556027 P.L.Graumann (2004).
Cytoskeletal elements in bacteria.
  Curr Opin Microbiol, 7, 565-571.  
15014504 R.B.Ravelli, B.Gigant, P.A.Curmi, I.Jourdain, S.Lachkar, A.Sobel, and M.Knossow (2004).
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
  Nature, 428, 198-202.
PDB codes: 1sa0 1sa1
15328358 R.Marrington, E.Small, A.Rodger, T.R.Dafforn, and S.G.Addinall (2004).
FtsZ fiber bundling is triggered by a conformational change in bound GTP.
  J Biol Chem, 279, 48821-48829.  
15576787 S.Pastoret, C.Fraipont, T.den Blaauwen, B.Wolf, M.E.Aarsman, A.Piette, A.Thomas, R.Brasseur, and M.Nguyen-Distèche (2004).
Functional analysis of the cell division protein FtsW of Escherichia coli.
  J Bacteriol, 186, 8370-8379.  
15043836 W.Margolin (2004).
Bacterial shape: concave coiled coils curve caulobacter.
  Curr Biol, 14, R242-R244.  
15159537 Z.Gitai, N.Dye, and L.Shapiro (2004).
An actin-like gene can determine cell polarity in bacteria.
  Proc Natl Acad Sci U S A, 101, 8643-8648.  
12813127 C.Siebold, L.F.García-Alles, B.Erni, and U.Baumann (2003).
A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase.
  Proc Natl Acad Sci U S A, 100, 8188-8192.
PDB codes: 1oi2 1oi3
12885631 C.W.Wolgemuth, O.Igoshin, and G.Oster (2003).
The motility of mollicutes.
  Biophys J, 85, 828-842.  
12486713 D.Carettoni, P.Gómez-Puertas, L.Yim, J.Mingorance, O.Massidda, M.Vicente, A.Valencia, E.Domenici, and D.Anderluzzi (2003).
Phage-display and correlated mutations identify an essential region of subdomain 1C involved in homodimerization of Escherichia coli FtsA.
  Proteins, 50, 192-206.  
12923524 E.H.Egelman (2003).
A tale of two polymers: new insights into helical filaments.
  Nat Rev Mol Cell Biol, 4, 621-630.  
14579253 G.Jékely (2003).
Small GTPases and the evolution of the eukaryotic cell.
  Bioessays, 25, 1129-1138.  
12646867 J.Errington (2003).
Dynamic proteins and a cytoskeleton in bacteria.
  Nat Cell Biol, 5, 175-178.  
12626683 J.Errington, R.A.Daniel, and D.J.Scheffers (2003).
Cytokinesis in bacteria.
  Microbiol Mol Biol Rev, 67, 52.  
12807907 J.M.González, M.Jiménez, M.Vélez, J.Mingorance, J.M.Andreu, M.Vicente, and G.Rivas (2003).
Essential cell division protein FtsZ assembles into one monomer-thick ribbons under conditions resembling the crowded intracellular environment.
  J Biol Chem, 278, 37664-37671.  
12896999 J.Stricker, and H.P.Erickson (2003).
In vivo characterization of Escherichia coli ftsZ mutants: effects on Z-ring structure and function.
  J Bacteriol, 185, 4796-4805.  
12804116 K.N.Lee, I.Padmalayam, B.Baumstark, S.L.Baker, and R.F.Massung (2003).
Characterization of the ftsZ gene from Ehrlichia chaffeensis, Anaplasma phagocytophilum, and Rickettsia rickettsii, and use as a differential PCR target.
  DNA Cell Biol, 22, 179-186.  
14527275 L.Romberg, and P.A.Levin (2003).
Assembly dynamics of the bacterial cell division protein FTSZ: poised at the edge of stability.
  Annu Rev Microbiol, 57, 125-154.  
12807911 M.A.Oliva, S.Huecas, J.M.Palacios, J.Martín-Benito, J.M.Valpuesta, and J.M.Andreu (2003).
Assembly of archaeal cell division protein FtsZ and a GTPase-inactive mutant into double-stranded filaments.
  J Biol Chem, 278, 33562-33570.  
14675535 N.Ausmees, J.R.Kuhn, and C.Jacobs-Wagner (2003).
The bacterial cytoskeleton: an intermediate filament-like function in cell shape.
  Cell, 115, 705-713.  
12535067 N.Grantcharova, W.Ubhayasekera, S.L.Mowbray, J.R.McCormick, and K.Flärdh (2003).
A missense mutation in ftsZ differentially affects vegetative and developmentally controlled cell division in Streptomyces coelicolor A3(2).
  Mol Microbiol, 47, 645-656.  
12939258 O.Espeli, C.Lee, and K.J.Marians (2003).
A physical and functional interaction between Escherichia coli FtsK and topoisomerase IV.
  J Biol Chem, 278, 44639-44644.  
14665465 P.R.Gilson, X.C.Yu, D.Hereld, C.Barth, A.Savage, B.R.Kiefel, S.Lay, P.R.Fisher, W.Margolin, and P.L.Beech (2003).
Two Dictyostelium orthologs of the prokaryotic cell division protein FtsZ localize to mitochondria and are required for the maintenance of normal mitochondrial morphology.
  Eukaryot Cell, 2, 1315-1326.  
12694607 R.Bernander (2003).
The archaeal cell cycle: current issues.
  Mol Microbiol, 48, 599-604.  
12808143 S.C.Cordell, E.J.Robinson, and J.Lowe (2003).
Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ.
  Proc Natl Acad Sci U S A, 100, 7889-7894.
PDB codes: 1oft 1ofu
12754232 S.Rueda, M.Vicente, and J.Mingorance (2003).
Concentration and assembly of the division ring proteins FtsZ, FtsA, and ZipA during the Escherichia coli cell cycle.
  J Bacteriol, 185, 3344-3351.  
12446699 T.K.Beuria, S.S.Krishnakumar, S.Sahar, N.Singh, K.Gupta, M.Meshram, and D.Panda (2003).
Glutamate-induced assembly of bacterial cell division protein FtsZ.
  J Biol Chem, 278, 3735-3741.  
12180916 A.G.Torres, N.T.Perna, V.Burland, A.Ruknudin, F.R.Blattner, and J.B.Kaper (2002).
Characterization of Cah, a calcium-binding and heat-extractable autotransporter protein of enterohaemorrhagic Escherichia coli.
  Mol Microbiol, 45, 951-966.  
12456788 C.Goffin, and J.M.Ghuysen (2002).
Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent.
  Microbiol Mol Biol Rev, 66, 702.  
12486237 C.Jenkins, R.Samudrala, I.Anderson, B.P.Hedlund, G.Petroni, N.Michailova, N.Pinel, R.Overbeek, G.Rosati, and J.T.Staley (2002).
Genes for the cytoskeletal protein tubulin in the bacterial genus Prosthecobacter.
  Proc Natl Acad Sci U S A, 99, 17049-17054.  
11952901 D.J.Scheffers, and A.J.Driessen (2002).
Immediate GTP hydrolysis upon FtsZ polymerization.
  Mol Microbiol, 43, 1517-1521.  
12486014 F.van den Ent, J.Møller-Jensen, L.A.Amos, K.Gerdes, and J.Löwe (2002).
F-actin-like filaments formed by plasmid segregation protein ParM.
  EMBO J, 21, 6935-6943.
PDB codes: 1mwk 1mwm
12215443 J.M.Andreu, M.A.Oliva, and O.Monasterio (2002).
Reversible unfolding of FtsZ cell division proteins from archaea and bacteria. Comparison with eukaryotic tubulin folding and assembly.
  J Biol Chem, 277, 43262-43270.  
11827810 J.Michiels, C.Xi, J.Verhaert, and J.Vanderleyden (2002).
The functions of Ca(2+) in bacteria: a role for EF-hand proteins?
  Trends Microbiol, 10, 87-93.  
12202752 K.Kawasaki, S.Maruyama, M.Nakayama, K.Matsumoto, and T.Shibata (2002).
Drosophila melanogaster RECQ5/QE DNA helicase: stimulation by GTP binding.
  Nucleic Acids Res, 30, 3682-3691.  
11997478 L.E.Kemp, C.S.Bond, and W.N.Hunter (2002).
Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development.
  Proc Natl Acad Sci U S A, 99, 6591-6596.
PDB code: 1gx1
12218043 O.A.Koksharova, and C.P.Wolk (2002).
A novel gene that bears a DnaJ motif influences cyanobacterial cell division.
  J Bacteriol, 184, 5524-5528.  
12101218 P.Datta, A.Dasgupta, S.Bhakta, and J.Basu (2002).
Interaction between FtsZ and FtsW of Mycobacterium tuberculosis.
  J Biol Chem, 277, 24983-24987.  
11906832 R.Reski (2002).
Rings and networks: the amazing complexity of FtsZ in chloroplasts.
  Trends Plant Sci, 7, 103-105.  
11994149 S.A.Robson, K.A.Michie, J.P.Mackay, E.Harry, and G.F.King (2002).
The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components.
  Mol Microbiol, 44, 663-674.  
11298280 A.Feucht, I.Lucet, M.D.Yudkin, and J.Errington (2001).
Cytological and biochemical characterization of the FtsA cell division protein of Bacillus subtilis.
  Mol Microbiol, 40, 115-125.  
11394965 C.Lu, J.Stricker, and H.P.Erickson (2001).
Site-specific mutations of FtsZ--effects on GTPase and in vitro assembly.
  BMC Microbiol, 1, 7.  
11747839 E.H.Egelman (2001).
Molecular evolution: actin's long lost relative found.
  Curr Biol, 11, R1022-R1024.  
11401687 E.J.Harry (2001).
Bacterial cell division: regulating Z-ring formation.
  Mol Microbiol, 40, 795-803.  
11441808 E.Nogales (2001).
Structural insight into microtubule function.
  Annu Rev Biophys Biomol Struct, 30, 397-420.  
11163134 H.P.Erickson (2001).
The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke.
  Curr Opin Cell Biol, 13, 55-60.  
11703663 J.C.Chen, and J.Beckwith (2001).
FtsQ, FtsL and FtsI require FtsK, but not FtsN, for co-localization with FtsZ during Escherichia coli cell division.
  Mol Microbiol, 42, 395-413.  
11454202 J.Mingorance, S.Rueda, P.Gómez-Puertas, A.Valencia, and M.Vicente (2001).
Escherichia coli FtsZ polymers contain mostly GTP and have a high nucleotide turnover.
  Mol Microbiol, 41, 83-91.  
11337401 K.W.Osteryoung, and R.S.McAndrew (2001).
THE PLASTID DIVISION MACHINE.
  Annu Rev Plant Physiol Plant Mol Biol, 52, 315-333.  
11700217 L.He, G.A.Orr, and S.B.Horwitz (2001).
Novel molecules that interact with microtubules and have functional activity similar to Taxol.
  Drug Discov Today, 6, 1153-1164.  
11406387 S.A.Teichmann, A.G.Murzin, and C.Chothia (2001).
Determination of protein function, evolution and interactions by structural genomics.
  Curr Opin Struct Biol, 11, 354-363.  
11285278 S.Vitha, R.S.McAndrew, and K.W.Osteryoung (2001).
FtsZ ring formation at the chloroplast division site in plants.
  J Cell Biol, 153, 111-120.  
11309118 Y.Wang, B.D.Jones, and Y.V.Brun (2001).
A set of ftsZ mutants blocked at different stages of cell division in Caulobacter.
  Mol Microbiol, 40, 347-360.  
11121746 B.R.Oakley (2000).
An abundance of tubulins.
  Trends Cell Biol, 10, 537-542.  
10960100 C.A.Hale, A.C.Rhee, and P.A.de Boer (2000).
ZipA-induced bundling of FtsZ polymers mediated by an interaction between C-terminal domains.
  J Bacteriol, 182, 5153-5166.  
11080634 C.E.Stevenson, F.Sargent, G.Buchanan, T.Palmer, and D.M.Lawson (2000).
Crystal structure of the molybdenum cofactor biosynthesis protein MobA from Escherichia coli at near-atomic resolution.
  Structure, 8, 1115-1125.
PDB code: 1e5k
10712701 D.J.Scheffers, T.den Blaauwen, and A.J.Driessen (2000).
Non-hydrolysable GTP-gamma-S stabilizes the FtsZ polymer in a GDP-bound state.
  Mol Microbiol, 35, 1211-1219.  
10869082 E.L.White, L.J.Ross, R.C.Reynolds, L.E.Seitz, G.D.Moore, and D.W.Borhani (2000).
Slow polymerization of Mycobacterium tuberculosis FtsZ.
  J Bacteriol, 182, 4028-4034.  
10966460 E.Nogales (2000).
Structural insights into microtubule function.
  Annu Rev Biochem, 69, 277-302.  
11032797 F.van den Ent, and J.Löwe (2000).
Crystal structure of the cell division protein FtsA from Thermotoga maritima.
  EMBO J, 19, 5300-5307.
PDB codes: 1e4f 1e4g
11076959 G.I.McFadden (2000).
Skeletons in the closet. How do chloroplasts stay in shape?
  J Cell Biol, 151, F19-F22.  
10766796 G.Rivas, A.López, J.Mingorance, M.J.Ferrándiz, S.Zorrilla, A.P.Minton, M.Vicente, and J.M.Andreu (2000).
Magnesium-induced linear self-association of the FtsZ bacterial cell division protein monomer. The primary steps for FtsZ assembly.
  J Biol Chem, 275, 11740-11749.  
  10706773 H.T.Idriss (2000).
Man to trypanosome: the tubulin tyrosination/detyrosination cycle revisited.
  Cell Motil Cytoskeleton, 45, 173-184.  
10747015 I.Lucet, A.Feucht, M.D.Yudkin, and J.Errington (2000).
Direct interaction between the cell division protein FtsZ and the cell differentiation protein SpoIIE.
  EMBO J, 19, 1467-1475.  
10818343 J.E.Ladner, P.Reddy, A.Davis, M.Tordova, A.J.Howard, and G.L.Gilliland (2000).
The 1.30 A resolution structure of the Bacillus subtilis chorismate mutase catalytic homotrimer.
  Acta Crystallogr D Biol Crystallogr, 56, 673-683.
PDB code: 1dbf
  10716188 J.F.Díaz, M.M.Escalona, S.Kuppens, and Y.Engelborghs (2000).
Role of the switch II region in the conformational transition of activation of Ha-ras-p21.
  Protein Sci, 9, 361-368.  
10747787 J.K.Dobrzynski, M.L.Sternlicht, I.Peng, G.W.Farr, and H.Sternlicht (2000).
Evidence that beta-tubulin induces a conformation change in the cytosolic chaperonin which stabilizes binding: implications for the mechanism of action.
  Biochemistry, 39, 3988-4003.  
11076976 J.Kiessling, S.Kruse, S.A.Rensing, K.Harter, E.L.Decker, and R.Reski (2000).
Visualization of a cytoskeleton-like FtsZ network in chloroplasts.
  J Cell Biol, 151, 945-950.  
11076032 J.Löwe, and L.A.Amos (2000).
Helical tubes of FtsZ from Methanococcus jannaschii.
  Biol Chem, 381, 993-999.  
11115109 K.Flärdh, E.Leibovitz, M.J.Buttner, and K.F.Chater (2000).
Generation of a non-sporulating strain of Streptomyces coelicolor A3(2) by the manipulation of a developmentally controlled ftsZ promoter.
  Mol Microbiol, 38, 737-749.  
11031231 K.H.Downing (2000).
Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics.
  Annu Rev Cell Dev Biol, 16, 89.  
10880432 L.Mosyak, Y.Zhang, E.Glasfeld, S.Haney, M.Stahl, J.Seehra, and W.S.Somers (2000).
The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.
  EMBO J, 19, 3179-3191.
PDB codes: 1f46 1f47
10972821 M.Marrec-Fairley, A.Piette, X.Gallet, R.Brasseur, H.Hara, C.Fraipont, J.M.Ghuysen, and M.Nguyen-Distèche (2000).
Differential functionalities of amphiphilic peptide segments of the cell-septation penicillin-binding protein 3 of Escherichia coli.
  Mol Microbiol, 37, 1019-1031.  
10753735 M.R.Leroux, and F.U.Hartl (2000).
Protein folding: versatility of the cytosolic chaperonin TRiC/CCT.
  Curr Biol, 10, R260-R264.  
11004395 M.Sarcina, and C.W.Mullineaux (2000).
Effects of tubulin assembly inhibitors on cell division in prokaryotes in vivo.
  FEMS Microbiol Lett, 191, 25-29.  
10792716 R.A.Daniel, and J.Errington (2000).
Intrinsic instability of the essential cell division protein FtsL of Bacillus subtilis and a role for DivIB protein in FtsL turnover.
  Mol Microbiol, 36, 278-289.  
11092821 S.Hiraga (2000).
Dynamic localization of bacterial and plasmid chromosomes.
  Annu Rev Genet, 34, 21-59.  
10978550 W.Margolin (2000).
Themes and variations in prokaryotic cell division.
  FEMS Microbiol Rev, 24, 531-548.  
10801435 W.Margolin (2000).
Organelle division: Self-assembling GTPase caught in the middle.
  Curr Biol, 10, R328-R330.  
  9922245 A.Mukherjee, and J.Lutkenhaus (1999).
Analysis of FtsZ assembly by light scattering and determination of the role of divalent metal cations.
  J Bacteriol, 181, 823-832.  
  10542160 B.Gullbrand, T.Akerlund, and K.Nordström (1999).
On the origin of branches in Escherichia coli.
  J Bacteriol, 181, 6607-6614.  
15216884 C.Lu, and H.P.Erickson (1999).
The straight and curved conformation of FtsZ protofilaments-evidence for rapid exchange of GTP into the curved protofilament.
  Cell Struct Funct, 24, 285-290.  
10228152 D.RayChaudhuri (1999).
ZipA is a MAP-Tau homolog and is essential for structural integrity of the cytokinetic FtsZ ring during bacterial cell division.
  EMBO J, 18, 2372-2383.  
10047529 E.Mandelkow, and A.Hoenger (1999).
Structures of kinesin and kinesin-microtubule interactions.
  Curr Opin Cell Biol, 11, 34-44.  
10231484 G.Di Lallo, D.Anderluzzi, P.Ghelardini, and L.Paolozzi (1999).
FtsZ dimerization in vivo.
  Mol Microbiol, 32, 265-274.  
10572304 I.B.Holland, H.E.Jones, A.K.Campbell, and A.Jacq (1999).
An assessment of the role of intracellular free Ca2+ in E. coli.
  Biochimie, 81, 901-907.  
  9882666 J.C.Chen, D.S.Weiss, J.M.Ghigo, and J.Beckwith (1999).
Septal localization of FtsQ, an essential cell division protein in Escherichia coli.
  J Bacteriol, 181, 521-530.  
10228151 J.Löwe, and L.A.Amos (1999).
Tubulin-like protofilaments in Ca2+-induced FtsZ sheets.
  EMBO J, 18, 2364-2371.  
  10508003 J.M.Ghuysen, and C.Goffin (1999).
Lack of cell wall peptidoglycan versus penicillin sensitivity: new insights into the chlamydial anomaly.
  Antimicrob Agents Chemother, 43, 2339-2344.  
15216882 K.H.Downing, and E.Nogales (1999).
Crystallographic structure of tubulin: implications for dynamics and drug binding.
  Cell Struct Funct, 24, 269-275.  
  10595546 K.Volz (1999).
A test case for structure-based functional assignment: the 1.2 A crystal structure of the yjgF gene product from Escherichia coli.
  Protein Sci, 8, 2428-2437.
PDB code: 1qu9
10074470 L.A.Amos, and J.Löwe (1999).
How Taxol stabilises microtubule structure.
  Chem Biol, 6, R65-R69.  
10690414 L.Rothfield, S.Justice, and J.García-Lara (1999).
Bacterial cell division.
  Annu Rev Genet, 33, 423-448.  
10580983 M.M.Heck (1999).
Dr. Dolittle and the making of the mitotic spindle.
  Bioessays, 21, 985-990.  
10545099 M.Yamazoe, T.Onogi, Y.Sunako, H.Niki, K.Yamanaka, T.Ichimura, and S.Hiraga (1999).
Complex formation of MukB, MukE and MukF proteins involved in chromosome partitioning in Escherichia coli.
  EMBO J, 18, 5873-5884.  
10449747 P.A.Levin, I.G.Kurtser, and A.D.Grossman (1999).
Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilis.
  Proc Natl Acad Sci U S A, 96, 9642-9647.  
10322543 R.G.Anthony, and P.J.Hussey (1999).
Dinitroaniline herbicide resistance and the microtubule cytoskeleton.
  Trends Plant Sci, 4, 112-116.  
  10464184 T.Den Blaauwen, N.Buddelmeijer, M.E.Aarsman, C.M.Hameete, and N.Nanninga (1999).
Timing of FtsZ assembly in Escherichia coli.
  J Bacteriol, 181, 5167-5175.  
10411886 X.Chen, D.L.Court, and X.Ji (1999).
Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif.
  Proc Natl Acad Sci U S A, 96, 8396-8401.
PDB code: 1ega
  10601211 X.Ma, and W.Margolin (1999).
Genetic and functional analyses of the conserved C-terminal core domain of Escherichia coli FtsZ.
  J Bacteriol, 181, 7531-7544.  
  9973366 Y.Ohashi, Y.Chijiiwa, K.Suzuki, K.Takahashi, H.Nanamiya, T.Sato, Y.Hosoya, K.Ochi, and F.Kawamura (1999).
The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.
  J Bacteriol, 181, 1348-1351.  
10611296 Z.Hu, A.Mukherjee, S.Pichoff, and J.Lutkenhaus (1999).
The MinC component of the division site selection system in Escherichia coli interacts with FtsZ to prevent polymerization.
  Proc Natl Acad Sci U S A, 96, 14819-14824.  
10209756 Z.Liu, A.Mukherjee, and J.Lutkenhaus (1999).
Recruitment of ZipA to the division site by interaction with FtsZ.
  Mol Microbiol, 31, 1853-1861.  
9722999 A.Desai, and T.J.Mitchison (1998).
Tubulin and FtsZ structures: functional and therapeutic implications.
  Bioessays, 20, 523-527.  
10447379 A.P.Pugsley, and T.J.Silhavy (1998).
Cell regulation: continually redefining the rules.
  Curr Opin Microbiol, 1, 141-144.  
  9841666 C.Goffin, and J.M.Ghuysen (1998).
Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs.
  Microbiol Mol Biol Rev, 62, 1079-1093.  
9605973 C.Lu, J.Stricker, and H.P.Erickson (1998).
FtsZ from Escherichia coli, Azotobacter vinelandii, and Thermotoga maritima--quantitation, GTP hydrolysis, and assembly.
  Cell Motil Cytoskeleton, 40, 71-86.  
9601632 D.M.Faguy, and W.F.Doolittle (1998).
Cytoskeletal proteins: the evolution of cell division.
  Curr Biol, 8, R338-R341.  
  9683493 D.Trusca, S.Scott, C.Thompson, and D.Bramhill (1998).
Bacterial SOS checkpoint protein SulA inhibits polymerization of purified FtsZ cell division protein.
  J Bacteriol, 180, 3946-3953.  
9628483 E.Nogales, K.H.Downing, L.A.Amos, and J.Löwe (1998).
Tubulin and FtsZ form a distinct family of GTPases.
  Nat Struct Biol, 5, 451-458.  
9704406 F.J.Kull, and R.J.Fletterick (1998).
Is the tubulin/FtsZ fold related to the G-protein fold?
  Trends Cell Biol, 8, 306-307.  
9742393 J.Lutkenhaus (1998).
Organelle division: from coli to chloroplasts.
  Curr Biol, 8, R619-R621.  
9914260 K.H.Downing, and E.Nogales (1998).
Tubulin structure: insights into microtubule properties and functions.
  Curr Opin Struct Biol, 8, 785-791.  
9821287 K.Mikulík (1998).
The role of GTP-binding proteins in mechanochemical movements of microorganisms and their potential to form filamentous structures.
  Folia Microbiol (Praha), 43, 339-352.  
9687500 K.Scheffzek, M.R.Ahmadian, L.Wiesmüller, W.Kabsch, P.Stege, F.Schmitz, and A.Wittinghofer (1998).
Structural analysis of the GAP-related domain from neurofibromin and its implications.
  EMBO J, 17, 4313-4327.
PDB code: 1nf1
10066635 K.W.Osteryoung, and K.A.Pyke (1998).
Plastid division: evidence for a prokaryotically derived mechanism.
  Curr Opin Plant Biol, 1, 475-479.  
9723913 L.Wang, and J.Lutkenhaus (1998).
FtsK is an essential cell division protein that is localized to the septum and induced as part of the SOS response.
  Mol Microbiol, 29, 731-740.  
  9603865 L.Wang, M.K.Khattar, W.D.Donachie, and J.Lutkenhaus (1998).
FtsI and FtsW are localized to the septum in Escherichia coli.
  J Bacteriol, 180, 2810-2816.  
9628027 M.Heinlein, M.R.Wood, T.Thiel, and R.N.Beachy (1998).
Targeting and modification of prokaryotic cell-cell junctions by tobacco mosaic virus cell-to-cell movement protein.
  Plant J, 14, 345-351.  
10066540 P.A.Levin, and A.D.Grossman (1998).
Cell cycle and sporulation in Bacillus subtilis.
  Curr Opin Microbiol, 1, 630-635.  
  9811667 P.A.Levin, J.J.Shim, and A.D.Grossman (1998).
Effect of minCD on FtsZ ring position and polar septation in Bacillus subtilis.
  J Bacteriol, 180, 6048-6051.  
  9841676 P.Giesbrecht, T.Kersten, H.Maidhof, and J.Wecke (1998).
Staphylococcal cell wall: morphogenesis and fatal variations in the presence of penicillin.
  Microbiol Mol Biol Rev, 62, 1371-1414.  
  9555885 Q.Sun, and W.Margolin (1998).
FtsZ dynamics during the division cycle of live Escherichia coli cells.
  J Bacteriol, 180, 2050-2056.  
9720867 Q.Sun, X.C.Yu, and W.Margolin (1998).
Assembly of the FtsZ ring at the central division site in the absence of the chromosome.
  Mol Microbiol, 29, 491-503.  
9675800 W.Margolin (1998).
A green light for the bacterial cytoskeleton.
  Trends Microbiol, 6, 233-238.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

spacer

spacer