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269 a.a.
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99 a.a.
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205 a.a.
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* Residue conservation analysis
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PDB id:
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Complex (receptor/immunoglobulin)
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Title:
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Crystal structure of the complex of rat neonatal fc receptor with fc
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Structure:
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Neonatal fc receptor. Chain: a. Engineered: yes. Beta 2-microglobulin. Chain: b. Engineered: yes. Igg fc. Chain: c. Engineered: yes
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Source:
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Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: serum (mixture of several subtypes). Gene: beta-2-microglobulin. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho.
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Biol. unit:
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Tetramer (from
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Resolution:
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Authors:
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W.P.Burmeister,P.J.Bjorkman
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Key ref:
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W.P.Burmeister
et al.
(1994).
Crystal structure of the complex of rat neonatal Fc receptor with Fc.
Nature,
372,
379-383.
PubMed id:
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Date:
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11-Nov-94
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Release date:
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14-Feb-95
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PROCHECK
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Headers
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References
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P13599
(FCGRN_RAT) -
IgG receptor FcRn large subunit p51 from Rattus norvegicus
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Seq:
Struc:
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366 a.a.
269 a.a.
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Nature
372:379-383
(1994)
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PubMed id:
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Crystal structure of the complex of rat neonatal Fc receptor with Fc.
|
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W.P.Burmeister,
A.H.Huber,
P.J.Bjorkman.
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ABSTRACT
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The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to
the bloodstream of the newborn. FcRn is structurally similar to class I major
histocompatibility complex (MHC) molecules, despite differences in the ligands
they bind (the Fc portion of IgG and antigenic peptides, respectively). A
low-resolution crystal structure of the complex between FcRn and Fc localizes
the binding site for Fc to the side of FcRn, distinct from the tops of the alpha
1 and alpha 2 domains which serve as the peptide and T-cell receptor binding
sites in class I molecules. FcRn binds to Fc at the interface between the Fc CH2
and CH3 domains, which contains several histidine residues that could account
for the sharply pH-dependent FcRn/IgG interaction. A dimer of FcRn heterodimers
observed in the co-crystals and in the crystals of FcRn alone could be involved
in binding Fc, correlating with the 2:1 binding stoichiometry between FcRn and
IgG (ref. 4) and suggesting an unusual orientation of FcRn on the membrane.
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Literature references that cite this PDB file's key reference
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| |
PubMed id
|
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Reference
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|
|
|
|
A.W.Barb,
and
J.H.Prestegard
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NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic.
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(2011).
Field flow fractionation for assessing neonatal Fc receptor and Fcγ receptor binding to monoclonal antibodies in solution.
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Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection.
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Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.
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| |
J Mol Biol,
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|
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PDB codes:
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|
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|
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H.Pan,
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Semin Immunopathol,
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The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.
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J Cell Biol,
185,
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|
|
|
T.T.Kuo,
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T.Nagaishi,
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(2009).
N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.
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| |
J Biol Chem,
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|
|
|
Y.He,
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Nanogold as a specific marker for electron cryotomography.
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Z.Khan,
A.Forster,
and
L.C.James
(2008).
TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
|
| |
Proc Natl Acad Sci U S A,
105,
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|
|
|
PDB codes:
|
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|
|
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|
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J.T.Andersen,
S.Justesen,
B.Fleckenstein,
T.E.Michaelsen,
G.Berntzen,
V.E.Kenanova,
M.B.Daba,
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S.Buus,
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Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues.
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N.E.Simister,
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Identification and characterization of an alternatively spliced variant of the MHC class I-related porcine neonatal Fc receptor for IgG.
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32,
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|
|
|
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Z.Li,
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N.K.Nanda,
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S.K.Samal,
and
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(2008).
The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments.
|
| |
J Immunol,
181,
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|
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H.Mojidi,
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Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG.
|
| |
J Immunol,
181,
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L.M.Pop,
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J.Watkins,
and
V.J.Wroblewski
(2007).
Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor.
|
| |
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282,
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|
|
D.C.Roopenian,
and
S.Akilesh
(2007).
FcRn: the neonatal Fc receptor comes of age.
|
| |
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7,
715-725.
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and
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(2007).
Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.
|
| |
Proc Natl Acad Sci U S A,
104,
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PDB code:
|
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|
|
|
|
|
|
J.Chen,
M.Chloupková,
J.Gao,
T.L.Chapman-Arvedson,
and
C.A.Enns
(2007).
HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions.
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282,
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J.D.Fraser,
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(2007).
Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1.
|
| |
Proc Natl Acad Sci U S A,
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|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.W.Qiao,
W.I.Lencer,
and
R.S.Blumberg
(2007).
How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis.
|
| |
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120,
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J.Q.Yang,
D.C.Roopenian,
and
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(2007).
NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences.
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| |
J Immunol,
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|
D.B.Tesar,
N.E.Tiangco,
and
P.J.Bjorkman
(2006).
Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor.
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| |
Traffic,
7,
1127-1142.
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S.E.Martin,
Q.Sun,
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A synthetic mimic of human Fc receptors: defined chemical modification of cell surfaces enables efficient endocytic uptake of human immunoglobulin-G.
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128,
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B.Tidor,
and
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Quantitative methods for developing Fc mutants with extended half-lives.
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Ann Biomed Eng,
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Recognition of the tryptophan-based endocytosis signal in the neonatal Fc Receptor by the mu subunit of adaptor protein-2.
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PDB code:
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P.J.Esteves,
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| |
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PDB codes:
|
|
|
|
|
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|
|
A.P.West,
and
P.J.Bjorkman
(2000).
Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,).
|
| |
Biochemistry,
39,
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|
PDB code:
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The unfolding/denaturation of immunogammaglobulin of isotype 2b and its F(ab) and F(c) fragments.
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(2000).
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and
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(2000).
CD1, tuberculosis, and the evolution of major histocompatibility complex molecules.
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(2000).
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| |
Immunology,
100,
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and
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(2000).
HFE--a novel nonclassical class I molecule that is involved in iron metabolism.
|
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13,
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V.Ghetie,
and
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(2000).
Multiple roles for the major histocompatibility complex class I- related receptor FcRn.
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| |
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18,
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W.L.DeLano,
M.H.Ultsch,
A.M.de Vos,
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(2000).
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PDB code:
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I.A.Wilson,
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EMBO J,
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PDB code:
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T.L.Chapman,
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Structural basis of pH-dependent antibody binding by the neonatal Fc receptor.
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Structure,
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PDB code:
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I.A.Wilson,
and
P.J.Bjorkman
(1998).
Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs.
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Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.
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Cell,
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PDB code:
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L.J.Harris,
S.B.Larson,
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High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors.
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J Biol Chem,
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Expression, purification, crystallization and crystallographic characterization of the human MHC class I related protein MICA.
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Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction.
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Nat Struct Biol,
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PDB code:
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A.Tamm,
and
R.E.Schmidt
(1997).
IgG binding sites on human Fc gamma receptors.
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and
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Biochemistry,
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J.V.Ravetch
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K.W.Hasel,
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(1997).
Refined structure of an intact IgG2a monoclonal antibody.
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Biochemistry,
36,
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PDB code:
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L.Riechmann,
and
P.Holliger
(1997).
Antibodies live long and prosper.
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Nat Biotechnol,
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M.Daëron
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Annu Rev Immunol,
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Structural bases of Fc gamma R functions.
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Int Rev Immunol,
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D.M.Davis,
L.Pazmany,
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The binding site of NK receptors on HLA-C molecules.
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Immunity,
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R.P.Junghans,
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(1997).
Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG.
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Increasing the serum persistence of an IgG fragment by random mutagenesis.
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Beta2-microglobulin-deficient mice are resistant to bullous pemphigoid.
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J Exp Med,
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Localization of the site of the IgG molecule that regulates maternofetal transmission in mice.
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W.R.Hein,
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The sheep CD1 gene family contains at least four CD1B homologues.
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Co-localization of beta 2-microglobulin and IgG in human placental syncytiotrophoblasts.
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The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.
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Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice.
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Effects of receptor dimerization on the interaction between the class I major histocompatibility complex-related Fc receptor and IgG.
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Structures of two classes of MHC molecules elucidated: crucial differences and similarities.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
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only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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