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PDBsum entry 1fdh
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protein ligands Protein-protein interface(s) links
Oxygen transport PDB id
1fdh

 

 

 

 

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Contents
Protein chains
141 a.a. *
147 a.a. *
Ligands
HEM ×4
* Residue conservation analysis
PDB id:
1fdh
Name: Oxygen transport
Title: Structure of human foetal deoxyhaemoglobin
Structure: Hemoglobin f (deoxy) (alpha chain). Chain: a, b. Engineered: yes. Hemoglobin f (deoxy) (gamma chain). Chain: g, h. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Biol. unit: Tetramer (from PQS)
Resolution:
2.50Å     R-factor:   not given    
Authors: J.A.Frierjunior
Key ref: J.A.Frier and M.F.Perutz (1977). Structure of human foetal deoxyhaemoglobin. J Mol Biol, 112, 97. PubMed id: 881729
Date:
18-Aug-76     Release date:   19-Aug-76    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P69905  (HBA_HUMAN) -  Hemoglobin subunit alpha from Homo sapiens
Seq:
Struc: 		142 a.a.
141 a.a.
Protein chains
Pfam   ArchSchema ?
P69892  (HBG2_HUMAN) -  Hemoglobin subunit gamma-2 from Homo sapiens
Seq:
Struc: 		147 a.a.
146 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
J Mol Biol 112:97 (1977)
PubMed id: 881729  
 
 
Structure of human foetal deoxyhaemoglobin.
J.A.Frier, M.F.Perutz.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21561349 M.A.Crowley, T.L.Mollan, O.Y.Abdulmalik, A.D.Butler, E.F.Goodwin, A.Sarkar, C.A.Stolle, A.J.Gow, J.S.Olson, and M.J.Weiss (2011).
A hemoglobin variant associated with neonatal cyanosis and anemia.
  N Engl J Med, 364, 1837-1843.  
20119626 J.Zhang, Q.Liu, W.Zhang, J.Li, Z.Li, Z.Tang, Y.Li, C.Han, S.H.Hall, and Y.Zhang (2010).
Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides.
  Acta Biochim Biophys Sin (Shanghai), 42, 145-153.  
20637064 K.L.Campbell, J.F.Storz, A.V.Signore, H.Moriyama, K.C.Catania, A.P.Payson, J.Bonaventura, J.Stetefeld, and R.E.Weber (2010).
Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole.
  BMC Evol Biol, 10, 214.  
20519321 T.Shibata, S.Nagao, H.Tai, S.Nagatomo, H.Hamada, H.Yoshikawa, A.Suzuki, and Y.Yamamoto (2010).
Characterization of the acid-alkaline transition in the individual subunits of human adult and foetal methaemoglobins.
  J Biochem, 148, 217-229.  
18379999 L.Manca, and B.Masala (2008).
Disorders of the synthesis of human fetal hemoglobin.
  IUBMB Life, 60, 94.  
12095481 T.Brittain (2002).
Molecular aspects of embryonic hemoglobin function.
  Mol Aspects Med, 23, 293-342.  
11742119 T.Yagami, B.T.Ballard, J.C.Padovan, B.T.Chait, A.M.Popowicz, and J.M.Manning (2002).
N-terminal contributions of the gamma-subunit of fetal hemoglobin to its tetramer strength: remote effects at subunit contacts.
  Protein Sci, 11, 27-35.  
11327822 L.R.Manning, and J.M.Manning (2001).
The acetylation state of human fetal hemoglobin modulates the strength of its subunit interactions: long-range effects and implications for histone interactions in the nucleosome.
  Biochemistry, 40, 1635-1639.  
11389734 M.Pellegrini, M.Corda, L.Manca, A.Olianas, M.T.Sanna, A.Fais, M.C.De Rosa, C.Bertonati, B.Masala, and B.Giardina (2001).
Functional and computer modelling studies of haemoglobin from horse. The haemoglobin system of the Sardinian wild dwarf horse.
  Eur J Biochem, 268, 3313-3320.  
11375530 R.D.Kidd, A.Mathews, H.M.Baker, T.Brittain, and E.N.Baker (2001).
Subunit dissociation and reassociation leads to preferential crystallization of haemoglobin Bart's (gamma4) from solutions of human embryonic haemoglobin Portland (zeta2gamma2) at low pH.
  Acta Crystallogr D Biol Crystallogr, 57, 921-924.  
11514664 R.D.Kidd, H.M.Baker, A.J.Mathews, T.Brittain, and E.N.Baker (2001).
Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia.
  Protein Sci, 10, 1739-1749.
PDB codes: 1i3d 1i3e
11304673 I.Hamachi, J.I.Watanabe, R.Eboshi, T.Hiraoka, and S.Shinkai (2000).
Incorporation of artificial receptors into a protein/peptide surface: a strategy for on/off type of switching of semisynthetic enzymes.
  Biopolymers, 55, 459-468.  
10713517 T.H.Lu, K.Panneerselvam, Y.C.Liaw, P.Kan, and C.J.Lee (2000).
Structure determination of porcine haemoglobin.
  Acta Crystallogr D Biol Crystallogr, 56, 304-312.
PDB code: 1qpw
10736177 W.Chen, A.Dumoulin, X.Li, J.C.Padovan, B.T.Chait, R.Buonopane, O.S.Platt, L.R.Manning, and J.M.Manning (2000).
Transposing sequences between fetal and adult hemoglobins indicates which subunits and regulatory molecule interfaces are functionally related.
  Biochemistry, 39, 3774-3781.  
10366844 J.M.Manning, A.Dumoulin, L.R.Manning, W.Chen, J.C.Padovan, B.T.Chait, and A.Popowicz (1999).
Remote contributions to subunit interactions: lessons from adult and fetal hemoglobins.
  Trends Biochem Sci, 24, 211-212.  
9857036 A.Dumoulin, J.C.Padovan, L.R.Manning, A.Popowicz, R.M.Winslow, B.T.Chait, and J.M.Manning (1998).
The N-terminal sequence affects distant helix interactions in hemoglobin. Implications for mutant proteins from studies on recombinant hemoglobin felix.
  J Biol Chem, 273, 35032-35038.  
9677349 J.M.Manning, A.Dumoulin, X.Li, and L.R.Manning (1998).
Normal and abnormal protein subunit interactions in hemoglobins.
  J Biol Chem, 273, 19359-19362.  
9395461 A.Dumoulin, L.R.Manning, W.T.Jenkins, R.M.Winslow, and J.M.Manning (1997).
Exchange of subunit interfaces between recombinant adult and fetal hemoglobins. Evidence for a functional inter-relationship among regions of the tetramer.
  J Biol Chem, 272, 31326-31332.  
8962033 T.L.Blundell, and N.Srinivasan (1996).
Symmetry, stability, and dynamics of multidomain and multicomponent protein systems.
  Proc Natl Acad Sci U S A, 93, 14243-14248.  
1617142 X.Q.Mu, and B.M.Fairchild (1992).
Computer models of a new deoxy-sickle cell hemoglobin fiber based on x-ray diffraction data.
  Biophys J, 61, 1638-1646.  
2017435 A.P.Korn, and R.M.Burnett (1991).
Distribution and complementarity of hydropathy in multisubunit proteins.
  Proteins, 9, 37-55.  
2107323 M.S.Johnson, M.J.Sutcliffe, and T.L.Blundell (1990).
Molecular anatomy: phyletic relationships derived from three-dimensional structures of proteins.
  J Mol Evol, 30, 43-59.  
6572894 D.J.Abraham, M.F.Perutz, and S.E.Phillips (1983).
Physiological and x-ray studies of potential antisickling agents.
  Proc Natl Acad Sci U S A, 80, 324-328.  
34149 B.Magdoff-Fairchild, and C.C.Chiu (1979).
X-ray diffraction studies of fibers and crystals of deoxygenated sickle cell hemoglobin.
  Proc Natl Acad Sci U S A, 76, 223-226.  
284392 R.L.Nagel, R.M.Bookchin, J.Johnson, D.Labie, H.Wajcman, W.A.Isaac-Sodeye, G.R.Honig, G.Schilirò, J.H.Crookston, and K.Matsutomo (1979).
Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S.
  Proc Natl Acad Sci U S A, 76, 670-672.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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